A comparison of modular self-timed design styles

technical reportState-machine sequencing methods in modular 2-phase and 4-phase asynchronous handshake control are compared. Design styles are discussed, and the sequencers are tested against each other using a medium-scale minicomputer test design implemented in FPGAs. Seven 4-phase sequencers are tested. In these comparisons, 2- phase control is faster than 4-phase. Within the 4-phase designs, speed is enhanced when work is overlapped with handshake restoration. Performance of asynchronous and synchronous designs is compared

Dimensionality, ideology and party positions towards European integration

<p>The rise of political contestation over European integration has led many scholars to examine the role that broader ideological positions play in structuring party attitudes towards European integration. This article extends the existing approaches in two important ways. First, it shows that whether the dimensionality of politics is imagined in a one-dimensional ‘general left‒right’ form or a two-dimensional ‘economic left‒right/social liberal-conservative’ form leads to very different understandings of the way ideology has structured attitudes towards European integration, with the two-dimensional approach offering greater explanatory power. Second, existing approaches have modelled the influence of ideology on attitudes towards European integration as a static process. This article shows that the relationship between ideology and European integration has changed substantially over the history of European integration: divisions over social issues have replaced economic concerns as the main driver of party attitudes towards European integration.</p

Giant cell tumor of the temporal bone – a case report

BACKGROUND: Giant cell tumor is a benign but locally aggressive bone neoplasm which uncommonly involves the skull. The petrous portion of the temporal bone forms a rare location for this tumor. CASE PRESENTATION: The authors report a case of a large giant cell tumor involving the petrous and squamous portions of the temporal bone in a 26 year old male patient. He presented with right side severe hearing loss and facial paresis. Radical excision of the tumor was achieved but facial palsy could not be avoided. CONCLUSION: Radical excision of skull base giant cell tumor may be hazardous but if achieved is the optimal treatment and may be curative

Withdrawal-associated injury site pain (WISP): a descriptive case series of an opioid cessation phenomenon.

Withdrawal pain can be a barrier to opioid cessation. Yet, little is known about old injury site pain in this context. We conducted an exploratory mixed-methods descriptive case series using a web-based survey and in-person interviews with adults recruited from pain and addiction treatment and research settings. We included individuals who self-reported a past significant injury that was healed and pain-free before the initiation of opioids, which then became temporarily painful upon opioid cessation-a phenomenon we have named withdrawal-associated injury site pain (WISP). Screening identified WISP in 47 people, of whom 34 (72%) completed the descriptive survey, including 21 who completed qualitative interviews. Recalled pain severity scores for WISP were typically high (median: 8/10; interquartile range [IQR]: 2), emotionally and physically aversive, and took approximately 2 weeks to resolve (median: 14; IQR: 24 days). Withdrawal-associated injury site pain intensity was typically slightly less than participants' original injury pain (median: 10/10; IQR: 3), and more painful than other generalized withdrawal symptoms which also lasted approximately 2 weeks (median: 13; IQR: 25 days). Fifteen surveyed participants (44%) reported returning to opioid use because of WISP in the past. Participants developed theories about the etiology of WISP, including that the pain is the brain's way of communicating a desire for opioids. This research represents the first known documentation that previously healed, and pain-free injury sites can temporarily become painful again during opioid withdrawal, an experience which may be a barrier to opioid cessation, and a contributor to opioid reinitiation

The mechanism of the hydrolysis of bromochloroiodomethane

M.S.Jack Hin