"Figuring it Out": A Grounded Theory of College to Post-College Transition

Before colleges and universities can be truly effective in preparing students for a post-college life, an understanding of the college to post-college transition process for recent college graduates is needed. Although there is extensive literature characterizing the college experience, little research exists surrounding the experiences of recent college graduates, especially during the transition out of college. The purpose of this study was to understand the transition from college to post-college life for recent college graduates. Conducted from a constructivist epistemological paradigm, this study employed grounded theory methods to understand how participants interpreted their post-college transition experience. Specifically, this study aimed to understand the post-college transition process, the experiences most salient during the transition, and how recent graduates make meaning of post-college life. In-depth interviews were conducted with a diverse sample of 13 recent graduates from a large, Mid-Atlantic research institution over 18 months. The result was the emergence of a theory of college to post-college transition grounded in the perspectives and experiences of the participants. The grounded theory of college to post-college transition builds upon three findings: the process of post-college transition, the construct of transitioning adult, and how recent graduates approach the transition. The post-college transition process was characterized by navigating a series of realizations about self and what matters. This process of "figuring it out," incorporated four active and overlapping characteristics germane to the transition: managing loss, establishing place, focusing on self, and searching for purpose. The transition process was also enhanced by participants' ability to negotiate external influences and internal coping strategies. Through the stories of the participants, it also emerged that recent college graduates equate the post-college transition with the transition to adulthood. The "transitioning adults" navigated the post-college transition through one of five distinct approaches: Initiator, Instrumentalist, Observer, Adaptor, and Traditionalist. The findings are relevant for recent college graduates and college students preparing to graduate, as well as for employers, parents, faculty, and college administrators. This research also has implications for student affairs practice and workforce preparedness. Finally, the findings inform both theory development and future research, particularly on lifespan development and transition theory

Choices of Contention: Decision Making Factors Leading to the Substitute Method Over In-Kind Repairs and Their Effectiveness at Lyndhurst Estate

Lyndhurst Mansion, located in Tarrytown, New York is a masterpiece of American Gothic Revival architecture designed by Alexander Jackson Davis beginning in 1838. Since its acquisition by the National Trust in 1961, the property has carried out a number of repairs to the mansion and other buildings on the estate in which a substitute material was chosen over an in-kind material. Financial constraints appear to be the driving force behind these decisions. Other factors, durability of materials and preservation philosophy, also played a role. An aim of this thesis is to determine the role these factors played in choosing methods and materials used in these repairs. Another aim is to assess the success of the substitute method compared to in-kind repair. Research conducted in Lyndhurst\u27s archives as well as interviews with current and past employees provided narrative data regarding the decision making process, while assessment of five case studies provided insight into the effectiveness of the decisions. Findings concluded that cost often outweighed the other considerations when choosing a repair method and materials. Substitute materials at Lyndhurst proved overall to be inferior to those of an in-kind replacement. The findings serve as an example of the financial challenges facing many historic sites

The Power of Open: Benefits, Barriers, and Strategies for Integration of Open Educational Resources

Open Educational Resources (OER) are becoming a significant, mission-driven trend within educational literature. To help address rising costs, instructors and designers are looking to OER to effectively replace traditional instructional content, which requires more than just identify and replace. Drawing from 51 OER studies conducted in countries across the five continents, this systematic literature review explored the empirical themes evident in the current research on a global scale. This review found (1) discoverability, sustainability, and remixing are significant barriers that stand in the way of OER disrupting traditional textbook models; (2) there is no significant difference in learning outcomes when instructors incorporate OER; and (3) implementation of OER as instructional strategies is challenging but can be effective in supporting positive learning outcomes when properly designed. The paper concludes with a discussion of gaps in the literature, considerations for implementation and further directions for future research

Applicant perception of virtual interviews in cardiothoracic surgery: A Thoracic Education Cooperative Group Study

OBJECTIVES: Cardiothoracic programs used virtual interviews exclusively this year. As programs consider using virtual interviews permanently, our goal was to evaluate the experience of applicants with virtual interviews. METHODS: All 2020-2021 traditional cardiothoracic fellowship applicants received an anonymous electronic survey after the Match process ended. The survey assessed the number of interviews, strengths, and inadequacies of virtual interviews and factors that affected rank decision. RESULTS: Forty-three percent of applicants responded (60/139). The average number of interviews was 16.0. Eighty percent (48/60) of respondents successfully matched. Eighty-seven percent (52/60) of respondents had a favorable experience with virtual interviews, and 97% (58/60) found them to be convenient. However, only 50% (30/60) were able to evaluate a program fully. Respondents who matched were more likely to have a favorable experience (P = .02), but not more likely to be able to evaluate a program fully (P = .35). The most valued aspect was the informal meet and greet session with fellows (4.2 of 5). The least valued aspect was the program\u27s social media site (2.0 of 5). The factors most frequently used to decide ranking were case numbers by 92% (55/60) and culture/personality by 82% (49/60). CONCLUSIONS: Virtual interviews were perceived more favorably compared with last year, but half of applicants were still unable to evaluate a program fully. Fellow interactions were the most popular aspect of virtual interviews. As programs consider using virtual interviews permanently, more exposure to current trainees and a more robust social media/online presence will improve favorability

Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity

Numerous studies support the fact that a genetically diverse mouse population may be useful as an animal model to understand and predict toxicity in humans. We hypothesized that cultures of hepatocytes obtained from a large panel of inbred mouse strains can produce data indicative of inter-individual differences in in vivo responses to hepato-toxicants. In order to test this hypothesis and establish whether in vitro studies using cultured hepatocytes from genetically distinct mouse strains are feasible, we aimed to determine whether viable cells may be isolated from different mouse inbred strains, evaluate the reproducibility of cell yield, viability and functionality over subsequent isolations, and assess the utility of the model for toxicity screening. Hepatocytes were isolated from 15 strains of mice (A/J, B6C3F1, BALB/cJ, C3H/HeJ, C57BL/6J, CAST/EiJ, DBA/2J, FVB/NJ, BALB/cByJ, AKR/J, MRL/MpJ, NOD/LtJ, NZW/LacJ, PWD/PhJ and WSB/EiJ, males) and cultured for up to 7 days in traditional 2-dimesional culture. Cells from B6C3F1, C57BL/6J, and NOD/LtJ strains were treated with acetaminophen, WY-14,643 or rifampin and concentration-response effects on viability and function were established. Our data suggest that high yield and viability can be achieved across a panel of strains. Cell function and expression of key liver specific genes of hepatocytes isolated from different strains and cultured under standardized conditions is comparable. Strain-specific responses to toxicant exposure have been observed in cultured hepatocytes and these experiments open new opportunities for further developments of in vitro models of hepatotoxicity in a genetically diverse population

Lateral frontal cortex volume reduction in Tourette syndrome revealed by VBM

<p>Abstract</p> <p>Background</p> <p>Structural changes have been found predominantly in the frontal cortex and in the striatum in children and adolescents with Gilles de la Tourette syndrome (GTS). The influence of comorbid symptomatology is unclear. Here we sought to address the question of gray matter abnormalities in GTS patients <it>with </it>co-morbid obsessive-compulsive disorder (OCD) and/or attention deficit hyperactivity disorder (ADHD) using voxel-based morphometry (VBM) in twenty-nine adult actually unmedicated GTS patients and twenty-five healthy control subjects.</p> <p>Results</p> <p>In GTS we detected a cluster of decreased gray matter volume in the left inferior frontal gyrus (IFG), but no regions demonstrating volume increases. By comparing subgroups of GTS with comorbid ADHD to the subgroup with comorbid OCD, we found a left-sided amygdalar volume increase.</p> <p>Conclusions</p> <p>From our results it is suggested that the left IFG may constitute a common underlying structural correlate of GTS with co-morbid OCD/ADHD. A volume reduction in this brain region that has been previously identified as a key region in OCD and was associated with the active inhibition of attentional processes may reflect the failure to control behavior. Amygdala volume increase is discussed on the background of a linkage of this structure with ADHD symptomatology. Correlations with clinical data revealed gray matter volume changes in specific brain areas that have been described in these conditions each.</p

Brucellosis Vaccines: Assessment of Brucella melitensis Lipopolysaccharide Rough Mutants Defective in Core and O-Polysaccharide Synthesis and Export

Background: The brucellae are facultative intracellular bacteria that cause brucellosis, one of the major neglected zoonoses. In endemic areas, vaccination is the only effective way to control this disease. Brucella melitensis Rev 1 is a vaccine effective against the brucellosis of sheep and goat caused by B. melitensis, the commonest source of human infection. However, Rev 1 carries a smooth lipopolysaccharide with an O-polysaccharide that elicits antibodies interfering in serodiagnosis, a major problem in eradication campaigns. Because of this, rough Brucella mutants lacking the O-polysaccharide have been proposed as vaccines. Methodology/Principal Findings: To examine the possibilities of rough vaccines, we screened B. melitensis for lipopolysaccharide genes and obtained mutants representing all main rough phenotypes with regard to core oligosaccharide and O-polysaccharide synthesis and export. Using the mouse model, mutants were classified into four attenuation patterns according to their multiplication and persistence in spleens at different doses. In macrophages, mutants belonging to three of these attenuation patterns reached the Brucella characteristic intracellular niche and multiplied intracellularly, suggesting that they could be suitable vaccine candidates. Virulence patterns, intracellular behavior and lipopolysaccharide defects roughly correlated with the degree of protection afforded by the mutants upon intraperitoneal vaccination of mice. However, when vaccination was applied by the subcutaneous route, only two mutants matched the protection obtained with Rev 1 albeit at doses one thousand fold higher than this reference vaccine. These mutants, which were blocked in O-polysaccharide export and accumulated internal O-polysaccharides, stimulated weak anti-smooth lipopolysaccharide antibodies. Conclusions/Significance: The results demonstrate that no rough mutant is equal to Rev 1 in laboratory models and question the notion that rough vaccines are suitable for the control of brucellosis in endemic areas.This work was funded by the European Commission (Research Contract QLK2-CT-2002-00918) and the Ministerio de Ciencia y Tecnología of Spain (Proyecto AGL2004-01162/GAN)