Psicomotricidad y desarrollo cognitivo en niños de 5 años de la Institución Educativa Inicial 95 Santa Rosa-Callao, 2022

Esta investigación abordó el tema de psicomotricidad y desarrollo cognitivo en niños de 5 años de la Institución Educativa Inicial 95 Santa Rosa – Callao, 2022. El interés del presente trabajo surgió debido a la poca atención brindada al área de psicomotricidad y también al resultado en el desarrollo cognitivo del estudiante, por esta razón este estudio tiene como objetivo determinar la relación entre la psicomotricidad y el desarrollo cognitivo, con el fin de contribuir con la Institución Educativa en tomar las decisiones oportunas para el adecuado desarrollo de la psicomotricidad. Esta investigación se ejecutó bajo un enfoque cuantitativo y de diseño no experimental correlacional, se puede decir que es de corte transversal. La población y muestra fueron de 90 niños de 5 años de la Institución Educativa Inicial 95 Santa Rosa – Callao. Los instrumentos aplicados fueron el TEPSI y el BATTELLE. Se concluye que la psicomotricidad tiene una asociación directa frente al desarrollo cognitivo, en la cual se obtiene una correlación positiva alta con una probabilidad de coeficiente Rho de Spearman =0.755; por tanto, la evidencia empírica nos lleva a deducir que el desarrollo cognitivo se encuentra asociado a las dimensiones de coordinación, lenguaje y motricidad

“Factores que obstruyen el cumplimiento de las sentencias por pensión alimenticia”

El presente trabajo de investigación es de tipo jurídico dogmático que ha tenido por objeto investigar cuales son los factores que obstruyen el cumplimiento de las sentencias por pensión alimenticia; posee cuatro capítulos: el Primer Capítulo de Planteamiento de Investigación que contiene la problemática y los objetivos trazados, el Segundo Capítulo de Fundamentos Teóricos que desarrolla las principales instituciones jurídicas analizadas como El Derecho Alimentario, El Empleo Informal, Las Medidas Cautelares y La Ejecución de las Sentencias, así como el marco normativo, generalidades, marco histórico y conceptual; el Tercer Capítulo referido a la Metodología de ésta Investigación, la cual es de Tipo Descriptivo – Explicativo, con método Cualitativo y el Cuarto Capítulo referido al Análisis de Resultados donde se describe e interpreta los resultados obtenidos, se comprobó la hipótesis, se establecieron las conclusiones y se efectuaron las recomendaciones

Análisis del control de inventarios de la anchoveta en la empresa "Pesquera El Delfín Dorado S.R.L."

El objetivo principal de este Trabajo Final de Titulación es realizar el análisis del control de inventarios de la empresa “Pesquera El Delfín Dorado S.R.L.”, específicamente es analizar el nacimiento y la aplicación de la obligación tributaria del control de inventarios de la anchoveta. Para lograr las pretensiones descritas anteriormente, se recopiló la información de las operaciones realizadas por la empresa en el periodo del mes de abril, por ser el mes de inicio de la temporada de pesca del año 2016. Este trabajo final consta de dos capítulos: En el capítulo uno, se muestra la problemática de la empresa con respecto al reconcomiendo y registro del control de inventarios, dando a conocer los objetivos tanto general como específicos y la justificación del problema. En el capítulo dos, se describe los conceptos generales que se mencionan en el desarrollo de este trabajo, las leyes y normas más relevantes con las que se rigen sus respectivas operaciones, además en este capítulo se realiza una descripción general de la empresa como es su historia, las políticas contables que aplican, el régimen laboral al que pertenecen sus trabajadores pesqueros y sobre todo como realizan el control de sus inventarios desarrollado en el caso práctico. Al finalizar se muestra las conclusiones y recomendaciones que se ha deducido al realizar el presente trabajo.Trabajo de suficiencia profesionalCampus Lima Centr

Vanadium Decreases Hepcidin mRNA Gene Expression in STZ-Induced Diabetic Rats, Improving the Anemic State

We are grateful for the support received from the Consejeria de Innovacion, Ciencia y Empresa, Andalusian Regional Government (Project P06-CTS-01435), and from the Spanish Ministry of Economy and Competitivity (SAF2011-29648); the CIBERehd is funded by the Instituto de Salud Carlos III.This paper forms part of the Doctoral Program in Nutrition and Food Science of the University of Granada.Diabetes is a disease with an inflammatory component that courses with an anemic state. Vanadium (V) is an antidiabetic agent that acts by stimulating insulin signaling. Hepcidin blocks the intestinal absorption of iron and the release of iron from its deposits. We aim to investigate the effect of V on hepcidin mRNA expression and its consequences on the hematological parameters in streptozotocin-induced diabetic Wistar rats. Control healthy rats, diabetic rats, and diabetic rats treated with 1 mgV/day were examined for five weeks. The mineral levels were measured in diet and serum samples. Hepcidin expression was quantified in liver samples. Inflammatory and hematological parameters were determined in serum or whole blood samples. The inflammatory status was higher in diabetic than in control rats, whereas the hematological parameters were lower in the diabetic rats than in the control rats. Hepcidin mRNA expression was significantly lower in the V-treated diabetic rats than in control and untreated diabetic rats. The inflammatory status remained at a similar level as the untreated diabetic group. However, the hematological profile improved after the V-treatment, reaching similar levels to those found in the control group. Serum iron level was higher in V-treated than in untreated diabetic rats. We conclude that V reduces gene expression of hepcidin in diabetic rats, improving the anemic state caused by diabetes.Consejeria de Innovacion, Ciencia y Empresa, Andalusian Regional Government P06-CTS-01435Spanish Ministry of Economy and Competitivity SAF2011-29648Instituto de Salud Carlos III European Commissio

Calcium Pyruvate Exerts Beneficial Effects in an Experimental Model of Irritable Bowel Disease Induced by DCA in Rats

Pyruvate is a normal constituent of the body that participates in carbohydrate metabolism and functions as a scavenger of free radicals. Calcium pyruvate monohydrate (CPM) is a more stable derivative that has proved its anti-inflammatory effect in experimental colitis, among other disorders, and that could also be considered a source of calcium. Thus, it would be useful for the treatment of diseases with an inflammatory component and a high prevalence of osteoporosis like the irritable bowel syndrome (IBS). The aim of the present study is to evaluate the effects of CPM in a rat model of chronic post-inflammatory visceral pain induced by deoxycholic acid (DCA) that resembles IBS. Rats were administered DCA for three days intracolonically and then treated daily with CPM (40 and 100 mg/kg) or gabapentin (70 mg/kg) (positive control) by oral gavage for 17 days. The treatments reduced the visceral hypersensitivity measured by response to colorectal distension and referred pain. DCA induced changes in the colonic immune response characterized by increased expression of the cytokine Il-1b and the inducible enzyme Cox-2, which was reduced by the treatments. DCA also decreased the gut expression of the mucins Muc-2 and Muc-3, which was normalized by CPM, whereas gabapentin only increased significantly Muc-3. Moreover, DCA increased the expression of Tlr3, which was decreased to basal levels by all the treatments. However, the serotonin receptor Htr-4, which was also elevated, was not affected by any of the treatments, indicating no effect through this signalling pathway. In conclusion, CPM ameliorated the visceral hypersensitivity and the referred pain caused by DCA, being as effective as the control drug. Furthermore, it improved the immune status of the animals, which could contribute to the visceral analgesia and the regeneration of the intestinal epithelial barrier integrity.This work was supported by the Junta de Andalucía (CTS 164) and by the Spanish Ministry of Economy and Competitiveness (AGL2015-67995-C3-3-R) with funds from the European Union. The CIBER-EHD is funded by the Instituto de Salud Carlos III

The Antioxidant Properties of Salvia verbenaca Extract Contribute to Its Intestinal Antiinflammatory Effects in Experimental Colitis in Rats

La enfermedad inflamatoria intestinal (EII) es una inflamación gastrointestinal crónica con fluctuaciones de síntomas impredecibles. Si bien no existe una cura eficaz para la EII, varios tratamientos tienen como objetivo controlar los síntomas y mejorar la calidad de vida de las personas afectadas. En los últimos años, ha habido un interés creciente en los beneficios potenciales de ciertas plantas y hierbas naturales en el tratamiento de la EII. En este sentido, este estudio tuvo como objetivo evaluar los efectos inmunomoduladores y antiinflamatorios de un extracto bien caracterizado de Salvia verbenaca (S. verbenaca) en un modelo experimental de colitis en ratas. Curiosamente, la administración diaria de S. verbenaca (10 y 25 mg/kg) alivió eficazmente los síntomas de la colitis, como lo demuestra la reducción de la relación peso/longitud y el daño colónico. Además, redujo los marcadores de estrés oxidativo (MPO y GSH), disminuyó la expresión de citocinas proinflamatorias (Il-6, Il-12a, Il-1β, Il-23, Icam-1, Mcp-1, Cinc-1) y conservó la integridad de la barrera intestinal (Villin, Muc-2, Muc-3). Estos efectos sugieren que el extracto de S. verbenaca podría representar un potencial candidato complementario para tratar los trastornos gastrointestinales. Sus acciones beneficiosas pueden estar relacionadas con sus propiedades antioxidantes, así como con la regulación negativa de la respuesta inmune, lo que puede resultar en la mejora de la barrera epitelial del intestino.Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammation with unpredictable symptom fluctuations. While there is no effective cure for IBD, various treatments aim to manage symptoms and improve the quality of life for affected individuals. In recent years, there has been growing interest in the potential benefits of certain natural plants and herbs in the management of IBD. In this regard, this study aimed to evaluate the immunomodulatory and anti-inflammatory effects of a well-characterized extract of Salvia verbenaca (S. verbenaca) in an experimental model of colitis in rats. Interestingly, the daily administration of S. verbenaca (10 and 25 mg/kg) effectively alleviated colitis symptoms, as evidenced by reduced weight/length ratio and colonic damage. Moreover, it reduced oxidative stress markers (MPO and GSH), decreased pro-inflammatory cytokine expression (Il-6, Il-12a, Il-1β, Il-23, Icam-1, Mcp-1, Cinc-1), and preserved the integrity of the intestinal barrier (Villin, Muc-2, Muc-3). These effects suggest S. verbenaca extract could represent a potential complementary candidate to treat gastrointestinal disorders. Its beneficial actions can be related to its antioxidant properties as well as the downregulation of the immune response, which can result in the improvement in the intestine epithelial barrier.Junta de Andalucia (AGR-6826)Junta de Andalucia (CTS-164)Ministerio de Economía y Competitividad (SAF2011-29648)Instituto de Salud Carlos III (pFIS (FI20/00159)Instituo de Saud Carlos III (Miguel Servet CP22/00153

The S2 Stream:the shreds of a primitive dwarf galaxy

We present a multi-instrument chemical analysis of the stars in the metal-poor S2 halo stream using both high- and low-resolution spectroscopy, complemented with a re-analysis of the archival data to give a total sample of 62 S2 members. Our high-resolution program provides alpha-elements (C, Mg, Si, Ca and Ti), iron-peak elements (V, Cr, Mn, Fe, Ni), n-process elements (Sr, Ba) and other elements such us Li, Na, Al, and Sc for a subsample of S2 objects. We report coherent abundance patterns over a large metallicity spread (~1dex) confirming that the S2 stream was produced by a disrupted dwarf galaxy. The S2's alpha-elements display a mildly decreasing trend with increasing metallicity which can be interpreted as a "knee" at [Fe/H]<-2. However, even at the high end of [Fe/H], S2's [alpha/Fe] ratios do not climb down from the halo plateau, signaling prehistoric enrichment pattern with minimal SN Ia contribution. At the low metallicity end, the n-capture elements in S2 are dominated by r-process production: several stars are Ba-enhanced but unusually extremely poor in Sr. Moreover, some of the low-[Fe/H] stars appear to be carbon-enhanced. We interpret the observed abundance patterns with the help of chemical evolution models that demonstrate the need for modest star-formation efficiency and low wind efficiency confirming that the progenitor of S2 was a primitive dwarf galaxy.Comment: Submitted to MNRAS. Comments are welcome

The Antioxidant Properties of Lavandula multifida Extract Contribute to Its Beneficial Effects in High-Fat Diet-Induced Obesity in Mice

Obesity is a worldwide public health problem whose prevalence rate has increased steadily over the last few years. Therefore, it is urgent to improve the management of obesity and its comorbidities, and plant-based treatments are receiving increasing attention worldwide. In this regard, the present study aimed to investigate a well-characterized extract of Lavandula multifida (LME) in an experimental model of obesity in mice and explore the underlying mechanisms. Interestingly, the daily administration of LME reduced weight gain as well as improved insulin sensitivity and glucose tolerance. Additionally, LME ameliorated the inflammatory state in both liver and adipose tissue by decreasing the expression of various proinflammatory mediators (Il-6, Tnf-a, Il-1b, Jnk-1, Ppara, Pparg, and Ampk) and prevented increased gut permeability by regulating the expression of mucins (Muc-1, Muc-2, and Muc-3) and proteins implicated in epithelial barrier integrity maintenance (Ocln, Tjp1, and Tff-3). In addition, LME showed the ability to reduce oxidative stress by inhibiting nitrite production on macrophages and lipid peroxidation. These results suggest that LME may represent a promising complementary approach for the management of obesity and its comorbidities.Junta de Andalucía (CTS 164), by the Instituto de Salud Carlos III (ISCIII) (PI19.01058)Spanish Ministry of Economy and Competitiveness (AGL2015-67995-C3-3-R)European Commission (FEDER/ERDF). The CIBEREHDInstituto de Salud Carlos II

Campaña de posicionamiento de la marca Terraza Grill

Terraza Grill es una empresa peruana dedicada a la producción y comercialización de embutidos, hamburguesas y salsas para parrilladas. La relevancia de la investigación en cuestión se encuentra en el desarrollo de un nuevo posicionamiento de marca con la que el público parrillero se sienta identificado. La investigación tiene como objetivo principal definir el posicionamiento de la marca Terraza Grill y construir su propósito, de modo que los consumidores la identifiquen y la reconozcan. Además, hemos desarrollado la metodología Pulso, la cual se basa en aportar algo mucho más valioso a la sociedad, a través de emoción, trasfondo, y resultados que impactan. Esto lo hicimos mediante la observación participante y las entrevistas cuali-vivenciales, que nos permitieron conocer a profundidad las experiencias de los consumidores con la marca y sus productos. Se concluye que para concretar el objetivo planteado se debe crear una campaña enfocada en dar a conocer la marca dentro del nicho parrillero y en generar recordación a través de sus canales digitales.Terraza Grill is a Peruvian company dedicated to producing and commercializing sausages, hamburgers, and sauces for barbecues. The relevance of the research in question lies in developing a new brand positioning with which the barbecue public feels identified. The main objective of the study is to define the positioning of the Terraza Grill brand and build its purpose so that consumers identify with and recognize it. In addition, we have developed the Pulse methodology, which is based on contributing something much more valuable to society, through emotion, background, and impactful results. We did this through participant observation and qualitative experiential interviews, which allowed us to learn in depth the experiences of consumers with the brand and its products. It is concluded that to achieve the stated objective, a campaign should be created focused on publicizing the brand within the grill niche and generating recall through its digital channels

The melatonergic agonist agomelatine ameliorates high fat diet-induced obesity in mice through the modulation of the gut microbiome

Background and purpose: Melatonin has shown beneficial effects on obesity, both in humans and experimental models, via regulating the altered circadian rhythm and thus ameliorating the gut dysbiosis associated with this metabolic condition. However, its clinical use is limited, mostly due to its short half-life. Agomelatine is an agonist of the melatonin receptors that could be used to manage obesity and offer a better profile than melatonin. Experimental approach: Male C57BL/6 mice were fed a high fat diet and orally treated for five weeks with agomelatine, or melatonin or metformin, used as control drugs. Metabolic profile, inflammatory status, vascular dysfunction and intestinal microbiota composition were assessed. Key results: Agomelatine lessened body weight gain, enhanced glucose and lipid metabolisms, and improved insulin resistance. It also reduced the obesity-associated inflammatory status and endothelial dysfunction, probably linked to its effect on gut dysbiosis, consisting of the restoration of bacterial populations with key functions, such as short chain fatty acid production. Conclusions and implications: Agomelatine can be considered as a novel therapeutic tool for the management of human obesity and its associated comorbidities.Junta de Andalucia CTS 164Instituto de Salud Carlos IIIEuropean Commission PI19/01058 European Commissio