Panthéon: um templo multirreligioso na cidade do Porto

A essência da religião reside na comunidade e, para isso, o lugar de culto é fundamental, pois é o espaço onde os crentes se reúnem e renovam a sua fé. Os movimentos migratórios em direção ao ocidente, assim como a globalização, vieram alterar a paisagem religiosa. O monolitismo católico de Portugal vai dando, assim, lugar ao pluralismo religioso. Esta dissertação propõe, por isso, um templo multirreligioso para a cidade do Porto - um lugar onde qualquer pessoa possa praticar o seu culto, independentemente da sua fé. A sua conceção é suportada pela análise do contexto religioso português, assim como pelo entendimento das religiões que o compõem e pelo estudo de espaços multirreligiosos. Uma vez que, no serviço prestado à comunidade, a religião não se limita à oração, o templo está associado a um complexo religioso que contém um espaço destinado à educação e a ações sociais, assim como um tanatório.Community is the essence of any religion. Therefore, the space of cult is fundamental, as the place where people get together and renovate their faith. The migratory movements towards the west, as well as the globalization, have had an impact in the religious landscape. Hence, the Catholic predominance in Portugal is giving way to religious plurality. The aim of this dissertation is to create a multireligious temple for Oporto - a place where anyone can practice their faith. Its conception is supported on the analysis of Portugal's religious context, alongside the understanding of the diverse faiths that compose it and the study of examples of previously existent multifaith spaces. Once religion is not only practiced through prayers, the temple is part of a wider complex that contains spaces destined to education and charity events, as well as a tanatorium

Effects of flavour variety on the intake and palatability of commercial feed in nursery pigs

Sensory-specific satiety (SSS) could negatively affect pigs' feed intake, even when diets satisfy their nutritional requirements. We evaluated the short-term effects of SSS on feed intake and palatability. Thirty-two nursery pigs (tested in pairs) were exposed to short-term feeding trials for six days. In trial 1, animals received for 90 minutes over three consecutive days three feeders: with different flavours (VAR); the same flavour (MON); or a mixture of the three flavours (MIX) in a 3x3 Latin square design. In trial 2, with the same animals and different flavours, the three feeders were delivered successively (1 feeder every 30 minutes). In trial 1, there was a day-by-diet interaction (F 4,36 = 2.98; P=0.032), where the VAR diet was least consumed on the first day but most consumed subsequently. In trial 2 a triple interaction between diet, day and delivery order modified pig`s intake (F 12,15 = 3.33; P=0.015), and consumption patterns (F 12,15 = 3.52; P=0.012); where VAR diet presented the highest values in the last delivery order on the third experimental day. Flavour variety may decrease the effect of SSS, increasing feed intake and hedonic value in nursery pigs when there was a previous experience with those flavours

Dentistry in Bandeira Cientifica 2015 Project - Limoeiro de Anadia - AL

The Bandeira Cientifica project is an extracurricular activity which takes place in vulnerable areas of Brazil. Since 2006, the dentistry department at the University of São Paulo (USP) has been responsible for oral health. These activities were developed between the 8th and 20th of December, 2015, in Limoeiro de Anadia - AL. 28 undergraduate students from FO-USP and FO- UFAL, 2 teachers and 5 dental surgeons participated in activities promoting health for 1,454 children in 20 primary schools, early childhood education centers and in the community. All the students participated in the educational activities on oral health and supervised tooth brushing, priority actions of the project. The epidemiological survey for oral health was developed for CPO-D and CEO-D indices. 2,500 children's toothbrush kits were distributed and 1,454 topical fluoride applications were performed. 752 students received clinical care: atraumatic restorative treatment with glass ionizer (1588), sealing holes with temporary cement (11), endodontic medication (2), extraction of primary (429) and permanent (50); periodontal scaling (20), totaling 2,165 clinical procedures and 296 preventive procedures: cariostatic application (123); sealant application (160) and fluoride varnish application (13), 24 prostheses were made for 12 residents. 358 children were referred for treatment of greater complexity to the Basic Health Unit.O Projeto Bandeira Científica é uma atividade de extensão universitária que atua em localidades vulneráveis do Brasil. Desde 2006 a Faculdade de Odontologia da USP é responsável pela saúde bucal. As atividades foram desenvolvidas entre 8 e 20 de dezembro de 2015, em Limoeiro de Anadia - AL. Participaram 28 alunos da graduação FO-USP e FO-UFAL, 2 professores e 5 Cirurgiões Dentistas em ações de promoção em saúde em 1.454 crianças de 20 escolas de Ensino Fundamental, Educação Infantil e População da Comunidade. Todos os escolares participaram das atividades de educação em saúde bucal e escovação supervisionada, ações prioritárias do projeto. Foi desenvolvido um levantamento epidemiológico de saúde bucal, foram distribuídos 2.500 kits de escovação infantil e realizadas 1.454 aplicações de flúor tópico, 752 escolares receberam atendimento clínico: tratamento restaurador atraumático com ionômero de vidro (1.588); selamento de cavidades com cimento provisório (11); medicação endodôntica (2); exodontia de decíduos (429) e permanentes (50); raspagem periodontal (20), totalizando 2.165 procedimentos clínicos e 296 procedimentos preventivos: aplicação de cariostático (123); aplicação de selante (160) e aplicação de verniz fluoretado (13), foram confeccionadas 24 próteses totais para 12 moradores e foram encaminhadas 358 crianças para tratamento de maior complexidade para a Unidade Básica de Saúde

Sexual Competence in Higher Education: Global Perspective in a Multicentric Project in the Nursing Degree

Sexuality is an important issue in the university careers of nursing students to ensure that they provide comprehensive care. It is necessary according to the recommendation of the World Health Organization. However, research reveals deficiencies and the need for further development. The aim of the study is to describe the perspective of teachers and students on the content of sexuality in nursing education. The project aims to analyze the attitudes and beliefs of the students about the sexuality of their patients. Furthermore, the experience and sexual lives of the future nurses, as well the teaching of sexuality content in the curriculum, will be analyzed. As for the educators, their level of knowledge about sexuality and vision of sexuality education in undergraduate nursing education will be analyzed. This study is an exploratory and descriptive study with a quantitative- qualitative approach in a multi-center context. The sample is composed of students and professors of nursing courses from five universities (Portugal, Spain, Italy and United States). Questionnaires and semistructured interviews will be used for data collection. The results of the study will allow the inclusion of sexual competence in the curriculum from the beginning in higher education. This article describes the research protocol

Loss of Ambra1 promotes melanoma growth and invasion

Melanoma is the deadliest skin cancer. Despite improvements in the understanding of the molecular mechanisms underlying melanoma biology and in defining new curative strategies, the therapeutic needs for this disease have not yet been fulfilled. Herein, we provide evidence that the Activating Molecule in Beclin-1-Regulated Autophagy (Ambra1) contributes to melanoma development. Indeed, we show that Ambra1 deficiency confers accelerated tumor growth and decreased overall survival in Braf/Pten-mutated mouse models of melanoma. Also, we demonstrate that Ambra1 deletion promotes melanoma aggressiveness and metastasis by increasing cell motility/invasion and activating an EMT-like process. Moreover, we show that Ambra1 deficiency in melanoma impacts extracellular matrix remodeling and induces hyperactivation of the focal adhesion kinase 1 (FAK1) signaling, whose inhibition is able to reduce cell invasion and melanoma growth. Overall, our findings identify a function for AMBRA1 as tumor suppressor in melanoma, proposing FAK1 inhibition as a therapeutic strategy for AMBRA1 low-expressing melanoma. The absence of scaffold protein Ambra1 leads to hyperproliferation and growth in mouse models. Here the authors show that Ambra1 deficiency accelerates melanoma growth and increases metastasis in mouse models of melanoma through FAK1 hyperactivation

Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells

© 2018, American Society for Clinical Investigation. This article has been published in final form at https://doi.org/10.1172/JCI120612First-generation immune checkpoint inhibitors, including anti-CTLA-4 and anti-programmed death 1 (anti-PD-1) antibodies, have led to major clinical progress, yet resistance frequently leads to treatment failure. Thus, new targets acting on T cells are needed. CD33-related sialic acid-binding immunoglobulin-like lectins (Siglecs) are pattern-recognition immune receptors binding to a range of sialoglycan ligands, which appear to function as self-associated molecular patterns (SAMPs) that suppress autoimmune responses. Siglecs are expressed at very low levels on normal T cells, and these receptors were not until recently considered as interesting targets on T cells for cancer immunotherapy. Here, we show an upregulation of Siglecs, including Siglec-9, on tumor-infiltrating T cells from non-small cell lung cancer (NSCLC), colorectal, and ovarian cancer patients. Siglec-9-expressing T cells coexpressed several inhibitory receptors, including PD-1. Targeting of the sialoglycan-SAMP/Siglec pathway in vitro and in vivo resulted in increased anticancer immunity. T cell expression of Siglec-9 in NSCLC patients correlated with reduced survival, and Siglec-9 polymorphisms showed association with the risk of developing lung and colorectal cancer. Our data identify the sialoglycan-SAMP/Siglec pathway as a potential target for improving T cell activation for immunotherapy.Peer reviewe

The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer

The natural history of cancers associated with virus exposure is intriguing, since only a minority of human tissues infected with these viruses inevitably progress to cancer. However, the molecular reasons why the infection is controlled or instead progresses to subsequent stages of tumorigenesis are largely unknown. In this article, we provide the first complete DNA methylomes of double-stranded DNA viruses associated with human cancer that might provide important clues to help us understand the described process. Using bisulfite genomic sequencing of multiple clones, we have obtained the DNA methylation status of every CpG dinucleotide in the genome of the Human Papilloma Viruses 16 and 18 and Human Hepatitis B Virus, and in all the transcription start sites of the Epstein-Barr Virus. These viruses are associated with infectious diseases (such as hepatitis B and infectious mononucleosis) and the development of human tumors (cervical, hepatic, and nasopharyngeal cancers, and lymphoma), and are responsible for 1 million deaths worldwide every year. The DNA methylomes presented provide evidence of the dynamic nature of the epigenome in contrast to the genome. We observed that the DNA methylome of these viruses evolves from an unmethylated to a highly methylated genome in association with the progression of the disease, from asymptomatic healthy carriers, through chronically infected tissues and pre-malignant lesions, to the full-blown invasive tumor. The observed DNA methylation changes have a major functional impact on the biological behavior of the viruses

Population Prevalence of Trachoma in Nine Rural Non-Indigenous Evaluation Units of Brazil.

Purpose: To assess the contemporary prevalence of trachoma in Brazil's non-indigenous population, surveys of those thought to be at greatest risk of disease were conducted.Methods: Rural census tracts of non-indigenous population from nine mesoregions were selected to compose the survey evaluation units (EUs) by considering previously endemic municipalities at greatest risk of trachoma. In each of the nine EUs, we conducted a population-based prevalence survey. Every resident of selected households aged ≥1 year was examined for trachomatous inflammation - follicular (TF) and trachomatous trichiasis (TT). Additionally, data were collected on household-level access to water, sanitation, hygiene (WASH) and education.Results: A total of 27,962 individuals were examined across nine EUs. The age-adjusted TF prevalence in 1-9-year-olds was 99% of surveyed children.Conclusions: The prevalence of TF was well below the target for elimination as a public health problem in all EUs. Because EUs surveyed were selected to represent the highest-risk non-indigenous areas of the country, TF prevalence is unlikely to be ≥5% in non-indigenous populations elsewhere. In one EU, the prevalence of TT was above the target threshold for elimination. Further investigation and possibly improvement in TT surgical provision are required in that EU

The psychological science accelerator’s COVID-19 rapid-response dataset

In response to the COVID-19 pandemic, the Psychological Science Accelerator coordinated three large-scale psychological studies to examine the effects of loss-gain framing, cognitive reappraisals, and autonomy framing manipulations on behavioral intentions and affective measures. The data collected (April to October 2020) included specific measures for each experimental study, a general questionnaire examining health prevention behaviors and COVID-19 experience, geographical and cultural context characterization, and demographic information for each participant. Each participant started the study with the same general questions and then was randomized to complete either one longer experiment or two shorter experiments. Data were provided by 73,223 participants with varying completion rates. Participants completed the survey from 111 geopolitical regions in 44 unique languages/dialects. The anonymized dataset described here is provided in both raw and processed formats to facilitate re-use and further analyses. The dataset offers secondary analytic opportunities to explore coping, framing, and self-determination across a diverse, global sample obtained at the onset of the COVID-19 pandemic, which can be merged with other time-sampled or geographic data