Leaving home, family support and intergenerational ties in Italy: Some regional differences

In Italy conditions at leaving home are characterized by high age at exit, high proximity with parents and widespread intergenerational support, showing important regional differences. According to the "familistic" approach such conditions spread from strong intergenerational ties. Proximity and support are considered proxies of ties’ strength so that different regional proximity and support correspond to different ties’ intensities. The study aims at analyzing similarities and differences about parent-child ties, proximity and support in selected Italian regions, Liguria, Umbria, Sicily and Sardinia. Results show important differences among regions with respect to proximity and support, suggesting different intensity of intergenerational ties.family ties, intergenerational proximity, intergenerational support, regional comparison

Towards a Strengthening of Non-Interference, Sovereignty, and Human Rights from Foreign Cyber Meddling in Democratic Electoral Processes

States have resorted to meddling in the elections of their counterparts throughout history. Recently, though, there has been an exponential increased in the use of the possibilities provided by technology. Attention to this phenomenon has deservedly grown quickly and exponentially. This has led to debates focusing on the adequacy of international legal rules and general principles to respond to foreign cyber election interference. In many of these debates some have expressed doubts and skepticism about the adequacy of current international law to confront foreign election interference through cyber means. There have also been disagreements about the applicable standards to fight against cyber interferences in electoral matters. One possible suggested measure is the adoption of a new UN treaty specifically addressing foreign cyber election interference. Rather than relying exclusively on the contingent drafting of a new hard law instrument, the present work defends two complementary ideas. Firstly, that existing hard and ‘soft law’ standards can provide guidance on the legal implications of acts that meddle in foreign elections through cyber means, which can sometimes amount to unlawful interventions in the affairs of another State. That said, the necessity of clarification and the filling of gaps call for progressive development of the law concerning the issue of cyber meddling in foreign elections. Furthermore, when political impasses preclude the adoption of new binding instruments cooperative approaches can provide a valuable way to address the cyber threats to democratic elections. Secondly, we argue that alongside discussions about non-interference and sovereignty, it is possible to interpret human rights guarantees, such as the right to participate in political processes, as already demanding protection from elements of cyber intervention in political processes, with those rights being applicable and demanding protection in cyberspace. An interpretation of existing human rights guarantees in light of the general rule of interpretation serves to identify circumstances under which cyber meddling in elections would be amount to extraterritorial violations contrary to them

A set of coherent indicators for the assessment of the energy profitability of energy systems

The concern on climate change and on the limitations of fossil fuels is leading to the promotion of renewable-based energy options. However, the assessment of the energy profitability of a technology is still a controversial topic, espe-cially when renewable-based systems are compared with non-renewable ones and when the depletion of the stocks of available resources is not accounted properly. As a matter of fact, some popular energy indicators do not seem to cover all the aspects of the problem, with the risk of drawing ambiguous conclusions. A set of life cycle-based indicators is proposed in order to establish a more reliable approach to the assessment of energy products which decouples the different contributions given by renewable and non-renewable resources. The proposed set of indicators has been quantified for different groups of energy products and compared with an en-ergy indicator frequently used (i.e. EROI). A coherent assessment of the depletion of energy resources and of the energy profitability of the products is presented. The indicators could even contribute to understand the feasibility of energy projects and plans by evaluating their impact on the stock of energy resources.JRC.J.5-Sustainable Production and Consumptio

Accurate pHEMT nonlinear modeling in the presence of low-frequency dispersive effects

Low-frequency (LF) dispersive phenomena due to device self-heating and/or the presence of "traps" (i.e., surface state densities and bulk spurious energy levels) must be taken into account in the large-signal dynamic modeling of III-V field-effect transistors when accurate performance predictions are pursued, since these effects cause important deviations between direct current (dc) and dynamic drain current characteristics. In this paper, a new model for the accurate characterization of these phenomena above their cutoff frequencies is presented, which is able to fully exploit, in the identification phase, large-signal current-voltage (I-V) measurements carried out under quasi-sinusoidal regime using a recently proposed setup. Detailed experimental results for model validation under LF small- and large-signal operating conditions are provided. Furthermore, the I-V model proposed has been embedded into a microwave large-signal pseudomorphic high electron-mobility transistor (pHEMT) model in order to point out the strong influence of LF modeling on the degree of accuracy achievable under millimeter-wave nonlinear operation. Large-signal experimental validation at microwave frequencies is provided for the model proposed, by showing the excellent intermodulation distortion (IMD) predictions obtained with different loads despite the very low power level of IMD products involved. Details on the millimeter-wave IMD measurement setup are also provided. Finally, IMD measurements and simulations on a Ka-band highly linear power amplifier, designed by Ericsson using the Triquint GaAs 0.25-/spl mu/m pHEMT process, are shown for further model validation

Recent developments in maleic acid synthesis from bio-based chemicals

This review paper presents the current state of the art on maleic acid synthesis from biomass-derived chemicals over homogeneous or heterogeneous catalysts. It is based on the most recent publications on the topic, which are discussed in details with respect to the observed catalytic performances. The recent developments and the technical drawbacks in the gas and the liquid phases are also reported. In addition, recent results on the mechanistic aspect are discussed giving insights into the probable reaction mechanisms depending on the starting molecule (furan, furfural and 5-hydroxymethylfurfural)

Topical use of tranexamic acid in coronary artery bypass operations: A double-blind, prospective, randomized, placebo-controlled study

AbstractObjectives: We sought to investigate the effect of topical application of tranexamic acid into the pericardial cavity in reducing postoperative blood loss in coronary artery surgery. Methods: A prospective, randomized, double-blind investigation with parallel groups was performed. Forty consecutive patients undergoing primary coronary surgery were randomly assigned to group 1 (tranexamic acid group) or group 2 (placebo group). Tranexamic acid (1 g in 100 mL of saline solution) or placebo was poured into the pericardial cavity and over the mediastinal tissues before sternal closure. The drainage of mediastinal blood was measured hourly. Results: Chest tube drainage in the first 24 hours was 485 ± 166 mL in the tranexamic acid group and 641 ± 184 mL in the placebo group (P = .01). Total postoperative blood loss was 573 ± 164 mL and 739 ± 228 mL, respectively (P = .01). The use of banked donor blood products was not significantly different between the two groups. Tranexamic acid could not be detected in any of the blood samples blindly collected from 24 patients to verify whether any systemic absorption of the drug occurred. There were no deaths in either group. None of the patients required reoperation for bleeding. Conclusions: Topical application of tranexamic acid into the pericardial cavity after cardiopulmonary bypass in patients undergoing primary coronary bypass operations significantly reduces postoperative bleeding. Further studies must be carried out to clarify whether a more pronounced effect on both bleeding and blood products requirement might be seen in procedures with a higher risk of bleeding. (J Thorac Cardiovasc Surg 2000;119:575-80

Site directed mutagenesis as a tool to understand the catalytic mechanism of human cytidine deaminase.

Cytidine deaminase (CDA), is one of the enzymes involved in the pyrimidine salvage pathways, which catalyzes the formation of uridine and deoxyuridine by the hydrolytic deamination of cytidine and deoxycytidine, respectively. Human CDA is a tetrameric enzyme of identical 15 kDa subunits, each containing an essential zinc atom in the active site. The substrate binds to each active site independently and the cooperativity between subunits has not been reported. CDA is able to recognize as substrates some antitumor and antiviral cytidine analogs rendering them pharmacologically inactive. In light of the role played by this enzyme, a deep knowledge of CDA active site and mechanism of catalysis is required. Site-directed mutagenesis, associated with molecular modeling studies, may be an important tool to discover the active site structure of an enzyme and consequently its mechanism of action. In this review are summarized the site-directed mutagenesis experiments performed on human CDA: through these studies it was possible to understand the role exerted by specific amino acid residues in CDA active site and in the contacts between subunits. The obtained results may open a way for designing new cytidine based drugs or more potent CDA inhibitors

Exsolution-enhanced reverse water-gas shift chemical looping activity of Sr2FeMo0.6Ni0.4O6-δ double perovskite

This study investigates the structural evolution and redox characteristics of the double perovskite Sr2FeMo0.6Ni0.4O6-delta (SFMN) during hydrogen (H2) and carbon dioxide (CO2) redox cycles and explores the material performance in the Reverse Water-Gas Shift Chemical Looping (RWGS-CL) reaction. In-situ and ex-situ X-Ray Diffraction (XRD) and High-Resolution Transmission Electron Microscopy (HRTEM) studies reveal that H2 reduction at temperatures above 800 degrees C leads to the exsolution of bimetallic Ni-Fe alloy particles and the formation of a Ruddlesden-Popper (RP) phase. A core-shell structure with Ni-Fe core and a perovskite oxide shell is formed with subsequent redox cycles, and the resulting material exhibits better performance and high stability in the RWGS-CL process. Thermogravimetric (TGA) and Temperature Programmed Reduction (TPR) and Oxidation (TPO) analyses show that the optimal reduction and oxidation temperatures for maximizing the CO yield are around 850 degrees C and 750 degrees C respectively, and that the cycled material is able to work steadily under isothermal conditions at 850 degrees C

Characterizing microglial senescence: Tau as a key player.

peer reviewedThe highest risk factor for the development of neurodegenerative diseases like tauopathies is aging. Many physiological decrements underlying aging are linked to cellular senescence. Senescent cells are characterized by an irreversible growth arrest and formation of a senescence-associated secretory phenotype (SASP), a proinflammatory secretome that modifies the cellular microenvironment and contributes to tissue deterioration. Microglia, the innate immune cells in the brain, can enter a senescent state during aging. In addition, senescent microglia have been identified in the brains of tau-transgenic mice and patients suffering from tauopathies. While the contribution of senescent microglia to the development of tauopathies and other neurodegenerative diseases is a growing area of research, the effect of tau on microglial senescence remains elusive. Here, we exposed primary microglia to 5 and 15 nanomolar (nM) of monomeric tau for 18 h, followed by a recovery period of 48 h. Using multiple senescence markers, we found that exposure to 15 nM, but not 5 nM of tau increased levels of cell cycle arrest and a DNA damage marker, induced loss of the nuclear envelope protein lamin B1 and the histone marker H3K9me3, impaired tau clearance and migration, altered the cell morphology and resulted in formation of a SASP. Taken together, we show that exposure to tau can lead to microglial senescence. As senescent cells were shown to negatively impact tau pathologies, this suggests the presence of a vicious circle, which should be further investigated in the future

Relationship Between Arterial-Alveolar Oxygen Gradient, Mortality and Admission to Intensive Care Unit in Severe Covid-19 Related Pneumonia: A Pilot Study

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV- 2) is the causative agent of the respiratory disease later named Coronavirus Disease 2019 (COVID-19), remaining a world public health emergency at present..