4,679 research outputs found
Finite-temperature scalar fields and the cosmological constant in an Einstein universe
We study the back reaction effect of massless minimally coupled scalar field
at finite temperatures in the background of Einstein universe. Substituting for
the vacuum expectation value of the components of the energy-momentum tensor on
the RHS of the Einstein equation, we deduce a relationship between the radius
of the universe and its temperature. This relationship exhibit a maximum
temperature, below the Planck scale, at which the system changes its behaviour
drastically. The results are compared with the case of a conformally coupled
field. An investigation into the values of the cosmological constant exhibit a
remarkable difference between the conformally coupled case and the minimally
coupled one.Comment: 7 pages, 2 figure
Revisiting the Training of Logic Models of Protein Signaling Networks with a Formal Approach based on Answer Set Programming
A fundamental question in systems biology is the construction and training to
data of mathematical models. Logic formalisms have become very popular to model
signaling networks because their simplicity allows us to model large systems
encompassing hundreds of proteins. An approach to train (Boolean) logic models
to high-throughput phospho-proteomics data was recently introduced and solved
using optimization heuristics based on stochastic methods. Here we demonstrate
how this problem can be solved using Answer Set Programming (ASP), a
declarative problem solving paradigm, in which a problem is encoded as a
logical program such that its answer sets represent solutions to the problem.
ASP has significant improvements over heuristic methods in terms of efficiency
and scalability, it guarantees global optimality of solutions as well as
provides a complete set of solutions. We illustrate the application of ASP with
in silico cases based on realistic networks and data
Enabling Proactive Adaptation through Just-in-time Testing of Conversational Services
Service-based applications (SBAs) will increasingly be composed of third-party services available over the Internet. Reacting to failures of those third-party services by dynamically adapting the SBAs will become a key enabler for ensuring reliability. Determining when to adapt an SBA is especially challenging in the presence of conversational (aka. stateful) services. A conversational service might fail in the middle of an invocation sequence, in which case adapting the SBA might be costly; e.g., due to the necessary state transfer to an alternative service. In this paper we propose just-in-time testing of conversational services as a novel approach to detect potential problems and to proactively trigger adaptations, thereby preventing costly compensation activities. The approach is based on a framework for online testing and a formal test-generation method which guarantees functional correctness for conversational services. The applicability of the approach is discussed with respect to its underlying assumptions and its performance. The benefits of the approach are demonstrated using a realistic example
Using EcoYieldSAFE to compare soil carbon dynamics under future climate in two contrasting agroforestry systems
N/
Hepatic progenitor cells from adult human livers for cell transplantation.
Objective: Liver regeneration is mainly based on cellular
self-renewal including progenitor cells. Efforts have been
made to harness this potential for cell transplantation, but
shortage of hepatocytes and premature differentiated
progenitor cells from extra-hepatic organs are limiting
factors. Histological studies implied that resident cells in
adult liver can proliferate, have bipotential character and
may be a suitable source for cell transplantation.
Methods: Particular cell populations were isolated after
adequate tissue dissociation. Single cell suspensions were
purified by Thy-1 positivity selection, characterised in vitro
and transplanted in immunodeficient Pfp/Rag2 mice.
Results: Thy-1+ cells that are mainly found in the portal
tract and the surrounding parenchyma, were isolated from
surgical liver tissue with high yields from specimens with
histological signs of regeneration. Thy-1+ cell populations
were positive for progenitor (CD34, c-kit, CK14, M2PK,
OV6), biliary (CK19) and hepatic (HepPar1) markers
revealing their progenitor as well as hepatic and biliary
nature. The potential of Thy-1+ cells for differentiation in
vitro was demonstrated by increased mRNA and protein
expression for hepatic (CK18, HepPar1) and biliary (CK7)
markers during culture while progenitor markers CK14,
chromogranin A and nestin were reduced. After
transplantation of Thy-1+ cells into livers of immunodeficient
mice, engraftment was predominantly seen in the
periportal portion of the liver lobule. Analysis of in situ
material revealed that transplanted cells express human
hepatic markers HepPar1 and albumin, indicating functional
engraftment.
Conclusion: Bipotential progenitor cells from human
adult livers can be isolated using Thy-1 and might be a
potential candidate for cell treatment in liver diseases
Thermodynamic Derivation of the Tsallis and R\'enyi Entropy Formulas and the Temperature of Quark-Gluon Plasma
We derive Tsallis entropy, Sq, from universal thermostat independence and
obtain the functional form of the corresponding generalized entropy-probability
relation. Our result for finite thermostats interprets thermodynamically the
subsystem temperature, T1, and the index q in terms of the temperature, T,
entropy, S, and heat capacity, C of the reservoir as T1 = T exp(-S/C) and q = 1
- 1/C. In the infinite C limit, irrespective to the value of S, the
Boltzmann-Gibbs approach is fully recovered. We apply this framework for the
experimental determination of the original temperature of a finite thermostat,
T, from the analysis of hadron spectra produced in high energy collisions, by
analyzing frequently considered simple models of the quark-gluon plasma.Comment: 4 pages 1 Figure PRL style, revised presentatio
Jordan-Wigner approach to dynamic correlations in spin-ladders
We present a method for studying the excitations of low-dimensional quantum
spin systems based on the Jordan-Wigner transformation. Using an extended
RPA-scheme we calculate the correlation function of neighboring spin flips
which well approximates the optical conductivity of . We
extend this approach to the two-leg --ladder by numbering the spin
operators in a meander-like sequence. We obtain good agreement with the optical
conductivity of the spin ladder compound (La,Ca)CuO for
polarization along the rungs. For polarization along the legs higher order
correlations are important to explain the weight of high-energy continuum
excitations and we estimate the contribution of 4-- and 6--fermion processes.Comment: 15 pages, 16 figure
Observation of diffractive orbits in the spectrum of excited NO in a magnetic field
We investigate the experimental spectra of excited NO molecules in the
diamagnetic regime and develop a quantitative semiclassical framework to
account for the results. We show the dynamics can be interpreted in terms of
classical orbits provided that in addition to the geometric orbits, diffractive
effects are appropriately taken into account. We also show how individual
orbits can be extracted from the experimental signal and use this procedure to
reveal the first experimental manifestation of inelastic diffractive orbits.Comment: 4 fig
Case studies
In this chapter, case studies are used as examples of how to gain a better understanding of the risks posed by extreme weather and climate-related events while identifying lessons and best practices from past responses to such occurrences. Using the information in Chapters 1 to 8, it was possible to focus on particular examples to reflect the needs of the whole Special Report. The chosen case studies are illustrative of an important range of disaster risk reduction, disaster risk management, and climate change adaptation issues. They are grouped to examine representative types of extreme events, vulnerable regions, and methodological approaches
Consequences of temperature fluctuations in observables measured in high energy collisions
We review the consequences of intrinsic, nonstatistical temperature
fluctuations as seen in observables measured in high energy collisions. We do
this from the point of view of nonextensive statistics and Tsallis
distributions. Particular attention is paid to multiplicity fluctuations as a
first consequence of temperature fluctuations, to the equivalence of
temperature and volume fluctuations, to the generalized thermodynamic
fluctuations relations allowing us to compare fluctuations observed in
different parts of phase space, and to the problem of the relation between
Tsallis entropy and Tsallis distributions. We also discuss the possible
influence of conservation laws on these distributions and provide some examples
of how one can get them without considering temperature fluctuations.Comment: Revised version of the invited contribution to The European Physical
Journal A (Hadrons and Nuclei) topical issue about 'Relativistic Hydro- and
Thermodynamics in Nuclear Physics' guest eds. Tamas S. Biro, Gergely G.
Barnafoldi and Peter Va
- …