82 research outputs found
Nanoinformatics: developing new computing applications for nanomedicine
Nanoinformatics has recently emerged to address the need of computing applications at the nano level. In this regard, the authors have participated in various initiatives to identify its concepts, foundations and challenges. While nanomaterials open up the possibility for developing new devices in many industrial and scientific areas, they also offer breakthrough perspectives for the prevention, diagnosis and treatment of diseases. In this paper, we analyze the different aspects of nanoinformatics and suggest five research topics to help catalyze new research and development in the area, particularly focused on nanomedicine. We also encompass the use of informatics to further the biological and clinical applications of basic research in nanoscience and nanotechnology, and the related concept of an extended ?nanotype? to coalesce information related to nanoparticles. We suggest how nanoinformatics could accelerate developments in nanomedicine, similarly to what happened with the Human Genome and other -omics projects, on issues like exchanging modeling and simulation methods and tools, linking toxicity information to clinical and personal databases or developing new approaches for scientific ontologies, among many others
Annual tree rings in Piptadenia gonoacantha (Mart.) J.F.Macbr. in a restoration experiment in the Atlantic Forest: potential for dendroecological research
Stable carbon isotopes in tree rings indicate improved water use efficiency and drought responses of a tropical dry forest tree species
Hypoxic Pulmonary Vasoconstriction in Humans:Tale or Myth
Hypoxic Pulmonary vasoconstriction (HPV) describes the physiological adaptive process of lungs to preserves systemic oxygenation. It has clinical implications in the development of pulmonary hypertension which impacts on outcomes of patients undergoing cardiothoracic surgery. This review examines both acute and chronic hypoxic vasoconstriction focusing on the distinct clinical implications and highlights the role of calcium and mitochondria in acute versus the role of reactive oxygen species and Rho GTPases in chronic HPV. Furthermore it identifies gaps of knowledge and need for further research in humans to clearly define this phenomenon and the underlying mechanism
Dietary supplementation and in ovo injection of 1α-OHD3 in a low-calcium and low-phosphorous diets for broilers
The impact of cedar processionary moth [Traumatocampa ispartaensis (DoÄanlar & AvcĂ) (Lepidoptera: Notodontidae)] outbreaks on radial growth of Lebanon cedar (Cedrus libani A. Rich.) trees in Turkey
Senescent cytotoxic T cells in acute myocardial infarction: innocent bystanders or the horsemen of apocalypse?
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