Quantum chaos and nuclear mass systematics

The presence of quantum chaos in nuclear mass systematics is analyzed by considering the differences between measured and calculated nuclear masses as a time series described by the power law 1/ f^alpha. While for the liquid droplet model plus shell corrections a quantum chaotic behavior alpha approx 1 is found, errors in the microscopic mass formula have alpha approx 0.5, closer to white noise. The chaotic behavior seems to arise from many body effects not included in the mass formula.Comment: 4 pages, 6 figures, replaced to match the published versio

Residual correlations in liquid drop mass calculations

A systematic study of correlations in the chart of calculated masses of Moller and Nix is presented. It is shown that the differences between the masses calculated by Moller at al and the measured ones have a well defined oscillatory component as function of N and Z, which can be removed with an appropriate fit, reducing significantly the error width, and concentrating the error distribution on a single peak around zero. The residual correlations can have important consequences in the errors as signaling the presence of chaos, as was recently proposed.Comment: 23 pages, 18 figures. A more focused article with imporved figure

How good are the Garvey-Kelson predictions of nuclear masses?

The Garvey-Kelson relations are used in an iterative process to predict nuclear masses in the neighborhood of nuclei with measured masses. Average errors in the predicted masses for the first three iteration shells are smaller than those obtained with the best nuclear mass models. Their quality is comparable with the Audi-Wapstra extrapolations, offering a simple and reproducible procedure for short range mass predictions. A systematic study of the way the error grows as a function of the iteration and the distance to the known masses region, shows that a correlation exists between the error and the residual neutron-proton interaction, produced mainly by the implicit assumption that $V_{np}$ varies smoothly along the nuclear landscape.Comment: 10 pages, 18 figure

Nuclear masses set bounds on quantum chaos

It has been suggested that chaotic motion inside the nucleus may significantly limit the accuracy with which nuclear masses can be calculated. Using a power spectrum analysis we show that the inclusion of additional physical contributions in mass calculations, through many-body interactions or local information, removes the chaotic signal in the discrepancies between calculated and measured masses. Furthermore, a systematic application of global mass formulas and of a set of relationships among neighboring nuclei to more than 2000 nuclear masses allows to set an unambiguous upper bound for the average errors in calculated masses which turn out to be almost an order of magnitude smaller than estimated chaotic components.Comment: 4 pages, Accepted for publication in Physical Review Letter

Severe course of Lyme neuroborreliosis in an HIV-1 positive patient; case report and review of the literature

<p>Abstract</p> <p>Background</p> <p>Lyme Neuroborreliosis (LNB) in a human immunodeficiency virus (HIV) positive patient is a rare co-infection and has only been reported four times in literature. No case of an HIV patient with a meningoencephalitis due to LNB in combination with HIV has been described to date.</p> <p>Case presentation</p> <p>A 51 year old woman previously diagnosed with HIV presented with an atypical and severe LNB. Diagnosis was made evident by several microbiological techniques. Biochemical and microbiological recovery during treatment was rapid, however after treatment the patient suffered from severe and persistent sequelae.</p> <p>Conclusions</p> <p>A clinician should consider LNB when being confronted with an HIV patient with focal encephalitis, without any history of Lyme disease or tick bites, in an endemic area. Rapid diagnosis and treatment is necessary in order to minimize severe sequelae.</p

A Distinct Urinary Biomarker Pattern Characteristic of Female Fabry Patients That Mirrors Response to Enzyme Replacement Therapy

Female patients affected by Fabry disease, an X-linked lysosomal storage disorder, exhibit a wide spectrum of symptoms, which renders diagnosis, and treatment decisions challenging. No diagnostic test, other than sequencing of the alpha-galactosidase A gene, is available and no biomarker has been proven useful to screen for the disease, predict disease course and monitor response to enzyme replacement therapy. Here, we used urine proteomic analysis based on capillary electrophoresis coupled to mass spectrometry and identified a biomarker profile in adult female Fabry patients. Urine samples were taken from 35 treatment-naive female Fabry patients and were compared to 89 age-matched healthy controls. We found a diagnostic biomarker pattern that exhibited 88.2% sensitivity and 97.8% specificity when tested in an independent validation cohort consisting of 17 treatment-naive Fabry patients and 45 controls. The model remained highly specific when applied to additional control patients with a variety of other renal, metabolic and cardiovascular diseases. Several of the 64 identified diagnostic biomarkers showed correlations with measures of disease severity. Notably, most biomarkers responded to enzyme replacement therapy, and 8 of 11 treated patients scored negative for Fabry disease in the diagnostic model. In conclusion, we defined a urinary biomarker model that seems to be of diagnostic use for Fabry disease in female patients and may be used to monitor response to enzyme replacement therapy

Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers.

This paper was originally published under a standard Springer Nature license