Correlation between aerobic threshold and cardiopulmonary response to exercise onset in patients with myocardial infarction

Purpose: This study aimed to identify the correlation between aerobic threshold (AT) and cardiopulmonary response at the start of exercise in patients with myocardial infarction (MI). Subjects and Methods: Thirty-one male patients with MI underwent a sub-maximal cardiopulmonary exercise test with expiratory gas analysis to determine their peak oxygen uptake (V̇O₂) level, using Ramp protocol. Results: The patients demonstrated an extended time constant (TC) and decline in AT in this study. Extended TC suggested impaired cardiac function due to reduced left ventricular ejection fraction (LVEF), as well as an LVEF of 59.8% on average. However, there was no significant correlation between TC and AT. Pearson product-moment correlation coefficients were 0.56 between AT and area under the oxygen uptake curve (V̇O₂AUC), -0.22 between TC and V̇O₂AUC, and -0.23 between AT and TC. Conclusion: V̇O₂AUC is representative of oxygen utilization and is correlated with AT in patients with MI.首都大学東京学位論文 乙第192号 副論

心機能低下を伴う心不全例における嫌気性代謝閾値の予測因子

首都大学東京, 2019-03-25, 博士（理学療法学）, 乙第192号首都大学東

Highly planar diarylamine-fused porphyrins and their remarkably stable radical cations

Oxidative fusion reactions of meso-phenoxazino Ni(II) porphyrin were found to be temperature dependent, giving rise to either a doubly phenylene-fused product at room temperature or a singly phenoxazine-fused product at 70 °C. The latter was further oxidized to a doubly phenoxazine-fused Ni(II) porphyrin, which was subsequently converted to the corresponding free base porphyrin and Zn(II) porphyrin. Compared to previously reported diphenylamine-fused porphyrins that displayed a molecular twist, doubly phenoxazine-fused porphyrins exhibited distinctly different properties owing to their highly planar structures, such as larger fluorescence quantum yields, formation of an offset face-to-face dimer both in solution and the solid state, and the generation of a mixed-valence π-radical cation dimer upon electrochemical oxidation. One-electron oxidation of the phenoxazine-fused Ni(II) porphyrin with Magic Blue gave the corresponding radical cation, which was certainly stable and could be isolated by separation over a silica gel column but slowly chlorinated at the reactive β-positions in the solid state. This finding led to us to examine β, β′-dichlorinated phenoxazine-fused and diphenylamine-fused Ni(II) porphyrins, which, upon treatment with Magic Blue, provided remarkably stable radical cations to an unprecedented level. It is actually possible to purify these radical cations by silica gel chromatography, and they can be stored for over 6 months without any sign of deterioration. Moreover, they exhibited no degradation even after the CH2Cl2 solution was washed with water. However, subtle structural differences (planar versus partly twisted) led to different crystal packing structures and solid-state magnetic properties