26 research outputs found

    Barriers and opportunities for implementation of a brief psychological intervention for post-ICU mental distress in the primary care setting – results from a qualitative sub-study of the PICTURE trial

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    Photo-Objects

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    Taking the material approach to photography as a starting point the volume offers new insights into the epistemological potential of analog and digital photographs and photo archives in the humanities and sciences from a comparative viewpoint

    Photo-Objects: On the Materiality of Photographs and Photo Archives

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    Photographs are not simply images but also historically shaped three-dimensional objects. They hold a physical presence, bear traces of handling and use, and circulate in social, political, and institutional networks. Beyond their visual content, they are increasingly acknowledged as material "actors", not only indexically representing the objects they depict, but also playing a crucial role in the processes of knowledge-making within scientific practices. This has a historical dimension: most scientific disciplines rapidly adopted photography as an important research tool. The various material qualities of photographs thereby afforded certain types of uses in those disciplines. Specialized photo archives were founded as interfaces of technology and science and as laboratories for scientific thought. This book highlights some recent approaches to photo-objects and photo archives as parts of a dynamic and material system of knowledge. Taking photographic materiality as its premise, it analyzes the epistemological potential of analog and digital photographs and photo archives in the humanities and sciences. Issues range from the circulation and distribution of photographs, the construction of disciplinary methods through the handling and use of photographs, the formation and transformation of a canon through photography and respective hierarchies of value, to the arrangement, classification, and working processes in photo archives and other institutions. The series Studies of the Max Planck Research Library for the History and Development of Knowledge is dedicated to key subjects in the history and development of knowledge. It brings together perspectives from different fields and combines source-based empirical research with theoretically guided approaches. Studies typically present collaborative working group volumes with integrative approaches to research. The volumes are available both as print-on-demand books and as open-access publications. The material is freely accessible online at www.mprl-series.mpg.de

    The current state of international research on the effectiveness of school nurses in promoting the health of children and adolescents: An overview of reviews.

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    ObjectiveSchool nurses are engaging worldwide to promote and protect children's health. Many researchers who examined the effectiveness of the school nurse criticized the inadequate methodology employed in many of the studies. We therefore carried out an evaluation on the effectiveness of school nurses based on a rigorous methodological approach.MethodsIn this overview of reviews we performed an electronic databank search and global research results on the effectiveness of school nurses were sought. We identified 1,494 records through database search. Abstracts and full texts were screened and summarized using the dual control principle. We summarized the aspects of quality criteria as well as the significance of the effectiveness of the school nurse. In the first step, k = 16 systematic reviews were summarized and evaluated following the AMSTAR-2 guidelines. In a second step, j = 357 primary studies included in these k = 16 reviews were summarized and assessed following the GRADE guidelines.ResultsResearch results on the effectiveness of school nurses show that school nurses play a key role in improving the health of children with asthma (j = 6) and diabetes (j = 2), results on combating obesity are less certain (j = 6). The quality of identified reviews is mostly very low with only six studies of medium quality, of which one identified as a meta-analysis. A total of j = 289 primary studies were identified. Approximately 25% (j = 74) of identified primary studies were either randomized controlled trials (RCT) or observational studies, of which roughly 20% (j = 16) had a low risk of bias. Studies with physiological variables such as blood glucose or asthma labeling led to higher quality results.ConclusionThis paper represents an initial contribution and recommends further evaluation of the effectiveness of school nurses, particularly in the areas of mental health or children from low socioeconomic backgrounds. The general lack of quality standards in school nursing research should be integrated into the scientific discourse of school nursing researchers to provide robust evidence for policy planners and researchers

    The current state of international research on the effectiveness of school nurses in promoting the health of children and adolescents: An overview of reviews

    No full text
    Objective School nurses are engaging worldwide to promote and protect children’s health. Many researchers who examined the effectiveness of the school nurse criticized the inadequate methodology employed in many of the studies. We therefore carried out an evaluation on the effectiveness of school nurses based on a rigorous methodological approach. Methods In this overview of reviews we performed an electronic databank search and global research results on the effectiveness of school nurses were sought. We identified 1,494 records through database search. Abstracts and full texts were screened and summarized using the dual control principle. We summarized the aspects of quality criteria as well as the significance of the effectiveness of the school nurse. In the first step, k = 16 systematic reviews were summarized and evaluated following the AMSTAR-2 guidelines. In a second step, j = 357 primary studies included in these k = 16 reviews were summarized and assessed following the GRADE guidelines. Results Research results on the effectiveness of school nurses show that school nurses play a key role in improving the health of children with asthma (j = 6) and diabetes (j = 2), results on combating obesity are less certain (j = 6). The quality of identified reviews is mostly very low with only six studies of medium quality, of which one identified as a meta-analysis. A total of j = 289 primary studies were identified. Approximately 25% (j = 74) of identified primary studies were either randomized controlled trials (RCT) or observational studies, of which roughly 20% (j = 16) had a low risk of bias. Studies with physiological variables such as blood glucose or asthma labeling led to higher quality results. Conclusion This paper represents an initial contribution and recommends further evaluation of the effectiveness of school nurses, particularly in the areas of mental health or children from low socioeconomic backgrounds. The general lack of quality standards in school nursing research should be integrated into the scientific discourse of school nursing researchers to provide robust evidence for policy planners and researchers

    Loss of the cleaved-protamine 2 domain leads to incomplete histone-to-protamine exchange and infertility in mice.

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    Protamines are unique sperm-specific proteins that package and protect paternal chromatin until fertilization. A subset of mammalian species expresses two protamines (PRM1 and PRM2), while in others PRM1 is sufficient for sperm chromatin packaging. Alterations of the species-specific ratio between PRM1 and PRM2 are associated with infertility. Unlike PRM1, PRM2 is generated as a precursor protein consisting of a highly conserved N-terminal domain, termed cleaved PRM2 (cP2), which is consecutively trimmed off during chromatin condensation. The carboxyterminal part, called mature PRM2 (mP2), interacts with DNA and together with PRM1, mediates chromatin-hypercondensation. The removal of the cP2 domain is believed to be imperative for proper chromatin condensation, yet, the role of cP2 is not yet understood. We generated mice lacking the cP2 domain while the mP2 is still expressed. We show that the cP2 domain is indispensable for complete sperm chromatin protamination and male mouse fertility. cP2 deficient sperm show incomplete protamine incorporation and a severely altered protamine ratio, retention of transition proteins and aberrant retention of the testis specific histone variant H2A.L.2. During epididymal transit, cP2 deficient sperm seem to undergo ROS mediated degradation leading to complete DNA fragmentation. The cP2 domain therefore seems to be a key aspect in the complex crosstalk between histones, transition proteins and protamines during sperm chromatin condensation. Overall, we present the first step towards understanding the role of the cP2 domain in paternal chromatin packaging and open up avenues for further research

    Experiences of discrimination and everyday racism among children and adolescents with an immigrant background – Results of a systematic literature review on the impact of discrimination on the developmental outcomes of minors worldwide

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    Finanziert aus dem Open-Access-Publikationsfonds der Universität Siegen für ZeitschriftenartikelExperiences of discrimination such as everyday racism can negatively affect the mental and physical health of children and adolescents with an immigrant background and impair their integration process in the host societies. Although experiences of racism are part of the everyday life of many minors affected by the process of “Othering” (e.g., those with an immigrant background), an overview of empirical findings is missing for this age group worldwide. A systematic review was conducted to identify and analyze international research on the impact of discrimination on the developmental outcomes and integration of immigrant children and adolescents. Three scientific databases were systematically searched up to June 11, 2021. A total of k = 4,769 identified publications were reviewed based on inclusion and exclusion criteria in terms of the PICOS format by independent reviewers. Thirty-four primary studies published between 1998 and 2021 met all inclusion criteria. The samples examined were mainly migrant youth (k = 30), with only k = 2 studies assessing refugee youth and k = 1 study assessing both migrant and refugee youth. The majority of included studies assessed perceived discrimination, with only k = 1 study directly assessing experiences of racism. The association between discrimination or racism and developmental outcomes was assessed by the included studies within the three main topics of (a) mental and physical health-related outcomes (k = 30, e.g., self-esteem, depressive symptoms), (b) school-related outcomes (k = 6, e.g., academic achievement), and (c) other developmental outcomes (k = 13, e.g., misconduct or delinquency). Data collection procedures were implemented, and findings on minors’ developmental outcomes and integration process who experience discrimination and racism were summarized and discussed. The current review suggests experienced (racial) discrimination as a negative predictor of children and adolescents’ (mental) health-related outcomes, while no clear results could be found for the association between discrimination and school-related outcomes. A need for more empirical research focusing on the path and (possibly) indirect link between discrimination and children and adolescents’ school-related outcomes as well as resulting school recommendations and the chosen career path was derived

    Examination of aboveground attributes to predict belowground biomass of young trees

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    International audienceJust as the aboveground tree organs represent the interface between trees and the atmosphere, roots act as the interface between trees and the soil. In this function, roots take-up water and nutrients, facilitate interactions with soil microflora, anchor trees, and also contribute to the gross primary production of forests. However, in comparison to aboveground plant organs, the biomass of roots is much more difficult to study. In this study, we analyzed 19 European datasets on above- and belowground biomass of juvenile trees of 14 species to identify generalizable estimators of root biomass based on tree sapling dimensions (e.g. height, diameter, aboveground biomass). Such estimations are essential growth and sequestration modelling. In addition, the intention was to study the effect of sapling dimension and light availability on biomass allocation to roots. All aboveground variables were significant predictors for root biomass. But, among aboveground predictors of root biomass plant height performed poorest. When comparing conifer and broadleaf species, the latter tended to have a higher root biomass at a given dimension. Also, with increasing size, the share of belowground biomass tended to increase for the sapling dimensions considered. In most species, there was a trend of increasing relative belowground biomass with increasing light availability. Finally, the height to diameter ratio (H/D) was negatively correlated to relative belowground biomass. This indicates that trees with a high H/D are not only more unstable owing to the unfavorable bending stress resistance, but also because they are comparatively less well anchored in the ground. Thus, single tree stability may be improved through increasing light availability to increase the share of belowground biomass
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