4. The Validity of ComputerBased Test Interpretations of the MMPI

With advances in computer technology, computer-based test interpretations (CBTI), first developed in the early 1960s (Fowler, 1985), have proliferated (Eyde & Kowal, 1987). CBTIs have been developed and marketed for a variety of tests used in clinical, counseling, educational, and employment settings. The largest number of commercial CBTI systems are available for the Minnesota Multiphasic Personality Inventory (MMPI; Krug, 1987), the most widely used inventory of its kind in the world, which has a continuously growing literature of more than 8,000 books and articles (Holden, 1986; Lanyon, 1984). According to Harris: CBTI refers to the automation of a set of pre-specified rules for use in analyzing, interpreting and assigning certain qualities to a response or response pattern (e .g., test score, profile pattern). The discrete rules are used to form an algorithm that guides the activity of the computer to interpret specific input data. (1987, p. 239) Consumers of CBTIs have very little information available on the development of the algorithm or the validity of the CBTI systems. Companies selling CBTIs often do not provide a user\u27s guide. The algorithms used in generating the computer interpretations are not available to CBTI users nor are they provided for scholarly review purposes. Notable exceptions to these business practices include Lachar\u27s (1974) presentation of all the rules and interpretive statements for the WPS Test Report, the MMPI CBTI sold by Western Psychological Services. National Computer Systems provided the algorithms for the Minnesota Report:Personnel Selection System, for scholarly review purposes, and gave an independent evaluation of the extent to which the interpretive statements were based on the MMPI\u27s research literature or on the clinical judgment of the CBTI\u27s author (Eyde, 1985). Numerous critics have pointed out serious problems arising from the growth of CBTIs. Mitchell (1984) observed that the advent of CBTIs presents the field of psychology with its most serious and consequential challenge of the next decade. Lanyon (1984) called attention to the exponential growth of available CBTI systems, noting that Meehl\u27s cookbook approach to MMPI interpretation (however carefully designed) has been used to justify and market many inadequate systems. Eyde and Kowal (1987) commented that the scientific basis for the C.B.T.I., namely the decision rules which codify the rationale and the evidence used to produce the computer interpretations, may wind up locked in a black box, inaccessible to test users (p. 402). Also, Matarazzo (1986) decried the lack of validity evidence for CBTIs. The problems associated with CBTIs have to do not only with the lack of validity data, but also with the problem of how to establish the validity of a computer interpretive report (Mitchell, 1984; Moreland, 1985, 1987; O\u27Dell, 1972). Mitchell (1984) notes that purists who want to do the job properly, are faced with the task of a conducting a statement-by-statement validation involving statements generated by decision rules and decision trees of almost incomprehensible complexity. Critics of prevailing practices in developing, marketing, and validating computerized applications of knowledge-based systems, may choose, as Eyde and Kowal (1985) have, to do some of the developmental work that should have been done before a computerized test product is sold. The intent of this chapter is to describe a methodology for studying the validity of the output of CBTI systems . The research focuses on a variety of CBTI systems developed as tools for interpreting the MMPI. The MMPI is the most widely used psychodiagnostic instrument with active-duty military populations (Parkison & Fishburne, 1984). Our methodology is designed so that it may be adapted to CBTIs for other tests or self-report inventories. The study involves a comparative analysis of the accuracy, relevancy, and usefulness of the output of seven CBTI systems for patients in a military hospital which draws its patients from a wide geographical area. The research design allows us to make some inferences about the relative accuracy of CBTI systems for different profile types. A secondary objective of the research was to identify racial differences, if any, in the accuracy of the CBTIs. This chapter will describe the study, provide basic data, and describe the results. Other chapters will cover (a) the Black/white differences in the accuracy of the CBTIs, which are minimal (Eyde, Kowal, & Fishburne, 1987); and (b) neuropsychological cases vs. non neuropsychological cases (Fishburne, Eyde, & Kowal, 1988)

The experience of accommodating privacy restrictions during implementation of a large-scale surveillance study of an osteoporosis medication.

PurposeTo explore whether privacy restrictions developed to protect patients have complicated research within a 15-year surveillance study conducted with US cancer registries.MethodsData from enrolling 27 cancer registries over a 10-year period were examined to describe the amount of time needed to obtain study approval. We also analyzed the proportion of patients that completed a research interview out of the total reported by the registries and examined factors thought to influence this measure.ResultsThe average length of the research review process from submission to approval of the research was 7 months (range, <1 to 24 months), and it took 6 months or more to obtain approval of the research at 41% of the cancer registries. Most registries (78%) required additional permission steps to gain access to patients for research. After adjustment for covariates, the interview response proportion was 110% greater (ratio of response proportion = 2.1; 95% confidence interval: 1.3, 3.3) when the least restrictive versus the most restrictive permission steps were required. An interview was more often completed for patients (or proxies) if patients were alive, within a year of being diagnosed, or identified earlier in the study.ConclusionsLengthy research review processes increased the time between diagnosis and provision of patient information to the researcher. Requiring physician permission for access to patients was associated with lower subject participation. A single national point of entry for use of cancer registry data in health research is worthy of consideration to make the research approval process efficient. © 2016 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons Ltd

G93-1171 Using a Chlorophyll Meter to Improve N Management

This NebGuide describes how to use a chlorophyll meter as a tool to improve nitrogen management by detecting nitrogen deficiency and determining the need for additional N fertilizer. Fertilizer nitrogen (N) is increasingly recognized as the source of nitrate contamination in much of Nebraska\u27s groundwater. Improving the efficiency of fertilizer N use reduces the amount of N that can potentially contaminate water resources. Effective management of fertilizer N is a major challenge for grain crop producers. Many factors that affect its efficiency are beyond a producer\u27s control. Weather, equipment limitations and breakdowns, and availability of labor and fertilizer during critical periods can lead to inadequate N supply to the crop. Fertilizer N is relatively inexpensive, and deficiencies can result in substantial yield reductions. Producers are inclined to manage fertilizer N to minimize the risk of deficiency, which can lead to excessive fertilizer applications. Although they understand fertilizer applied at excessive rates costs money and may lead to contamination of the environment, producers also want assurance that applying less fertilizer N will not reduce crop yields

Pain Coping Skills Training for Patients Who Catastrophize About Pain Prior to Knee Arthroplasty: A Multisite Randomized Clinical Trial

BACKGROUND: Pain catastrophizing has been identified as a prognostic indicator of poor outcome following knee arthroplasty. Interventions to address pain catastrophizing, to our knowledge, have not been tested in patients undergoing knee arthroplasty. The purpose of this study was to determine whether pain coping skills training in persons with moderate to high pain catastrophizing undergoing knee arthroplasty improves outcomes 12 months postoperatively compared with usual care or arthritis education. METHODS: A multicenter, 3-arm, single-blinded, randomized comparative effectiveness trial was performed involving 5 university-based medical centers in the United States. There were 402 randomized participants. The primary outcome was the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Scale, measured at baseline, 2 months, 6 months, and 12 months following the surgical procedure. RESULTS: Participants were recruited from January 2013 to June 2016. In 402 participants, 66% were women and the mean age of the participants (and standard deviation) was 63.2 ± 8.0 years. Three hundred and forty-six participants (90% of those who underwent a surgical procedure) completed a 12-month follow-up. All 3 treatment groups had large improvements in 12-month WOMAC pain scores with no significant differences (p > 0.05) among the 3 treatment arms. No differences were found between WOMAC pain scores at 12 months for the pain coping skills and arthritis education groups (adjusted mean difference, 0.3 [95% confidence interval (CI), -0.9 to 1.5]) or between the pain coping and usual-care groups (adjusted mean difference, 0.4 [95% CI, -0.7 to 1.5]). Secondary outcomes also showed no significant differences (p > 0.05) among the 3 groups. CONCLUSIONS: Among adults with pain catastrophizing undergoing knee arthroplasty, cognitive behaviorally based pain coping skills training did not confer pain or functional benefit beyond the large improvements achieved with usual surgical and postoperative care. Future research should develop interventions for the approximately 20% of patients undergoing knee arthroplasty who experience persistent function-limiting pain. LEVEL OF EVIDENCE: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence

Methodologies to improve product life cycle decision making in the telecommunications industry

As pressure from regulation and customers increases on telecommunications equipment manufacturers and service providers to reduce the hazardous material content of telecommunications products and generally improve environmental performance, new methods for Product Life Cycle Management are required. Supplier and component environmental evaluation are vital and fundamental elements of any Product Life Cycle Management programme, as is the capture of data from the supply base. The information that needs to be captured from the supply base to meet the requirements of customers of telecommunications equipment providers; to meet the requirements of legislation; and to provide data for improving ecodesign and facilitating product-focused continual improvement for ISO 14001 has been identified. A method for capturing data from the supply base has been developed and recommendations made for implementation. A hierarchical supplier and component eco-evaluation methodology has been developed and tested. This methodology incorporates supplier environmental management performance, component inherent human toxicity, ecotoxicity and resource depletion. It provides component qualifiers and purchasers with a method of supplier environmental performance comparison and enables this criterion to be integrated with existing criteria such as quality and cost in the component and supplier selection decision-making process. Recommendations are made regarding the implementation of an industry-wide system to enable the capture of detailed product material composition data from the supply chain and the implementation of the eco-evaluation methodology to identify the supplier that has superior environmental performance. The result will be enhanced decision making in product design and manufacture, improved transparency in communication to customers and more informed decision-making at the end-of-life stage of the product life cycle.EThOS - Electronic Theses Online ServiceEngineering and Physical Sciences Research CouncilGBUnited Kingdo

Anaemia in HIV positive mothers on antiretroviral therapy for prevention of mother-to-child transmission HIV in a tertiary health institution in North Central Nigeria

Background: Anaemia in pregnancy and HIV infection are two common public health issues in sub-Saharan African with Nigeria bearing the greatest burden. The duo occurring together poses a higher risk of morbidity and mortality for both the foetus and the mother. We therefore conducted this study to determine the burden of anaemia and other haematological abnormalities among HIV positive pregnant mothers on antiretroviral therapy who attended antenatal clinical services in our health institution.Methods: A 10-year retrospective review from January 2010 to December 2019 of medical records of HIV positive mothers on highly anti-retroviral therapy in attendance for antenatal clinical services in our health institution was carried out for the above objectives. Information extracted were, age, HIV status, gestational age at delivery, type of antiretroviral drugs used, duration of use, haemoglobin level, platelet, and complete blood count at booking of the positive mothers.Results: Of a total of 330 HIV positive mothers seen during the review period, 82.7% were from rural communities, 88.8% were from middle socio-economic class, 80.0% were Christians, and 80.3% started their highly active antiretroviral therapy before their index pregnancy. Most, 51.5% and 42.7% were on zidovudine, lamivudine and nevirapine, and tenofovir with lamivudine and lopinavir boasted ritonavir combinations, while 94.2% were on 1st line antiretroviral medication. Their mean age, gestational age at delivery, and parity were 31.11±4.7 years, 38.57±3.1 weeks, and 2.0±1.6 respectively. The prevalence of anaemia, thrombocytopenia and leucopoenia were 36.1%, 4.8%, and 6.7% respectively while their mean CD4 cell count and viral loads at the point of booking were 543.63±283.7 cells/μl, and 2953.02±1619.9 copies/ml. The two maternal variables that showed significant relationship with haemoglobin concentration of <10 gm/dl was mother’s level of education x2=6.29, p=0.043, and her socio=economic class, x2=10.162, p=0.006.Conclusions: There is high burden of anaemia among HIV positive mothers on antiretroviral therapy in our environment. The prevalence of thrombocytopenia and leucopoenia was much lower. The burden of maternal anaemia was associated with maternal level of education and her socio-economic class

Use of Remote-Sensing Imagery to Estimate Corn Grain Yield

Remote sensing—the process of acquiring information about objects from remote platforms such as ground-based booms, aircraft, or satellites—is a potentially important source of data for site-specific crop management, providing both spatial and temporal information. Our objective was to use remotely sensed imagery to compare different vegetation indices as a means of assessing canopy variation and its resultant impact on corn (Zea mays L.) grain yield. Treatments consisted of five N rates and four hybrids, which were grown under irrigation near Shelton, NE on a Hord silt loam in 1997 and 1998. Imagery data with 0.5-m spatial resolution were collected from aircraft on several dates during both seasons using a multispectral, four-band [blue, green, red, and near-infrared reflectance] digital camera system. Imagery was imported into a geographical information system (GIS) and then geo-registered, converted into reflectance, and used to compute three vegetation indices. Grain yield for each plot was determined at maturity. Results showed that green normalized difference vegetation index (GNDVI) values derived from images acquired during midgrain filling were the most highly correlated with grain yield; maximum correlations were 0.7 and 0.92 in 1997 and 1998, respectively. Normalizing GNDVI and grain yield variability within hybrids improved the correlations in both years, but more dramatic increases were observed in 1997 (0.7 to 0.82) than in 1998 (0.92 to 0.95). This suggested GNDVI acquired during midgrain filling could be used to produce relative yield maps depicting spatial variability in fields, offering a potentially attractive alternative to use of a combine yield monitor

Effective Feedback to Improve Primary Care Prescribing Safety (EFIPPS) a pragmatic three-arm cluster randomised trial:designing the intervention (ClinicalTrials.gov registration NCT01602705)

Peer reviewedPublisher PD

Perturbation of cytokinin and ethylene-signalling pathways explain the strong rooting phenotype exhibited by Arabidopsis expressing the Schizosaccharomyces pombe mitotic inducer, cdc25

Background Entry into mitosis is regulated by cyclin dependent kinases that in turn are phosphoregulated. In most eukaryotes, phosphoregulation is through WEE1 kinase and CDC25 phosphatase. In higher plants a homologous CDC25 gene is unconfirmed and hence the mitotic inducer Schizosaccharomyces pombe (Sp) cdc25 has been used as a tool in transgenic plants to probe cell cycle function. Expression of Spcdc25 in tobacco BY-2 cells accelerates entry into mitosis and depletes cytokinins; in whole plants it stimulates lateral root production. Here we show, for the first time, that alterations to cytokinin and ethylene signaling explain the rooting phenotype elicited by Spcdc25 expression in Arabidopsis. Results Expressing Spcdc25 in Arabidopsis results in increased formation of lateral and adventitious roots, a reduction of primary root width and more isodiametric cells in the root apical meristem (RAM) compared with wild type. Furthermore it stimulates root morphogenesis from hypocotyls when cultured on two way grids of increasing auxin and cytokinin concentrations. Microarray analysis of seedling roots expressing Spcdc25 reveals that expression of 167 genes is changed by > 2-fold. As well as genes related to stress responses and defence, these include 19 genes related to transcriptional regulation and signaling. Amongst these was the up-regulation of genes associated with ethylene synthesis and signaling. Seedlings expressing Spcdc25 produced 2-fold more ethylene than WT and exhibited a significant reduction in hypocotyl length both in darkness or when exposed to 10 ppm ethylene. Furthermore in Spcdc25 expressing plants, the cytokinin receptor AHK3 was down-regulated, and endogenous levels of iPA were reduced whereas endogeous IAA concentrations in the roots increased. Conclusions We suggest that the reduction in root width and change to a more isodiametric cell phenotype in the RAM in Spcdc25 expressing plants is a response to ethylene over-production. The increased rooting phenotype in Spcdc25 expressing plants is due to an increase in the ratio of endogenous auxin to cytokinin that is known to stimulate an increased rate of lateral root production. Overall, our data reveal important cross talk between cell division and plant growth regulators leading to developmental changes

Phenotypic covariance of longevity, immunity and stress resistance in the Caenorhabditis nematodes

Background \ud Ageing, immunity and stresstolerance are inherent characteristics of all organisms. In animals, these traits are regulated, at least in part, by forkhead transcription factors in response to upstream signals from the Insulin/Insulin– like growth factor signalling (IIS) pathway. In the nematode Caenorhabditis elegans, these phenotypes are molecularly linked such that activation of the forkhead transcription factor DAF-16 both extends lifespan and simultaneously increases immunity and stress resistance. It is known that lifespan varies significantly among the Caenorhabditis species but, although DAF-16 signalling is highly conserved, it is unclear whether this phenotypic linkage occurs in other species. Here we investigate this phenotypic covariance by comparing longevity, stress resistance and immunity in four \ud Caenorhabditis species. \ud \ud Methodology/Principal Findings \ud We show using phenotypic analysis of DAF-16 influenced phenotypes that among four closely related Caenorhabditis nematodes, the gonochoristic species (Caenorhabditis remanei and Caenorhabditis brenneri) have diverged \ud significantly with a longer lifespan, improved stress resistance and higher immunity than the hermaphroditic species (C. elegans and Caenorhabditis briggsae). Interestingly, we also observe significant differences in expression levels between the daf-16 homologues in these species using Real-Time PCR, which positively correlate with the observed phenotypes. Finally, we provide additional evidence in support of a role for DAF-16 in regulating phenotypic coupling by using a combination of wildtype isolates, constitutively active daf-16 mutants and bioinformatic analysis. \ud \ud Conclusions \ud The gonochoristic species display a significantly longer lifespan (p < 0.0001)and more robust immune and stress response (p<0.0001, thermal stress; p<0.01, heavy metal stress; p<0.0001, pathogenic stress) than the hermaphroditic species. Our data suggests that divergence in DAF-16 mediated phenotypes may underlie many of the differences observed between these four species of Caenorhabditis nematodes. These findings are further supported by the correlative higher daf-16 expression levels among the gonochoristic species and significantly higher lifespan, immunity and stress tolerance in the constitutively active daf-16 hermaphroditic mutants