O trabalho do pedagogo da Secretaria de Educação do Distrito Federal para a organização pedagógica da escola

Dissertação (mestrado)—Universidade de Brasília, Faculdade de Educação, Programa de Pós-Graduação em Educação, 2019.O estudo visa investigar o trabalho do pedagogo da Equipe Especializada de Apoio à Aprendizagem (EEAA) da Secretaria de Educação do Distrito Federal (SEEDF) a partir do seguinte problema: considerando as diferentes atuações do Pedagogo, qual o trabalho do pedagogo da EEAA/SEEDF quanto a organização pedagógica da escola? O objetivo: analisar o trabalho do pedagogo atuante na Equipe Especializada de Apoio à Aprendizagem – EEAA para a organização pedagógica das escolas públicas do DF. A EEAA atua no programa de intervenção educacional e no trabalho pedagógico para onde são encaminhados estudantes com dificuldades de aprendizagem. Na fundamentação teórica, foram tratados os conceitos de trabalho e educação. Pautou-se, também, nas principais legislações referentes à EEAA: a Orientação Pedagógica do Serviço Especializado de Apoio à Aprendizagem (GDF, 2010a), Regimento Interno da Secretaria de Educação do DF (GDF, 2015), os Referenciais para atuação do Serviço Especializado de Apoio à Aprendizagem (GDF, 2014) e a Portaria nº 254 (12/08/2008). A base teórica que sustentou o estudo encontra-se em autores como Marx (1982, 1989, 2004), Antunes (2012), Pimenta (1999), Dantas (2001, 2003, 2007), Nóvoa (1999), Gauthier e Tardif (2010), Franco (2003, 2008), Imbernón (2010), Cruz (2012), entre outros. Na metodologia, adotou-se o Materialismo Histórico Dialético situado na abordagem qualitativa (TRIVIÑOS, 1987), (CRESWELL, 2007). Para análise dos dados, optou-se por utilizar a técnica da Análise do Discurso Crítica (ORLANDI, 2005), (FAIRCLOUGH, 2001) e categorias do Materialismo Histórico Dialético. Os instrumentos utilizados foram: pesquisa documental, grupo focal, entrevistas semiestruturadas e questionários (BARBOUR, 2009), (GIL, 2008). As conclusões demonstraram que, com este estudo, foi possível entender quem é o pedagogo da EEAA na SEEDF, as contradições existentes entre os documentos, legislações e o seu real trabalho na escola. Compreendeu-se que há uma articulação entre os pedagogos, os docentes, estudantes e família, proporcionando a organização do trabalho pedagógico. Foi possível entender que os professores se beneficiam do trabalho do pedagogo, mesmo não tendo conhecimento acerca de sua função. Percebeu-se que há carência na formação continuada específica aos pedagogos da EEAA e que o trabalho pedagógico desenvolvido em escolas públicas do DF merece ser visto como resistência às políticas neoliberais que invadem as práticas, desde que seja um trabalho comprometido e crítico.The study aims to investigate the work of the pedagogue of the Specialized Learning Support Team (EEAA) of the Federal District Education Secretariat (SEEDF) based on the following problem: considering the different acts of the Pedagogue, what is the work of the Pedagogue of the EEAA/SEEDF regarding the pedagogical organization of the school? The objective: to analyze the work of the pedagogue working in the Specialized Learning Support Team - EEAA for the pedagogical organization of public schools of df. The EEAA operates in the educational intervention program and pedagogical work to which students with learning difficulties are sent. In the theoretical foundation, the concepts of work and education were treated. It was also focused on the main legislations related to the EEAA: the Pedagogical Guidance of the Specialized Learning Support Service (GDF, 2010a), The Internal Rules of The Federal Department of Education (GDF, 2015), the References for the performance of the Specialized Learning Support Service (GDF, 2014) and Ordinance No. 254 (12/08/2008). The theoretical basis that supported the study is found in authors such as Marx (1982, 1989, 2004), Antunes (2012), Pimenta (1999), Dantas (2001, 2003, 2007), Nóvoa (1999), Gauthier and Tardif (2010), Franco (2003, 2008), Imbernón (2010), Cruz (2012), among others. In the methodology, dialectical historical materialism was adopted situated in the qualitative approach (TRIVIÑOS, 1987), (CRESWELL, 2007). For data analysis, we chose to use the critical discourse analysis technique (ORLANDI, 2005), (FAIRCLOUGH, 2001) and categories of Dialectical Historical Materialism. The instruments used were: documentary research, focus group, semi-structured interviews and questionnaires (BARBOUR, 2009), (GIL, 2008). The conclusions showed that, with this study, it was possible to understand who is the pedagogue of the EEAA in seedf, the contradictions between documents, legislation and their real work at school. It was understood that there is a articulation between pedagogues, teachers, students and families, providing the organization of pedagogical work. It was possible to understand that teachers benefit from the work of the pedagogue, even though they are not aware of their function. It was noticed that there is a lack in the continuing training specific to EEAA pedagogues and that the pedagogical work developed in public schools of the Federal District deserves to be seen as resistance to neoliberal policies that invade practices, provided that it is a committed and critical work

A produção acadêmica sobre ensino híbrido na formação de professores(as) de ciências e Biologia

Este estudo é um mapeamento das pesquisas sobre Ensino Híbrido na formação docente (2012 – 2022), o Estado da Questão (EQ). Objetivou analisar as publicações sobre Ensino Híbrido na formação de professores(as) de Ciências e Biologia e tentar identificar possíveis contribuições dessa proposta para a qualificação docente. O levantamento foi realizado nas bases de dados Portal de Periódicos Capes, Plataforma SciELO e Google Acadêmico, utilizando os descritores: Ensino Híbrido; Blended Learning; tecnologias educacionais; formação de professores(as); ensino de Ciências e ensino de Biologia. Foram encontrados 16 trabalhos relativos, mas nenhum aborda o Ensino Híbrido na formação de professores(as) de Ciências e Biologia, reforçando a necessidade de investigações na área

Combinação de celecoxibe com 5-fluorouracil induz apoptose em linhagem celular de adenocarcinoma colorretal HT-29

Este trabalho se propôs a analisar o efeito da combinação do 5-fluorouracil (5-FU) e Celeboxibe (CLX), na linhagem celular de carcinoma humano HT-29. As células foram expostas a tratamentos isolados com 5-FU por 48h e combinados com CLX por 24 h + 5-FU por 24 h. Para determinar o efeito sobre citotoxicidade foi realizado o ensaio de SRB; para verificar a distribuição das células no ciclo celular foi realizado citometria de fluxo e para atividade de genes relacionados à apoptose (BIRC-5) e à autofagia (BENC-1) ensaio de expressão gênica. Nossos resultados demonstraram que a linhagem HT-29 é sensível ao 5-FU através do aumento da morte celular e, quando analisado o tratamento combinado, as células tiveram sua sensibilidade ao quimioterápico aumentada. Dados obtidos nos ensaios do ciclo celular e expressão gênica corroboram com os achados, uma vez que genes associados aos processos de morte celular apresentam-se alterados, confirmando ativação de processos de morte, mais provavelmente apoptose

Erica: Prevalences Of Hypertension And Obesity In Brazilian Adolescents

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)To estimate the prevalence of arterial hypertension and obesity and the population attributable fraction of hypertension that is due to obesity in Brazilian adolescents. METHODS: Data from participants in the Brazilian Study of Cardiovascular Risks in Adolescents (ERICA), which was the first national school-based, cross-section study performed in Brazil were evaluated. The sample was divided into 32 geographical strata and clusters from 32 schools and classes, with regional and national representation. Obesity was classified using the body mass index according to age and sex. Arterial hypertension was defined when the average systolic or diastolic blood pressure was greater than or equal to the 95th percentile of the reference curve. Prevalences and 95% confidence intervals (95% CI) of arterial hypertension and obesity, both on a national basis and in the macro-regions of Brazil, were estimated by sex and age group, as were the fractions of hypertension attributable to obesity in the population. RESULTS: We evaluated 73,399 students, 55.4% female, with an average age of 14.7 years (SD = 1.6). The prevalence of hypertension was 9.6% (95% CI 9.0-10.3); with the lowest being in the North, 8.4% (95% CI 7.7-9.2) and Northeast regions, 8.4% (95% CI 7.6-9.2), and the highest being in the South, 12.5% (95% CI 11.0-14.2). The prevalence of obesity was 8.4% (95% CI 7.9-8.9), which was lower in the North region and higher in the South region. The prevalences of arterial hypertension and obesity were higher in males. Obese adolescents presented a higher prevalence of hypertension, 28.4% (95% CI 25.5-31.2), than overweight adolescents, 15.4% (95% CI 17.0-13.8), or eutrophic adolescents, 6.3% (95% CI 5.6-7.0). The fraction of hypertension attributable to obesity was 17.8%. CONCLUSIONS: ERICA was the first nationally representative Brazilian study providing prevalence estimates of hypertension in adolescents. Regional and sex differences were observed. The study indicates that the control of obesity would lower the prevalence of hypertension among Brazilian adolescents by 1/5.501Brazilian Department of Science and Technology at the Secretariat of Science and TechnologyStrategic Inputs of the Ministry of Health (Departamento de Ciencia e Tecnologia da Secretaria de Ciencia e Tecnologia e Insumos Estrategicos do Ministerio da Saude - Decit/SCTIE/MS)Health Fund Sector (Fundo Setorial de Saude - CT-health) at the Ministry of science, Technology and Innovation (Ministerio da Ciencia, Tecnologia e Inovacao - MCTI)FINEP [01090421]CNPq [2010/565037-2]hospital research incentive fund for Clinics in Porto Alegre (fundo de incentivo a Pesquisa do Hospital de Clinicas de Porto Alegre - HCPA) [405,009/FIPE-2012-7]Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Erica: Prevalence Of Metabolic Syndrome In Brazilian Adolescents

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)To determine the prevalence of metabolic syndrome and its components in Brazilian adolescents. METHODS: We evaluated 37,504 adolescents who were participants in the Study of Cardiovascular Risks in Adolescents (ERICA), a cross-sectional, school-based, national study. The adolescents, aged from 12 to 17 years, lived in cities with populations greater than 100,000 inhabitants. The sample was stratified and clustered into schools and classes. The criteria set out by the International Diabetes Federation were used to define metabolic syndrome. Prevalences of metabolic syndrome were estimated according to sex, age group, school type and nutritional status. RESULTS: Of the 37,504 adolescents who were evaluated: 50.2% were female; 54.3% were aged from 15 to 17 years, and 73.3% were from public schools. The prevalence of metabolic syndrome was 2.6% (95% CI 2.3-2.9), slightly higher in males and in those aged from 15 to 17 years in most macro-regions. The prevalence was the highest in residents from the South macro-region, in the younger female adolescents and in the older male adolescents. The prevalence was higher in public schools (2.8% [95% CI 2.4-3.2]), when compared with private schools (1.9% [95% CI 1.4-2.4]) and higher in obese adolescents when compared with nonobese ones. The most common combinations of components, referring to 3/4 of combinations, were: enlarged waist circumference (WC), low HDL-cholesterol (HDL-c) and high blood pressure; followed by enlarged WC, low HDL-c and high triglycerides; and enlarged WC, low HDL-c, high triglycerides and blood pressure. Low HDL was the second most frequent component, but the highest prevalence of metabolic syndrome (26.8%) was observed in the presence of high triglycerides. CONCLUSIONS: ERICA is the first Brazilian nation-wide study to present the prevalence of metabolic syndrome and describe the role of its components. Despite the prevalence of Metabolic Syndrome being low, the high prevalences of some components and participation of others in the syndrome composition shows the importance of early diagnosis of this changes, even if not grouped within the metabolic syndrome.501Department of Science and Technology of the Secretariat of Science, Technology and Strategic Inputs of the Ministry of Health (Decit/SCTIE/MS)Health Sectorial Fund (Fundo Setorial de Saude - CT-Saude) of the Ministry of Science, Technology and Innovation (MCTI)FINEP [01090421]CNPq [2010/565037-2]Research Incentive Fund of the Hospital de Clinicas de Porto Alegre - (Fundo de Incentivo a Pesquisa do Hospital de Clinicas de Porto Alegre - FIPE-HCPA) [405.009/2012-7]Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Erratum to: The study of cardiovascular risk in adolescents – ERICA: rationale, design and sample characteristics of a national survey examining cardiovascular risk factor profile in Brazilian adolescents

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Polymorphisms in the MBL2 gene are associated with the plasma levels of MBL and the cytokines IL-6 and TNF-α in severe COVID-19

IntroductionMannose-binding lectin (MBL) promotes opsonization, favoring phagocytosis and activation of the complement system in response to different microorganisms, and may influence the synthesis of inflammatory cytokines. This study investigated the association of MBL2 gene polymorphisms with the plasma levels of MBL and inflammatory cytokines in COVID-19.MethodsBlood samples from 385 individuals (208 with acute COVID-19 and 117 post-COVID-19) were subjected to real-time PCR genotyping. Plasma measurements of MBL and cytokines were performed by enzyme-linked immunosorbent assay and flow cytometry, respectively.ResultsThe frequencies of the polymorphic MBL2 genotype (OO) and allele (O) were higher in patients with severe COVID-19 (p< 0.05). The polymorphic genotypes (AO and OO) were associated with lower MBL levels (p< 0.05). IL-6 and TNF-α were higher in patients with low MBL and severe COVID-19 (p< 0.05). No association of polymorphisms, MBL levels, or cytokine levels with long COVID was observed.DiscussionThe results suggest that, besides MBL2 polymorphisms promoting a reduction in MBL levels and therefore in its function, they may also contribute to the development of a more intense inflammatory process responsible for the severity of COVID-19