12 research outputs found
Electrodeposition of PbO2 on glassy carbon electrodes: influence of ultrasound frequency
The influence of the ultrasonic frequency on the electrocrystallisation of lead dioxide on glassy carbon electrodes was studied in 1 mol dm−3 HNO3 + 0.1 mol dm−3 Pb(NO3)2 using chronoamperometry and numerical approximations of the current transients obtained. The effects of the ultrasound frequency have been compared with the effects produced by other operational variables such as electrode potential.Universidad de Alicante (project GR03-05)
VACCELERATE Site Network: Real-time definition of clinical study capacity in Europe
Background: The inconsistent European vaccine trial landscape rendered the continent of limited interest for vaccine developers. The VACCELERATE consortium created a network of capable clinical trial sites throughout Europe. VACCELERATE identifies and provides access to state-of-the-art vaccine trial sites to accelerate clinical development of vaccines. Methods: Login details for the VACCELERATE Site Network (vaccelerate.eu/site-network/) questionnaire can be obtained after sending an email to. Interested sites provide basic information, such as contact details, affiliation with infectious disease networks, main area of expertise, previous vaccine trial experience, site infrastructure and preferred vaccine trial settings. In addition, sites can recommend other clinical researchers for registration in the network. If directly requested by a sponsor or sponsor representative, the VACCELERATE Site Network pre-selects vaccine trial sites and shares basic study characteristics provided by the sponsor. Interested sites provide feedback with short surveys and feasibility questionnaires developed by VACCELERATE and are connected with the sponsor to initiate the site selection process. Results: As of April 2023, 481 sites from 39 European countries have registered in the VACCELERATE Site Network. Of these, 137 (28.5 %) sites have previous experience conducting phase I trials, 259 (53.8 %) with phase II, 340 (70.7 %) with phase III, and 205 (42.6 %) with phase IV trials, respectively. Infectious diseases were reported as main area of expertise by 274 sites (57.0 %), followed by any kind of immunosuppression by 141 (29.3 %) sites. Numbers are super additive as sites may report clinical trial experience in several indications. Two hundred and thirty-one (47.0 %) sites have the expertise and capacity to enrol paediatric populations and 391 (79.6 %) adult populations. Since its launch in October 2020, the VACCELERATE Site Network has been used 21 times for academic and industry trials, mostly interventional studies, focusing on different pathogens such as fungi, monkeypox virus, Orthomyxoviridae/influenza viruses, SARS-CoV-2, or Streptococcus pneumoniae/pneumococcus. Conclusions: The VACCELERATE Site Network enables a constantly updated Europe-wide mapping of experienced clinical sites interested in executing vaccine trials. The network is already in use as a rapid-turnaround single contact point for the identification of vaccine trials sites in Europe.The VACCELERATE Site Network has received funding from the European Union’s Horizon 2020 research and innovation pro gramme (grant agreement No 101037867) and the German Federal Ministry of Education and Research (Bundesministerium für Bil dung und Forschung [BMBF]) (grant agreement No BMBF01KX2040).S
Sono-electrochemical degradation of perchloroethylene in aqueous solution
Póster presentado en el 10th Meeting of the European Society of Sonochemistry, Hamburg, June 4-8, 2006
Degradación sonoquímica de disoluciones acuosas de percloroetileno: efecto de la intensidad del campo de ultrasonidos
Resumen de la comunicación presentada en la XXX Reunión Bienal de la Real Sociedad Española de Química, Lugo, 19-23 Septiembre 2005
Sonoelectrochemical degradation of perchloroethylene at 850kHz
Presentación realizada en Electrochem 2005, Newcastle, September 4-7, 2005
Sonoelectrochemistry: fundamental and applied studies
Póster presentado en "First workshop of COST D32 Action", Alicante, 8-9 Julio 2004
Aplicación de la medida de conductividad: análisis de curvas de distribución de tiempos de residencia en reactores electroquímicos
La Ingeniería Electroquímica como materia
multidisciplinar está íntimamente relacionada
con la ciencia de materiales, mecánica de fluidos
y técnicas de computación entre otras temáticas.
Como ejemplo de esta interrelación, se pretende
analizar la hidrodinámica de un reactor
electroquímico mediante el análisis de la
distribución de tiempos de residencia (DTR) por
métodos de simulación con ordenador. A través
de una simulación por ordenador de la respuesta
experimental obtenida con un modelo de patrón
de flujo se obtienen una serie de parámetros
cuantitativos que caracterizan el
comportamiento de reactor en función del
caudal (Qv), que se empleará como variable de
operación. Estos parámetros se pueden
contrastar con otros obtenidos por métodos
electroquímicos
Optimisation of 20kHz sonoreactor geometry on the basis of numerical simulation of local ultrasonic intensity and qualitative comparison with experimental results
The intensity distribution of the ultrasonic energy is, after the frequency, the most significant parameter to characterize ultrasonic fields in any sonochemical experiment.
Whereas in the case of low intensity ultrasound the measurement of intensity and its distribution is well solved, in the case of high intensity (when cavitation takes place) the measurement is much more complicated. That is why the predicting the acoustic pressure
distribution within the cell is desirable.
A numerical solution of the wave equation gave the distribution of intensity within the cell. The calculations together with experimental verification have shown that the whole reactor behaves like a resonator and the energy distribution depends strongly on its shape. The agreement between computational simulations and experiments allowed
optimisation of the shape of the sonochemical reactor. The optimal geometry resulted in astrong increase in intensity along a large part of the cell. The advantages of such optimised
geometry are (i) the ultrasonic power necessary for obtaining cavitation is low, (ii) low power delivered to the system results in only weak heating; consequently no cooling is necessary and (iii) the "active volume" is large, i.e. the fraction of the reactor volume with high intensity is large and is not limited to a vicinity close to the horn tip.COST D32 for STSM grant, the Ministry of
Education, Youth and Sports (MSMT) of the Czech Republic - grant number 1P05OC074 and
the Grant Agency of the Academy of Sciences of the Czech Republic - grant number
A4040304; Generalidad Valenciana (Project GV05/104)
Characterization of 20kHz sonoreactor. Part I: analysis of mechanical effects by classical and numerical methods
Resumen de la comunicación presentada en el 9th Conference of the European Society of Sonochemistry (ESS), Badajoz, 25-30 Abril 2004.Universidad de Alicante (Proyecto GR03-05)