551 research outputs found
Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer.
- Author
- A HĂŒbner
- AB DâAssoro
- AJ Lee
- AN Hata
- Andrei Goga
- Andrew D. Simmons
- Angel Ku
- AS Nikonova
- Ashley Maynard
- B Melichar
- CA Eberlein
- CK Lee
- CM Blakely
- CM Blakely
- Collin M. Blakely
- D Ercan
- DB Costa
- F Varghese
- Frank McCormick
- Golzar Hemmati
- Gregor Krings
- Hayley J. Donnella
- Henry J. Haringsma
- J Chen
- J Fu
- Jacqueline Galeas
- JJ Chabon
- Jonathan Kuhn
- Julia Rohrberg
- Julia Rotow
- K Shien
- Khyati N. Shah
- KS Thress
- L Li
- Liliane Robillard
- LV Sequist
- LV Sequist
- M Moustafa-Kamal
- M Ramirez
- Maria M. Martins
- MJ Niederst
- MS Cragg
- MW Karaman
- OJ Gruss
- PA JĂ€nne
- R Rosell
- RA Burrell
- Roma Bhatt
- S Anand
- S Stewart
- Sophie Dumont
- Sourav Bandyopadhyay
- SV Sharma
- Swati Kaushik
- T Sharifnia
- TC Chou
- TG Bivona
- TG Bivona
- Thomas C. Harding
- TM Kim
- Trever G. Bivona
- V Bavetsias
- Victor Olivas
- Victoria E. Wang
- Y Zhou
- Z Piotrowska
- Z Yang
- Publication venue
- eScholarship, University of California
- Publication date
- 01/01/2019
- Field of study
Although targeted therapies often elicit profound initial patient responses, these effects are transient due to residual disease leading to acquired resistance. How tumors transition between drug responsiveness, tolerance and resistance, especially in the absence of preexisting subclones, remains unclear. In epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma cells, we demonstrate that residual disease and acquired resistance in response to EGFR inhibitors requires Aurora kinase A (AURKA) activity. Nongenetic resistance through the activation of AURKA by its coactivator TPX2 emerges in response to chronic EGFR inhibition where it mitigates drug-induced apoptosis. Aurora kinase inhibitors suppress this adaptive survival program, increasing the magnitude and duration of EGFR inhibitor response in preclinical models. Treatment-induced activation of AURKA is associated with resistance to EGFR inhibitors in vitro, in vivo and in most individuals with EGFR-mutant lung adenocarcinoma. These findings delineate a molecular path whereby drug resistance emerges from drug-tolerant cells and unveils a synthetic lethal strategy for enhancing responses to EGFR inhibitors by suppressing AURKA-driven residual disease and acquired resistance
Layer-by-layer deposition of open-pore mesoporous TiO 2- NafionÂź film electrodes
- Author
- AJ Bard
- DA Buttry
- DA Buttry
- DJ Neivandt
- DV Bavykin
- E Chalkova
- E Milson
- Elizabeth V. Milsom
- F Fabregat-Santiago
- F Marken
- F Scholz
- F Schuth
- Frank Marken
- G Decher
- H Park
- H Park
- J Bisquert
- Jan Novak
- Karen Edler
- KJ McKenzie
- KJ McKenzie
- KJ McKenzie
- M Bockmeyer
- M GrÀtzel
- M Majda
- MA Correa-Duarte
- MA Murphy
- MD Ward
- OK Varghese
- P Bertoncello
- PJ Cameron
- RJ Mortimer
- RJ Mortimer
- Roger J. Mortimer
- S Yuan
- SJ Stott
- Stephen J. Green
- Susan J. Stott
- T Serizawa
- TA Davis
- TL Ma
- TR Farhat
- U Diebold
- Xiaohang Zhang
- Y Wang
- ZG Shao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study
The formation of variable thickness TiO2 nanoparticle-NafionÂź composite films with open pores is demonstrated via a layer-by-layer deposition process. Films of about 6 nm diameter TiO2 nanoparticles grow in the presence of NafionÂź by âclusteringâ of nanoparticles into bigger aggregates, and the resulting hierarchical structure thickens with about 25 nm per deposition cycle. Film growth is characterized by electron microscopy, atomic force microscopy, and quartz crystal microbalance techniques. Simultaneous small-angle X-ray scattering and wide-angle X-ray scattering measurements for films before and after calcination demonstrate the effect of NafionÂź binder causing aggregation. Electrochemical methods are employed to characterize the electrical conductivity and diffusivity of charge through the TiO2-NafionÂź composite films. Characteristic electrochemical responses are observed for cationic redox systems (diheptylviologen2+/+, Ru(NH3)3+/2+6, and ferrocenylmethyl-trimethylammonium2+/+) immobilized into the TiO2-NafionÂź nanocomposite material. Charge conduction is dependent on the type of redox system and is proposed to occur either via direct conduction through the TiO2 backbone (at sufficiently negative potentials) or via redox-center-based diffusion/electron hopping (at more positive potentials)
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume
- Author
- Adeli A.
- Agostino D.D.
- Aisen P.
- Albers C.S.
- Albert M.
- Allard J.
- Ames D.
- Ances B.
- Anderson H.S.
- Anderson K.
- Apostolova L.
- Armstrong N.J.
- Arnold S.E.
- Arrastia R.D.
- Asthana S.
- Bachman D.
- Bartha R.
- Bartzokis G.
- Bates V.
- Beccera M.
- Beckett L.
- Belden C.M.
- Bell K.L.
- Bergman H.
- Bernick C.
- Bernstein M.
- Bird P.
- Black S.
- Blank K.
- Boles Ponto L.L.
- Bomke J.
- Borowski B.
- Borrie M.
- Bourgeat P.
- Bourgeat P.
- Brand C.
- Brewer J.
- Brockington J.
- Brown A.D.
- Brown B.M.
- Budson A.E.
- Burnham S.C.
- Burnham S.C.
- Burns J.M.
- Bush A.I.
- Cairns N.J.
- Caldwell C.
- Capote H.
- Carlsson C.M.
- Carmichael O.
- Carroll M.
- Carson R.E.
- Carter R.
- Cellar J.S.
- Celmins D.
- Cerbone B.
- Chadunow C.
- Chaing G.
- Chen K.
- Chertkow H.
- Chowdhury M.
- Clark D.
- Collins S.
- Conrad G.
- Cook K.M.
- Correia S.
- Crawford K.
- Dang M.
- de Leon M.J.
- De Santi S.
- DeCArli C.
- DeCarli C.
- deToledo-Morrell L.
- DeVous M.
- Doecke J.
- Doecke J.
- Dolen S.
- Donohue M.
- Doody R.S.
- Doraiswamy P.M.
- Dore V.
- Doré V.
- Drost D.
- Duara R.
- Ellis K.A.
- Evered L.
- Fargher K.
- Farlow M.R.
- Fazlollahi A.
- Feldman H.
- Figurski M.
- Finger E.
- Fleisher A.
- Fleisher A.
- Fletcher E.
- Foroud T. M.
- Foster N.
- Fowler C.
- Fox N.
- Frank R.
- Frey M.
- Fripp J.
- Galvin J.E.
- Gardener S.L.
- Garg P.
- Geldmacher D.
- Gessert D.
- Gibson S.
- Glodzik L.
- Goldstein B.S.
- Green R.C.
- Greig M.T.
- Grenfell R.
- Griffith R.
- Grossman H.
- Gunter J.
- Hake A.M.
- Hardy P.
- Harrison E.
- Harvey D.
- Head R.
- Heidebrink J.L.
- Hernando R.
- Herring S.
- Honig L.S.
- Hosein C.
- Householder E.
- Householder E.
- Hsiung G.Y.R.
- Hudson L.
- Hunt C.
- Ismail M.S.
- Jack C.R.
- Jacobson S.A.
- Jagust W.
- Jicha G.
- Jiminez G.
- Jin L.
- Johnson H.
- Johnson K.
- Johnson K.
- Johnson K.A.
- Johnson N.
- Johnson P.L.
- Johnson S.
- Jones D.
- Kachaturian Z.
- Kamer A.
- Kantarci K.
- Karlawish J.H.
- Kataki M.
- Kaye J.
- Kelley F.
- Kendall T.
- Kertesz A.
- Kertesz A.
- Kerwin D.
- Kielb S.
- Killiany R.
- Kim S.
- King R.
- Kittur S.
- Kitzmiller T.J.
- Knopman D.
- Koeppe R.A.
- Korecka M.
- Kowall N.
- Lah J.J.
- Lamb F.
- Landau S.
- Lane B.
- Lautenschlager N.T.
- Laws S.M.
- Laws S.M.
- Lee T.Y.
- Lee V.
- Leon S.
- Lerner A.
- Levey A.I.
- Li Q-X
- Lim L.
- Lim Y.Y.
- Lind B.
- Lipowski K.
- Liu E.
- Lopez O.L.
- Lord J.L.
- Louey A.
- Lu P.H.
- Macaulay S.L.
- MacAvoy M.G.
- Mackintosh L.
- Makino K.M.
- Malloy P.
- Marshall G.
- Martin K.
- Martinez W.
- Martins R.N.
- Maruff P.
- Maruff P.
- Mason S.S.
- Masters C.L.
- Masters C.L.
- Mathews D.
- Mathis C.
- Matthews B.R.
- Mc Adams Ortiz C.
- McBride S.
- Mesulam M.M.
- Meyer J.V.
- Michel C.A.
- Milicic L.
- Milicic L.
- Miller B.L.
- Mintun M.A.
- Mintzer J.
- Mitsis E.
- Molchan S.
- Montine T.
- Morris J.C.
- Mudge B.
- Mulnard R.A.
- Munic D.
- Neumann S.
- Nguyen D.
- Nho K.
- Norbash A.
- Oakley M.A.
- Oates E.
- Obisesan T.O.
- Ogrocki P.
- Olichney J.
- OliverNG A.
- Onyike C.
- Ott B.R.
- ParfittH F.
- Past M.A.
- Pasternak S.
- Pawluczyk S.
- Pearlson G.D.
- Pertile K.
- Petersen R.
- Petersen R.
- Petrella J.R.
- Pogorelec D.M.
- Pomara N.
- Porsteinsson A.P.
- Porter T.
- Porter T.
- Potkin S.
- Potkin S.G.
- Preda A.
- Querfurth H.
- Quiceno M.
- Quinn J.
- Rachinsky I.
- Radford N.R.G.
- Radler M.
- Rainey-Smith S.R.
- Rainka M.
- Raj B.A.
- Raudin L.
- Reeder S.
- Reiman E.M.
- Reinwald L.T.
- Relkin N.
- Reynolds B.
- Roberson E.
- Roberts P.
- Robertson J.
- Rodrigues M.
- Rogers J.
- Rogers J.
- Rosen A.
- Rosen H. J.
- Rountree S.
- Rowe C.C.
- Rowe C.C.
- Rumble R.
- Rusinek H.
- Sabbagh M.N.
- Sadowsky C.
- Salloway S.
- Salvado O.
- Santulli R.B.
- Sarrael A.
- Sather T.
- Savage G.
- Saykin A.J.
- Scharre D.W.
- Schneider L.S.
- Schneider S.
- Schuff N.
- Schultz S.K.
- Schwartz E.S.
- Senjem M.
- Shah R.C.
- Shaw L.M.
- Shen L.
- Shim H.
- Shishegar R.
- Shishegar R.
- Silbert B.
- Silverman D.H.S.
- Simpson D.M.
- Sinha P.
- SinkS K.M.
- Sirrel S.A.
- Smith A.
- Smith C.D.
- Smith K.E.
- Snyder P.J.
- Soh M.
- Sohrabi H.R.
- Spann B.M.
- Sperling R.A.
- Spicer K.
- Stefanovic B.
- Stern Y.
- Swerdlow R.H.
- Taddei K.
- Taddei T.
- Tankard R.
- Tariot P.
- Taylor J.L.
- Teodoro L.
- Thai C.
- Thai G.
- Thomas R.G.
- Thompson P.
- Tingus K.
- Tinklenberg J.
- Toga A.W.
- Tremont G.
- Trojanowki J.Q.
- Trost D.
- Trounson B.
- Turner R.S.
- Tyrrell R.
- Vacher M.
- Vacher M.
- van Dyck C.H.
- Vanderswag H.
- Varghese S.
- Varon D.
- Vemuri P.
- Villemagne V.L.
- Villemagne V.L.
- Villena T.
- Walter S.
- Ward C.
- Watkins F.
- Weinborn M.
- Weiner M.
- Weiner M.
- Williamson J.D.
- Wolday S.
- Wolk D.A.
- Womack K.
- Wong T.Z.
- Woo E.
- Woodward M.
- Wu C.K.
- Xia Y.
- Yesavage J.
- Zimmerman E.A.
- Publication venue
- Springer Nature
- Publication date
- 01/01/2022
- Field of study
The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimerâs Disease (AD). Whilst studies have reported associations with AD risk and related phenotypes, there remains a lack of consensus on these associations. Here we aimed to comprehensively investigate the relationship between five recognised measures of age acceleration, based on DNA methylation patterns (DNAm age), and cross-sectional and longitudinal cognition and AD-related neuroimaging phenotypes (volumetric MRI and Amyloid-ÎČ PET) in the Australian Imaging, Biomarkers and Lifestyle (AIBL) and the Alzheimerâs Disease Neuroimaging Initiative (ADNI). Significant associations were observed between age acceleration using the Hannum epigenetic clock and cross-sectional hippocampal volume in AIBL and replicated in ADNI. In AIBL, several other findings were observed cross-sectionally, including a significant association between hippocampal volume and the Hannum and Phenoage epigenetic clocks. Further, significant associations were also observed between hippocampal volume and the Zhang and Phenoage epigenetic clocks within Amyloid-ÎČ positive individuals. However, these were not validated within the ADNI cohort. No associations between age acceleration and other Alzheimerâs disease-related phenotypes, including measures of cognition or brain Amyloid-ÎČ burden, were observed, and there was no association with longitudinal change in any phenotype. This study presents a link between age acceleration, as determined using DNA methylation, and hippocampal volume that was statistically significant across two highly characterised cohorts. The results presented in this study contribute to a growing literature that supports the role of epigenetic modifications in ageing and AD-related phenotypes
Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial
- Author
- Abarca Javiera
- Abarca Luis
- Abdlaziz Ihab
- Abraham Valsamma
- Accetta Riccardo
- Adhye Bharati Anil
- Adili Anthony
- Adinarayanan S
- Aframian Arash
- Aguado Hector J
- Aguilar Marc
- Ahmed Tashfeen
- Ahn Henry
- Ali Arif
- Almas Ayesha
- Alvarado Kim A
- AmbroĆŒy Wojciech
- Anaya Rafael
- Andres-Peiro Jose-Vicente
- Anjum Anila
- Arnuntasupakul Vanlapa
- Arroyo Marta
- Ashraf Mohammed
- Ashraf Muhammad
- Atrey Amit
- Avram Victoria RA
- Balaguer-Castro Mariano
- Balasubramanian Kumar
- Balonov Konstantin
- Bangdiwala Shrikant I
- Bardana Davide D
- Barnawal Satish Prasad
- Bartley Debra
- Baños Victoria
- Beaupre Lauren
- Begum Dilshad
- Belley-Cote Emilie P
- Bentoumi Souad
- Beretta Luigi
- Bergese Sergio D
- Bernaus MartĂ
- Beroud Sebastien
- Bhandari Mohit
- Bhutia Jigme Tshering
- Biccard Bruce M
- Bicknell Ryan T
- Bidkar Prasanna Udupi
- Bilchod Prashanth Nabhirajappa
- Binda Mirko
- Biscardi Anna
- Bisland Stuart
- Bogallo Jose Manuel
- Bohm Eric R
- Bokhari Syedah Saira
- Bonadies Marika
- Boon Huck Wee
- Borate Madhav Pandurang
- Borges Flavia K
- Brokelman Roy B.G.
- Campbell Aaron R
- Campbell Ryan Jonathan
- Cano Juan Ramon
- Carey Timothy
- Carreras-Castañer Anna
- Cassidy Charles
- CastillĂłn Pablo
- Cecconi Maurizio
- Chalacheewa Theerawat
- Chandran Nitheesh
- Chaudier Philippe
- Chaw Sook Hui
- Chee KH
- Chen Brian P-J
- Chetty Sean
- Chin Im Im
- Choi Stephen
- Chouhan Devendra K
- Clark Molly E
- Clinckaert Carol
- Cobben Jan-Hein MG
- Coles Chad P
- Colnaghi Eleonora
- Colombo Chiara
- Colomina Maria J
- Comstock Curt
- Conen David
- Cornu Olivier
- Correia Patricia
- Coughlin Ryan
- Coupal Stephanie A
- Cowan David D
- Crawford Gordon A
- Cruz Encarnacion
- Cullinan Claude
- CĂĄmara-Cabrera Jaume
- Daniels Timothy R
- Dashputra Ravi Prabhakar
- David Jean Stephane
- de Beer Justin
- De Blasio Giuseppe
- De Caso Julio
- De Clippeleir Dirk
- Dealbert Alfred
- Deheshi Benjamin
- Dehghan Niloofar
- Denaro Giuseppe
- Devereaux PJ
- Dhillon Mandeep S
- Dillane Derek
- Dillingham Sally
- Ding Anthony
- Dongre Himanshu Vijaykumar
- Douplat Marion
- Dragic-Taylor Sanela
- Dresser George K
- Droll Kurt
- Duncan Andrew W
- DÄ bek Piotr
- Elnaggar Mohamed
- Elskamp-Meijerman Hannie F
- Estrada Cristina
- Fang Christian Xinshuo
- Farooque Kamran
- Farrell Janet C
- Fayet Jean Marie
- Feibel Robert J
- Feijoo-MassĂł Carlos
- Fergusson Dean A
- Fessy Michel Henri
- Firth Gregory Bodley
- Flikweert Elvira R
- Flint Margot
- Foo Li Lian
- Forget Patrice
- Fourtounas Maria
- Fozzato Stefania
- Fraguas-Castany Antoni
- Frank Christopher C
- Friggeri Arnaud
- Furgan Ahmad
- Gallant Catherine
- Gamangati Shivanand
- Garcia-Sanchez Yaiza
- Garg Amit X
- Garrido Clua Miriam
- Gattu Uttam Vaidya
- Gauthier Leslie P
- George Carolin Elizabeth
- George Preetha Elizabeth
- Georgekutty AM
- Giardina Giuseppe
- Giilck Stephen M
- Gnanadurai Kingsly Robert
- Gonzalez Posada MA
- Gonzalez Zacarias Alicia A
- Grant Heather
- Greene James
- Gregus Krysten K
- Grzelak Adrian
- Gucwa Jaroslaw
- Guerado Enrique
- Guerra-Farfan Ernesto
- Guilabert Patricia
- Gupta Babita
- Guy Pierre
- Guyatt Gordon H
- Guzzetti Luca
- GĂłmez Olga
- Hadden William J
- Haider Syed Y
- Haire Kevin
- Hall Jeremy A
- Halman Samantha
- Harrison Mark M
- Harvey Valerie
- Hashmi Pervaiz Mehmood
- Henry Patrick DG
- Herranz Susana
- Herrera-Mateo Sergio
- Higa-Sansone JL
- Hiremath Santosh Angad
- Horst Maarten R
- Hunt Stephen B
- Hupel Tom
- Imbuldeniya Arjuna
- Iqbal Muhammad Nasir
- Irwin Marleen
- Ivanov Alexia
- Jacka Michael J
- Jaeger Melanie T
- Janjua Kholood Abid
- Jawali Abhijit
- Jenkinson Richard J
- John Bobby
- John Joby
- Jornet-Gibert Monsant
- Joseph Katherine
- Joseph Philip G
- Juman Naveed Muhammed
- K Varghese Zachariah
- Kadry Miriam Adel
- Karbassi Arsha
- Karera Mwalimu
- Kearon Clive
- Khan Abdus Salam
- Khan Eraj Khurshid
- Khan Hammad Naqi
- Khan Moin
- Khan Muhammad Kashif
- Khan Robyna Irshad
- Khan Siddra Ahmed
- Khanna Vickas
- Khattak Mujahid Jamil
- Khor HM
- Khoshbin Amir
- Kishta Waleed
- Kleinlugtenbelt Ydo V
- Koo Kevin
- KP Mary KP
- Kreder Hans J
- Kudrimoti Kiran Bhalchandra
- Kulachote Noratep
- Kumar CS
- KumoĆ Adam
- Kunz Monica R
- Labrador Gregorio
- Lai Hou Yee
- Lakdawala Riaz Hussain
- Lal Purushotham
- Lalueza-Broto Pilar
- Lamy Andre
- Landais Paul
- Landman Ellie BM
- Landoni Giovanni
- Lavand'homme Patricia
- Lawendy Abdel-Rahman
- Lawrence Kelly H
- Le Manach Yannick
- le Polain de Waroux Bernard
- Lee Jacques S
- Lee Meng-Li
- Lefrancois Tina
- Leong Darryl P
- Leung Frankie Ka Li
- LeĂłn Ricardo
- Liu Yang
- Loh PS
- Louboutin Lucie
- M Niranjan
- MacDonald Anne Marie
- MacDonald Shelley
- Machala Waldemar
- Macho Oscar
- Macleod Mark D
- Maddipati Tatarao
- Magloire Patrick
- Malhotra Rajesh
- Maluleke Matimba Lenny
- Mann Stephen M
- Maqungo Sithombo
- Marcantonio Andrew J
- Marcato Anna
- Marcucci Maura
- Marion Travis
- Marmor Meir T
- Martin Nuria
- Martinez-Municio Gonzalo
- Martinez-Ripol Pedro
- MartĂnez-Sañudo Luis
- Mateo Llorenç
- Mathur Purva
- Matityahu Amir
- Maxwell Chelsea
- Mayor Amy SE
- McClellan Robert Trigg
- McGillion Michael H
- McIlquham Katie
- McLean Lisa M
- McMahon Stephen J
- Menon Jagdish
- Menon Matthew
- Menon Prem Haridas
- Mestre-Torres Jaume
- Millan Angelica
- Minguell-Monyart Joan
- Mishra Sandeep Kumar
- Mittal Samarth
- Molero-Garcia Vicente
- Moller Carien
- Molnar Sarah
- Moppett Iain K
- Morelli Ilaria
- Mozzon Lise
- Mustafa Khawaja Junaid
- Muñoz Juan Manuel
- Naidoo Rubendren
- Nam Diane
- Nanjayan Shashi Kumar
- Naratreekoon Bundit
- Narayan Ravi
- Nauth Aaron
- NC Madhusudhan
- Neary John D
- Nejthardt Marcin B
- Ngim Joanne HL
- Nhlapo Lerato
- Nicholson Laura
- Noordin Shahryar
- Nousiainen Markku
- Novellas Marga
- Nur Aamer Nabi
- Nuñez Camarena Jorge
- O'Brien Peter J
- O'Sullivan Susan
- O'Toole Robert
- Olivieri Loretta
- Omran Sherif
- Orakzai Sajjad Hassan
- Oxner William
- Oyenubi Ademilola N
- Pandey Ritesh Arvind
- Parker Martyn J
- Patel Ameen
- Patil Atul Ashok
- Patil Sharanu
- Patil Shashank
- Payendeh Jubin
- Paños Gozalo M Luisa
- Peig-Font Anna
- Pengrung Nachapan
- Perazzo Paolo
- Pettit Shirley M
- Pey Borja
- Phieffer Laura S
- Piccirillo Fabio
- Pino Fabio
- Piriou Vincent
- Placella Giacomo
- Ploeg Leone
- Popova Ekaterine
- Porcel-Vazquez Juan A
- Pradhan Chetan Vijay
- Prakasam Komella
- Puram Chetan Prabhakar
- Puskas David
- Quintas Saioa
- Quraishi Faraaz A
- Rahate Prashant Vitthal
- Rajkumar Arti
- Ramokgopa Mmampapatla T
- Ramokgopa Mmampapatla Thomas
- Rashid Haroon Ur
- Rashid Rizwan Haroon
- Ravi Bheeshma
- Reul Maike
- Riaz Muhammad Mehmood
- Richardson C Glen
- Ricol Laura
- Roerdink Herbert W
- Ruggiero Sara
- Ryan Scott P
- Rycombel Jacek
- Sa-ngasoongsong Paphon
- Sadoughi Mehdi
- Salini Vincenzo
- SalomĂł-DomĂšnech MĂČnica
- Salvador Jordi
- Sancheti Parag K
- Sancheti Parag Kantilal
- Sanchez-Raya Judith
- Sanders David W
- Santiago-Maniega Silvia
- Santone David J
- Satora Wojciech
- Sawhney Chavi
- Schemitsch Emil
- Schemitsch Emil H
- Sciadini Marcus
- Selga Marsa Jordi
- Serrano-Sanz Jorge
- Shadowitz Steven
- Shan Lei
- Shanthanna Harsha
- Sharma Achal
- Sharma Deep
- Sharma Vijay
- Shirali Hemant R
- Shiraz Muhammad
- Shrikumar Mopina
- Sianes-GallĂ©n MĂČnica
- Sigamani Alben
- Sigamani Alen
- Simpson Diane L
- Singh Simmrat
- Singh Surya Udai
- Singh Virsen
- Sirisreetreerux Norachart
- Sivilotti Marco LA
- Slobogean Gerard
- Smith Christopher A
- Smith Crystal A
- Sohail Mian Amjad
- Stella Daniele
- Stephen David JG
- Stephen Manesh
- Stiegelmahr Robert
- Sulthan Ahamad Shaheel
- Swaminathan Srinivasan
- Szczeklik Wojciech
- Tan Kit Mun
- Tandon Vikas
- Teixidor-Serra Jordi
- Thayaparan Surendini
- Thiruganasambandamoorth Venkatesh
- Tiboni Maria E
- Tieszer Christina
- Tomas-Hernandez Jordi
- Toogood Paul
- Torner Pere
- Torra MercĂš
- Touil Nassim
- Tran Sarah
- Trask Kelly
- Trenholm J Andrew I
- Tribak Karim
- Tripathy Vijaylaxmi
- Tuazon Ravianne
- Turgeon Thomas R
- Turiel Maurizio
- Tushinski Daniel M
- Umar Muhammad
- Umer Masood
- Usua Gemma
- Valldosera Esther
- Vasarhelyi Edward
- Veevaete Laurent
- Villar-Casares Maria del Mar
- Vincent Jessica
- Vizcaychipi Marcela Paola
- Wahab Hussain
- Wang Chew Yin
- Ward Sarah E
- Wasserstein David
- Watts Evan
- Wells Jennifer R
- Whelan Daniel B
- White Neil J
- Whitlock Richard
- Wikkerink Spencer
- Wilson David AJ
- Winemaker Mitchell
- Wong Steven CW
- Wood Gavin CA
- Wood Thomas J
- Worster Andrew
- Wright Douglas Steven
- Wu Anshi
- Yach Jeff D
- Yee Allan J
- Yee Dennis King Hang
- Yela-VerdĂș Christian
- Yingchoncharoen Teerapat
- Yombi Jean Cyr
- Yuste Antoni
- Yusuf Salim
- Zabalza Ana
- Zaki Amna
- Zhao Yanrui
- Zhou Junlin
- ĆlÄczka PaweĆ
- ĆwiÄch Mariusz
- Publication venue
- 'Elsevier BV'
- Publication date
- 29/02/2020
- Field of study
Cardiovascular magnetic resonance phase contrast imaging
- Author
- A Brandts
- A Chernobelsky
- A Frydrychowicz
- A Frydrychowicz
- A Frydrychowicz
- A Frydrychowicz
- A Harloff
- A Harloff
- A Hsiao
- A Hsiao
- A Hsiao
- A Prakash
- A Stadlbauer
- AA Joseph
- AC Rossum Van
- AE Arai
- AF Stalder
- AH Aletras
- AM Malek
- B Johansson
- B Jung
- B Jung
- BJ Holland
- Bob S. Hu
- BP Paelinck
- C Cottrell
- C Tang
- CA Taylor
- CD Lew
- Christine Lorenz
- CJ Hardy
- CJ Hardy
- CL Dumoulin
- CM Prado
- D Frakes
- D Föll
- D Föll
- D Giese
- D Giese
- D Kim
- David Saloner
- DB Plewes
- DC Ghiglia
- DG Nishimura
- DG Nishimura
- DJ Atkinson
- DJ Bryant
- DL Dicks
- DN Firmin
- DN Firmin
- DN Firmin
- DR Enzmann
- E Bergvall
- E Bollache
- E Nagel
- E Nagel
- E Suzuki
- EA Zerhouni
- EJ Nett
- EL Hahn
- EM Haacke
- F Grigioni
- F Ong
- Frederick H. Epstein
- G Greil
- GB Pike
- GK Lund
- GL Nayler
- GP Chatzimavroudis
- GP Chatzimavroudis
- GZ Yang
- H Haraldsson
- H Liu
- H Sakuma
- H Sakuma
- H Sakuma
- H-Y Yu
- Han Wen
- HG Bogren
- HM Nagaraj
- IE Vignon-Clementel
- IGH Jansen
- J Bock
- J Busch
- J Busch
- J Cho
- J Hennig
- J Keegan
- J Keegan
- J Keegan
- J Keegan
- J Lotz
- J Schwitter
- J Tsao
- J-PE Kvitting
- J-PE Kvitting
- J-W Lankhaar
- JA Polzin
- JA Polzin
- JC Nielsen
- JE Hippelheuser
- JF Debatin
- JG Delfino
- JG Delfino
- JJM Westenberg
- JL Carvalho
- JM Plasencia MartĂnez
- JN Oshinski
- JO Fredrickson
- John N. Oshinski
- Jon-Fredrik Nielsen
- JP Hulet
- JR Cebral
- JR Singer
- JS Milner
- JUG Streif
- K Debl
- K Johnson
- K Valen-Sendstad
- KM Johnson
- KM Lagerstrand
- KMJ Chan
- KP Pruessmann
- KR Hoffmann
- KR OâBrien
- KR OâBrien
- Krishna S. Nayak
- KS Nayak
- KS Nayak
- L Axel
- L Axel
- L Boussel
- L Dempere-Marco
- L Grosse-Wortmann
- L SĂžndergaard
- L SĂžndergaard
- L Wigström
- L Wigström
- LEJ Thomson
- LR Frank
- LR Frank
- LR Pelc
- M Drangova
- M Drangova
- M Drangova
- M Gutberlet
- M Hansen
- M Markl
- M Markl
- M Markl
- M Markl
- M Markl
- M Markl
- M Markl
- M Nahrendorf
- M OâDonnell
- M Shibata
- MA Bernstein
- MA Bernstein
- MA Bernstein
- MA Bernstein
- MA Griswold
- Matt A. Bernstein
- MB Hofman
- MB Hofman
- MD Hope
- MD Hope
- MH Buonocore
- MH Buonocore
- MI Argyropoulou
- Michael Markl
- MJ Middione
- MJ Middione
- MO Khan
- MS Hansen
- N Chaosuwannakit
- N Kawada
- NJ Pelc
- NJ Pelc
- NJ Pelc
- NJ Pelc
- P Beerbaum
- P Beerbaum
- P Beerbaum
- P Dijk Van
- P Festa
- P Hou
- P Ooij Van
- P Ooij Van
- P Reymond
- P Selskog
- P Thunberg
- PA Turski
- PD Gatehouse
- PD Gatehouse
- PD Gatehouse
- Peter D. Gatehouse
- PG Walker
- PJ Kilner
- PJ Kilner
- PR Moran
- PR Moran
- QS Xiang
- R Bammer
- R Moftakhar
- R Nezafat
- R Simpson
- R Thompson
- Rene M. Botnar
- RH Mohiaddin
- RJ Geest Van der
- RL Wolf
- RL Wolf
- RL Wolf
- RM Wald
- RO Bonow
- RR Edelman
- RT Constable
- S Kecskemeti
- S Kozerke
- S Kutty
- S Ley
- S Meckel
- S Napel
- S Oyre
- S Petersson
- S Schnell
- S Uretsky
- S Uribe
- S-L Lee
- SA Rebergen
- SD Caruthers
- SE Langerak
- SE Petersen
- SJ Lin
- SM Song
- SP Karwatowski
- SP Karwatowski
- SS Varghese
- Subha V. Raman
- T Ebbers
- T Ebbers
- T Gu
- TA Hope
- TK Foo
- TL Chenevert
- U Tariq
- V Herold
- V Knobloch
- VL Marrero
- W Li
- W Nichols
- WG Hundley
- WG Hundley
- WG Hundley
- WG Hundley
- WH Perman
- WH Perman
- WJ Rogers
- Y Zhu
- Y Zhu
- Y Zhu
- Y Zhu
- Y Zur
- Z Stankovic
- ZM Metafratzi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension
- Author
- Acary Souza Bulle Oliveira
- Adam Hart
- Adife Veske
- Aditya Kumar
- Aikaterini Dimitriou
- Akihiro Mukaino
- Akiko Kanzaki
- Akiyuki Uzawa
- Akshay Shah
- Alan Ross Berger
- Albert Hietala
- Alberta Locatelli
- Alejandra Dalila Garcia
- Alejandro Tobon Gonzalez
- Alessandro Filla
- Alex Fondaw
- Alexandre Guerreiro
- Alexandre Guerreiro
- Ali Malekniazi
- Aline de Cassia Santos
- Alzira Alves de Siqueira Carvalho
- Amaiak Chilingaryan
- Amanda Anderson
- Amelia Evoli
- Amna Shah
- Amy Saklad
- Amy Woodall
- Ana Carolina Amaral de Andrade
- Ana Lazaro
- Ana Paula Macagnan
- Ana Paula Melo
- Andrea Corse
- Andrea Kelley
- Andrea Swenson
- Angela Ardoin
- Angela Campanella
- Angela Marsili
- Angela Micheels
- Angiola Fasanaro
- Anh Tran
- Anita Mogensen
- Ann D'Hont
- Anna Gonzalez
- Anne Cooley
- Anne Mette Ostergaard Autzen
- Anneke van der Kooi
- Annelies Depreitere
- Annelies Vanhee
- Anthony Amato
- Antonella Di Pasquale
- Antonella Di Pasquale
- April McVey
- Arshira Seddigh
- Arzu Meherremova
- Ashley Mallon
- Aya Mizugami
- Ayse Kutlu
- Baki Dogan
- Barbara Lokaitis
- Barbora Kurkova
- Bengu Balkan
- Benison Keung
- Benjamin Brooks
- Beth DiSanzo
- Betsy Mosmiller
- Booth H. D. E.
- Brajesh Agrawal
- Brian Droker
- Brian Minton
- Brigitta Szabadosne
- Brittany Harvey
- Bruno Bezerra Rosa
- Bryan Kim
- Byoung Joon Kim
- Byung-Jo Kim
- Can Ebru Bekircan-Kurt
- Cansu Semiz
- Carlo Antozzi
- Carlos Casasnovas
- Carol Herbert
- Carolina Miranda
- Caroline Schotte
- Cecile Phan
- Celal Tuga
- Chae Won Shin
- Chafic Karam
- Chafic Karam
- Chang Nyoung Lee
- Charlene Hafer-Macko
- Charlotte Smetcoren
- Christian Homedes-Pedret
- Christopher Nance
- Claire Brown
- Clara Schommer
- Claudio Gabriel Mazia
- Colleen Pineda
- Craig Donahue
- Cristiani Fernanda Butinhao
- Csilla Rozsa
- Cynthia Bodkin
- Cynthia Carter
- Da Yoon Koh
- Dae Lim Koo
- Dai Matsuse
- Daiane da Cruz Pacheco
- Daisuke Yamamoto
- Dallas Forshew
- Daniel Ambrosio
- Daniel Dicapua
- Danielle Sheldon
- Dave Watling
- David Feder
- Debbie Davies
- Debora Dada Martineli Torres
- Dennis Jeffery
- Derrick Blackmore
- Diana Dimitrova
- Diego Lopergolo
- Donna Carnes
- Doreen Ho
- DĂ©lphine Mahieu
- Edina Varga
- Elaine Weiner
- Elena Bravver
- Elena Cortes Vicente
- Elena Giacomelli
- Eliana Reyes
- Elisabet Arribas-Ibar
- Elizabeth Watt
- Emanuela Onesti
- Emiko Tsuda
- Enrico Marano
- Eri Kobayashi
- Erica Nogueira Coelho
- Eriko Higuchi
- Eriko Miyawaki
- Eun Bi Hwang
- Eun Bin Cho
- Eun Haw Choi
- Exuperio Diez Tejedor
- Ezgi Yilmaz
- Fabio Barroso
- Faisal Sohail
- Fatima Maqsood
- Fernanda Carrara
- Fernanda Troili
- Filiz Muharrem
- Fiona Norwood
- Floyd Jones
- Francesco SaccĂ
- Francisco Javier Rodriguez de Rivera
- Frank Lin
- Fredrik Piehl
- Fujita K. P.
- Fumie Meguro
- Gabor Lovas
- Gabor Lovasamela CĂ©sar
- Gabriel Paiva
- Gabrielle Rico
- Gal Maier
- Gedeonne Jakab
- Gedeonne Jakab
- Giannis Sokratous
- Giorgia Camera
- Giorgia Puorro
- Giovanni Antonini
- Girija Sadalage
- Gisela Gili
- Gonzalo Mazuela
- Gonzalo Vidal
- Graziela Pinto
- Gulmohor Roy
- Gulsah Becerikli
- Gulsah Orsel
- Gustavo Duran
- Guy Van den Abeele
- Gyorgyi Szabo
- H James Jones
- Ha Young Shin
- Ha-Neul Jeong
- Hakan Cavus
- Harpreet Kaur
- Heena Olalde
- Heike Arndt
- Henning Andersen
- Henrique Mohr
- Hidekazu Suzuki
- Hirokazu Shiraishi
- Hiroyuki Murai
- Hisako Kobayashi
- Hong Vu
- Hoo Nam Kang
- Howard J. F.
- Hui Gong
- Huned Patwa
- Hung Youl Seok
- Husnu Efendi
- HyeJin Ra
- HyeLim Lee
- Hyung Seok Lee
- Iandra Souza
- Igor Dias Brockhausen
- Ihsan Sengun
- Ikuko Kamegamori
- Ikuko Yasuda
- Irene Yang
- Isabel Illa
- Ivana Jurajdova
- Iveta Novakova
- Jaana Eriksson
- Jae-Sung Lim
- Jaimin Shah
- Jakit Gollogly
- James Gilchrist
- Jan De Bleecker
- Jan Vynckier
- Jana Junkerova
- Jane Distad
- Jane Pedersen
- Janice Massey
- Jasmine Hewlett
- Jaya Trivedi
- Jayashri Srinivasan
- Jeffery Statland
- Jeffrey Guptill
- Jeffrey Narayan
- Jeffrey Rosenfeld
- Jenna Seelbach
- Jeri Sieren
- Jerry Locheke
- Ji Ye Hwang
- JiEun Lee
- Jinmyoung Seok
- JinWoo Jung
- Jiri Pitha
- Joan HĂžjgaard
- Joan Nye
- Joanne Nemeth
- John Kincaid
- John Kissel
- John Loor
- John Vissing
- Jonathan Katz
- Jonathan McKinnon
- Jordan Jara
- Jordana Gonçalves Geraldo
- Jordi Diaz-Manera
- Josef Bednarik
- Josep Gamez Carbonell
- Joseph Chad Hoyle
- Ju-Hong Min
- Judit Matolcsi
- Juha-Pekka ErÀlinna
- Julie Agriesti
- Julie Khoury
- Julie Steele
- Juliet Saba
- Jun Kawamata
- Justin Kwan
- JuYoung Kwon
- Kaitlyn McKenna
- Kaori Osakada
- Kaori Uwasa
- Kara Patrick
- Karan Alcon
- Karen Callison
- Karen Zakalik
- Katarina Reguliova
- Kate Beck
- Katherine Amato
- Kathryn Johns
- Kathy de Koning
- Katrien De Mey
- Katsuhisa Masaki
- Kazumi Futono
- Kazumi Takada
- Keiko Kikutake
- Kelley Emmons
- Kendrick Henderson
- Kenichi Tsukita
- Kenkichi Nozaki
- Kerry Naunton
- Kevin Daniels
- Khema Sharma
- Kimberly Robeson
- Kimiaki Utsugisawa
- Koichi Narikawa
- Krishna Polaka
- Kristen Roe
- Kristin Huynh
- Lara Katzin
- Laszlo Vecsei
- Laura Diez Porras
- Laura Echevarria
- Laura Fionda
- Laura Fionda
- Laura Golden
- Laura Haar
- Laura Herbelin
- Lauren Wheeler
- Laurie Gutmann
- Lena Bjarbo
- Lesly Welsh
- Liang Lu
- Liene Duarte Silva
- Linda Wagemaekers
- Lindsay Zilliox
- Lisa Hobson-Webb
- Lisa Smith
- Livia Dezsi
- Lorenzo Maggi
- Lorraine Dishman
- Lotte Vinge
- Louisa Mezache
- Lucas Eduardo Pazetto
- Luciana Ferreira
- Luciana Renata Cubas Volpe
- Luciana Souza Duca
- Ludwig Gutmann
- Luis Antonio Querol Gutiérrez
- Luiz Augusto da Silva
- Luiz Otavio Maia Gonçalves
- Maeda Yasuko
- Magda Chmelikova
- Maki Jingu
- Makoto Samukawa
- Mamatha Pasnoor
- Manisha Chopra
- Mantegazza R.
- Marcela Silva
- Marcela Wolfova
- Marcelo Annes
- Marcelo Chaves
- Marcelo Rugiero
- Marek Cierny
- Marguerite Engel
- Maria Antonia Alberti Aguilo
- Maria da Penha Ananias Morita
- Maria Gabriele
- Maria Gori
- Maria Pasanisi
- Maria Salvado Figueras
- Maria Sastre
- Marianne de Visser
- Mariela Bettini
- Marina Pozo
- Martin Bilsker
- Mary Varghese
- Maryanne Burdette
- Masahiro Mori
- Masakatsu Motomura
- Masaki Saitoh
- Masako Tsurumaru
- Masanori Takahashi
- Masayuki Nakamori
- Matteo Garibaldi
- Maureen Walsh
- Maurer Pereira Martins
- Maurizio Inghilleri
- MaurĂcio AndrĂ©Gheller Friedrich
- Mayuko Noshiro
- Mazen Dimachkie
- Megan Kramer
- Megumi Koga
- Meinoshin Okumura
- Melanie Glenn
- Melinda Horvath
- Michael Benatar
- Michael Hehir
- Michael Pulley
- Michael Weiss
- Michaela Tyblova
- Michal Vytopil
- Miguel Wilken
- Mihoko Takada
- Miju Shin
- Mikko Laaksonen
- Mireya Fernandez-Fournier
- Mireya Fernandez-Fournier
- Miri Kim
- Miriam Freimer
- Misa Shimpo
- MiSong Choi
- Miwako Sato
- Miyuki Morikawa
- Mohamed Kazamel
- Mohamed Mahdi-Rogers
- Mohammad Alsharabati
- Mohammed Salajegheh
- Mohammed Sanjak
- Mollie Vanderhook
- Mona Elsayed
- Monika Konyane
- Muppidi S.
- Murat Terzi
- Murilo Santos Engel
- Musa Kazim Onar
- Muzeyyen Ugur
- Nadia Sattar
- Namie Taichi
- Namita Goyal
- Nanna Witting
- Naoki Kawaguchi
- Naoko Ishiyama
- Natalia Julia Palacios
- Natalia Prando
- NatĂĄlia Assis
- Naya McKinnon
- Nazire Pinar Acar
- Neelam Goyal
- Nicholas Silvestri
- Nicholas Ventura
- Nicolas Vandenbussche
- Nicole Jenci
- Nicole Kressin
- Nivedita Jerath
- Nuria Vidal
- O'Brien F. L.
- Ohito Tano
- Olga Zapletalova
- Olivier Stevens
- Olli Oksaranta
- Ozlem Tun
- Paolo Emilio Alboini
- Patricia Padilla
- PatrĂcia Fernandes
- Pedro Lopez Ruiz
- Petra Tilkin
- Philip Van Damme
- Pilar Gomez Salcedo
- Pilar Sune
- Pinar Ozcelik
- Pravin Torane
- Pravin Torane
- Raffaele Iorio
- Ratna Bhavaraju-Sanka
- Rebecca Traub
- Rebekah Garcia
- Rekha Pillai
- Renata Martins Ribeiro
- Ricardo Rojas Garcia
- Richard Barohn
- Richard Nowak
- Rikako Kurihara
- Rikki Roderus
- Riley Snook
- Robert Miller
- Robert Pascuzzi
- Rosana Rocha
- Rudy Mercelis
- Rumi Takeyama
- Rup Tandan
- Sabrina Pol
- Sachiko Kamakura
- Said Beydoun
- Saiju Jacob
- Salma Akhter
- Sanaz Karimi
- Sandi Mumfrey-Thomas
- Sandra Guingrich
- SangAe Park
- Sara-Claude Michon
- Sarada Sakamuri
- Sarah Plevka
- Sarah Verjans
- Scott Cunningham
- Seda Aydinlik
- Sedat Sen
- Seiko Yoshida
- Seung Min Kim
- Sevim Erdem-Ozdamar
- Shachie Aranke
- Shannon Lucy
- Sharmeen Alam
- Sharon Chelnick
- Sharon Downing
- Sharon Nations
- Shin Hisahara
- Shirley Paulose
- Shirli Toska
- Shizuka Asada
- Shoko Amamoto
- Shuichiro Suzuki
- Shun Shimohama
- Shun Shimohama
- Shunsuke Yoshimura
- Sien Van Daele
- Silvia Bonanno
- Sivakumar Sathasivam
- So-Hyun Ahn
- Soichiro Funaka
- Sonia Garcia
- Stanislav Vohanka
- Stanislava Toncrova
- Stefania Morino
- Stephanie Kohlrus
- Stephanie Scala
- Steve Hopkins
- Susan Strom
- Susanne Krogh
- Tahseen Mozaffar
- Taira Uehara
- Takashi Hayashi
- Takashi Murahara
- Takuya Matsushita
- Tamar Gibson
- Tamires Cristina Gomes da Silva
- Taylor Darnell
- Teiichiro Miyazaki
- Teresa Costabile
- Terry McClain
- Terry McClain
- Tessa Marburger
- Tetsuya Akiyama
- Tetsuya Kanai
- Thabata Veiga
- Thomas Arnold
- Thomas Cochrane
- Thomas Harbo
- Tierney Scott
- Tina Liu
- Tiyonnoh Cash
- Tomihiro Imai
- Tomihiro Imai
- Tomohiro Kawamura
- Tomoko Tsuda
- Tomomi Kobashikawa
- Tomoya Hasuike
- TomĂĄs Augusto Suriane Fialho
- Tuan Vu
- Tugce Kirbas Cavdar
- Tulio Bertorini
- Tuula Harrison
- Valentina D'Amato
- Valentina Velez Santamaria
- Valeria Cavalcante Lino
- Valerie Young
- Veena Mathew
- Vern Juel
- Victor Doan
- Vinay Chaudhry
- Vittorio Frasca
- Vittorio Frasca
- Waqar Waheed
- Wiendl H.
- Wladimir Pinto
- Wolfe G. I.
- Yagmur Caliskan
- Yasmeen Shabbir
- Yasmeen Shabbir
- Yasushi Suzuki
- Ye Liu
- Yoko Ishiyama
- Yoko Kaneko
- Yong Seo Koo
- Yool-Hee Kim
- Yoon-Ho Hong
- Yoshiko Sano
- Yuen T So
- Yuka Saito
- Yukiko Ozawa
- Yuko Fujii
- Yumi Yamashita
- Yumiko Nakamura
- Yunxia Wang
- Yuriko Nagane
- Yusuke Fukuda
- Zaeem Siddiqi
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2021
- Field of study
OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo
Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab
- Author
- Agrawal Brajesh
- Agriesti Julie
- Ahn So-Hyun
- Akhter Salma
- Akiyama Tetsuya
- Alam Sharmeen
- Alcon Karan
- Alsharabati Mohammad
- Alves de Siqueira Carvalho Alzira
- Amamoto Shoko
- Amato Anthony
- Amato Katherine
- Ambrosio Daniel
- Andersen Henning
- Anderson Amanda
- Andoin Angela
- AndrĂ© Gheller Friedrich MaurĂcio
- Annes Marcelo
- Antonia Alberti Aguilo Maria
- Antonini Giovanni
- Antonio Querol Gutiérrez Luis
- Antozzi Carlo
- Aranke Shachie
- Arndt Heike
- Arnold Thomas
- Arribas-Ibar Elisabet
- Asada Shizuka
- Assis NatĂĄlia
- Augusto da Silva Luiz
- Augusto Suriane Fialho TomĂĄs
- Aydinlik Seda
- Balkan Bengu
- Barohn Richard
- Barroso Fabio
- Becerikli Gulsah
- Beck Kate
- Bednarik Josef
- Benatar Michael
- Bertorini Tulio
- Bettini Mariela
- Beydoun Said
- Bezerra Rosa Bruno
- Bhavaraju-Sanka Ratna
- Bi Hwang Eun
- Bilsker Martin
- Bin Cho Eun
- Bjarbo Lena
- Blackmore Derrick
- Bodkin Cynthia
- Bonanno Silvia
- Bravver Elena
- Brooks Benjamin
- Brown Claire
- Burdette Maryanne
- Caliskan Yagmur
- Callison Karen
- Camera Giorgia
- Campanella Angela
- Carnes Donna
- Carolina Amaral de Andrade Ana
- Carrara Fernanda
- Carter Cynthia
- Casasnovas Carlos
- Cash Tiyonnoh
- Cavalcante Lino Valeria
- Cavus Hakan
- Chad Hoyle Joseph
- Chaudhry Vinay
- Chaves Marcelo
- Chelnick Sharon
- Chilingaryan Amaiak
- Chmelikova Magda
- Choi MiSong
- Chopra Manisha
- Cierny Marek
- Cochrane Thomas
- Cooley Anne
- Corse Andrea
- Cortes Vicente Elena
- Costabile Teresa
- Cristina Gomes da Silva Tamires
- Cunningham Scott
- CĂ©sar Pamela
- D'Amato Valentina
- D'Hont Ann
- da Cruz Pacheco Daiane
- da Penha Ananias Morita Maria
- Dada Martineli Torres Debora
- Dalila Garcia Alejandra
- Daniels Kevin
- Darnell Taylor
- Davies Debbie
- De Bleecker Jan
- de Cassia Santos Aline
- de Koning Kathy
- De Mey Katrien
- de Visser Marianne
- Depreitere Annelies
- Dezsi Livia
- Di Pasquale Antonella
- Dias Brockhausen Igor
- Diaz-Manera Jordi
- Dicapua Daniel
- Diez Porras Laura
- Diez Tejedor Exuperio
- Dimachkie Mazen
- Dimitriou Aikaterini
- Dimitrova Diana
- DiSanzo Beth
- Dishman Lorraine
- Distad Jane
- Doan Victor
- Dogan Baki
- Donahue Craig
- Downing Sharon
- Droker Brian
- Duarte Silva Liene
- Duran Gustavo
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- Zapletalova Olga
- Zilliox Lindsay
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
- Author
- A Kaldun Nossuli
- Aamir Jamal
- Adalbert Schiller
- Adam Cheifetz
- Adarsh Daswani
- Adeera Levin
- Adline Ghazi
- Adrian Guinsburg
- Adriana Cif
- Adriana Gabriela Onaca
- Adriana Ilavska
- Adriana Villarino
- Agarwal R.
- Agnieszka Starzec
- Ahmed Arif
- Ahmed Awad
- Aiping Yin
- Akimichi Asano
- Alan Jackson
- Alan McMahon
- Alan Perlman
- Alberto Di Carlo
- Alberto Esquenazi
- Alejandra Oviedo
- Alejandro Valdes Depeda
- Aleksandra Kendereski
- Alex Valenzuela
- Alexander Dreval
- Alexander Gonzalez
- Alexander Shinkov
- Alexander Turchin
- Alexandre Klein
- Alfonso Soto Gonzalez
- Alfred Penfornis
- Alfredo Chew Wong
- Alfredo Wassermann
- Ali Torshizi
- Alicia Chilito
- Alina Agafyina
- Alison Dawson
- Alva Hansraj
- Amer Al-Karadsheh
- Amorin Remus Popa
- Amrendra Kumar
- Amy Sprague
- Ana Limos
- Ana Maria Cusumano
- Ana Maria Elosegui
- Anabella Amigo
- Anatoliy Kazmirchuk
- Andrea Phillips
- Andrea Stella
- Andreas Maddux
- Andrej Dzupina
- Andres Alvarisqueta
- Andrew Johnson
- Andrew O'Shaughnessy
- Andrew Steele
- Andrian Yakov
- Andrzej Januszewicz
- Andrzej Madej
- Angelina Angelova
- Anibal Gastaldi
- Anil Gupta
- Anita Bhajan Manocha
- Anjanette Tan
- Anna Kaminska
- Anna Maria Veronelli
- Anna Strzelecka
- Anna Zateyshchikova
- Anselmo Bordonava
- Antanas Navickas
- Anthony Gunstone
- Anthony Roberts
- Antonio Ceriello
- Antonio Galan Serrano
- Antonio Scafuto Scotton
- Antonio Terrelonge
- AntĂŽnio Roberto Chacra
- Anupama Gowda
- Arjun D Sinha
- Armando Perez
- Ashot Mkrtumyan
- Atanas Koundurdjiev
- Augusto Vallejos
- Aurelian-Emil Ranetti
- Ayim Akyea-Djamson
- Aysha Badat
- Bakris G.
- Baldev Singh
- Barbara Greco
- Barbara Kaczmarek
- Barbara Rewerska
- Barry M Brenner
- Belia Martin Del Camp Blanco
- Bernard Zinman
- Bertrand Cariou
- Bertrand Dussol
- Bhasker Mehta
- Bhimavarapu Sudhakar
- Björn Paschen
- Bompoint S.
- Borys Mankovskyy
- Botond Csiky
- Boyan Nonchev
- Brenner B. M.
- Brett Kissela
- Brian Nichol
- Bruce Neal
- Bruce Trippe
- Bruno Geloneze Neto
- Bull S.
- Byung-Wan Lee
- C B Keshavamurthy
- Cannon C. P.
- Capuano G.
- Carlo Giorda
- Carlos Alberto Cuneo
- Carlos Arauz-Pacheco
- Carlos Barrera
- Carlos Perez
- Carmel Hawley
- Carmen Crisan
- Carol Pollock
- Carolyn Droste
- Caroucel Chuateco
- Caryl David
- Cecilia Garcia Ballesteros
- Cecilia Jimeno
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- Cesar Yoiti Hayashida
- Chamberlain Obialo
- Chang-Hsun Hsieh
- Charles Cook
- Charles Kaupke
- Charytan D. M.
- Chek Loong Loh
- Chen Leia
- Cheol-Young Park
- Chih-Ching Lin
- Christopher P Cannon
- Christy Yao
- Chu P. -L.
- Chwen-Tzuei Chang
- Chye Lee Gan
- Clara Barrios
- Claude Galphin
- Claudia Goycoa
- Claudia Moreira de Brito
- Clodoaido Caringal
- Cristian Serafinceanu
- Cristina Toarba
- Cristobal Morales Portillo
- Csaba Kovesdy
- Cynthia Bowman-Stroud
- Cynthia Christiano
- Cynthia Mustieles Rocha
- Cyrus Desouza
- CĂĄssio Slompo Ramos
- Dagmar Bartaskova
- Dale Crawford Allison
- Dalia Kozloviene
- Dan Scharfstein
- Dana Cosma
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- Daniel Hiser
- Daniel Kolansky
- Daniel Panarotto
- Daniel Pella
- Daniel Weiner
- Daniil Chizhov
- Dariusz Sowinski
- Darren K McGuire
- Davesh Sennik
- David C Wheeler
- David Cherney 3rd
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- SĂ©rgio Yamada
- Tadashi Iitsuka
- Takamoto Kodera
- Takashi Wada
- Takayuki Watanabe
- Tamara Malek Marin
- Tamas Oroszlan
- Tara Chang
- Tareq Nassar
- Tarissa Beatrice Zanata Petry
- Tatiana Koroleva
- Tatiana Morugova
- Tatiana Raskina
- Tatyana Zykova
- Te-Lin Hsia
- Terue Sakakibara
- Tetiana Zlova
- Tetsuji Niiya
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- Tonatiu Diaz Escalante
- Toshihiko Yanase
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- Veselka Genadieva
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- Victor Saavedra Gajardo
- Vijayaraman Arutchelvam
- Viktor Margaritov
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- Viktoria Andreeva
- Vimladhevi Govender
- Vincent Pichette
- Vincent Woo
- Vira Tseluyko
- Virginia Esther Visco
- Vivek Sood
- Vivekan Jha
- Vladimir Dobronravov
- Vladimir Khirmanov
- Vladimir Tesar
- Vlado Perkovic
- Volker Burst
- Volodymyr Botsyurko
- Walter Guillermo Douthat
- Walter Pharr
- Wasim Hanif
- Wataru Yumita
- Wayne H-H Sheu
- Wayne Turner
- Wei Yen Kong
- Weihong Song
- Weiping Lu
- Wendy Lane
- Wenge Li
- Wheeler D. C.
- Wladmir Saporito
- Xuemei Li
- Xueqing Yu
- Yamil Canaan
- Yan Ren
- Yannick Le Meur
- Yaozhong Kong
- Yasuro Kumeda
- Yasushi Wakida
- Yavin Y.
- Yeong Hoon Kim
- Yevgeniya Svyshchenko
- Young Min Cho
- Yulia Samoylova
- Yung-Chuan Lu
- Yuriy Mostovoy
- Yuriy Shwartz
- Yvette Ethel Yap
- Zaynab Abejuela
- Zdravko Kamenov
- Zeid Khitan
- Zhang H.
- Zinman B.
- Zishan Ali
- Zuzana Ochodnicka
- Ăngela Regina Nazario Sabbag
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodiumâglucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with reninâangiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
Observation of gravitational waves from the coalescence of a 2.5â4.5 Mâ compact object and a neutron star
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- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
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- Agarwal Deepali
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- Aghaei Abchouyeh Maryam
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- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
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- Todd M. R.
- Toivonen Andrew
- Toland Karl
- Tolley Arthur E.
- Tomita K.
- Tomura Tomonobu
- Tong Hui
- Tong-Yu C.
- Toriyama A.
- Toropov Nikita
- Torres Forne Alejandro
- Torrie C. I.
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- Tosta e Melo Iara
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- Undheim Vegard
- Ushiba Takafumi
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- Villa-Ortega VerĂłnica
- Villarreal F. Llamas
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- Virgo Collaboration
- Virtuoso Andrea
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- Wang Haoyu
- Wang J. Z.
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- Washimi Tatsuki
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- Weizmann Kiendrebeogo R.
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- Wen L.
- Wette Karl
- WeĂels P.
- Whelan John
- Whiting Bernard F.
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- Wilken Dennis
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- Williams Michael
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- Won Seo Jin
- Wong Henry T.
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- Wright Mick
- Wu Chien-Ming
- Wu David S.
- Wu Hsun-Chung
- Wuchner E.
- Wysocki Daniel
- Xu Victoria
- Xu Yumeng
- Yaala M. Ben
- Yadav Nikesh
- Yamamoto Hiroaki
- Yamamoto Kazuhiro
- Yamamoto Takahiro
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- Yamamura S.
- Yamazaki Ryo
- Yan S.
- Yan T.
- Yang F.
- Yang Fengwei
- Yang Kate Z.
- Yang Yi
- Yarbrough Zach
- Yasui H.
- Yeh S. -W.
- Yelikar A. B.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
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- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Xingjiang
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- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- éœäžž éèĄ
- Publication venue
- Publication date
- 23/04/2024
- Field of study
- âŠ