753 research outputs found
A role for TSPO in mitochondrial Ca2+ homeostasis and redox stress signaling
The 18 kDa translocator protein TSPO localizes on the outer mitochondrial membrane (OMM). Systematically overexpressed at sites of neuroinflammation it is adopted as a biomarker of brain conditions. TSPO inhibits the autophagic removal of mitochondria by limiting PARK2-mediated mitochondrial ubiquitination via a peri-organelle accumulation of reactive oxygen species (ROS). Here we describe that TSPO deregulates mitochondrial Ca2+ signaling leading to a parallel increase in the cytosolic Ca2+ pools that activate the Ca2+-dependent NADPH oxidase (NOX) thereby increasing ROS. The inhibition of mitochondrial Ca2+ uptake by TSPO is a consequence of the phosphorylation of the voltage-dependent anion channel (VDAC1) by the protein kinase A (PKA), which is recruited to the mitochondria, in complex with the Acyl-CoA binding domain containing 3 (ACBD3). Notably, the neurotransmitter glutamate, which contributes neuronal toxicity in age-dependent conditions, triggers this TSPO-dependent mechanism of cell signaling leading to cellular demise. TSPO is therefore proposed as a novel OMM-based pathway to control intracellular Ca2+ dynamics and redox transients in neuronal cytotoxicity
Extracting Scattering Phase-Shifts in Higher Partial-Waves from Lattice QCD Calculations
L\"uscher's method is routinely used to determine meson-meson, meson-baryon
and baryon-baryon s-wave scattering amplitudes below inelastic thresholds from
Lattice QCD calculations - presently at unphysical light-quark masses. In this
work we review the formalism and develop the requisite expressions to extract
phase-shifts describing meson-meson scattering in partial-waves with
angular-momentum l<=6 and l=9. The implications of the underlying cubic
symmetry, and strategies for extracting the phase-shifts from Lattice QCD
calculations, are presented, along with a discussion of the signal-to-noise
problem that afflicts the higher partial-waves.Comment: 79 pages, 41 figure
The pion-pion Interaction in the rho Channel in Finite Volume
The aim of this paper is to investigate an efficient strategy that allows to
obtain pi-pi phase shifts and rho meson properties from QCD lattice data with
high precision. For this purpose we evaluate the levels of the pi-pi system in
the rho channel in finite volume using chiral unitary theory. We investigate
the dependence on the pi mass and compare with other approaches which use QCD
lattice calculations and effective theories. We also illustrate the errors
induced by using the conventional Luscher approach instead of a more accurate
one recently developed that takes into account exactly the relativistic two
meson propagators. Finally we make use of this latter approach to solve the
inverse problem, getting pi-pi phase shifts from "synthetic" lattice data,
providing an optimal strategy and showing which accuracy is needed in these
data to obtain the properties with a desired accuracy.Comment: 16 pages, 13 figures, 1 table, substantially modified with practical
examples of use to lattice researchers, new comments and references adde
High-throughput single-cell analysis reveals progressive mitochondrial DNA mosaicism throughout life
Methods for removal of unwanted signals from gravity time-series : comparison using linear techniques complemented with analysis of system dynamics
We thanks the participants of the 35th General Assembly of the European Seismological Commission for comments on preliminary results. The authors are grateful to all IGETS contributors, particularly to the station operators and to ISDC/GFZ-Potsdam for providing the original gravity data used in this study. We also thank the developers of ATLANTIDA3.1 and UTide. Part of this work was performed using the ICSMB High Performance Computing Cluster, University of Aberdeen. We also thanks M. Thiel and A. Moura for reviewing a preliminary version and making comments on the methods section and M.A. Ara´ujo for comments on Lyapunov exponents. Funding: A. Valencio is supported by CNPq, Brazil [206246/2014-5]; and received a travel grant from the School of Natural and Computing Sciences, University of Aberdeen [PO2073498], for a presentation including preliminary results.Peer reviewedPostprintPublisher PD
Experimental quantum tossing of a single coin
The cryptographic protocol of coin tossing consists of two parties, Alice and
Bob, that do not trust each other, but want to generate a random bit. If the
parties use a classical communication channel and have unlimited computational
resources, one of them can always cheat perfectly. Here we analyze in detail
how the performance of a quantum coin tossing experiment should be compared to
classical protocols, taking into account the inevitable experimental
imperfections. We then report an all-optical fiber experiment in which a single
coin is tossed whose randomness is higher than achievable by any classical
protocol and present some easily realisable cheating strategies by Alice and
Bob.Comment: 13 page
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