Superconducting cosmic strings as sources of cosmological fast radio bursts

In this paper we calculate the radio burst signals from three kinds of structures of superconducting cosmic strings. By taking into account the observational factors including scattering and relativistic effects, we derive the event rate of radio bursts as a function of redshift with the theoretical parameters $G\mu$ and $\mathcal{I}$ of superconducting strings. Our analyses show that cusps and kinks may have noticeable contributions to the event rate and in most cases cusps would dominate the contribution, while the kink-kink collisions tend to have secondary effects. By fitting theoretical predictions with the normalized data of fast radio bursts, we for the first time constrain the parameter space of superconducting strings and report that the parameter space of $G\mu \sim [10^{-14}, 10^{-12}]$ and $\mathcal{I} \sim [10^{-1}, 10^{2}] ~ \rm{GeV}$ fit the observation well although the statistic significance is low due to the lack of observational data. Moreover, we derive two types of best fittings, with one being dominated by cusps with a redshift $z = 1.3$, and the other dominated by kinks at the range of the maximal event rate.Comment: 13 pages, 2 figures, 1 table; references update

New progress of ranging technology at Wuhan Satellite Laser Ranging Station

A satellite laser ranging system with an accuracy of the level of centimeter has been successfully developed at the Institute of Seismology, State Seismological Bureau with the cooperation of the Institute of Geodesy and Geophysics, Chinese Academy of Science. With significant improvements on the base of the second generation SLR system developed in 1985, ranging accuracy of the new system has been upgraded from 15 cm to 3-4 cm. Measuring range has also been expanded, so that the ETALON satellite with an orbit height of 20,000 km launched by the former U.S.S.R. can now be tracked. Compared with the 2nd generation SLR system, the newly developed system has the following improvements. A Q modulated laser is replaced by a mode-locked YAG laser. The new device has a pulse width of 150 ps and a repetition rate of 1-4 pps. A quick response photomultiplier has been adopted as the receiver for echo; for example, the adoption of the MCP tube has obviously reduced the jitter error of the transit time and has improved the ranging accuracy. The whole system is controlled by an IBM PC/XT Computer to guide automatic tracking and measurement. It can carry out these functions for satellite orbit calculation, real-time tracking and adjusting, data acquisition and the preprocessed of observing data, etc. The automatization level and reliability of the observation have obviously improved

Synthesis of Bis-β-Diketonate Lanthanide Complexes with an Azobenzene Bridge and Studies of Their Reversible Photo/Thermal Isomerization Properties.

The ligand, bis-β-diketone with an azobenzene bridge (4,4’-(4,4,4-trifluoro-1,3-butanedione)azobenzene, H 2 L ), was prepared for the synthesis of a series of dinuclear lanthanide complexes with the formula [Ln 2 L 3 (DMSO) 4 ] (Ln = Eu3+, Gd3+, Tb3+, and DMSO = dimethyl sulfoxide). X-ray crystallographic analysis reveals that the three complexes are triple-stranded dinuclear structures formed by three bis-β-diketonate ligands with two lanthanide ions (Ln3+). The trans-to-cis photoisomerization rates of the azobenzene group of the three [Ln 2 L 3 (DMSO) 4 ] complexes in ethanol and acetonitrile solutions are similar to those of the pure H 2 L ligand and other azobenzene-containing mononuclear lanthanide complexes, but the trans-to-cis quantum yields (Φt→c = 10-3) are 1 order of magnitude smaller. The first-order rate constant for the cis-to-trans thermal isomerization at 50 °C of the H 2 L ligand is similar to those of azobenzene derivatives, while those for the [Ln 2 L 3 (DMSO) 4 ] complexes ( k iso = 10-4 s-1) are higher than those of the mononuclear azobenzene-containing lanthanide complexes. Furthermore, as the lanthanide ionic radius becomes smaller from Eu3+ to Gd3+ to Tb3+, the thermal isomerization rate constant decreases and the half-life increases. All these results are proposed to arise from the rigidity at both ends of the azo group by coordination to the dinuclear lanthanide ions and the different isomerization mechanisms. These are the first examples of bis-β-diketonate dinuclear lanthanide complexes with an azobenzene bridge and help illustrate the mechanism of azobenzene isomerization

The Chinese (Cantonese) Montreal Cognitive Assessment in Patients with Subcortical Ischemic Vascular Dementia

Background: Subcortical ischemic vascular dementia (SIVD) has been proposed as the most frequent subtype of vascular cognitive impairment. The aim of this study was to evaluate the psychometric properties of the Chinese (Cantonese) Montreal Cognitive Assessment (CC- MoCA) in patients with SIVD in the Guangdong Province of China. Methods: 71 SIVD patients and 60 matched controls were recruited for the CC-MoCA, Mini Mental State Examination and executive clock drawing tasks. Receiver-operating characteristic curve analyses were performed to determine optimal sensitivity and specificity of the CC-MoCA total score in differentiating mild vascular dementia (VaD) patients from moderate VaD patients and controls. Results: The mean CC-MoCA scores of the controls, and mild and moderate VaD patients were 25.2 ± 3.8, 16.4 ± 3.7, and 10.0 ± 5.1, respectively. In our study, the optimal cutoff value for the CC-MoCA to be able to differentiate patients with mild VaD from controls is 21/22, and 13/14 to differentiate mild VaD from moderate VaD. Conclusion: The CC-MoCA is a useful cognitive screening instrument in SIVD patients

Testing the equivalence principle via the shadow of black holes

Funding: H.Z. acknowledges support from the USTC fellowship for international visiting professors and from Shanghai Astronomical Observatory. This work is sup- ported in part by the NSFC (No. 11722327, No. 11653002, No. 11961131007, No. 11725312, No. 11421303), by the CAST (No. 2016QNRC001), by the National Youth Talents Program of China, and by the Fundamental Research Funds for Central Universities. The work of D.A.E. is supported in part by the Foundational Questions Institute.We study the equivalence principle, regarded as the cornerstone of general relativity, by analyzing the deformation observable of black hole shadows. Such deformation can arise from new physics and may be expressed as a phenomenological violation of the equivalence principle. Specifically, we assume that there is an additional background vector field that couples to the photons around the supermassive black hole. This type of coupling yields impact on the way the system depends on initial conditions and affects the black hole shadow at different wavelengths by a different amount, and therefore observations of the shadow in different wavelengths could constrain such couplings. This can be tested by future multiband observations. Adopting a specific form of the vector field, we obtain constraints on model parameters from Event Horizon Telescope observations and measurements of gas/stellar orbits.Publisher PDFPeer reviewe

Raman fiber laser harmonically mode-locked by exploiting the intermodal beating of CW multimode pump source

We report here the first demonstration of a harmonic mode-locked Raman fiber laser using the intermodal beating of a continuous-wave (CW) multiple-longitudinal-mode pump laser. By matching the Raman-cavity round-trip frequency with the intermodal-beating one of a 1064 nm CW pump source, harmonic mode-locking in phosphosilicate Raman fiber laser is stably initiated at the first-order Stokes of 1239.5 nm, and generates rectangular-shape nanosecond pulses with the pulse energy up to 4.25 nJ. Using the new type of mode-locking, the harmonic order can be discretely tuned from 78th-to 693rd-order, and the cavity supermode is suppressed up to 51.1 dB with the signal-to-noise ratio of more than 65 dB. (C) 2012 Optical Society of AmericaNational Nature Science Foundation of China [61107038, 61177044]; Fundamental Research Funds for the Central Universities [2010121057

A Reliable Energy-Efficient Multi-Level Routing Algorithm for Wireless Sensor Networks Using Fuzzy Petri Nets

A reliable energy-efficient multi-level routing algorithm in wireless sensor networks is proposed. The proposed algorithm considers the residual energy, number of the neighbors and centrality of each node for cluster formation, which is critical for well-balanced energy dissipation of the network. In the algorithm, a knowledge-based inference approach using fuzzy Petri nets is employed to select cluster heads, and then the fuzzy reasoning mechanism is used to compute the degree of reliability in the route sprouting tree from cluster heads to the base station. Finally, the most reliable route among the cluster heads can be constructed. The algorithm not only balances the energy load of each node but also provides global reliability for the whole network. Simulation results demonstrate that the proposed algorithm effectively prolongs the network lifetime and reduces the energy consumption

Proteomic profiling reveals the potential mechanisms and regulatory targets of sirtuin 4 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s mouse model

IntroductionParkinson’s disease (PD), as a common neurodegenerative disease, currently has no effective therapeutic approaches to delay or stop its progression. There is an urgent need to further define its pathogenesis and develop new therapeutic targets. An increasing number of studies have shown that members of the sirtuin (SIRT) family are differentially involved in neurodegenerative diseases, indicating their potential to serve as targets in therapeutic strategies. Mitochondrial SIRT4 possesses multiple enzymatic activities, such as deacetylase, ADP ribosyltransferase, lipoamidase, and deacylase activities, and exhibits different enzymatic activities and target substrates in different tissues and cells; thus, mitochondrial SIRT4 plays an integral role in regulating metabolism. However, the role and mechanism of SIRT4 in PD are not fully understood. This study aimed to investigate the potential mechanism and possible regulatory targets of SIRT4 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice.MethodsThe expression of the SIRT4 protein in the MPTP-induced PD mouse mice or key familial Parkinson disease protein 7 knockout (DJ-1 KO) rat was compared against the control group by western blot assay. Afterwards, quantitative proteomics and bioinformatics analyses were performed to identify altered proteins in the vitro model and reveal the possible functional role of SIRT4. The most promising molecular target of SIRT4 were screened and validated by viral transfection, western blot assay and reverse transcription quantitative PCR (RT-qPCR) assays.ResultsThe expression of the SIRT4 protein was found to be altered both in the MPTP-induced PD mouse mice and DJ-1KO rats. Following the viral transfection of SIRT4, a quantitative proteomics analysis identified 5,094 altered proteins in the vitro model, including 213 significantly upregulated proteins and 222 significantly downregulated proteins. The results from bioinformatics analyses indicated that SIRT4 mainly affected the ribosomal pathway, propionate metabolism pathway, peroxisome proliferator-activated receptor (PPAR) signaling pathway and peroxisome pathway in cells, and we screened 25 potential molecular targets. Finally, only fatty acid binding protein 4 (FABP4) in the PPAR signaling pathway was regulated by SIRT4 among the 25 molecules. Importantly, the alterations in FABP4 and PPARγ were verified in the MPTP-induced PD mouse model.DiscussionOur results indicated that FABP4 in the PPAR signaling pathway is the most promising molecular target of SIRT4 in an MPTP-induced mouse model and revealed the possible functional role of SIRT4. This study provides a reference for future drug development and mechanism research with SIRT4 as a target or biomarker