Study of the fracture process of Al Hoceima earthquake (24/02/2004, Mw=6.2) from regional and teleseismic data.

We studied the source time function (STF) and rupture process of the 2004 Alhoceima, Morocco earthquake of Mw = 6.2 using teleseismic and regional broad-band data. From regional broad-band data, STF function was determined using three large after- shocks as empirical Green functions. We inverted of body wave forms at teleseismic distances using an extended source model with rupture velocity between 2.5-3.0 km and using as preliminary orientation the fault plane solution derived from 126 P-wave polarities. Results show a complex bilateral rupture formed by four shallow subevents (2-8 km) with a maximum seismic moment release during the first seconds (more than 80% of a total of 1.8x1018 Nm) and time duration of 8-10 s. The focal mechanism shows a strike slip motion with a normal component. Nodal planes strike on NNE- SSW and WNW-ESE direction with horizontal pressure axes in NNW-SSE direction. The rupture propagated mainly towards the North. This propagation is in agreement with the damages caused in the epicentral region. The larger aftershocks have been relocated using a master event method. Comparisson of these results with those ob- tained for the 1994 earthquake shown similar behaviour: complex rupture process and, apparently, no relation of the 1994 nor the 2004 shocks with the Nekor fault, the most important geological feature in the area. The stress pattern derived from focal mech- anisms of 1994 and 2004 are in agreement with the regional stress pattern, horizontal compression in NNW-SSE and horizontal extension in E-W direction in the Alboran Sea

Intermediate depth and deep earthquakes: complexity of the Ibero-Magrhebian region

The Ibero-Magrhebian region is located at the plate boundary between Eurasia and Africa and it is a tectonically complex region. A sign of the complexity, is the occurrence of intermediate depth earthquakes (40<h<150 km), located in south Spain, between Granada- Malaga and at the west part of Alboran Sea, together with the occurrence of very deep earthquakes (h≈650 km) near Dúrcal (Granada). Intermediate depth shocks are mostly confined within a relatively narrow region (50 km width) located East of Gibraltar, extending NNE-SSW from the Malaga (Spain) area to a region offshore the Moroccan coast. We have studied focal mechanisms of these earthquakes from inversion of body wave. The stress pattern in the Ibero-Maghrebian region obtained from solutions of selected shallow, intermediate depth and deep shocks show the complexity of the region. The seismotectonic scheme show horizontal compression in NNW-SSE direction in the Gulf of Cádiz. In northern Africa, the stress pattern changes and it corresponds to strike-slip motion, with extends from west of the Gibraltar Strait until the western Algeria, where in the Oran region the horizontal compression N-S reapers, with a clear domain of the thrusting faults in Algeria. In the Alboran Sea there is horizontal extension in E-W direction for shallow events. The intermediate depth shock located at the western part of the Alboran Sea show a change on the stress pattern: to the west of 4.5oW, focal mechanisms show vertical tension axis, while to the east, they show vertical pressure axis. These stress orientations are not present in deep earthquakes, where the pressure axes dip 45o to the east. The intermediate and deep earthquakes may be related to some kind of subduction or delamination processes, more recent for the intermediate depth shocks and older for the very deep activity

VO2max changes in English futsal players after a 6-week period of specific small-sided games training

Futsal is a high-intensity, intermittent sport where accelerations and short sprints are performed at maximal or sub-maximal intensity. These efforts are interspersed by brief recovery periods, during 2 halves of 20 minutes stopping clock. Aerobic endurance inevitably plays a key role in the players’ performance. The aim of this study was to analyse the VO2 max progression and the agility (with and without ball) of English futsal players during a 6-week period of small-sided games practice. Two teams volunteered to participate in this study; an experimental group (EG), which performed a specialised small-sided training regime and a control group (CG) (normal training regime). VO2max was estimated from the results of the 20-metre Multi-Stage Fitness Test. The VO2max of the futsal players in the EG improved significantly (58.73±2.41 ml/kg/min vs. 60.11 ± 2.99 ml/kg/min, p=0.04). The same player's agility and agility with ball performance did not report any significant changes in either group. The results showed that periodisation, training sessions and methods based on small-sided games, which implied a change in the number of players, the size of the pitch and the task constraints, were adequate to increase aerobic endurance

XML Markup for maintenance management of critical care medical devices

Preventive maintenance of biomedical devices is of particular concern to avoid failures and breakdowns, especially for critical care and life supporting devices. Signs of potential failures are not always visible and so, they should be inspected and tested periodically using the appropriate technology. Patient simulators have become one of the essential tools for any biomedical department on every health institution, but its cost is still high to be afforded by everyone. The Labview interactive virtual instrument SIMPAC, a simple PC-based patient simulator, showed to be a low cost powerful tool for simulation of healthy and pathological conditions using signals repositories of different biomedical devices such as EEG, ECG, etc., and also to record the output signals of devices like pacemakers, defibrillators, etc. Here we present an enhancement of the tool which consists of adding a secure reporting feature using XML for presenting tests results, applying digital signature for granting report integrity, assuring this way that reports can not be altered by intentional or accidental manipulation of the data contained on it, according to the terms of the medical technology law. In addition, SIMPAC brings a low cost solution for teaching and practical purposes.Sociedad Argentina de Informática e Investigación Operativa (SADIO

Interactions of human galectins with Trypanosoma cruzi: binding profile correlate with genetic clustering of lineages

This is a pre-copyedited, author-produced PDF of an article accepted for publication in Glycobiology following peer review. The version of record Pineda, M.A. et al. Interactions of human galectins with Trypanosoma cruzi: binding profile correlate with genetic clustering of lineages. Glycobiology 25.2 (2015): 197-210 is available online at: http://dx.doi.org/10.1093/glycob/cwu103We report here the specific interaction between several members of the human galectin family with the three developmental stages of several genetic lineages of the protozoan parasite Trypanosoma cruzi. We provide data of specific and differential binding of human galectins-1, 3, 4, 7 and 8 to 14 strains of T. cruzi that belong to the six genetic lineages representing the genetic diversity of the parasite. It is shown that galectins preferentially bind forms present in the host, trypomastigotes and amastigotes, compared to the non-infective epimastigote present on the intestinal tract of the vector, reflecting the changes on glycosylation that occur during the metacyclogenesis and amastigogenesis process. Also, it is evidenced that galectin binding to the parasites promotes binding to the host cells and higher infection rates. In addition evidence is provided indicating that the intracellular amastigotes may take over the cytosolic pool of some galectins when released to the extracellular medium. Finaly, by applying unweighted pair group method analysis to the galectin binding profile to either cell-derived trypomastigotes or amastigotes we show that the differential binding profile by the host galectins to the six lineages resembles the clustering based in genetic data. Therefore, the differential binding profile for the six lineages could have implications in the immunopathology of Chagas’ disease, affecting the complex network of immune responses on which galectins mediate, thus providing linkage clues to the notion that different lineages may be related to different clnical forms of the disease.This work was supported by grants from the Fondo de Investigaciones Sanitarias-Ministerio de Sanidad (FIS-PI11/00033) to PB and (FIS-PI11/0095) to MS, and grant ChagasEpiNet (European VII framework Program) to MF. The financial support Network RICET from the FIS, Ministerio de Sanidad and Fundacion Ramon Areces is acknowledge

Numerical and Experimental Evaluation of a CFRP Fatigue Strengthening for Stringer-Floor Beam Connections in a 19th Century Riveted Railway Bridge

ABSTRACT: A local and global finite element analysis of the stringer-floor beam connection of a 19th century riveted railway bridge in Spain made of puddle iron were performed to obtain the maximum principal strains in the riveted connecting angles corresponding to bending moments from train loading on the bridge. Due to the anisotropic nature of puddle iron, the connecting angles were modelled using Hill anisotropic plasticity potential and a parametric study in the local FE model of the connection was performed. A laboratory specimen fabricated with original stringers dismantled from the railway bridge was tested to calibrate the numerical models, so the yield stress ratio that best fitted experimental results was obtained. Based on the method of constant fatigue-life diagram and modified Goodman fatigue failure criterion, it was detected that the connecting angles were prone to fatigue crack initiation, as the combination of mean stress and alternating stress amplitude at the toe of the angle fillet remained outside the infinite fatigue-life region. An innovative strengthening system based on adhesively-bonded carbon-fiber reinforced polymer (CFRP) angles was designed to prevent fatigue crack initiation in the connecting angles of the stringer-floor beam connection. Different CFRP laminate layouts were numerically evaluated and a proper configuration was obtained that reduced both the mean stress and the alternating stress amplitude in the connecting angle to shift from finite fatigue-life region to infinite fatigue-life region in the constant fatigue-life diagram. To validate the effectiveness of the proposed CFRP strengthening method, its application on a second laboratory specimen fabricated with original stringers was evaluated experimentally and compared with numerical results. The research study conducted showed that the use of adhesively-bonded CFRP angles was an effective strengthening system in reducing the stress level in the fillet region of the puddle iron connecting angles (where fatigue cracks are prone to initiate) and consequently could increase fatigue life of the stringer-floor beam connection

Leishmania infantum HSP70-II null mutant as candidate vaccine against leishmaniasis: a preliminary evaluation

<p>Abstract</p> <p>Background</p> <p>Visceral leishmaniasis is the most severe form of leishmaniasis and no effective vaccine exists. The use of live attenuated vaccines is emerging as a promising vaccination strategy.</p> <p>Results</p> <p>In this study, we tested the ability of a <it>Leishmania infantum </it>deletion mutant, lacking both <it>HSP70-II </it>alleles (ΔHSP70-II), to provide protection against <it>Leishmania </it>infection in the <it>L. major</it>-BALB/c infection model. Administration of the mutant line by either intraperitoneal, intravenous or subcutaneous route invariably leads to the production of high levels of NO and the development in mice of type 1 immune responses, as determined by analysis of anti-<it>Leishmania </it>IgG subclasses. In addition, we have shown that ΔHSP70-II would be a safe live vaccine as immunodeficient SCID mice, and hamsters (<it>Mesocricetus auratus</it>), infected with mutant parasites did not develop any sign of pathology.</p> <p>Conclusions</p> <p>The results suggest that the ΔHSP70-II mutant is a promising and safe vaccine, but further studies in more appropriate animal models (hamsters and dogs) are needed to appraise whether this attenuate mutant would be useful as vaccine against visceral leishmaniasis.</p