Research on optimization-based design

Research on optimization-based design is discussed. Illustrative examples are given for cases involving continuous optimization with discrete variables and optimization with tolerances. Approximation of computationally expensive and noisy functions, electromechanical actuator/control system design using decomposition and application of knowledge-based systems and optimization for the design of a valve anti-cavitation device are among the topics covered

Mobile phone-based interventions for improving contraception use (Review)

This is the protocol for a review and there is no abstract. The objectives are as follows: To determine wheth er inter ventions delivered by mobile phone can improve contraception us

An analysis of the factors involved in the formation of a cluster of honeybees

It has been found that the stimuli of scent, vibration, and heat, which are produced by a cluster of bees, can each, provided they are of sufficient magnitude, attract individual bees to join it. 2. Bees can be attracted by sight alone towards actively moving bees. 3. Hungry bees prefer to join a cluster of bees from whom they can obtain food; and well-fed bees are more attractive to individual bees than are hungry bees, even when the individual bees are unable to obtain food from well-fed ones

The Neutral Hydrogen Bridge between M31 and M33

The Green Bank Telescope has been used to search for 21cm HI emission over a large area between the galaxies M31 and M33 in an attempt to confirm at 9.1 arcmin angular resolution the detection by Braun and Thilker (2004) of a very extensive neutral gas "bridge" between the two systems at the level NHI approximately 10^{17} cm^{-2}. We detect HI emission at several locations up to 120 kpc in projected distance from M31, at least half the distance to M33, with velocities similar to that of the galaxies, confirming the essence of the Braun and Thilker discovery. The HI does not appear to be associated with the extraplanar high-velocity clouds of either galaxy. In two places we measure NHI > 3 x 10^{18} cm^{-2}, indicative of concentrations of HI with ~10^5 solar masses on scales <2 kpc, but over most of the field we have only 5sigma upper limits of NHI <= 1.4 x 10^{18} cm^{-2}. In very deep measurements in two directions HI lines were detected at a few 10^{17} cm^{-2}. The absence of emission at another location to a 5sigma limit NHI <= 1.5 x 10^{17} cm^{-2} suggests that the HI bridge is either patchy or confined to within ~125 kpc of M31. The measurements also cover two of M31's dwarf galaxies, And II and And XV, but in neither case is there evidence for associated HI at the 5sigma level of 1.4 x 10^4 solar masses of HI for And II, and 9.3 x 10^3 solar masses for And XV.Comment: Submitted to the Astronomical Journa

An auditory brainstem implant for treatment of unilateral tinnitus:protocol for an interventional pilot study

INTRODUCTION: Tinnitus may have a very severe impact on the quality of life. Unfortunately, for many patients, a satisfactory treatment modality is lacking. The auditory brainstem implant (ABI) was originally indicated for hearing restoration in patients with non-functional cochlear nerves, for example, in neurofibromatosis type II. In analogy to a cochlear implant (CI), it has been demonstrated that an ABI may reduce tinnitus as a beneficial side effect. For tinnitus treatment, an ABI may have an advantage over a CI, as cochlear implantation can harm inner ear structures due to its invasiveness, while an ABI is presumed to not damage anatomical structures. This is the first study to implant an ABI to investigate its effect on intractable tinnitus. METHODS AND ANALYSIS: In this pilot study, 10 adults having incapacitating unilateral intractable tinnitus and ipsilateral severe hearing loss will have an ABI implanted. The ABI is switched on 6 weeks after implantation, followed by several fitting sessions aimed at finding an optimal stimulation strategy. The primary outcome will be the change in Tinnitus Functioning Index. Secondary outcomes will be tinnitus burden and quality of life (using Tinnitus Handicap Inventory and Hospital Anxiety and Depression Scale questionnaires), tinnitus characteristics (using Visual Analogue Scale, a tinnitus analysis), safety, audiometric and vestibular function. The end point is set at 1 year after implantation. Follow-up will continue until 5 years after implantation. ETHICS AND DISSEMINATION: The protocol was reviewed and approved by the Institutional Review Board of the University Medical Centre Groningen, The Netherlands (METc 2015/479). The trial is registered at www.clinicialtrials.gov and will be updated if amendments are made. Results of this study will be disseminated in peer-reviewed journals and at scientific conferences. TRIAL REGISTRATION NUMBER: NCT02630589. TRIAL STATUS: Inclusion of first patient in November 2017. Data collection is in progress. Trial is open for further inclusion. The trial ends at 5 years after inclusion of the last patient

Giant Shapiro Resonances in a Flux Driven Josephson Junction Necklace

We present a detailed study of the dynamic response of a ring of $N$ equally spaced Josephson junctions to a time-periodic external flux, including screening current effects. The dynamics are described by the resistively shunted Josephson junction model, appropriate for proximity effect junctions, and we include Faraday's law for the flux. We find that the time-averaged $I-V$ characteristics show novel {\em subharmonic giant Shapiro voltage resonances}, which strongly depend on having phase slips or not, on $N$, on the inductance and on the external drive frequency. We include an estimate of the possible experimental parameters needed to observe these quantized voltage spikes.Comment: 8 pages RevTeX, 3 figures available upon reques

Open Access Publishing in Business Research: The Authors’ Perspective

Open access (OA) publishing is now accepted as an integral part of the emerging trends within scholarly communication. Business librarians, like their subject specialist colleagues in other disciplines, are increasingly called upon to interpret scholarly communication trends to their faculty. This study surveys 1,293 business faculty from American schools of business accredited by the Association to Advance Collegiate Schools of Business. Issues explored include business faculty publishing practices within the discipline and how these affect academic advancement, obtaining articles for their own research, electronic publishing, self-archiving, and their perceptions about OA publishing generally.With support from the Emerald Publishing Research Award 2009