Stokes方程式とNavier-Stokes方程式における動的特異点

早大学位記番号:新9236博士（理学）早稲田大

Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal

Fibroblast-like synoviocytes (FLS) are joint-lining cells that promote rheumatoid arthritis (RA) pathology. Current disease-modifying antirheumatic agents (DMARDs) operate through systemic immunosuppression. FLS-targeted approaches could potentially be combined with DMARDs to improve control of RA without increasing immunosuppression. Here, we assessed the potential of immunoglobulin-like domains 1 and 2 (Ig1&2), a decoy protein that activates the receptor tyrosine phosphatase sigma (PTPRS) on FLS, for RA therapy. We report that PTPRS expression is enriched in synovial lining RA FLS and that Ig1&2 reduces migration of RA but not osteoarthritis FLS. Administration of an Fc-fusion Ig1&2 attenuated arthritis in mice without affecting innate or adaptive immunity. Furthermore, PTPRS was down-regulated in FLS by tumor necrosis factor (TNF) via a phosphatidylinositol 3-kinase–mediated pathway, and TNF inhibition enhanced PTPRS expression in arthritic joints. Combination of ineffective doses of TNF inhibitor and Fc-Ig1&2 reversed arthritis in mice, providing an example of synergy between FLS-targeted and immunosuppressive DMARD therapies.publishedVersio

Automatic Detection of Facial Midline And Its Contributions To Facial Feature Extraction

We propose a novel approach for detection of the facial midline from a frontal face image. Using midline as a guide reduces computational cost required for facial feature extraction (FFE) because the midline is capable of restricting multi-dimensional searching process into one-dimensional search. The proposed method detects the facial midline from an edge image as the symmetry axis using the generalized Hough transformation. Experimental results on the FERET database indicate that the proposed algorithm can accurately detect facial midlines over many different scales and rotation. The total computational time for facial feature extraction has been reduced by a factor of 280 using the midline detected by this method