Introducing new technology into italian certified electronic mail: a proposal

Over the last decade, an increasing number of Certified E-Mail systems (CEM) have been implemented in Europe and worldwide, but their diffusion and validity are mainly restricted in a national arena. Despite the effort of European Union (EU) that recently defined a specification for guaranteeing interoperability of CEM systems between Member States, its adoption has not be not yet fuelled, mainly since any CEM system receives a legal value by its State legislation. It is difficult to extend the legal value of CEM security mechanisms, e.g. receipts with timestamps which are considered evidences and legal proofs in disputes that may arise from different Parties inside a State, unless a common political and legal agreement will be created. At this aim, recently EU introduce the new Regulation on Electronic Identification and Trust Services (eIDAS), to address this issue. We believe that the first step for encouraging a more large adoption between communities is to implement CEMs using standard worldwide recognized solutions.In this paper we propose a technical evolution of the Italian CEM, called Posta Elettronica Certificata (PEC) moving from a close mechanisms to the adoption of a more standardized, distributed solution, based on DNS Security Extensions (DNSSec). This proposal would have a minimal impact on the legislation, restricted to the annex that defines PEC technical rules.

A Development of a New Image Analysis Technique for Detecting the Flame Front Evolution in Spark Ignition Engine under Lean Condition

The aim of herein work is to develop an automatized algorithm for detecting, as objectively as possible, the flame front evolution of lean/ultra-lean mixtures ignited by low temperature plasma-based ignition systems. The low luminosity characterizing the latter conditions makes both kernel formation and combustion development difficult to detect accurately. Therefore, to estimate the igniter capability to efficiently ignite the mixture, ever more performing tools are required. The present work proposes a new image analysis technique, based on a dual-exposure fusion algorithm and on Convolutional Neural Networks (CNNs), to process low brightness images captured via high-speed camera on an optical engine. The performance of the proposed algorithm (PA) is compared to the one of a base reference (BR) algorithm used by the same research group for the imaging analysis. The comparison shows the capability of PA to quantify the flame radius of consecutive combustion cycles with lower dispersion if compared to BR and to correctly detect some events considered as misfires or anomalies by BR. Moreover, the proposed method shows greater capability to detect, in advance, the kernel formation with respect to BR, thus allowing a more detailed analysis of the performance of the igniters. A metric quantitative analysis is carried out, as well, to confirm the above-mentioned results. Therefore, PA results to be more suitable for analyzing ultra-lean combustions, heavily investigated to meet the increasingly stringent legislation on the internal combustion engines. Finally, the proposed algorithm allows us to automatically estimate the flame front evolution, regardless of the user’s interpretation of the phenomenon

The Monument to the Fallen of Arquata del Tronto: a Symbol of Rebirth for the Reconstruction of a Village Destroyed by the Earthquake

The study of the monuments to the fallen of the First World War is today a highly debated field. This paper focuses on the events regarding the Monument to the fallen of the First World War of Arquata del Tronto (AP). Designed between 1925 and 1937 by Vincenzo Pilotti, the monument was placed on a pre-existing civic tower. Pilotti conceived a vertical commemorative plaque framed by travertine moldings carved by Pietro Cinelli; five bronze eagles, made by Enrico Brunelleschi, were placed as crowning element. The monument was destroyed by the 2016/17 central Italy earthquake. Its reconstruction, which is strongly demanded by the local community, can represent a symbol of rebirth, a new memorial both to the Great War fallen soldiers and to those who lost their lives because of the earthquake

Design and environmental sustainability assessment of energy-independent communities: The case study of a livestock farm in the North of Italy

Abstract This paper investigates the energy and economic performance of several energy schemes that could potentially be applied to agricultural and zootechnical communities contributing to the international objectives of sustainable development. The proposed energy schemes involve integrated energy efficiency technologies and novel system layouts aiming at reaching the zero-energy goal at a community level, by considering collective energy actions with provision of benefits for members and stakeholders. The proposed scenarios include different innovative technologies, such as anaerobic digestion, cogeneration, biogas upgrading, solar, district heating and cooling. These layouts are modelled in TRNSYS simulation environment to perform dynamic simulations and parametric analyses of the pivotal system parameters. Such analyses are conducted to find out the best scenario and the size of its system components which optimize different energy and economic objective functions. To assess the feasibility of all proposed scenarios and energy schemes, as well as to investigate the potential of the developed models, proposed scenarios are studied for an existing community. This existing agricultural community named "La Bellotta", is served through different technologies, including a gas fuelled co-generator and an anaerobic biodigester. Simulation results show that the investigated scenarios allow for achieving very high self consumption ratios of energy produced on-site (from 57 to 100%), high economic performance (measured by the profitability index up to 1.35 for the best investigated scenario) and environmental benefits. The case study provides examples of energy schemes in which citizens and communities have a major benefit to invest in projects including renewables technologies, energy efficiency, and positive energy services

Release of Palladium from Biomechanical Prostheses in Body Fluids Can Induce or Support PD-Specific IFNγ T Cell Responses and the Clinical Setting of a Palladium Hypersensitivity:

The increased use of Palladium (Pd) for biomedical applications, which has more than doubled in the last ten years, appears to be associated with an increased frequency of adverse reactions to Pd. The aim of this study is to investigate the relationship between the implant of a biomechanical apparatus containing Pd and the setting of a hypersensitivity to Pd by determining the levels of the metal released in biological fluids, assessing the effects of Pd on peripheral blood mononuclear cell (PBMC) cytokine production and exploring the clinical setting of skin sensitization. Of a total of 3,093 subjects examined in 2006, sensitization to Pd alone or in association with nickel (Ni) was observed in 1.6% and 13.03% of the individuals, respectively. Of these, a group of six subjects positive to Pd and negative to Ni at patch testing were selected on the basis of the oral clinical symptoms in order to measure both the levels of Pd in biological fluids and the degradation of the dental prostheses. Specific Pd measurements were carried out on salivary fluid, urine and serum samples by High Resolution Inductively Coupled Plasma-Mass Spectrometry. In addition, the degradation of the dental prostheses was assessed by both a "leaching test" and an analysis of the micro morphology of orthodontic prostheses. The induction of IFN-γ production by Pd was assessed in PBMC by the ELISpot assay. Skin sensitization to Pd was evaluated by patch testing and clinical examination. Ten healthy subjects were comparatively tested as controls. We found a specific induction of an IFN-γ response by Pd in PBMC collected from all the subjects positive to Pd at patch testing. On the contrary, control subjects did not show any response to Pd as assessed by IFN-γ ELISpot assay or by skin testing. Remarkably, the levels of Pd in all biological samples (saliva, sera, urine) were significantly higher in Pd-sensitized patients than in those collected from controls, reaching the highest concentrations in the urine. The leaching studies gave additional evidence that the dental appliances can release measurable levels of Pd in saliva. Oral clinical symptoms in patients with Pd dental prostheses were associated with measurable levels of Pd in the biological fluids, the induction of Pd-specific IFN-γ responses in PBMC and the clinical evidence of skin sensitization to Pd. These data suggest that dental appliances may represent an active source of Pd in the body, and this, in turn, can favour the clinical setting of a hypersensitivity to this metal

Outcome of COVID-19 patients with haematological malignancies after the introduction of vaccination and monoclonal antibodies. Results from the HM-COV 2.0 study

Patients with haematological malignancies (HM) and SARS-CoV-2 infection present a higher risk of severe COVID-19 and mortality. The aim of the study was to investigate whether vaccination and monoclonal antibodies (mAbs) have modified the outcomes of HM patients with COVID-19. This is a single-centre retrospective study in HM patients hospitalized due to SARS-CoV-2 infection from March 2020 to April 2022. Patients were divided into PRE-V-mAb group (patients hospitalized before the introduction of vaccination and mAbs) and POST-V-mAb group (patients hospitalized after the use of vaccine and mAbs). A total of 126 patients were included (65 PRE-V-mAb and 61 POST-V-mAb). POST-V-mAb patients showed a significantly lower risk of intensive care unit (ICU) admission (8.2% vs. 27.7%, p = 0.005), shorter viral shedding [17 (IQR 10–28) vs. 24 days (IQR 15–50), p = 0.011] and shorter hospitalization length [13 (IQR 7–23) vs. 20 (IQR 14–41) days, p = 0.0003] compared to the PRE-V-mAb group. Nevertheless, both in-hospital and 30-day mortality rates did not significantly differ between the two groups (29.5% POST-V-mAb vs. 36.9% PRE-V-mAb and 21.3% POST-V-mAb vs. 29.2% PRE-V-mAb, respectively). At the multivariable analysis, an active malignancy (p = 0.042), a critical COVID-19 at admission (p = 0.025) and the need for high-level of oxygen support at respiratory worsening [either HFNC/CPAP (p = 0.022) or mechanical ven- tilation (p = 0.011)] were independently associated with in-hospital mortality. In the subgroup of POST-V-mAb patients, receiving therapy with mAbs was a protective factor (p = 0.033). Despite the new therapeutic and preventive strategies avail- able, HM patients with COVID-19 disease represent an extremely vulnerable group with still high mortality rates

RELAZIONE TRA HANDGRIP E FAMILIARITÀ AL DIABETE DI TIPO 2: UNO STUDIO PILOTA/ RELATIONSHIP BETWEEN TYPE 2 DIABETES AND HANDGRIP: RESULTS OF A PILOT STUDY

Obiettivo: È stata analizzata la possibile relazione, su un campione della popolazione siciliana, tra il grado di familiarità al diabete di tipo 2, i parametri antropometrici ed alcuni test di forza specifica. Materiali e metodi: In modalità random sono stati selezionati 88 uomini e 27 donne, distinti in FH- (assenza di familiarità per il diabete di tipo 2), FH+ (con un componente in linea indiretta con la malattia) ed FH++ (con un genitore affetto dalla malattia). Sono stati rilevati i parametri antropometrici, i parametri cardiovascolari ed è stato rilevato l’handgrip ad entrambe le mani. Le differenze tra i gruppi sono state analizzate con il test ANOVA ed attraverso correlazioni parametriche abbiamo verificato eventuali associazioni (Pearson). Risultati: È emerso che uomini e donne FH++ tendono ad avere un significativo incremento dell’indice di massa corporea (p<0,05) associato ad un incremento statisticamente significativo dei valori basali di pressione arteriosa diastolica (p<0,05). Non sono emerse differenze statisticamente significative tra i gruppi (FH- vs FH+ vs FH++) relativamente ai valori di handgrip espressi dalla mano destra e sinistra, in valore assoluto e relativo. Dallo studio delle correlazioni emerge una importante influenza del peso corporeo sul rendimento dei soggetti al test dell’handgrip (>.40). Conclusioni: La familiarità diretta al diabete di tipo 2 si correla con degli incrementi statisticamente significativi del peso corporeo e dei valori pressori cardiovascolari, indicando che questa popolazione risulta essere maggiormente a rischio per l’evoluzione della stessa malattia. Progetti di prevenzione sono auspicabili in tal senso. L’handgrip risulta essere fortemente correlato ai parametri antropometrici, pertanto indirettamente anche con la familiarità alla malattia. Un’estensione dello studio è auspicabile, al fine di poter meglio comprendere i fenomeni.Objectives: the purpose of this study was to analyze the relationship between family history to type 2 diabetes, anthropometrics characteristics and some fitness tests. Materials and methods: we randomly selected 88 men and 27 women, distinguishing on FH- (absence of family history to type 2 diabetes), on FH+ (with a familiar component with disease) and FH++ (with parent affected to diabetes). We recorded anthropometric parameters, basal blood pressure values and handgrip of both hands. The differences between the groups were analyzed with ANOVA test and Pearson’s correlation. Results: participants FH++ of both sexes showed a statistically significant increase of body mass index (p<0,05) and a significant increase of basal diastolic blood pressure (p<0,05). No family history-related differences were found on handgrip results in absolute and relative values, but the lower numbers of subgroups might have affected the statistical analysis. Correlation analysis showed that parameters like body weight, body mass index and body surface area are able to influence the handgrip test of both hands. Conclusion: family history to type 2 diabetes is strongly related to body weight and basal blood pressure values, confirming that FH++ participants have a major risk to develop disease compared to FH- participants. Handgrip test is strongly related to anthropometric parameters. The sample size represents the major limit of the study. More data are needed to confirm the association between variables