Imaging along-strike variations in mechanical properties of the Gofar transform fault, East Pacific Rise

Author Posting. © American Geophysical Union, 2014. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Solid Earth 119 (2014): 7175–7194, doi:10.1002/2014JB011270.A large part of global plate motion on mid-ocean ridge transform faults (RTFs) is not accommodated as major earthquakes. When large earthquakes do occur, they often repeat quasiperiodically. We focus here on the high slip rate (∼14 cm/yr) Gofar transform fault on the equatorial East Pacific Rise. This fault is subdivided into patches that slip during Mw 5.5–6 earthquakes every 5 to 6 years. These patches are separated by rupture barriers that accommodate slip through swarms of smaller events and/or aseismic creep. We performed an imaging study to investigate which spatiotemporal variations of the fault zone properties control this segmentation in mechanical behavior and could explain the specific behavior of RTFs at the global scale. We adopt a double-difference approach in a joint inversion of active air gun shots and microseismicity recorded for 1 year. This data set includes the 2008 Mw 6 Gofar earthquake. The along-strike P wave velocity structure reveals an abrupt transition between the barrier area, characterized by a damaged fault zone of 10–20% reduced Vp and a nearly intact fault zone in the asperity area. The importance of the strength of the damage zone on the mechanical behavior is supported by the temporal S wave velocity changes which suggest increased damage within the barrier area, during the week preceding the Mw 6 earthquake. Our results support the conclusion that extended highly damaged zones are the key factor in limiting the role of major earthquakes to accommodate plate motion along RTFs.The material presented here is based on work supported by the National Science Foundation grants 1232725 and 0242117.2015-03-2

The Genetic Structure and History of Africans and African Americans.

Africa is the source of all modern humans, but characterization of genetic variation and of relationships among populations across the continent has been enigmatic. We studied 121 African populations, four African American populations, and 60 non-African populations for patterns of variation at 1327 nuclear microsatellite and insertion/deletion markers. We identified 14 ancestral population clusters in Africa that correlate with self-described ethnicity and shared cultural and/or linguistic properties. We observed high levels of mixed ancestry in most populations, reflecting historical migration events across the continent. Our data also provide evidence for shared ancestry among geographically diverse hunter-gatherer populations (Khoesan speakers and Pygmies). The ancestry of African Americans is predominantly from Niger-Kordofanian (approximately 71%), European (approximately 13%), and other African (approximately 8%) populations, although admixture levels varied considerably among individuals. This study helps tease apart the complex evolutionary history of Africans and African Americans, aiding both anthropological and genetic epidemiologic studies

Clinical characteristics and outcome of dogs with presumed primary renal lymphoma

Objectives: To characterise the presentation, clinicopathologic data and outcome of 29 dogs with presumed primary renal lymphoma. Materials and methods: Retrospective analysis of medical records of dogs with suspected primary renal lymphoma from 11 institutions. Results: All dogs were substage b, and lethargy and gastrointestinal signs were common presenting complaints, as were azotaemia (n=25; 86%) and erythrocytosis (n=15; 51%) on biochemical testing. Ultrasonography typically revealed bilateral renal lesions (n=23; 79%), renomegaly (n=22; 76%) and abdominal lymphadenopathy (n=14; 48%). Chemotherapy was the only treatment in 23 dogs, of which 11 responded, all considered partial responses. For all dogs the median progression-free survival and median overall survival times were 10 days (range: 1 to 126) and 12 days (range: 1 to 212), respectively, and for dogs that responded to chemotherapy 41 days (range: 10 to 126) and 47 days (range: 10 to 212), respectively. Clinical significance: Primary renal lymphoma in dogs appears to be associated with a poor prognosis and short-lived response to chemotherapy

Magnetic Imaging of the Outer Solar Atmosphere (MImOSA): Unlocking the driver of the dynamics in the upper solar atmosphere

The magnetic activity of the Sun directly impacts the Earth and human life. Likewise, other stars will have an impact on the habitability of planets orbiting these host stars. The lack of information on the magnetic field in the higher atmospheric layers hampers our progress in understanding solar magnetic activity. Overcoming this limitation would allow us to address four paramount long-standing questions: (1) How does the magnetic field couple the different layers of the atmosphere, and how does it transport energy? (2) How does the magnetic field structure, drive and interact with the plasma in the chromosphere and upper atmosphere? (3) How does the magnetic field destabilise the outer solar atmosphere and thus affect the interplanetary environment? (4) How do magnetic processes accelerate particles to high energies? New ground-breaking observations are needed to address these science questions. We suggest a suite of three instruments that far exceed current capabilities in terms of spatial resolution, light-gathering power, and polarimetric performance: (a) A large-aperture UV-to-IR telescope of the 1-3 m class aimed mainly to measure the magnetic field in the chromosphere by combining high spatial resolution and high sensitivity. (b) An extreme-UV-to-IR coronagraph that is designed to measure the large-scale magnetic field in the corona with an aperture of about 40 cm. (c) An extreme-UV imaging polarimeter based on a 30 cm telescope that combines high throughput in the extreme UV with polarimetry to connect the magnetic measurements of the other two instruments. This mission to measure the magnetic field will unlock the driver of the dynamics in the outer solar atmosphere and thereby greatly advance our understanding of the Sun and the heliosphere.Comment: Submitted to Experimental Astronomy (on 28. Jul. 2020). Based on a proposal submitted in response to a call for white papers in the Voyage 2050 long-term plan in the ESA science programme. 36 pages, 10 figure

Magnetic reconnection as a mechanism to produce multiple protonpopulations and beams locally in the solar wind

Context. Spacecraft observations early revealed frequent multiple proton populations in the solar wind. Decades of research on their origin have focused on processes such as magnetic reconnection in the low corona and wave-particle interactions in the corona and locally in the solar wind.Aims.This study aims to highlight that multiple proton populations and beams are also produced by magnetic reconnection occurring locally in the solar wind. Methods. We use high resolution Solar Orbiter proton velocity distribution function measurements, complemented by electron and magnetic field data, to analyze the association of multiple proton populations and beams with magnetic reconnection during a period of slow Alfv\'enic solar wind on 16 July 2020. Results. At least 6 reconnecting current sheets with associated multiple proton populations and beams, including a case of magnetic reconnection at a switchback boundary, are found during this day. This represents 2% of the measured distribution functions. We discuss how this proportion may be underestimated, and how it may depend on solar wind type and distance from the Sun. Conclusions. Although suggesting a likely small contribution, but which remains to be quantitatively assessed, Solar Orbiter observations show that magnetic reconnection must be considered as one of the mechanisms that produce multiple proton populations and beams locally in the solar wind

Seismic constraints from a Mars impact experiment using InSight and Perseverance

NASA’s InSight (Interior Exploration using Seismic Investigations, Geodesy and Heat Transport) mission has operated a sophisticated suite of seismology and geophysics instruments on the surface of Mars since its arrival in 2018. On 18 February 2021, we attempted to detect the seismic and acoustic waves produced by the entry, descent and landing of the Perseverance rover using the sensors onboard the InSight lander. Similar observations have been made on Earth using data from both crewed1,2 and uncrewed3,4 spacecraft, and on the Moon during the Apollo era5, but never before on Mars or another planet. This was the only seismic event to occur on Mars since InSight began operations that had an a priori known and independently constrained timing and location. It therefore had the potential to be used as a calibration for other marsquakes recorded by InSight. Here we report that no signal from Perseverance’s entry, descent and landing is identifiable in the InSight data. Nonetheless, measurements made during the landing window enable us to place constraints on the distance–amplitude relationships used to predict the amplitude of seismic waves produced by planetary impacts and place in situ constraints on Martian impact seismic efficiency (the fraction of the impactor kinetic energy converted into seismic energy)

X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition

X-linked myotubular myopathy (XLMTM) is a fatal neuromuscular disorder caused by loss of function mutations in MTM1. At present, there are no directed therapies for XLMTM, and incomplete understanding of disease pathomechanisms. To address these knowledge gaps, we performed a drug screen in mtm1 mutant zebrafish and identified four positive hits, including valproic acid, which functions as a potent suppressor of the mtm1 zebrafish phenotype via HDAC inhibition. We translated these findings to a mouse XLMTM model, and showed that valproic acid ameliorates the murine phenotype. These observations led us to interrogate the epigenome in Mtm1 knockout mice; we found increased DNA methylation, which is normalized with valproic acid, and likely mediated through aberrant 1-carbon metabolism. Finally, we made the unexpected observation that XLMTM patients share a distinct DNA methylation signature, suggesting that epigenetic alteration is a conserved disease feature amenable to therapeutic intervention