90 research outputs found

    Index to Volumes 26-35 of Pennsylvania Folklife, 1976-1986

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    • Introduction • Subject Index • Genealogy Indexhttps://digitalcommons.ursinus.edu/pafolklifemagindex/1001/thumbnail.jp

    25 Year Index to Pennsylvania Folklife (Including The Pennsylvania Dutchman and The Dutchman): Volumes 1-25, 1949-1976

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    • Introduction • Index to Pennsylvania Folklife (including The Dutchman) volumes 1-25 • Surname Index to Genealogy and Immigration Articles in Pennsylvania Folklife (including The Dutchman) volumes 1-25https://digitalcommons.ursinus.edu/pafolklifemagindex/1000/thumbnail.jp

    Pennsylvania Folklife Vol. 28, No. 2

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    • The Pennsylvania Dutchman • Miz Ukraini: We are From the Ukraine • Pennsylvania German Astronomy and Astrology XVII: German Language Almanacs • Pennsylvania Dutch Dialect Stories • Taufscheine: A New Index for People Hunters, Part II • Aldes un Neieshttps://digitalcommons.ursinus.edu/pafolklifemag/1081/thumbnail.jp

    Pennsylvania Folklife Vol. 28, No. 1

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    • Women, Servants and Family Life in Early America • Be it Remembered that these Indentured Servants and Apprentices • Gute Socha fer Hame tzu Nemma • Taufscheine: A New Index for People Hunters • Aldes / Neieshttps://digitalcommons.ursinus.edu/pafolklifemag/1080/thumbnail.jp

    Reward processing electrophysiology in schizophrenia : effects of age and illness phase

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    Background: Reward processing abnormalities may underlie characteristic pleasure and motivational impairments in schizophrenia. Some neural measures of reward processing show age-related modulation, highlighting the importance of considering age effects on reward sensitivity. We compared event-related potentials (ERPs) reflecting reward anticipation (stimulus-preceding negativity, SPN) and evaluation (reward positivity, RewP; late positive potential, LPP) across individuals with schizophrenia (SZ) and healthy controls (HC), with an emphasis on examining the effects of chronological age, brain age (i.e., predicted age based on neurobiological measures), and illness phase. Methods: Subjects underwent EEG while completing a slot-machine task for which rewards were not dependent on performance accuracy, speed, or response preparation. Slot-machine task EEG responses were compared between 54 SZ and 54 HC individuals, ages 19 to 65. Reward-related ERPs were analyzed with respect to chronological age, categorically-defined illness phase (early; ESZ versus chronic schizophrenia; CSZ), and were used to model brain age relative to chronological age. Results: Illness phase-focused analyses indicated there were no group differences in average SPN or RewP amplitudes. However, a group x reward outcome interaction revealed that ESZ differed from HC in later outcome processing, reflected by greater LPP responses following loss versus reward (a reversal of the HC pattern). While brain age estimates did not differ among groups, depressive symptoms in SZ were associated with older brain age estimates while controlling for negative symptoms. Conclusions: ESZ and CSZ did not differ from HC in reward anticipation or early outcome processing during a cognitively undemanding reward task, highlighting areas of preserved functioning. However, ESZ showed altered later reward outcome evaluation, pointing to selective reward deficits during the early illness phase of schizophrenia. Further, an association between ERP-derived brain age and depressive symptoms in SZ extends prior findings linking depression with reward-related ERP blunting. Taken together, both illness phase and age may impact reward processing among SZ, and brain aging may offer a promising, novel marker of reward dysfunction that warrants further study

    The Grizzly, March 2, 1999

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    Vaccination for Meningitis a Success • Dr. England to Speak on Social Crowds • Middle States Presents Findings • Ursinus Alum Named Principal of Vanguard Group • Ursinus Students Called to Aid Project for Peace • Middle States Team Praises Ursinus Students • Ursinus Students Battle Against Sickness • Dean\u27s Office Recognizes Resident Scholars • Opinion: Lessons From Space Ghost; Higher Education: Meal Ticket or Soul Food?; Dan Quayle: Eight Years Later, What has Changed? • Grizzly Wrestlers to Take Trenton State by Storm • Positive Outlook for New Field Hockey Coachhttps://digitalcommons.ursinus.edu/grizzlynews/1436/thumbnail.jp

    The causal role of breakfast in energy balance and health: a randomized controlled trial in lean adults

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    Background: Popular beliefs that breakfast is the most important meal of the day are grounded in cross-sectional observations that link breakfast to health, the causal nature of which remains to be explored under real-life conditions. Objective: The aim was to conduct a randomized controlled trial examining causal links between breakfast habits and all components of energy balance in free-living humans. Design: The Bath Breakfast Project is a randomized controlled trial with repeated-measures at baseline and follow-up in a cohort in southwest England aged 21–60 y with dual-energy X-ray absorptiometry–derived fat mass indexes #11 kg/m2 in women (n = 21) and #7.5 kg/m2 in men (n = 12). Components of energy balance (resting metabolic rate, physical activity thermogenesis, energy intake) and 24-h glycemic responses were measured under free-living conditions with random allocation to daily breakfast ($700 kcal before 1100) or extended fasting (0 kcal until 1200) for 6 wk, with baseline and follow-up measures of health markers (eg, hematology/biopsies). Results: Contrary to popular belief, there was no metabolic adaptation to breakfast (eg, resting metabolic rate stable within 11 kcal/d), with limited subsequent suppression of appetite (energy intake remained 539 kcal/d greater than after fasting; 95% CI: 157, 920 kcal/d). Rather, physical activity thermogenesis was markedly higher with breakfast than with fasting (442 kcal/d; 95% CI: 34, 851 kcal/d). Body mass and adiposity did not differ between treatments at baseline or follow-up and neither did adipose tissue glucose uptake or systemic indexes of cardiovascular health. Continuously measured glycemia was more variable during the afternoon and evening with fasting than with breakfast by the final week of the intervention (CV: 3.9%; 95% CI: 0.1%, 7.8%). Conclusions: Daily breakfast is causally linked to higher physical activity thermogenesis in lean adults, with greater overall dietary energy intake but no change in resting metabolism. Cardiovascular health indexes were unaffected by either of the treatments, but breakfast maintained more stable afternoon and evening glycemia than did fasting

    Nicotinic Acetylcholine Receptor Variants Are Related to Smoking Habits, but Not Directly to COPD

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    Genome-wide association studies identified single nucleotide polymorphisms (SNPs) in the nicotinic acetylcholine receptors (nAChRs) cluster as a risk factor for nicotine dependency and COPD. We investigated whether SNPs in the nAChR cluster are associated with smoking habits and lung function decline, and if these potential associations are independent of each other. The SNPs rs569207, rs1051730 and rs8034191 in the nAChR cluster were analyzed in the Vlagtwedde-Vlaardingen cohort (n = 1,390) that was followed for 25 years. We used GEE and LME models to analyze the associations of the SNPs with quitting or restarting smoking and with the annual FEV1 decline respectively. Individuals homozygote (CC) for rs569207 were more likely to quit smoking (OR (95%CI) = 1.58 (1.05–2.38)) compared to wild-type (TT) individuals. Individuals homozygote (TT) for rs1051730 were less likely to quit smoking (0.64 (0.42; 0.97)) compared to wild-type (CC) individuals. None of the SNPs was significantly associated with the annual FEV1 decline in smokers and ex-smokers. We show that SNPs in the nAChR region are associated with smoking habits such as quitting smoking, but have no significant effect on the annual FEV1 decline in smokers and ex-smokers, suggesting a potential role of these SNPs in COPD development via smoking habits rather than via direct effects on lung function

    Transient Astrophysics Probe: White Paper

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    The Transient Astrophysics Probe (TAP) is a wide-field multi-wavelength transient mission proposed for flight starting in the late 2020s. The mission instruments include unique ``Lobster-eye'' imaging soft X-ray optics that allow an approximately 1600-degrees-squared Field of View (FoV); a high sensitivity, 1-degree-squared FoV soft X-ray telescope; a 1-degree-squared FoV Infrared telescope with bandpass 0.6 to 3 microns; and a set of 8 NaI gamma-ray detectors. TAP's most exciting capability will be the observation of tens per year of X-ray and Infrared counterparts of gravitational waves (GWs) involving stellar-mass black holes and neutron stars detected by LIGO (Laser Interferometer Gravitational-Wave Observatory ) / Virgo / KAGRA (Kamioka (Japan) Gravitational Wave Detector) / LIGO-India, and possibly several per year X-ray counterparts of GWs from supermassive black holes, detected by LISA (Laser Interferometer Space Antenna) and Pulsar Timing Arrays. TAP will also discover hundreds of X-ray transients related to compact objects, including tidal disruption events, supernova shock breakouts, and Gamma-Ray Bursts from the epoch of reionization
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