Single-Phase Grid Connected Converters for Photovoltaic Plants

Non

SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children

Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children who are allergic to drugs have low diagnostic accuracy and predictive value. The gold standard to diagnose DHR is represented by the drug provocation test (DPT), that aims of ascertaining the causative role of an allergen and evaluating the tolerance to the suspected drug. Different protocols through the administration of divided increasing doses have been postulated according to the type of drug and the onset of the reaction (immediate or non immediate reactions). DPT protocols differ in doses and time interval between doses. In this position paper, the Italian Pediatric Society for Allergy and Immunology provides a practical guide for provocation test to antibiotics and NSAIDs in children and adolescents

A experiência do atendimento educacional especializado no contexto do Instituto Federal de Educação

The experience report presented here deals with the context of the special educator and the Núcleo de Apoio as Necessidades Educacionais Especificas (NAPNE) in a lightning bolt of the Federal Institute of São Paulo in the countryside. The objective of this article is to share positive experiences of an action with assumptions of coeducation or collaborative teaching and to point out challenges experienced in the institution regarding the schooling of the Public-Target Student of Special Education (PAEE) of the Technological Professional Network. The present text shares practices of curricular accessibility, brings for discussion the importance of the special educator in the context of the NAPNE and the forecast of the Specialized Educational Assistance. It was realized that the construction of accessibility for the student is based on a joint construction of different professionals and with the student himself, that the actions carried out by the special educator were focused on the work developed in the context of common room and not in the contract, with possibilities of work based on collaborative teaching. The report brings the beginning of this path, as Specialized Educational Care is a recent practice in this context, leaving as a suggestion the importance of studies on the performance of these professionals and greater socialization of the work performed. O relato de experiência aqui apresentado trata do contexto da atuação do educador especial e do Núcleo de Apoio as Necessidades Educacionais Especificas (NAPNE) em um câmpus do Instituto Federal de São Paulo do interior. O objetivo desse artigo consiste então em compartilhar experiências positivas de uma atuação com pressupostos do coensino ou ensino colaborativo e apontar desafios vivenciados na instituição referentes à escolarização do estudante Público-Alvo da Educação Especial (PAEE) da Rede Profissional Tecnológica. O presente texto compartilha práticas de acessibilidade curricular, traz para discussão a importância do educador especial no contexto do NAPNE e da previsão do Atendimento Educacional Especializado. Percebeu-se que a construção da acessibilidade para o estudante é realizada com base em uma construção conjunta de diferentes profissionais e com o próprio aluno, que as ações realizadas pela educadora especial tiveram como foco o trabalho desenvolvido no contexto de sala comum e não no contra turno, com possibilidades de trabalho baseadas em ensino colaborativo. O relato traz o início desse caminho, por ser o Atendimento Educacional Especializado uma prática recente nesse contexto, deixando como sugestão a importância de estudos sobre a atuação desses profissionais e de maior socialização do trabalho realizado.&nbsp

Dietary Pattern and Macronutrients Profile on the Variation of Inflammatory Biomarkers: Scientific Update

It is known that the dietary pattern and macronutrients profile may influence the expression and secretion of inflammatory biomarkers, and the low-grade inflammation is associated with the manifestation of noncommunicable chronic diseases. Therefore, this review aimed to present and discuss the role of dietary patterns and macronutrients on the variation of inflammatory markers related to NCD risk. Scientific evidences within the last five years based on clinical trials, case-controls, cohorts, and cross-sectional studies indicate that normocaloric, carbohydrate-moderated, low-glycemic index, protein-moderated, monounsaturated and polyunsaturated fatty acid-rich, omega-3, and low-saturated fat diets display positive effects on the inflammatory state, both in healthy individuals and in those with cardiovascular risk, although the second group seems to benefit more from changes in the dietary profile

Micronutrient supplementation adherence and influence on the prevalences of anemia and iron, zinc and vitamin A deficiencies in preemies with a corrected age of six months

OBJECTIVE: To analyze adherence to the recommended iron, zinc and multivitamin supplementation guidelines for preemies, the factors associated with this adherence, and the influence of adherence on the occurrence of anemia and iron, zinc and vitamin A deficiencies. METHODS: This prospective cohort study followed 58 preemies born in 2014 until they reached six months corrected age. The preemies were followed at a referral secondary health service and represented 63.7% of the preterm infants born that year. Outcomes of interest included high or low adherence to iron, zinc and multivitamin supplementation guidelines; prevalence of anemia; and prevalences of iron, zinc, and vitamin A deficiencies. The prevalence ratios were calculated by Poisson regression. RESULTS: Thirty-eight (65.5%) preemies presented high adherence to micronutrient supplementation guidelines. At six months of corrected age, no preemie had vitamin A deficiency. The prevalences of anemia, iron deficiency and zinc deficiency were higher in the low-adherence group but also concerning in the high-adherence group. Preemies with low adherence to micronutrient supplementation guidelines were 2.5 times more likely to develop anemia and 3.1 times more likely to develop zinc deficiency. Low maternal education level increased the likelihood of nonadherence to all three supplements by 2.2 times. CONCLUSIONS: Low maternal education level was independently associated with low adherence to iron, zinc and vitamin A supplementation guidelines in preemies, which impacted the prevalences of anemia and iron and zinc deficiencies at six months of corrected age

Pre-treatment risk factors to predict early cisplatin-related nephrotoxicity in locally advanced head and neck cancer patients treated with chemoradiation: A single Institution experience

Objectives: Cisplatin is essential in the curative treatment of locally advanced head and neck squamous cell carcinoma (LA-HNSCC) patients. The assessment of risk factors to predict an early cisplatin-induced nephrotoxicity could help in better managing one of the most relevant cisplatin-related dose-limiting factors. Material and methods: We retrospectively collected data of LA-HNSCC patients treated at our Institution from 2008 to 2019. Patients received cisplatin in a curative setting concurrently with radiation. Acute Kidney Injury (AKI) was assessed as a dichotomous variable (CreaIncr) based on pre-treatment values, and values recorded at days 6-20 post-first cycle of cisplatin. Univariable logistic regression models were performed to investigate associations between CreaIncr and clinical characteristics. A multivariable logistic model on a priori selected putative covariates was performed. Results: Of the 350 LA-HNSCC treated patients, 204 were analyzed. Ninety (44 %) suffered from any grade AKI (grade I 51.1 %): out of them, 84.4 % received high-dose cisplatin (100 mg/m2 q21). On the univariable logistic regression model, male sex, age, serum uric acid, creatinine, concomitant drugs, and cisplatin schedule were significantly associated with a higher rate of AKI. At multivariable model, age (p = 0.034), baseline creatinine (p = 0.027), concomitant drugs (p = 0.043), and cisplatin schedule (one-day bolus or fractionated high-dose vs. weekly; p = 0.001) maintained their significant association. Conclusions: Identifying pre-treatment risk factors in LA-HNSCC patients may improve decision-making in a setting where cisplatin has a curative significance. A strict monitoring of AKI could avoid cisplatin dose adjustments, interruptions, and treatment delays, thus limiting a negative impact on outcomes

A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease

Protein acetylation, which is central to transcriptional control as well as other cellular processes, is disrupted in Huntington's disease (HD). Treatments that restore global acetylation levels, such as inhibiting histone deacetylases (HDACs), are effective in suppressing HD pathology in model organisms. However, agents that selectively target the disease-relevant HDACs have not been available. SirT1 (Sir2 in Drosophila melanogaster) deacetylates histones and other proteins including transcription factors. Genetically reducing, but not eliminating, Sir2 has been shown to suppress HD pathology in model organisms. To date, small molecule inhibitors of sirtuins have exhibited low potency and unattractive pharmacological and biopharmaceutical properties. Here, we show that highly selective pharmacological inhibition of Drosophila Sir2 and mammalian SirT1 using the novel inhibitor selisistat (selisistat; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide) can suppress HD pathology caused by mutant huntingtin exon 1 fragments in Drosophila, mammalian cells and mice. We have validated Sir2 as the in vivo target of selisistat by showing that genetic elimination of Sir2 eradicates the effect of this inhibitor in Drosophila. The specificity of selisistat is shown by its effect on recombinant sirtuins in mammalian cells. Reduction of HD pathology by selisistat in Drosophila, mammalian cells and mouse models of HD suggests that this inhibitor has potential as an effective therapeutic treatment for human disease and may also serve as a tool to better understand the downstream pathways of SirT1/Sir2 that may be critical for H

Análise da rotulagem de alimentos provenientes de uma feira de economia solidária da Zona da Mata de Minas Gerais

Objective: Analyze the labeling of food sold, according to current rules and legislation related to production and sale, to the promotion of Food and Nutritional Security of the population that consumes it. Methods: This is a cross-sectional study with members who process food by hand and sell it at a Solidarity Economy and Family Agriculture fair located in the Zona da Mata of Minas Gerais. Socioeconomic, demographic and housing characterization of those responsible for the undertakings was carried out, analysis of marketed labels and semi-structured interviews with farmers in order to assess their perception of the importance of nutrition labeling. Results: The sample consisted of 11 enterprises. It was found that 63.3% (n = 7) of the entrepreneurs were female, 45.4% (n = 5) aged between 30 and 43 age range, 54.5% (n = 6) had in their residence of 3 to 5 residents and 27.3% (n = 3) lived in poverty. Regarding the products sold by the enterprises, of the total of 72 analyzed, 12.5% ​​(n = 9) had labels with complete information, 47.2% (n = 34) incomplete and 40.3% (n = 29) did not had labeling.In relation on the responses of the interview conducted, a similarity analysis was carried out in order to qualitatively evaluate the sample's responses. Conclusion: The inclusion of complete labels in the processed products is an advance for the producer, who has the possibility of increasing his sales to institutional markets, bringing greater profitability to the family and also favorable to the consumer who is able to have easy and clear access to the complete information of what he will be consuming. Keywords: Food Labeling. Food and nutrition security. Family farming.Objetivo: Analisar a rotulagem de alimentos vendidos, conforme normas e legislações vigentes relacionadas a produção e venda, visando à promoção da Segurança Alimentar e Nutricional da população que os consome. Métodos: Trata-se de um estudo transversal com integrantes que processam alimentos artesanalmente e os comercializam em uma feira de Economia Solidária e Agricultura Familiar localizada na Zona da Mata de Minas Gerais. Realizou-se caracterização socioeconômica, demográfica e de moradia dos responsáveis pelos empreendimentos, análise dos rótulos comercializados e entrevista semiestruturada com os agricultores a fim de avaliar a percepção destes quanto à importância da rotulagem nutricional. Resultados: A amostra foi composta por 11 empreendimentos. Constatou-se que 63,3% (n=7) dos empreendedores eram do sexo feminino, 45,4% (n=5) com faixa etária entre 30 e 43 anos, 54,5% (n=6) possuíam em sua residência de 3 a 5 moradores e 27,3% (n=3) viviam em situação de pobreza. Em relação aos produtos comercializados pelos empreendimentos, do total de 72 analisados, 12,5% (n=9) possuíam rótulos com informações completas, 47,2% (n=34) incompletas e 40,3% (n=29) não apresentavam rotulagem. Com base nas respostas da entrevista realizada, foi feito a análise de similitude com o objetivo de avaliar qualitativamente as respostas da amostra. Conclusão: A inclusão de rótulos completos nos produtos processados é um avanço para o produtor, que tem possibilidade de aumentar suas vendas para mercados institucionais trazendo maior rentabilidade à família e favorável também ao consumidor que consegue ter acesso fácil e claro às informações completas do que estará consumindo. Palavras-chave: Rotulagem de Alimentos; Segurança Alimentar e Nutricional; Agricultura Familiar

Implementation of the type III seesaw model in FeynRules/MadGraph and prospects for discovery with early LHC data

We discuss the implementation of the "minimal" type III seesaw model, i.e. with one fermionic triplet, in FeynRules/MadGraph. This is the first step in order to realize a real study of LHC data recorded in the LHC detectors. With this goal in mind, we comment on the possibility of discovering this kind of new physics at the LHC running at 7 TeV with a luminosity of few fb^-1.Comment: 28 pages, 7 figures, Tables with cross sections are updated, a channel was missing. Version to appear on Eur. Phys. J.