API NATURALS – Productos de cosmética a base de insumos naturales y orgánicos eco-sostenibles

El siguiente proyecto de investigación se basa en la introducción de productos ecológicos y orgánicos, hechos de manera artesanal al mercado peruano, partiendo de las propiedades naturales para así lograr obtener una cartera de productos para el cuidado de la piel.  Sin embargo, a este proyecto se le adiciona un valor agregado, y es relacionarlo con la enseñanza de transición del uso de cosmetología tradicional hacia la cosmetología natural, es decir, no solo se brinda un producto al usuario, sino que se le enseña a cómo mantener una rutina de cuidado personal a base de productos de insumos naturales y un estilo de vida ecológico.  Así mismo, se tiene en cuenta que el actual mercado peruano ha ido en constante crecimiento a pesar de la actual situación en la que se encuentra atravesando el país como también la competencia directa e indirecta en el rubro de negocio. Es por ello que, se procederá a detallar el análisis, estrategias ejecutadas y la respuesta del mercado al lanzamiento, introducción y crecimiento de los productos de skincare a base de insumos naturales, con el objetivo de lograr una máxima rentabilidad para el negocio y un óptimo servicio para los consumidores. The following research project is based on the introduction of ecological and organic products, made in a traditional way to the Peruvian market, starting from natural properties in order to achieve a portfolio of skin care products. However, an added value is added to this project, and is to relate it to the teaching of transition from the use of traditional cosmetology to natural cosmetology, that is, not only is a product provided to the user, but it is taught how maintain a personal care routine based on natural input products and an ecological lifestyle. Likewise, it is taken into account that the current Peruvian market has been in constant growth despite the current situation in which the country is going through as well as direct and indirect competition in the business area. That is why we will proceed to detail the analysis, implemented strategies and the market response to the launch, introduction and growth of skincare products based on natural inputs, with the aim of achieving maximum profitability for the business and optimal service for consumers.Trabajo de investigació

Comparison of Human and Soil Candida tropicalis Isolates with Reduced Susceptibility to Fluconazole

Infections caused by treatment-resistant non-albicans Candida species, such as C. tropicalis, has increased, which is an emerging challenge in the management of fungal infections. Genetically related diploid sequence type (DST) strains of C. tropicalis exhibiting reduced susceptibility to fluconazole circulated widely in Taiwan. To identify the potential source of these wildly distributed DST strains, we investigated the possibility of the presence in soil of such C. tropicalis strains by pulsed field gel electrophoresis (PFGE) and DST typing methods. A total of 56 C. tropicalis isolates were recovered from 26 out of 477 soil samples. Among the 18 isolates with reduced susceptibility to fluconazole, 9 belonged to DST149 and 3 belonged to DST140. Both DSTs have been recovered from our previous studies on clinical isolates from the Taiwan Surveillance of Antimicrobial Resistance of Yeasts (TSARY) program. Furthermore, these isolates were more resistant to agricultural azoles. We have found genetically related C. tropicalis exhibiting reduced susceptibility to fluconazole from the human hosts and environmental samples. Therefore, to prevent patients from acquiring C. tropicalis with reduced susceptibility to azoles, prudent use of azoles in both clinical and agricultural settings is advocated

Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases

Age-associated neurodegenerative disorders such as Alzheimer’s disease are a major public health challenge, due to the demographic increase in the proportion of older individuals in society. However, the relatively few currently approved drugs for these conditions provide only symptomatic relief. A major goal of neurodegeneration research is therefore to identify potential new therapeutic compounds that can slow or even reverse disease progression, either by impacting directly on the neurodegenerative process or by activating endogenous physiological neuroprotective mechanisms that decline with ageing. This requires model systems that can recapitulate key features of human neurodegenerative diseases that are also amenable to compound screening approaches. Mammalian models are very powerful, but are prohibitively expensive for high-throughput drug screens. Given the highly conserved neurological pathways between mammals and invertebrates, Caenorhabditis elegans has emerged as a powerful tool for neuroprotective compound screening. Here we describe how C. elegans has been used to model various human ageing-associated neurodegenerative diseases and provide an extensive list of compounds that have therapeutic activity in these worm models and so may have translational potential