Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis

Tuberculosis (TB) remains a global pandemic and drug resistance is rising. Multicellular granuloma formation is the pathological hallmark of Mycobacterium tuberculosis infection. The membrane type 1 matrix metalloproteinase (MT1-MMP or MMP-14) is a collagenase that is key in leukocyte migration and collagen destruction. In patients with TB, induced sputum MT1-MMP mRNA levels were increased 5.1-fold compared with matched controls and correlated positively with extent of lung infiltration on chest radiographs (r = 0.483; p < 0.05). M. tuberculosis infection of primary human monocytes increased MT1-MMP surface expression 31.7-fold and gene expression 24.5-fold. M. tuberculosis-infected monocytes degraded collagen matrix in an MT1-MMP-dependent manner, and MT1-MMP neutralization decreased collagen degradation by 73%. In human TB granulomas, MT1-MMP immunoreactivity was observed in macrophages throughout the granuloma. Monocyte-monocyte networks caused a 17.5-fold increase in MT1-MMP surface expression dependent on p38 MAPK and G protein-coupled receptor-dependent signaling. Monocytes migrating toward agarose beads impregnated with conditioned media from M. tuberculosis-infected monocytes expressed MT1-MMP. Neutralization of MT1-MMP activity decreased this M. tuberculosis network-dependent monocyte migration by 44%. Taken together, we demonstrate that MT1-MMP is central to two key elements of TB pathogenesis, causing collagen degradation and regulating monocyte migration

Nambu-Hamiltonian flows associated with discrete maps

For a differentiable map $(x_1,x_2,..., x_n)\to (X_1,X_2,..., X_n)$ that has an inverse, we show that there exists a Nambu-Hamiltonian flow in which one of the initial value, say $x_n$, of the map plays the role of time variable while the others remain fixed. We present various examples which exhibit the map-flow correspondence.Comment: 19 page

Do many-particle neutrino interactions cause a novel coherent effect?

We investigate whether coherent flavor conversion of neutrinos in a neutrino background is substantially modified by many-body effects, with respect to the conventional one-particle effective description. We study the evolution of a system of interacting neutrino plane waves in a box. Using its equivalence to a system of spins, we determine the character of its behavior completely analytically. We find that, if the neutrinos are initially in flavor eigenstates, no coherent flavor conversion is realized, in agreement with the effective one-particle description. This result does not depend on the size of the neutrino wavepackets and therefore has a general character. The validity of the several important applications of the one-particle formalism is thus confirmed.Comment: 25 pages, 1 figur

Spatial and vertical distribution of mercury in upland forest soils across the northeastern United States

Assessing current Hg pools in forest soils of the northeastern U.S. is important for monitoring changes in Hg cycling. The forest floor, upper and lower mineral horizons were sampled at 17 long-term upland forest sites across the northeastern U.S. in 2011. Forest floor Hg concentration was similar across the study region (274 +/- 13 mu g kg(-1)) while Hg amount at northern sites (39 +/- g ha(-1)) was significantly greater than at western sites (11 +/- 4 g ha(-1)). Forest floor Hg was correlated with soil organic matter, soil pH, latitude and mean annual precipitation and these variables explained approximately 70% of the variability when multiple regressed. Mercury concentration and amount in the lower mineral soil was correlated with Fe, soil organic matter and latitude, corresponding with Bs horizons of Spodosols (Podzols). Our analysis shows the importance of regional and soil properties on Hg accumulation in forest soils. (C) 2013 Elsevier Ltd. All rights reserved

The influence of collective neutrino oscillations on a supernova r-process

Recently, it has been demonstrated that neutrinos in a supernova oscillate collectively. This process occurs much deeper than the conventional matter-induced MSW effect and hence may have an impact on nucleosynthesis. In this paper we explore the effects of collective neutrino oscillations on the r-process, using representative late-time neutrino spectra and outflow models. We find that accurate modeling of the collective oscillations is essential for this analysis. As an illustration, the often-used "single-angle" approximation makes grossly inaccurate predictions for the yields in our setup. With the proper multiangle treatment, the effect of the oscillations is found to be less dramatic, but still significant. Since the oscillation patterns are sensitive to the details of the emitted fluxes and the sign of the neutrino mass hierarchy, so are the r-process yields. The magnitude of the effect also depends sensitively on the astrophysical conditions - in particular on the interplay between the time when nuclei begin to exist in significant numbers and the time when the collective oscillation begins. A more definitive understanding of the astrophysical conditions, and accurate modeling of the collective oscillations for those conditions, is necessary.Comment: 27 pages, 10 figure

Invariant varieties of periodic points for some higher dimensional integrable maps

By studying various rational integrable maps on $\mathbf{\hat C}^d$ with $p$ invariants, we show that periodic points form an invariant variety of dimension $\ge p$ for each period, in contrast to the case of nonintegrable maps in which they are isolated. We prove the theorem: {\it `If there is an invariant variety of periodic points of some period, there is no set of isolated periodic points of other period in the map.'}Comment: 24 page

Testing matter effects in propagation of atmospheric and long-baseline neutrinos

We quantify our current knowledge of the size and flavor structure of the matter effects in the evolution of atmospheric and long-baseline neutrinos based solely on the analysis of the corresponding neutrino data. To this aim we generalize the matter potential of the Standard Model by rescaling its strength, rotating it away from the e-e sector, and rephasing it with respect to the vacuum term. This phenomenological parametrization can be easily translated in terms of non-standard neutrino interactions in matter. We show that in the most general case, the strength of the potential cannot be determined solely by atmospheric and long-baseline data. However its flavor composition is very much constrained and the present determination of the neutrino masses and mixing is robust under its presence. We also present an update of the constraints arising from this analysis in the particular case in which no potential is present in the e-mu and e-tau sectors. Finally we quantify to what degree in this scenario it is possible to alleviate the tension between the oscillation results for neutrinos and antineutrinos in the MINOS experiment and show the relevance of the high energy part of the spectrum measured at MINOS.Comment: PDFLaTeX file using JHEP3 class, 25 pages, 7 figures included. Accepted for publication in JHE

Lower Bounds for Heights in Relative Galois Extensions

The goal of this paper is to obtain lower bounds on the height of an algebraic number in a relative setting, extending previous work of Amoroso and Masser. Specifically, in our first theorem we obtain an effective bound for the height of an algebraic number $\alpha$ when the base field $\mathbb{K}$ is a number field and $\mathbb{K}(\alpha)/\mathbb{K}$ is Galois. Our second result establishes an explicit height bound for any non-zero element $\alpha$ which is not a root of unity in a Galois extension $\mathbb{F}/\mathbb{K}$, depending on the degree of $\mathbb{K}/\mathbb{Q}$ and the number of conjugates of $\alpha$ which are multiplicatively independent over $\mathbb{K}$. As a consequence, we obtain a height bound for such $\alpha$ that is independent of the multiplicative independence condition

Magneto infra-red absorption in high electronic density GaAs quantum wells

Magneto infra-red absorption measurements have been performed in a highly doped GaAs quantum well which has been lifted off and bonded to a silicon substrate, in order to study the resonant polaron interaction. It is found that the pinning of the cyclotron energy occurs at an energy close to that of the transverse optical phonon of GaAs. This unexpected result is explained by a model taking into account the full dielectric constant of the quantum well.Comment: 4 pages, 4 figures, to be published in Phys. Rev. Let