Catastrophic long-term care expenditure: associated socio demographic and economic factors

Objective An increasing number of persons across the world require long-term care (LTC). In Spain, access to LTC involves individuals incurring out-of-pocket (OOP) expenditure. There is a large body of literature on the incidence of catastrophic OOP payments in access and participation in health systems, but not in the field of LTC nor the determinants of these expenses. Our aim was to analyse the socio-demographic and economic factors associated with different levels of catastrophic LTC expenditure in the form of private out-of-pocket payments among dependent persons in Spain. Materials and methods The study used the Spanish Disability and Dependency Survey (SDDS) conducted by the Spanish National Statistics Institute to obtain the socioeconomic, demographic and health profiles. The households were classified into those below the poverty threshold and those above the threshold of catastrophe, using measures of impoverishment and catastrophe. We estimated two logistic regression models, one binary (impoverishment) and one ordinal (catastrophe). Results The results show that OOP expenditure on LTC increases the probability of impoverishment by 18.90%. The factors associated with higher probability of experiencing catastrophe were age, being single, widowed or separated, lower levels of household income and education, higher level of dependence and living in an autonomous community with lower per capita income. Conclusions These findings highlight the need to include exemptions or insurance in the design of LTC policies to protect dependent persons from the risk of financial burden

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Contribución a la mejora de la vinificación y la calidad de vinos tintos de Monastrell en la D.O. Jumilla / Francisco Pardo Minguez ; director Ginés Navarro García.

Tesis-Universidad de Murcia.Consulte la tesis en: BCA. GENERAL. ARCHIVO UNIVERSITARIO. T.M.-1193.CRAI CIENCIAS. DEPOSITO. T.D. 256

The cognitive and psychiatric subacute impairment in severe Covid-19.

Neurologic impairment persisting months after acute severe SARS-CoV-2 infection has been described because of several pathogenic mechanisms, including persistent systemic inflammation. The objective of this study is to analyze the selective involvement of the different cognitive domains and the existence of related biomarkers. Cross-sectional multicentric study of patients who survived severe infection with SARS-CoV-2 consecutively recruited between 90 and 120 days after hospital discharge. All patients underwent an exhaustive study of cognitive functions as well as plasma determination of pro-inflammatory, neurotrophic factors and light-chain neurofilaments. A principal component analysis extracted the main independent characteristics of the syndrome. 152 patients were recruited. The results of our study preferential involvement of episodic and working memory, executive functions, and attention and relatively less affectation of other cortical functions. In addition, anxiety and depression pictures are constant in our cohort. Several plasma chemokines concentrations were elevated compared with both, a non-SARS-Cov2 infected cohort of neurological outpatients or a control healthy general population. Severe Covid-19 patients can develop an amnesic and dysexecutive syndrome with neuropsychiatric manifestations. We do not know if the deficits detected can persist in the long term and if this can trigger or accelerate the onset of neurodegenerative diseases

EnREDate en el Ribera

Se desarrolla un proyecto de innovación educativa que pretende conectar con el profesorado e implicarlo en la utilización de las Tecnologías de la Información y la Comunicación para aplicarlas en sus asignaturas y repercutir en la formación del alumnado para que igualmente utilicen las Nuevas Tecnologías como complemento a su formación. EnREDate consiste en la divulgación de una forma atractiva y puesta en práctica de una herramienta telemática de trabajo cooperativo desarrollado para centros de enseñanza. Dicha herramienta permite al profesorado y al alumnado colocar sus apuntes, trabajos y sugerencias, y un medio de comunicación La realización del proyecto se ha dividido en tres partes. En la primera parte se ha realizado la formación del profesorado en el uso de la herramienta informática Claroilex en dos turnos de formación, uno de mañana y otro de tarde. El profesorado ha recibido la información necesaria en el uso de Intranet, incidiendo especialmente en la subida de apuntes al servidor para que el alumnado pueda consultarlo, para la realización de exámenes, para la entrega de trabajos y para la comunicación de incidencias. En la segunda fase se ha informado al alumnado sobre la utilización de los recursos a través de regalos con información sobre el funcionamiento del recurso. Se distribuyen dípticos con información sobre el uso de Intranet y carpetas dónde en su portada se narra las posibilidades que pueden realizarse en la plataforma. En tercer lugar se realiza una campaña de concienciación para el uso de esta herramienta informática por parte del profesorado y del alumnado. Finalmente se desarrolla y se lleva a cabo el proyecto de Intranet, siendo exclusivo para el IES Ribera de Castilla y utilizado principalmente por el profesorado y el alumnado de conocimientos centrados en ciencias.Castilla y LeónConsejería de Educación. Dirección General de Universidades e Investigación; Monasterio de Nuestra Señora de Prado, Autovía Puente Colgante s. n.; 47071 Valladolid; +34983411881; +34983411939ES