Full-wave simulations on ultrashort-pulse reflectometry for helical plasmas

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Determining the 7Li(n,gamma) cross section via Coulomb dissociation of 8Li

The applicability of Coulomb dissociation reactions to determine the cross section for the inverse neutron capture reaction was explored using the reaction 8Li(gamma,n)7Li. A 69.5 MeV/nucleon 8Li beam was incident on a Pb target, and the outgoing neutron and 7Li nucleus were measured in coincidence. The deduced (n,gamma) excitation function is consistent with data for the direct capture reaction 7Li(n,gamma)8Li and with low-energy effective field theory calculations.Comment: Accepted for publication in Phys. Rev.

βdecay of the 21/2^+ isomer in ^<93>Mo and level structure of ^<93>Nb

The γ rays associated with β decay of the 21/2^+ isomer in ^Mo (Ex=2.425 MeV, T_=6.85 h) were measured with a selective sensitivity to long-lived isomer decays. A new 1262-keV transition was found in the γ-γ coincidence measurement, and it was attributed to a transition in ^Nb, which is the daughter nucleus of the β decay of the ^Mo isomer, from the 2.753- to the 1.491-MeV levels. Accurate γ-ray intensity balances have determined the β-decay intensity from the ^Mo isomer to the 2.753-MeV level in ^Nb and placed no appreciable intensity for the previously reported β-decay branching to the 2.180-MeV level, for which a recent in-beam γ-ray experiment assigned to be I^π = 17/2^-. Based on the γ-ray intensities from the 2.753-MeV level, spin-parity assignment of this level was revised from 21/2^+ to 19/2^+. The observed β-decay intensity and the spin-parity assignment were explained by the jj-coupling shell model calculations

TGF-beta(2)- and H2O2-Induced Biological Changes in Optic Nerve Head Astrocytes Are Reduced by the Antioxidant Alpha-Lipoic Acid

Background/Aims: The goal of the present study was to determine whether transforming growth factor-beta(2) (TGF-beta(2))- and oxidative stress-induced cellular changes in cultured human optic nerve head (ONH) astrocytes could be reduced by pretreatment with the antioxidant alpha-lipoic acid (LA). Methods: Cultured ONH astrocytes were treated with 1.0 ng/ml TGF-beta(2) for 24 h or 200 mu M hydrogen peroxide (H2O2) for 1 h. Lipid peroxidation was measured by a decrease in cis-pari-naric acid fluorescence. Additionally, cells were pretreated with different concentrations of LA before TGF-beta 2 or H2O2 exposure. Expressions of the heat shock protein (Hsp) alpha B-crystallin and Hsp27, the extracellular matrix (ECM) component fibronectin and the ECM-modulating protein connective tissue growth factor (CTGF) were examined with immunohistochemistry and real-time PCR analysis. Results: Both TGF-beta(2) and H2O2 increased lipid peroxidation. Treatment of astrocytes with TGF-beta(2) and H2O2 upregulated the expression of alpha B-crystallin, Hsp27, fibronectin and CTGF. Pretreatment with different concentrations of LA reduced the TGF-beta(2)- and H2O2-stimulated gene expressions. Conclusion: We showed that TGF-beta(2)- and H2O2-stimulated gene expressions could be prevented by pretreatment with the antioxidant LA in cultured human ONH astrocytes. Therefore, it is tempting to speculate that the use of antioxidants could have protective effects in glaucomatous optic neuropathy. Copyright (C) 2012 S. Karger AG, Base

ナンキョク ケンキュウ カガク イインカイ ノ レンゾク プランクトン サイシュウキ センモンカ グループ ワークショップ ホウコク

2010年11月22-26日に国立極地研究所にて「南極研究科学委員会(以下SCAR)連続プランクトン採集器(以下CPR)専門家グループワークショップ」を開催した.4カ国から12名が参加し,南大洋CPR観測実務担当者の間で,観測データの品質管理,種同定やデータ分析手法の再確認,及び今後の活動についての詳細な討議を行った.前半は文献資料及び顕微鏡観察を通して,動物プランクトンの分類群ごとに種同定の情報交換及び具体的な分類カテゴリーの統一を図った.まとめられた種同定基準を用いて新たにマニュアルを作成することとなった.後半はデータ分析手法とデータマネージメント,さらには将来的な観測計画を確認した.今後,定期的にワークショップを開催し,各国間で統一された試料処理及びデータ管理を維持していくことで合意した."Southern Ocean Continuous Plankton Recorder (SO-CPR) Standards Workshop: SCAR Expert Group on CPR Research" was held at the National Institute of Polar Research (NIPR) on 22-26 November 2011. Twelve participants from four countries attended. The purposes of the workshop were to ensure that consistent and high standards of species identification, methodology, and data quality were being maintained amongst all participants and laboratories in the SO-CPR survey, and to discuss future contributions of the SO-CPR program to a global CPR network. The first three and a half days of the workshop were focused on assessing the accuracy and consistency of species identifications. We concluded that our species identifications and procedures are accurate and uniform, and that the SO-CPR database is of the highest possible standard. Certain taxonomic criteria developed at the workshop will be described in a new laboratory procedures manual. Four major gaps in the database (spatial, temporal, taxonomic, and data analysis gaps) were identified and discussed. Participants concurred that there should be more regular workshops to ensure that the high standards of the SO-CPR program are maintained

Super-long Anabiosis of Ancient Microorganisms in Ice and Terrestrial Models for Development of Methods to Search for Life on Mars, Europa and other Planetary Bodies

Successful missions to Mars, Europe and other bodies of the Solar system have created a prerequisite to search for extraterrestrial life. The first attempts of microbial life detection on the Martian surface by the Viking landed missions gave no biological results. Microbiological investigations of the Martian subsurface ground ice layers seem to be more promising. It is well substantiated to consider the Antarctic ice sheet and the Antarctic and Arctic permafrost as terrestrial analogues of Martian habitats. The results of our long-standing microbiological studies of the Antarctic ice would provide the basis for detection of viable microbial cells on Mars. Our microbiological investigations of the deepest and thus most ancient strata of the Antarctic ice sheet for the first time gave evidence for the natural phenomenon of long-term anabiosis (preservation of viability and vitality for millennia years). A combination of classical microbiological methods, epifluorescence microscopy, SEM, TEM, molecular diagnostics, radioisotope labeling and other techniques made it possible for us to obtain convincing proof of the presence of pro- and eukaryotes in the Antarctic ice sheet. In this communication, we will review and discuss some critical issues related to the detection of viable microorganisms in cold terrestrial environments with regard to future searches for microbial life and/or its biological signatures on extraterrestrial objects

A public dataset of running biomechanics and the effects of running speed on lower extremity kinematics and kinetics Reginaldo K Fukuchi

View the peer-reviewed version (peerj.com/articles/3298), which is the preferred citable publication unless you specifically need to cite this preprint

Large-scale comparative genomic ranking of taxonomically restricted genes (TRGs) in bacterial and archaeal genomes

BACKGROUND: Lineage-specific, or taxonomically restricted genes (TRGs), especially those that are species and strain-specific, are of special interest because they are expected to play a role in defining exclusive ecological adaptations to particular niches. Despite this, they are relatively poorly studied and little understood, in large part because many are still orphans or only have homologues in very closely related isolates. This lack of homology confounds attempts to establish the likelihood that a hypothetical gene is expressed and, if so, to determine the putative function of the protein. METHODOLOGY/PRINCIPAL FINDINGS: We have developed "QIPP" ("Quality Index for Predicted Proteins"), an index that scores the "quality" of a protein based on non-homology-based criteria. QIPP can be used to assign a value between zero and one to any protein based on comparing its features to other proteins in a given genome. We have used QIPP to rank the predicted proteins in the proteomes of Bacteria and Archaea. This ranking reveals that there is a large amount of variation in QIPP scores, and identifies many high-scoring orphans as potentially "authentic" (expressed) orphans. There are significant differences in the distributions of QIPP scores between orphan and non-orphan genes for many genomes and a trend for less well-conserved genes to have lower QIPP scores. CONCLUSIONS: The implication of this work is that QIPP scores can be used to further annotate predicted proteins with information that is independent of homology. Such information can be used to prioritize candidates for further analysis. Data generated for this study can be found in the OrphanMine at http://www.genomics.ceh.ac.uk/orphan_mine