Chapter Applicazioni di Motion graphic per la valorizzazione del patrimonio museale del Museo di Arte Orientale di Torino (MAO)

The 43rd UID conference, held in Genova, takes up the theme of ‘Dialogues’ as practice and debate on many fundamental topics in our social life, especially in these complex and not yet resolved times. The city of Genova offers the opportunity to ponder on the value of comparison and on the possibilities for the community, naturally focused on the aspects that concern us, as professors, researchers, disseminators of knowledge, or on all the possibile meanings of the discipline of representation and its dialogue with ‘others’, which we have broadly catalogued in three macro areas: History, Semiotics, Science / Technology. Therefore, “dialogue” as a profitable exchange based on a common language, without which it is impossible to comprehend and understand one another; and the graphic sign that connotes the conference is the precise transcription of this concept: the title ‘translated’ into signs, derived from the visual alphabet designed for the visual identity of the UID since 2017. There are many topics which refer to three macro sessions: - Witnessing (signs and history) - Communicating (signs and semiotics) - Experimenting (signs and sciences) Thanks to the different points of view, an exceptional resource of our disciplinary area, we want to try to outline the prevailing theoretical-operational synergies, the collaborative lines of an instrumental nature, the recent updates of the repertoires of images that attest and nourish the relations among representation, history, semiotics, sciences

Molecular basis, diagnosis and clinical management of mucopolysaccharidoses

Mucopolysaccharidoses (MPSs) are a group of hereditary, monogenic disorders caused by lysosomal storage of glycosaminoglycans. Their incidence as a group is between 1:25,000 and 1:45,000. At present 11 different enzyme deficiencies are know to be responsible of 7 similar but distinct diseases. The diagnosis is suspected clinically but must be confirmed through biochemical, enzymatic and molecular analysis. Prenatal diagnosis is feasible for each disease. The phenotype worsens with age, due to progressive storage, and mainly involves mucosal tissue, upper airways and lungs, bones and joints, central and peripheral nervous system, heart, liver, eye and ear. Any type of MPSs, is characterized by a wide variability of phenotype ranging from a severe fetal-neonatal disease to an attenuated form diagnosed in adult individuals. Recently new treatments, like hematopoietic stem cell transplantation and enzymatic replacement therapy, became available for many of these disorders entailing the urgency of early diagnosis to allow access to therapies. Thanks to therapies these patients have a longer life than in the past and this implies that also palliative treatments, of which the cardiological ones have a prominent part, must be undertaken diligently. The cardiologist may face, more frequently than expected, with the need to diagnose a patient with MPS who was not recognized by other specialists. The echocardiographic features of these patients are typical and may help in the clinical diagnosis. The future probably deserves to these disorders other new treatments or combination therapies, which might further improve prognosis of these diseases

AI+AR: Cultural Heritage, Museum Institutions, Plastic Models and Prototyping. A State of Art

The links between representation and artificial intelligence (AI) invade many fields of architectural research, recording continuous and significant advances: they require, on the one hand, a constant update of the state of the art and, on the other hand, careful consideration of the role of Representation in interdisciplinary research in this field. The present contribution intends to investigate these intertwining in some of the most frequented research fields in recent years: the valorization and communication of Cultural Heritage and cultural tourism, the experiences in the museum field, the research on the role of the prototype within the processes of artificial intelligence applied to architecture

Figure-of-eight velocity curves: UGC10205

We measured the velocity curve and the velocity dispersion profile of the ionized gas along the major axis of the edge-on galaxy UGC~10205. The observed kinematics extends up to about 40 arcsec from the nucleus. In the inner 13 arcsec of this early-type spiral three kinematically distinct gaseous components are present. We disentangle a fast-rotating and a slow-rotating component. They give to the UGC10205 velocity curve a ``figure-of-eight'' appearance. A third velocity component is also detected on the southeast side of the galaxy. Possibly it is produced by gas in non-circular motions.Comment: 8 pages, 3 figures, Latex macro A&A and psfig macro to insert figure

Plastic models of military architecture: value of a cultural heritage to be preserved and enhanced in the digital age

[EN] The contribution intends to bring to the attention of the scientific community the important Heritage made of plastic models, more or less homogeneously spread throughout Europe, which constitutes a patrimony of knowledge that links theoretical contributions on fortification, realizations, historical studies, archive documentation, technical representations, surveys, iconographic material. The enhancement process records an orientation that in recent years has found in the relevant digital tools one of the possible keys for setting up a data system and, in digital modeling, the medium for interesting developments also in relation to the use. Starting from the studies conducted in recent years on this specific topic, the research group is trying to identify the best strategies to be locally applied to enhance and make available on web different models at the various scales that describe Turin fortification's system and some portions of it.Vitali, M.; Bertola, G.; Natta, F.; Ronco, F. (2020). Modelli plastici di architettura militare: valore di un patrimonio culturale da preservare e valorizzare nell’era digitale. Editorial Universitat Politècnica de València. 503-510. https://doi.org/10.4995/FORTMED2020.2020.1153750351

Digitisation, 3D modelling and digital fabrication: an accessibility project for MAO in Turin

The activities presented are part of the project PNRR M1C3-3 aimed at removing physical and cognitive barriers in museums and public cultural places. In the first phase, curatorial investigation of the artefacts and documentary research flank digital survey through photogrammetry and structure-from-motion (SfM) technology. The interpretive phase includes 3D modelling and texturing of the artworks through the creation of high-poly and low-poly models, the result of digital twins that can be used in the conservation and restoration project, and the production of physical replicas for the expansion of the museum experience from a Design for All perspective. The third phase of presentation, communication, sharing, and interaction with the public involves the creation, through digital fabrication processes, of physical models in full or 1:2 scale, depending on the actual size of the object about the object's manipulability aims. The models, printed in polylactic acid (PLA) by the Departmental Labs at the Politecnico di Torino, take on a prototype meaning and are made for tactile enjoyment for the hypo- and visually-impaired and, in general, for inclusive communication for different age groups and users. Such objects may, in particular, be used with an educational function for younger age groups. At the same time, the optimised digital models may form the basis for 3D printing with materials able to restore the characteristics of the original materials, made by specialised firms

Variant on chromosome 9p is associated with left ventricular mass: results from two cohorts of essential hypertensive individuals

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The chemerin/CMKLR1 axis regulates intestinal graft-versus-host disease

: Gastrointestinal graft-versus-host disease (GvHD) is a major cause of mortality and morbidity following allogeneic bone marrow transplantation (allo-BMT). Chemerin is a chemotactic protein that recruits leukocytes to inflamed tissues by interacting with ChemR23/CMKLR1, a chemotactic receptor expressed by leukocytes, including macrophages. During acute GvHD, chemerin plasma levels were strongly increased in allo-BM-transplanted mice. The role of the chemerin/CMKLR1 axis in GvHD was investigated using Cmklr1-KO mice. WT mice transplanted with an allogeneic graft from Cmklr1-KO donors (t-KO) had worse survival and more severe GvHD. Histological analysis demonstrated that the gastrointestinal tract was the organ mostly affected by GvHD in t-KO mice. The severe colitis of t-KO mice was characterized by massive neutrophil infiltration and tissue damage associated with bacterial translocation and exacerbated inflammation. Similarly, Cmklr1-KO recipient mice showed increased intestinal pathology in both allogeneic transplant and dextran sulfate sodium-induced colitis. Notably, the adoptive transfer of WT monocytes into t-KO mice mitigated GvHD manifestations by decreasing gut inflammation and T cell activation. In patients, higher chemerin serum levels were predictive of GvHD development. Overall, these results suggest that CMKLR1/chemerin may be a protective pathway for the control of intestinal inflammation and tissue damage in GvHD

Baraitser-Winter cerebrofrontofacial syndrome: Delineation of the spectrum in 42 cases

Baraitser-Winter, Fryns-Aftimos and cerebrofrontofacial syndrome types 1 and 3 have recently been associated with heterozygous gain-of-function mutations in one of the two ubiquitous cytoplasmic actin-encoding genes ACTB and ACTG1 that encode β- and γ-actins. We present detailed phenotypic descriptions and neuroimaging on 36 patients analyzed by our group and six cases from the literature with a molecularly proven actinopathy (9 ACTG1 and 33 ACTB). The major clinical anomalies are striking dysmorphic facial features with hypertelorism, broad nose with large tip and prominent root, congenital non-myopathic ptosis, ridged metopic suture and arched eyebrows. Iris or retinal coloboma is present in many cases, as is sensorineural deafness. Cleft lip and palate, hallux duplex, congenital heart defects and renal tract anomalies are seen in some cases. Microcephaly may develop with time. Nearly all patients with ACTG1 mutations, and around 60% of those with ACTB mutations have some degree of pachygyria with anteroposterior severity gradient, rarely lissencephaly or neuronal heterotopia. Reduction of shoulder girdle muscle bulk and progressive joint stiffness is common. Early muscular involvement, occasionally with congenital arthrogryposis, may be present. Progressive, severe dystonia was seen in one family. Intellectual disability and epilepsy are variable in severity and largely correlate with CNS anomalies. One patient developed acute lymphocytic leukemia, and another a cutaneous lymphoma, indicating that actinopathies may be cancer-predisposing disorders. Considering the multifaceted role of actins in cell physiology, we hypothesize that some clinical manifestations may be partially mutation specific. Baraitser-Winter cerebrofrontofacial syndrome is our suggested designation for this clinical entity