Spending more is spending less: on the desirability of enforcing migration

We study the migration policy set by a welfare maximizing government in a model where immigrant workers differ in their skills and are imperfectly matched with heterogenous occupations. The policy fixes a minimum skill level for legal migrants, and foreign workers that fall below it can only enter the country illegally. We start by analyzing under which conditions an amnesty is desirable compared to tolerating undocumented immigrants. Next, we study when it is preferable to have ex-ante lax enforcement, rather than to carry out costly enforcement. We show that three channels play an important role in this decision: an amnesty is more likely the larger are the output gains brought about by the legalization, the less redistributive is the welfare state and the higher is the expected cost of criminal activities carried out by illegal immigrants. Importantly, we also find that, when an amnesty is desirable, the destination country would reach an even higher welfare level investing in enforcement ex-ante. Empirical evidence based on a novel panel dataset of legalization programs carried out by a group of OECD countries between 1980-2007 broadly supports the role played by the channels identified in our theoretical model.Illegal immigration, Immigration Policy, Amnesties.

Illegal immigration: policy perspectives and challenges

The combination of increasing immigration pressures and restrictive policies imperfectly enforced by many destination countries has made illegal immigration widespread. This paper provides an overview of the mechanisms behind the formation of migration policies and how they lead to or they limit the presence of illegal immigrants. We also study how governments deal ex-post with the presence of undocumented foreign workers by introducing immigration amnesties. We review the determinants of their introduction and address their desirability from the point of view of aggregate welfare. As countries in the EU differ substantially in the implementation of both ex-ante and ex-post immigration policies, we emphasize the need for more coordination in the area of migration policy enforcement, both at the border and within each country

The role of managers in enacting two-step institutional work for radical innovation in professional organizations.

Radical innovation in professional settings faces an institutional challenge. Professionals enjoy autonomy predicated on jurisdictional knowledge and can resist radical innovation if their interests are threatened. Our study examines if and how managers mediate professional resistance and ensure that radical innovation can take hold. A comparative case study of 12 Italian hospitals introducing integrated service configurations shows that managers may hold back from introducing radical innovation where they judge professional resistance as insurmountable. Executives reinforce, rather than challenge, the status quo, and discourage middle managers from further actions. Where the professional context is more receptive because of micro-institutional affordances, then, managers enact different tactics. Managers may centralize decision-making through political work, which however increases professional resistance and hinder radical innovation. Managers may adopt project management approaches, which facilitate local experiments, but struggle to scale-up the radical innovation. Most successful cases are characterized by executive and middle managers enacting a two-step institutional work, which reconfigures the regulative, normative and cognitive foundations of professional boundaries and practice. The comparative study shows how managers can support radical innovation in collaboration with professionals. In the two-step institutional work, executive and middle managers develop stable alliances with local professional groups to provide cognitive/normative foundations of radical innovation; second, they allow professionals to inhabit nascent institutional arrangements to make sense of how these fit with their prevailing interests, norms, and beliefs; third, they co-develop new structures/rules that encourage professionals to pursue radical innovation; finally, they perform maintenance work to preserve professionals’ attachment to new institutions

Users’ search mechanisms and risks of inappropriateness in healthcare innovations : the role of literacy and trust in professional contexts

In the context of professional service organizations, user engagement with knowledge search might generate significant risks of inappropriateness to innovation processes. Previous research suggests that professionals would then keep users at arms' length, controlling the design and implementation of innovations internally. This study overcomes this view investigating how professional service organizations can enable users' knowledge search while controlling for the risks of inappropriateness. Combining a qualitative research on 5 innovation processes in healthcare organizations with quantitative research on 110 service users, our findings highlight that professional providers, such as senior clinicians, shaped their tactics according to the ‘threats’ of laggards, i.e. users searching knowledge outside of professional logics of appropriateness; more than to the opportunities of lead-user communities. Professional providers sought to “activate” users' engagement with knowledge search by investing on their literacy, i.e. showing the basics of the logic of appropriateness informing their decision; and on trust relationships, i.e. becoming transparent on the criteria of knowledge selection during the innovation processes

What drives the legalization of immigrants?: evidence from IRCA

We develop a model to understand the trade–offs faced by an elected representative in supporting an amnesty when a restrictive immigration policy is in place. We show that an amnesty is more desirable the more restricted are the occupational opportunities of undocumented immigrants and the smaller is the fiscal leakage to undocumented immigrants via the welfare state. Empirical evidence based on the voting behavior of U.S. Congressmen on the Immigration Reform and Control Act of 1986 provides strong support for the predictions of our theoretical model

A regional-scale conceptual and numerical groundwater flow model in fluvio-glacial sediments for the Milan Metropolitan area (Northern Italy)

Study region: The Milan metropolitan area lies on one of the most important aquifer in Italy, heavily exploited for public and industrial water supply. The area, covering 3135 km2 in the Po Plain (Northern Italy) with a continental climate, is bounded by the Po, the Adda and the Ticino rivers and by the prealpine foothills. Regional hydrology is characterised by a network of natural and man-made elements, and lowland springs. The sedimentary sequence, from bottom to top, is formed by meandering river plain deposits, the distal fringe of the glacial outwash plains and proximal braid-plain deposits. Study focus: This study proposes a general approach for aquifer geometry reconstruction and hydrodynamic parametrization of hydrofacies in fluvio-glacial deposits, and their implementation into a 3D regional groundwater flow model. This approach is based on sedimentologically-defined lithofacies/hydrofacies and their correlation in space to obtain nearly homogeneous subunits starting from available data (i.e. 8628 borehole logs, grain size distributions, well tests) and sedimentological knowledge. New hydrological insights for the region: The calibrated 3D FEM groundwater model allows quantifying the main components of the hydrogeological budget at the regional scale, and the fluxes among the different hydro-stratigraphic units. A sensitivity analysis of groundwater levels to the main recharge components suggests importance of anthropogenic disturbances with respect to natural recharge, and that land-use change may impact water resources more than climate change

Mid-term results of complex distal humeral fractures.

The aim of this study was to assess outcomes following open reduction and internal fixation in complex fractures of the distal humerus. Between 2000 and 2006, 34 patients were operated for complex fractures of the distal humerus. Bone fixation was obtained with a reverse Y-shaped reconstruction plate in 13 cases and with double plating in 21 cases. At final follow-up, all the patients were assessed with the Mayo Elbow Performance Score. Satisfactory results were observed in 71% of the cases despite a high rate of complications. Age over 65 years is correlated with increased risk for an inferior postoperative result. Complex distal humeral fractures are difficult to treat and are associated with a high incidence of complications. It is therefore mandatory to obtain good anatomical reduction and a stable fixation of lateral and medial columns of the distal humerus. The results observed in older patients suggest that an alternative treatment for these patients may be joint replacement

An Analytical Approach for the Design of Class-E Resonant DC-DC Converters

We present a new approach to design resonant dc-dc converters, that allows us to achieve both a more accurate implementation and a simpler architecture, by reducing the number of required passive components. The approach is applied to a class-E topology, and it is based on the analytic solution of the system of differential equations regulating the converter evolution. Our technique is also capable of taking into account the most important circuit nonidealities. This represents an important breakthrough with respect to the state of the art, where class-E circuit analysis is based on strong simplifying assumptions, and the final circuit design is achieved by means of numerical simulations after many time-consuming parametric sweeps. The developed methodology is dimensionless, and the achieved design curves can be denormalized to easily get the desired circuit design. Measurements on two different prototypes confirm an extremely high adherence to the developed mathematical approach.We present a new approach to design resonant dc-dc converters, that allows us to achieve both a more accurate implementation and a simpler architecture, by reducing the number of required passive components. The approach is applied to a class-E topology, and it is based on the analytic solution of the system of differential equations regulating the converter evolution. Our technique is also capable of taking into account the most important circuit nonidealities. This represents an important breakthrough with respect to the state of the art, where class-E circuit analysis is based on strong simplifying assumptions, and the final circuit design is achieved by means of numerical simulations after many time-consuming parametric sweeps. The developed methodology is dimensionless, and the achieved design curves can be denormalized to easily get the desired circuit design. Measurements on two different prototypes confirm an extremely high adherence to the developed mathematical approach

Donor Cell Acute Myeloid Leukemia after Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease: A Case Report and Literature Review

The patient reported here underwent hematopoietic stem cell transplantation (HSCT) due to chronic granulomatous disease (CGD) caused by biallelic mutations of the NCF1 gene. Two years later, he developed AML, which was unexpected and was recognized via sex-mismatched chromosomes as deriving from the donor cells; the patient was male, and the donor was his sister. Donor cell leukemia (DCL) is very rare, and it had never been reported in patients with CGD after HSCT. In the subsequent ten years, the AML relapsed three times and the patient underwent chemotherapy and three further HSCTs; donors were the same sister from the first HSCT, an unrelated donor, and his mother. The patient died during the third relapse. The DCL was characterized since onset by an acquired translocation between chromosomes 9 and 11, with a molecular rearrangement between the MLL and MLLT3 genes-a quite frequent cause of AML. In all of the relapses, the malignant clone had XX sex chromosomes and this rearrangement, thus indicating that it was always the original clone derived from the transplanted sister's cells. It exhibited the ability to remain quiescent in the BM during repeated chemotherapy courses, remission periods and HSCT. The leukemic clone then acquired different additional anomalies during the ten years of follow-up, with cytogenetic results characterized both by anomalies frequent in AML and by different, non-recurrent changes. This type of cytogenetic course is uncommon in AML

Enhanced p53 Levels Are Involved in the Reduced Mineralization Capacity of Osteoblasts Derived from Shwachman–Diamond Syndrome Subjects

14noopenShwachman–Diamond syndrome (SDS) is a rare autosomal recessive disorder characterized by bone marrow failure, exocrine pancreatic insufficiency, and skeletal abnormalities, caused by loss-of-function mutations in the SBDS gene, a factor involved in ribosome biogenesis. By analyzing osteoblasts from SDS patients (SDS-OBs), we show that SDS-OBs displayed reduced SBDS gene expression and reduced/undetectable SBDS protein compared to osteoblasts from healthy subjects (H-OBs). SDS-OBs cultured in an osteogenic medium displayed a lower mineralization capacity compared to H-OBs. Whole transcriptome analysis showed significant differences in the gene expression of SDS-OBs vs. H-OBs, particularly in the ossification pathway. SDS OBs expressed lower levels of the main genes responsible for osteoblastogenesis. Of all downregulated genes, Western blot analyses confirmed lower levels of alkaline phosphatase and collagen type I in SDS-OBs than in H-OBs. Interestingly, SDS-OBs showed higher protein levels of p53, an inhibitor of osteogenesis, compared to H-OBs. Silencing of Tp53 was associated with higher collagen type I and alkaline phosphatase protein levels and an increase in SDS-OB mineralization capacity. In conclusion, our results show that the reduced capacity of SDS-OBs to mineralize is mediated, at least in part, by the high levels of p53 and highlight an important role of SBDS in osteoblast functions.openFrattini, Annalisa; Bolamperti, Simona; Valli, Roberto; Cipolli, Marco; Pinto, Rita Maria; Bergami, Elena; Frau, Maria Rita; Cesaro, Simone; Signo, Michela; Bezzerri, Valentino; Porta, Giovanni; Khan, Abdul Waheed; Rubinacci, Alessandro; Villa, IsabellaFrattini, Annalisa; Bolamperti, Simona; Valli, Roberto; Cipolli, Marco; Pinto, Rita Maria; Bergami, Elena; Frau, Maria Rita; Cesaro, Simone; Signo, Michela; Bezzerri, Valentino; Porta, Giovanni; Khan, Abdul Waheed; Rubinacci, Alessandro; Villa, Isabell