Radiogenic isotopes: New tools help reconstruct paleocean circulation and erosional input

Ocean and atmosphere circulation and continental weathering regimes have undergone great changes over thousands of years as well as tens of millions of years. During the glacial stages of the Pleistocene, ocean circulation was generally more sluggish and deep water circulation in the Atlantic had a shallower flow. At the same time, weathering on the continents was enhanced by glacial erosion, particularly in high northern latitudes, which increased the input of erosional detritus into the ocean. In addition, atmospheric pressure gradients were larger, leading to higher wind speeds and increased supply of aeolian dust to the ocean. Prior to the onset of Northern Hemisphere glaciation and pronounced glacial/interglacial cyclicity at ∼3 m.ya., global climate was warmer than at present. There is also evidence for a more vigorous thermohaline circulation during the early Pliocene

Investigation of the high momentum component of nuclear wave function using hard quasielastic A(p,2p)X reactions

We present theoretical analysis of the first data on the high energy and momentum transfer (hard) quasielastic $C(p,2p)X$ reactions. The cross section of hard $A(p,2p)X$ reaction is calculated within the light-cone impulse approximation based on two-nucleon correlation model for the high-momentum component of the nuclear wave function. The nuclear effects due to modification of the bound nucleon structure, soft nucleon-nucleon reinteraction in the initial and final states of the reaction with and without color coherence have been considered. The calculations including these nuclear effects show that the distribution of the bound proton light-cone momentum fraction $(\alpha)$ shifts towards small values ($\alpha < 1$), effect which was previously derived only within plane wave impulse approximation. This shift is very sensitive to the strength of the short range correlations in nuclei. Also calculated is an excess of the total longitudinal momentum of outgoing protons. The calculations are compared with data on the $C(p,2p)X$ reaction obtained from the EVA/AGS experiment at Brookhaven National Laboratory. These data show $\alpha$-shift in agreement with the calculations. The comparison allows also to single out the contribution from short-range nucleon correlations. The obtained strength of the correlations is in agreement with the values previously obtained from electroproduction reactions on nuclei.Comment: 30 pages LaTex file and 19 eps figure

A factor IX variant that functions independently of factor VIII mitigates the hemophilia A phenotype in patient plasma

BackgroundRecombinant factor (F)IX-FIAV has previously been shown to function independently of activated FVIII (FVIIIa) and ameliorate the hemophilia A (HA) phenotype in vitro and in vivo.ObjectivesThe aim of this study was to assess the efficacy of FIX-FIAV in plasma from HA patients using thrombin generation (TG) and intrinsic clotting activity (activated partial thromboplastin time [APTT]) analyses.MethodsPlasma obtained from 21 patients with HA (>18 years; 7 mild, 7 moderate, and 7 severe patients) was spiked with FIX-FIAV. The FXIa-triggered TG lag time and APTT were quantified in terms of FVIII-equivalent activity using FVIII calibration for each patient plasma.ResultsThe linear, dose-dependent improvement in the TG lag time and APTT reached its maximum with approximately 400% to 600% FIX-FIAV in severe HA plasma and with approximately 200% to 250% FIX-FIAV in nonsevere HA plasma. The cofactor-independent contribution of FIX-FIAV was therefore suggested and confirmed by the addition of inhibitory anti-FVIII antibodies to nonsevere HA plasma, resulting in a FIX-FIAV response similar to severe HA plasma. Addition of 100% (5 μg/mL) FIX-FIAV mitigated the HA phenotype from severe to moderate (from ConclusionFIX-FIAV is capable of increasing the FVIII-equivalent activity and coagulation activity in plasma from HA patients, thereby mitigating the HA phenotype. Hence, FIX-FIAV could serve as a potential treatment for HA patients with or without inhibitors.Thrombosis and Hemostasi

Desmopressin to prevent and treat bleeding in pregnant women with an inherited bleeding disorder:a systematic literature review

Background: Although desmopressin (DDAVP) is an accessible and inexpensive hemostatic drug, its use in pregnancy is still debated due to safety uncertainties. Objectives: We aimed to review the safety and effectiveness of DDAVP in women with an inherited bleeding disorder during pregnancy and delivery. Methods: Databases were searched for articles up to July 25, 2022, reporting maternal and/or neonatal outcomes. PRISMA methodology for systematic reviews and meta-analyses was followed (PROSPERO CRD42022316490). Results: Fifty-three studies were included, comprising 273 pregnancies. Regarding maternal outcomes, DDAVP was administered in 73 women during pregnancy and in 232 during delivery. Safety outcome was reported in 245 pregnancies, with severe adverse events reported in 2 (1%, hyponatremia with neurologic symptoms). Overall, DDAVP was used as monotherapy in 234 pregnancies, with effectiveness reported in 153 pregnancies (82% effective; 18% ineffective). Regarding neonatal outcomes, out of 60 pregnancies with reported neonatal outcomes after DDAVP use during pregnancy, 2 children (3%) had a severe adverse event (preterm delivery n = 1; fetal growth restriction n = 1). Of the 232 deliveries, 169 neonates were exposed to DDAVP during delivery, and in 114 neonates, safety outcome was reported. Two children (2%) experienced a moderate adverse event (low Apgar score n = 1; transient hyperbilirubinemia not associated with DDAVP n = 1). Conclusion: DDAVP use during pregnancy and delivery seems safe for the mother, with special attention to the occurrence of hyponatremia and for the child, especially during delivery. However, due to poor study designs and limited documentation of outcomes, a well-designed prospective study is warranted.</p

The use of synchrotron edge topography to study polytype nearest neighbour relationships in SiC

A brief review of the phenomenon of polytypism is presented and its prolific abundance in Silicon Carbide discussed. An attempt has been made to emphasise modern developments in understanding this unique behaviour. The properties of Synchrotron Radiation are shown to be ideally suited to studies of polytypes in various materials and in particular the coalescence of polytypes in SiC. It is shown that with complex multipolytypic crystals the technique of edge topography allows the spatial extent of disorder to be determined and, from the superposition of Laue type reflections, neighbourhood relationships between polytypes can be deduced. Finer features have now been observed with the advent of second generation synchrotrons, the resolution available enabling the regions between adjoining polytypes to be examined more closely. It is shown that Long Period Polytypes and One Dimensionally Disordered layers often found in association with regions of high defect density are common features at polytype boundaries. An idealised configuration termed a "polytype sandwich" is presented as a model for the structure of SiC grown by the modified Lely technique. The frequency of common sandwich edge profiles are classified and some general trends of polytype neighbourism are summarised

The π\pi, K+K^+, and K0K^0 electromagnetic form factors

The rainbow truncation of the quark Dyson-Schwinger equation is combined with the ladder Bethe-Salpeter equation for the meson amplitudes and the dressed quark-photon vertex in a self-consistent Poincar\'e-invariant study of the pion and kaon electromagnetic form factors in impulse approximation. We demonstrate explicitly that the current is conserved in this approach and that the obtained results are independent of the momentum partitioning in the Bethe-Salpeter amplitudes. With model gluon parameters previously fixed by the condensate, the pion mass and decay constant, and the kaon mass, the charge radii and spacelike form factors are found to be in good agreement with the experimental data.Comment: 8 pages, 6 figures, Revte

Rms-flux relation in the optical fast variability data of BL Lacertae object S5 0716+714

The possibility that BL Lac S5 0716+714 exhibits a linear root mean square (rms)-flux relation in its IntraDay Variability (IDV) is analysed. The results may be used as an argument in the existing debate regarding the source of optical IDV in Active Galactic Nuclei. 63 time series in different optical bands were used. A linear rms-flux relation at a confidence level higher than 65% was recovered for less than 8% of the cases. We were able to check if the magnitude is log-normally distributed for eight timeseries and found, with a confidence > 95%, that this is not the case.Comment: Accepted by Astrophysics and Space Scienc