Cryogenic Stress-Driven Grain Growth Observed via Microcompression with in situ Electron Backscatter Diffraction

The deformation of materials at cryogenic temperature is of interest for space, arctic, and fundamental science applications. In this work, a custom-built cooling system attached to a commercial picoindenter was used for in situ cryogenic microcompression testing of equal-channel angular-pressed copper with real-time electron backscatter diffraction. Stress-driven grain growth at cryogenic temperatures was observed during a series of elastic and plastic deformations. These results provide direct evidence for the previously predicted phenomenon, whereas previous ex situ examinations demonstrated coarsening after cryogenic loading when samples were not maintained at cryogenic temperatures between deformation and characterization

Real-time analysis keratometer

A computer assisted keratometer in which a fiducial line pattern reticle illuminated by CW or pulsed laser light is projected on a corneal surface through lenses, a prismoidal beamsplitter quarterwave plate, and objective optics. The reticle surface is curved as a conjugate of an ideal corneal curvature. The fiducial image reflected from the cornea undergoes a polarization shift through the quarterwave plate and beamsplitter whereby the projected and reflected beams are separated and directed orthogonally. The reflected beam fiducial pattern forms a moire pattern with a replica of the first recticle. This moire pattern contains transverse aberration due to differences in curvature between the cornea and the ideal corneal curvature. The moire pattern is analyzed in real time by computer which displays either the CW moire pattern or a pulsed mode analysis of the transverse aberration of the cornea under observation, in real time. With the eye focused on a plurality of fixation points in succession, a survey of the entire corneal topography is made and a contour map or three dimensional plot of the cornea can be made as a computer readout in addition to corneal radius and refractive power analysis

The modest professor:Interpretive charity and interpretive humility in John Rawls's lectures on the history of political philosophy

Governmen

The Far-Infrared/Radio Correlation in Nearby Abell Clusters

A comprehensive study of the effect of the cluster environment on the far- infrared (FIR)/radio correlation in nearby Abell clusters is presented. Using the cluster radio galaxy database from Miller & Owen (2001) and optical spectroscopy and high resolution radio images to remove AGN, we assess the FIR/radio correlation of cluster galaxies from the centers of the clusters out well past the classical Abell radius. The FIR/radio correlation is shown to hold quite well for star forming galaxies, and the FIR and radio fluxes for cluster AGN are also well correlated. In the case of AGN, the relative radio- to-FIR fluxes are greater and the scatter in the correlation is larger than those seen for star forming galaxies. We also find that there is a rare but statistically significant excess of star forming galaxies with enhanced radio emission in the centers of the clusters, and that the degree of this enhancement is typically a factor of two or three. The FIR/radio correlation for cluster star forming galaxies is also tested against line-of-sight velocity relative to the cluster systemic velocities, but no significant correlation is found. While the radial dependence of the FIR/radio correlation is consistent with the model wherein ram pressure increases the cluster galaxies' magnetic field strengths through compression, the velocity data do not confirm this model. Although a contribution from ram pressure can not be ruled out, the thermal pressure due to the ICM alone is an equally viable alternative. The high resolution radio images largely reject the hypothesis that the increased radio emission arises from an AGN component, strengthening the claim that the change in the correlation is caused by a change in the environment of the galaxies.Comment: 26 pages, including 5 figures (uses AASTeX 5.0). Accepted for publication in the Astronomical Journa

The X-ray Luminosity Function of Nearby Rich and Poor Clusters of Galaxies: A Cosmological Probe

In this letter, we present a new determination of the local (z<0.09) X-ray luminosity function (XLF) using a large, statistical sample of 294 Abell clusters and the ROSAT All-Sky-Survey. Given our large sample size, we have reduced errors by a factor of two for L(X)(0.5-2keV)>10^43 ergs/sec. We combine our data with previous work in order to explore possible constraints imposed by the shape of the XLF on cosmological models. A set of currently viable cosmologies is used to construct theoretical XLFs assuming Lx is proportional to M^p and a sigma_8-Omega_0 constraint (from Viana & Liddle 1996) based on the local X-ray temperature function. We fit these models to our observed XLF and verify that the simplest adiabatic, analytic scaling relation (e.g. Kaiser 1986) disagrees strongly with observations. If we assume that clusters can be described by the pre-heated, constant core-entropy models of Evrard & Henry (1991) then the observed XLF is consistent only with 0.1 < Omega_0 < 0.4 if the energy per unit mass in galaxies is roughly equal to the gas energy (ie if beta=1). (abridged)Comment: 4 pages, 2 figures, accepted for publication in ApJ Letters. uses emulateapj.st

Effect of component variations on the gate fidelity in linear optical networks

We investigate the effect of variations in beam-splitter transmissions and path-length differences in the nonlinear sign gate that is used for linear optical quantum computing. We identify two implementations of the gate and show that the sensitivity to variations in their components differs significantly between them. Therefore, circuits that require a precision implementation will generally benefit from additional circuit analysis of component variations to identify the most practical implementation. We suggest possible routes to efficient circuit analysis in terms of quantum parameter estimation

Murine HPV16 E7-expressing transgenic skin effectively emulates the cellular and molecular features of human high-grade squamous intraepithelial lesions.

Currently available vaccines prevent HPV infection and development of HPV-associated malignancies, but do not cure existing HPV infections and dysplastic lesions. Persistence of infection(s) in immunocompetent patients may reflect induction of local immunosuppressive mechanisms by HPV, providing a target for therapeutic intervention. We have proposed that a mouse, expressing HPV16 E7 oncoprotein under a Keratin 14 promoter (K14E7 mice), and which develops epithelial hyperplasia, may assist with understanding local immune suppression mechanisms that support persistence of HPV oncogene-induced epithelial hyperplasia. K14E7 skin grafts recruit immune cells from immunocompetent hosts, but consistently fail to be rejected. Here, we review the literature on HPV-associated local immunoregulation, and compare the findings with published observations on the K14E7 transgenic murine model, including comparison of the transcriptome of human HPV-infected pre-malignancies with that of murine K14E7 transgenic skin. We argue from the similarity of i) the literature findings and ii) the transcriptome profiles that murine K14E7 transgenic skin recapitulates the cellular and secreted protein profiles of high-grade HPV-associated lesions in human subjects. We propose that the K14E7 mouse may be an appropriate model to further study the immunoregulatory effects of HPV E7 expression, and can facilitate development and testing of therapeutic vaccines