39,511 research outputs found

    Theory of resonant spin Hall effect

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    A biref review is presented on resonant spin Hall effect, where a tiny external electric field induces a saturated spin Hall current in a 2-dimensional electron or hole gas in a perpendicular magnetic field. The phenomenon is attributted to the energy level crossing associated with the spin-orbit coupling and the Zeeman splitting. We summarize recent theoretical development of the effect in various systems and discuss possible experiments to observe the effect.Comment: 5 pages with 1 figure

    IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline

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    Alzheimer’s disease (AD) is a devastating condition with no known effective treatment. AD is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment. Emerging evidence suggests that the innate immune response plays a major role in the pathogenesis of AD. In AD, the accumulation of β-amyloid (Aβ) in the brain perturbs physiological functions of the brain, including synaptic and neuronal dysfunction, microglial activation, and neuronal loss. Serum levels of soluble ST2 (sST2), a decoy receptor for interleukin (IL)-33, increase in patients with mild cognitive impairment, suggesting that impaired IL-33/ST2 signaling may contribute to the pathogenesis of AD. Therefore, we investigated the potential therapeutic role of IL-33 in AD, using transgenic mouse models. Here we report that IL-33 administration reverses synaptic plasticity impairment and memory deficits in APP/PS1 mice. IL-33 administration reduces soluble Aβ levels and amyloid plaque deposition by promoting the recruitment and Aβ phagocytic activity of microglia; this is mediated by ST2/p38 signaling activation. Furthermore, IL-33 injection modulates the innate immune response by polarizing microglia/macrophages toward an antiinflammatory phenotype and reducing the expression of proinflammatory genes, including IL-1β, IL-6, and NLRP3, in the cortices of APP/PS1 mice. Collectively, our results demonstrate a potential therapeutic role for IL-33 in AD

    Seasonal variations of stable carbon isotopic composition and biogenic tracer compounds of water-soluble organic aerosols in a deciduous forest

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    To investigate the seasonal changes in biogenic water-soluble organic carbon (WSOC) aerosols in a boreal forest, aerosol samples were collected continuously in the canopy of a deciduous forest in northern Japan during 2009–2010. Stable carbon isotopic composition of WSOC (δ<sup>13</sup>C<sub>WSOC</sub>) in total suspended particulate matter (TSP) exhibited a distinct seasonal cycle, with lower values from June through September (−25.5±0.5 ‰). This cycle follows the net CO<sub>2</sub> exchange between the forest ecosystem and the atmosphere, indicating that δ<sup>13</sup>C<sub>WSOC</sub> likely reflects the biological activity at the forest site. WSOC concentrations showed the highest values in early summer and autumn. Positive matrix factorization (PMF) analysis indicated that the factor in which biogenic secondary organic aerosols (BSOAs) dominated accounted for ~40 % of the highest concentrations of WSOC, where BSOAs mostly consisted of α-/β-pinene SOA. In addition, primary biological aerosol particles (PBAPs) made similar contributions (~57 %) to the WSOC near the forest floor in early summer. This finding indicates that the production of both primary and secondary WSOC aerosols is important during the growing season in a deciduous forest. The methanesulfonic acid (MSA) maximum was also found in early summer and had a distinct vertical gradient with larger concentrations near the forest floor. Together with the similar vertical gradients found for WSOC and δ<sup>13</sup>C<sub>WSOC</sub> as well as the α-/β-pinene SOA tracers, our results indicate that the forest floor, including ground vegetation and soil, acts as a significant source of WSOC in TSP within a forest canopy at the study site

    An investigation of atmospheric temperature profiles in the Australian region using collocated GPS radio occultation and radiosonde data

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    GPS radio occultation (RO) has been recognised as an alternative atmospheric upper air observation technique due to its distinct features and technological merits. The CHAllenging Minisatellite Payload (CHAMP) RO satellite and FORMOSAT-3/COSMIC (Constellation Observing System for Meteorology, Ionosphere and Climate) RO constellation together have provided about ten years of high quality global coverage RO atmospheric profiles. This technique is best used for meteorological studies in the difficult-to-access areas such as deserts and oceans. To better understand and use RO data, effective quality assessment using independent radiosonde data and its associated collocation criteria used in tempo-spatial domain are important. This study compares GPS RO retrieved temperature profiles from both CHAMP (between May 2001 and October 2008) and FORMOSAT-3/COSMIC (between July 2006 and December 2009) with radiosonde data from 38 Australian radiosonde stations. The overall results show a good agreement between the two data sets. Different collocation criteria within 3 h and 300 km between the profile pairs have been applied and the impact of these different collocation criteria on the evaluation results is found statistically insignificantly. The CHAMP and FORMOSAT-3/COSMIC temperature profiles have been evaluated at 16 different pressure levels and the differences between GPS RO and radiosonde at different levels of the atmosphere have been studied. The result shows that the mean temperature difference between radiosonde and CHAMP is 0.39 °C (with a standard deviation of 1.20 °C) and the one between radiosonde and FORMOSAT-3/COSMIC is 0.37 °C (with a standard deviation of 1.24 °C). Different collocation criteria have been applied and insignificant differences were identified amongst the results

    Dynamics of Neural Networks with Continuous Attractors

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    We investigate the dynamics of continuous attractor neural networks (CANNs). Due to the translational invariance of their neuronal interactions, CANNs can hold a continuous family of stationary states. We systematically explore how their neutral stability facilitates the tracking performance of a CANN, which is believed to have wide applications in brain functions. We develop a perturbative approach that utilizes the dominant movement of the network stationary states in the state space. We quantify the distortions of the bump shape during tracking, and study their effects on the tracking performance. Results are obtained on the maximum speed for a moving stimulus to be trackable, and the reaction time to catch up an abrupt change in stimulus.Comment: 6 pages, 7 figures with 4 caption

    Modeling mass transfer and reaction of dilute solutes in a ternary phase system by the lattice Boltzmann method

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    In this work, we propose a general approach for modeling mass transfer and reaction of dilute solute(s) in incompressible three-phase flows by introducing a collision operator in lattice Boltzmann (LB) method. An LB equation was used to simulate the solute dynamics among three different fluids, in which the newly expanded collision operator was used to depict the interface behavior of dilute solute(s). The multiscale analysis showed that the presented model can recover the macroscopic transport equations derived from the Maxwell-Stefan equation for dilute solutes in three-phase systems. Compared with the analytical equation of state of solute and dynamic behavior, these results are proven to constitute a generalized framework to simulate solute distributions in three-phase flows, including compound soluble in one phase, compound adsorbed on single-interface, compound in two phases, and solute soluble in three phases. Moreover, numerical simulations of benchmark cases, such as phase decomposition, multilayered planar interfaces, and liquid lens, were performed to test the stability and efficiency of the model. Finally, the multiphase mass transfer and reaction in Janus droplet transport in a straight microchannel were well reproduced

    The first operation and results of the Chung-Li VHF radar

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    The Chung-Li Very High Frequency (VHF) radar is used in the dual-mode operations, applying Doppler beam-swinging as well as the spaced-antenna-drift method. The design of the VHF radar is examined. Results of performance tests are discussed

    Exploring the Influence of Patient-Professional Partnerships on the Self-Management of Chronic Back Pain: A Qualitative Study

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    Patients are encouraged to take an active role in self-managing their chronic back pain and functional problems. However, research suggests that patients do not self-manage, and they expect health professionals to fulfill a comprehensive role in managing pain. A partnership between patients and health professionals is called for, and self-management works best when they share knowledge and work together toward optimal goals. To explore how patients' partnerships with health professionals may influence their ability to self-manage pain by exploring patients' experiences. A grounded theory approach with in-depth, semistructured interviews was undertaken. Each interview was analyzed using constant comparative analysis. This study was nested within a larger study on patient-professional partnerships and the self-management of chronic back pain. Twenty-six patients with chronic back pain were recruited in a community-based pain management service in Northern England, United Kingdom. Three themes emerged: building partnerships with health professionals; being supported by health professionals to self-manage the pain; and experiencing a change in self-management. Five approaches that underpinned health professionals' self-management support were identified. Facilitators of and barriers to a good partnership were reported. This study suggests that a good patient-professional partnership has a positive effect on patients’ self-management ability. A theoretical model explaining how such partnership may influence self-management was developed. It is necessary for both patients and health professionals to be aware of their partnerships, which may enhance the effect of pain management services

    A Framework for Evaluating Security in the Presence of Signal Injection Attacks

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    Sensors are embedded in security-critical applications from medical devices to nuclear power plants, but their outputs can be spoofed through electromagnetic and other types of signals transmitted by attackers at a distance. To address the lack of a unifying framework for evaluating the effects of such transmissions, we introduce a system and threat model for signal injection attacks. We further define the concepts of existential, selective, and universal security, which address attacker goals from mere disruptions of the sensor readings to precise waveform injections. Moreover, we introduce an algorithm which allows circuit designers to concretely calculate the security level of real systems. Finally, we apply our definitions and algorithm in practice using measurements of injections against a smartphone microphone, and analyze the demodulation characteristics of commercial Analog-to-Digital Converters (ADCs). Overall, our work highlights the importance of evaluating the susceptibility of systems against signal injection attacks, and introduces both the terminology and the methodology to do so.Comment: This article is the extended technical report version of the paper presented at ESORICS 2019, 24th European Symposium on Research in Computer Security (ESORICS), Luxembourg, Luxembourg, September 201
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