Sex differences in emotional concordance.

Emotions involve response synchronization across experiential, physiological, and behavioral systems, referred to as concordance or coherence. Women are thought to be more emotionally aware and expressive than men and may therefore display stronger response concordance; however, research on this topic is scant. Using a random-order film-average design, we assessed concordance among experiential (arousal, valence), autonomic (electrodermal activity, heart rate, preejection period, respiratory sinus arrhythmia), respiratory (respiratory rate), and behavioral (corrugator and zygomatic electromyography) responses to 15 two-minute films varying in valence and arousal. We then calculated for each participant and pair of measures a within-subject correlation index using averages from the 15 films. Pronounced individual concordance of up to 0.9 was observed. Arousal-physiology and valence-behavior concordances were particularly pronounced. Women displayed higher concordance than men for almost all pairs of measures. Findings indicate stronger psychophysiological response coupling in women than men and provide novel insights into affective differences between the sexes

Continuous electronic data capture of physiology, behavior and experience in real life: towards ecological momentary assessment of emotion

Emotions powerfully influence our physiology, behavior, and experience. A comprehensive assessment of affective states in health and disease would include responses from each of these domains in real life. Since no single physiologic parameter can index emotional states unambiguously, a broad assessment of physiologic responses is desirable. We present a recently developed system, the LifeShirt, which allows reliable ambulatory monitoring of a wide variety of cardiovascular, respiratory, metabolic, motor-behavioral, and experiential responses. The system consists of a garment with embedded inductive plethysmography and other sensors for physiologic data recording and a handheld computer for input of experiential data via touch screen. Parameters are extracted offline using sophisticated analysis and display software. The device is currently used in clinical studies and to monitor effects of physical and emotional stress in naturalistic settings. Further development of signal processing and pattern recognition algorithms will enhance computerized identification of type and extent of physical and emotional activatio

Sleep’s role in updating aversive autobiographical memories

Aversive autobiographical memories play a key role in the development and maintenance of many mental disorders. Imagery rescripting is a well-established psychotherapeutic intervention aiming to create a more adaptive version of an aversive memory by modifying its interpretation. Sleep has been shown to support reconsolidation of updated neutral memories. Here, we investigated in healthy participants whether a 90-min nap compared to wake supports the adaptive reconsolidation of autobiographical memories. Forty-four university students received a single 50-min imagery rescripting session. Thereafter, half of the participants took a 90-min nap, whereas the other half stayed awake. Subjective (arousal ratings, reports of emotions and dysfunctional cognitions) and heart rate (HR) responses to individual memory scripts were measured before the intervention (pre), after the 90-min retention interval (post 1) and 7 days later (post 2). Results demonstrate a significant decrease in distress of aversive memories pre to post imagery rescripting. The nap group showed less distressing dysfunctional cognitions along with a lower HR in response to the negative memory script as compared to the wake group at post 1. These differences were no longer evident 1 week later (post 2). Central sleep spindle density during the nap was correlated with the reduction in HR in response to the negative memory script from pre to post 1. Our results provide first evidence for sleep benefitting adaptive reconsolidation of aversive autobiographical memories. Future research should expand this approach to clinical populations and investigate precise conditions under which sleep may benefit psychotherapeutic interventions utilizing reconsolidation mechanisms

Rubidium spacecraft atomic timing system Final report

Rubidium 87 atomic time and frequency reference system for manned space fligh

Supercurrent in a mesoscopic proximity wire

Recent experiments on the proximity induced supercurrent in mesoscopic normal wires revealed a surprising temperature dependence. They suggest clean-limit behavior although the wires are strongly disordered. We demonstrate that this unexpected scaling is actually contained in the conventional description of diffusive superconductors and find excellent agreement with the experimental results. In addition we propose a SQUID-like proximity structure for further experimental investigations of the effects in question.Comment: 6 pages LaTeX, 4 postscript figures; to appear in J. Low Temp. Phys. (Proceedings of WSS '96

Lectin ligands: New insights into their conformations and their dynamic behavior and the discovery of conformer selection by lectins

The mysteries of the functions of complex glycoconjugates have enthralled scientists over decades. Theoretical considerations have ascribed an enormous capacity to store information to oligosaccharides, In the interplay with lectins sugar-code words of complex carbohydrate structures can be deciphered. To capitalize on knowledge about this type of molecular recognition for rational marker/drug design, the intimate details of the recognition process must be delineated, To this aim the required approach is garnered from several fields, profiting from advances primarily in X-ray crystallography, nuclear magnetic resonance spectroscopy and computational calculations encompassing molecular mechanics, molecular dynamics and homology modeling. Collectively considered, the results force us to jettison the preconception of a rigid ligand structure. On the contrary, a carbohydrate ligand may move rather freely between two or even more low-energy positions, affording the basis for conformer selection by a lectin. By an exemplary illustration of the interdisciplinary approach including up-to-date refinements in carbohydrate modeling it is underscored why this combination is considered to show promise of fostering innovative strategies in rational marker/drug design

Nonequilibrium stabilization of charge states in double quantum dots

We analyze the decoherence of charge states in double quantum dots due to cotunneling. The system is treated using the Bloch-Redfield generalized master equation for the Schrieffer-Wolff transformed Hamiltonian. We show that the decoherence, characterized through a relaxation $\tau_{r}$ and a dephasing time $\tau_{\phi}$, can be controlled through the external voltage and that the optimum point, where these times are maximum, is not necessarily in equilibrium. We outline the mechanism of this nonequilibrium-induced enhancement of lifetime and coherence. We discuss the relevance of our results for recent charge qubit experiments.Comment: 5 pages, 5 figure

Coupling a Superconducting Qubit to a Left-Handed Metamaterial Resonator

Metamaterial resonant structures made from arrays of superconducting lumped circuit elements can exhibit microwave mode spectra with left-handed dispersion, resulting in a high density of modes in the same frequency range where superconducting qubits are typically operated, as well as a bandgap at lower frequencies that extends down to dc. Using this novel regime for multi-mode circuit quantum electrodynamics, we have performed a series of measurements of such a superconducting metamaterial resonator coupled to a flux-tunable transmon qubit. Through microwave measurements of the metamaterial, we have observed the coupling of the qubit to each of the modes that it passes through. Using a separate readout resonator, we have probed the qubit dispersively and characterized the qubit energy relaxation as a function of frequency, which is strongly affected by the Purcell effect in the presence of the dense mode spectrum. Additionally, we have investigated the ac Stark shift of the qubit as the photon number in the various metamaterial modes is varied. The ability to tailor the dense mode spectrum through the choice of circuit parameters and manipulate the photonic state of the metamaterial through interactions with qubits makes this a promising platform for analog quantum simulation and quantum memories.Comment: 12 pages, 11 figure