An enhanced component based model for steel links in hybrid structures

In the present paper the development, calibration and experimental validation of an enhanced component based model of a dissipative steel link connecting a reinforced concrete wall and a steel gravity frame is presented. The structural consists in an hybrid coupled shear wall (HCSW), developed within the INNOHYCO project (Dall’Asta et al., 2014), obtained coupling an RC wall with two side steel columns by means of steel links where the energy dissipation takes place. The experimental results carried on a subsystem representing a portion of the shear wall, the dissipative link and one side column, showed that the global dissipative behavior is strongly affected by the characteristics of the link-to-column connection. In particular the prestressing force of the seat angle connection bolts influence in a decisive way the dissipative capacity of the system, especially for the low amplitude cycle. For this reason, an experimental campaign on two different hybrid system containing the dissipative element and the aforementioned connections has been carried out. A non-linear cyclic component- based model of the entire sub-assemblage is then developed and calibrated on the base of experimental result

Admission of foreign citizens to the general teaching hospital of Bologna, northeastern Italy: an epidemiological and clinical survey.

BACKGROUND: The emergency regarding recent immigration waves into Italy makes continued healthcare monitoring of these populations necessary. METHODS: Through a survey of hospital admissions carried out during the last five years at the S. Orsola-Malpighi General Hospital of Bologna (Italy), all causes of admission of these subjects were evaluated, together with their correlates. Subsequently, we focused on admissions due to infectious diseases. All available data regarding foreign citizens admitted as inpatients or in Day-Hospital settings of our teaching hospital from January 1, 1999, to March 31, 2004, were assessed. Diagnosis-related group (DRG) features, and single discharge diagnoses, were also evaluated, and a further assessment of infectious diseases was subsequently made. RESULTS: Within a comprehensive pool of 339,051 hospitalized patients, foreign citizen discharges numbered 7,312 (2.15%), including 2,542 males (34.8%) and 4,769 females (65.2%). Males had a mean age of 36.8±14.7 years, while females were aged 30.8±12.2 years. In the assessment of the areas of origin, 34.6% of hospitalizations were attributed to patients coming from Eastern Europe, 15.3% from Northern Africa, 7.3% (comprehensively) from Western Europe and United States, 6.9% from the Indian subcontinent, 5.9% from sub-Saharan Africa, 5.7% from Latin America, 4.1% from China, 2.5% from the Philippines, and 1.1% from the Middle East. Among women, most hospitalizations (58.8%) were due to obstetrical-gynecological procedures or diseases, including assistance with delivery (27.1%), and pregnancy complications (18.7%), followed by psycho-social disturbances (5.9%), malignancies (5.1%), gastrointestinal diseases (4.7%), and voluntary pregnancy interruption (4.4%). Among men, the most frequent causes of admissions were related to trauma (15.9%), followed by gastroenteric disorders (12%), heart-vascular diseases (8.9%), psycho-social disorders (8.4%), respiratory (7.1%), kidney (6.1%), liver (5.2%), and metabolic (4.9%) diseases, and alcohol or substance abuse (4.2%). Infectious diseases (alone or with concurrent disorders) were reported in 881 discharged individuals, representing 12.1% of the 7,312 DRGs attributed to foreign patients. The comprehensive patient population discharged from our hospital with at least one infectious disease diagnosis had lower rates of respiratory tract infections, followed by chronic viral hepatitis, HIV infection and related diseases, enterocolitis, pulmonary tuberculosis, pyelonephritis, severe skin and soft tissue infection, meningoencephalitis, and malaria, as the most frequently-reported disorders. CONCLUSIONS: Our survey, through a combined analysis of both DRGs and discharge diagnoses, allowed us to conclude that 12.1% of foreign citizens hospitalized at our General teaching Hospital of Bologna (Italy) suffered from at least one infectious disease. Respiratory tract, liver, and gastrointestinal infections, and HIV infection, were found with an appreciable frequency among discharge diagnoses, while the frequency of malaria and meningoencephalitis was lower, compared with other series. Among disorders other than infectious diseases, obstetric-gynecological conditions and post-traumatic episodes (for male patients) were the most frequent causes of hospitalization

Distributed Bragg reflectors for the colorimetric detection of bacterial contaminants and pollutants for food quality control

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General methods for measuring and comparing medical interventions in childbirth: a framework

Abstract Background: The continue increase of interventions during labour in low risk population is a controversial issue of the current obstetric literature, given the lack of evidence demonstrating the benefits of unnecessary interventions for women or infants’ health. This makes it important to have approaches to assess the burden of all medical interventions performed. Methods: Exploiting the nature of childbirth intervention as a staged process, we proposed graphic representations allowing to generate alternative formulas for the simplest measures of the intervention intensity namely, the overall and type-specific treatment ratios. We applied the approach to quantify the change in interventions following a protocol termed Comprehensive Management (CM), using data from Robson classification, collected in a prospective longitudinal cohort study carried out at the Obstetric Unit of the Cà Granda Niguarda Hospital in Milan, Italy. Results: Following CM a substantial reduction was observed in the Overall Treatment Ratio, as well as in the ratios for augmentation (amniotomy and synthetic oxytocin use) and for caesarean section ratio, without any increase in neonatal and maternal adverse outcomes. The key component of this reduction was the dramatic decline in the proportion of women progressing to augmentation, which resulted not only the most practiced intervention, but also the main door towards further treatments. Conclusions: The proposed framework, once combined with Robson Classification, provides useful tools to make medical interventions performed during childbirth quantitatively measurable and comparable. The framework allowed to identifying the key components of interventions reduction following CM. In its turn, CM proved useful to reduce the number of medical interventions carried out during childbirth, without worsening neonatal and maternal outcomes

Simplified Model for Strengthening Design of Beam–Column Internal Joints in Reinforced Concrete Frames

The beam-column joints are very restricted areas in which the internal forces, generated by boundary elements, act on the concrete core and reinforcing bars with a very high gradient. They are the link between horizontal and vertical structural elements, and therefore, they are directly involved in the transfer of seismic forces. Thus, they are crucial to study the seismic behavior of reinforced concrete (RC) structures. To fully understand the seismic performances and failure modes of beam-column joints in RC buildings, a simplified analytical model of joint behavior is proposed and theoretical simulations are performed. The aim of the model, focusing on internal perimetric joints, is to identify the strength hierarchy in terms of capacity for different failure modes (namely failure of cracked joint, bond failure of passing through bars, flexural/shear failures of columns or beams). It could represent a tool for the designers of new joints to quantify the performance of new structures, but also as a tool for the designers of external strengthening of existing joints in order to calculate the benefits of the retrofit and pushing the initial failure to a more desirable failure mode. Further, some experimental results of tests available in the scientific literature are reported, analyzed and compared

UML design and AWL programming for reconfigurable control software development of a robotic manipulator

The goal of the presented research is to face the topic of reconfigurable control software development in a concrete fashion, i.e., by presenting a control software system development approach which has been used for a specific, although easy to be generalized, robotized manufacturing cell component. In particular, a methodology for the control software development of a planar robot (2-degrees of freedom) is presented, from the conceptual design to the actual implementation. The methodology suggests UAL and object-oriented modeling and programming techniques for the design phase, while AWL programming language run by a PLC for the implementation phase. The analysis has been conducted considering the internal and external requirements of the manufacturing system which comprises the. robot, mostly driven by the contemporary industrial need of reconfigurable control systems, critical key to succeed in the new era of mass customization

Circulating MicroRNAs in Elderly Type 2 Diabetic Patients

The circulating microRNAs (miRNAs) associated with type 2 diabetes (T2D) in elderly patients are still being defined. To identify novel miRNA biomarker candidates for monitoring responses to sitagliptin in such patients, we prospectively studied 40 T2D patients (age > 65) with HbA1c levels of 7.5–9.0% on metformin. After collection of baseline blood samples (t0), the dipeptidyl peptidase-IV (DPP-IV) inhibitor (DPP-IVi) sitagliptin was added to the metformin regimen, and patients were followed for 15 months. Patients with HbA1c0.5% after 3 and 15 months of therapy were classified as “responders” (group R, n = 34); all others were classified as “nonresponders” (group NR, n = 6). Circulating miRNA profiling was performed on plasma collected in each group before and after 15 months of therapy (t0 and t15). Intra- and intergroup comparison of miRNA profiles pinpointed three miRNAs that correlated with responses to sitagliptin: miR-378, which is a candidate biomarker of resistance to this DPP-IVi, and miR-126-3p and miR-223, which are associated with positive responses to the drug. The translational implications are as immediate as evident, with the possibility to develop noninvasive diagnostic tools to predict drug response and development of chronic complications

Economic development with deadly communicable diseases and public prevention

Infectious diseases have been a major determinant of human mortality in history and the key regulator of population size, including the first epoch of the Industrial Revolution (until the 1950s) in Western countries and still now in developing countries, especially in Sub-Saharan Africa. In recent times, a new vein of economic research dealing with the interplay between communicable diseases and economic development has grown. However, pioneering previous research (Chakraborty et al., 2010, 2016) has analysed this issue in a framework where prevention decisions were the outcome of private individual rational choices. This assumption neither seems to hold for least-developed countries, primarily due to a lack of resources, nor for developed countries, where prevention policies are mostly planned by the public authority through its (public) health system, as also well documented by the current COVID-19 crisis. Our aim in this article is twofold. First, we pinpoint the properties of Chakraborty et al.'s basic epidemiological equation to fully enlighten its usability in economic-epidemiology modelling. Second, we apply this framework to analyse prevention activities against a range of infectious diseases by endogenous public (rather than private) health expenditures. Our results identify the relationships governing the interplay between -- on one hand -- typical epidemiological phenomena, namely invasion (that is, the tendency of infection to establish in a population) versus endemicity (that is, the tendency of infection to persist in the long term) and -- on the other hand -- economic variables, such as capital accumulation, GDP and taxation. This is done by identifying threshold quantities, depending on both epidemiological and economic parameters, and by bifurcation analysis showing the effects that public intervention can have on previously uncontrolled infectious diseases. Both direct and indirect, that is, partial and general equilibrium, effects of control interventions are identified

Directional Fluorescence Spectral Narrowing in All-Polymer Microcavities Doped with CdSe/CdS Dot-in-Rod Nanocrystals

We report on the fluorescence properties of high optical quality all-polymer planar microcavities embedding core 12shell dot-in-rod CdSe/CdS nanocrystals. Properly tuned microcavities allow a 10-fold sharpening of the nanocrystals fluorescence spectrum, resulting in a reduction of the bandwidth from 24 to 2.4 nm, which corresponds to a quality factor larger than 250. A 5-fold peak photoluminescence intensity enhancement is measured, while the overall number of emitted photons is reduced. Time-resolved photoluminescence and quantum yield for microcavities and suitable references show the presence of two decays related to differences in nanocrystal size distribution. The slower decay rate, which becomes faster when the nanocrystals are embedded into the microcavity, is assigned to longer nanorods with emission spectrally overlapped to the cavity mode. Conversely, the short-living component, which is assigned to an impurity of shorter nanorods, remains unaffected by the microcavity