Polymorphisms in the bradykinin B2 receptor gene and childhood asthma

Bradykinin has been suggested as one of the key mediators of bronchial asthma. Polymorphisms with a potential functional relevance have been described in the B2 bradykinin receptor gene. Study of these polymorphisms in 77 children with asthma and 73 controls revealed no association. However, when comparing the asthmatics according to their age at onset (before and after age 4), the exon 1 allele BE1-2G was significantly associated with late-onset asthma (p <0.05). Since BE1-2G has previously been shown to lead to a higher transcription rate of the B2 receptor, this result warrants further investigation of the role of bradykinin in conferring susceptibility to pediatric asthma

Her Life Depends On It: Sport, Physical Activity and the Health and Well-Being of American Girls

This report is a comprehensive compendium of research that points to physical activity and sport as fundamental solutions for many of the serious health and social problems faced by American girls. An appreciable mass of evidence-based knowledge about girls' involvement with sport and physical activity has been generated during the last decade. The amount and quality of this research are uneven and varied. For example, a good deal of research examines the associations between physical activity and risk for coronary heart disease, but studies that focus on risk for Alzheimer's disease are just beginning to issue. Researchers have verified links between high school athletic participation and teen pregnancy prevention, although more longitudinal research is needed to thoroughly confirm the connections. Overall, however, this report shows that the current state of knowledge on the relationship of physical activity to the health and social needs of American girls warrants the serious attention of public health officials, educators and sport leaders

Director\u27s report of research in Kansas 2002

This report contains the title, author, and publication information for manuscripts published by station scientists. It also contains a list of the research projects that were active during that period and a financial statement for the fiscal year

Biodiversity climate change impacts report card technical paper:10. Implications of climate change for coastal and inter-tidal habitats in the UK

Executive summary - Coastal habitats are complex, dynamic and interdependent. They are important in providing sea defences, areas for recreation, biodiversity and a range of other ecosystem services. - Increased air- and sea-surface temperatures have resulted in changes in the distribution of marine and coastal species. Both warmer- and colder-water species are shifting northwards. However, warmer-water species are shifting northwards faster than colder-water species are retreating, resulting in changes in community composition. Changes in the abundance of keystone taxa can cause a cascade of responses, further altering community composition. - Changes in the phenology of coastal species have been observed, with the rates of change in marine species being considerably greater than those in terrestrial and freshwater systems. Recent advances in the phenology of species have not all occurred at the same rate, in some cases resulting in mismatches of timing of annual cycles of animals and their food organisms. - Changes in precipitation are likely to affect coastal habitats, but the projected increase in winter rainfall and decrease in summer rainfall will tend to have opposing effects; the net result of these is not known. High winter rainfall and milder winter temperatures may extend the growing season and lead to faster succession and dominance by taller competitive plant species. This will be exacerbated by anthropogenic nutrient enrichment. However, increasing frequency and severity of summer droughts may counteract the effects of nutrient enrichment and winter precipitation. Increased drought will have impacts on habitats that are highly dependent on the maintenance of hydrological regimes, such as machair lochs and dune slacks. - Rising sea levels have been associated with the loss of coastal habitats. Predicted future rises will have significant impacts on coastal and intertidal habitats, including changing geomorphological processes, further habitat loss and increasing the vulnerability of infrastructure. However, coastal systems are dynamic and have the potential to adapt to rising sea levels, but only if there is an adequate supply of sediment to allow accretion and if there is landward space for the coast to roll-back into. Sea defences and other coastal management interrupt the movement of sediment between systems and prevent natural coastal realignment. - Managed coastal realignment is beneficial because it offers the potential to create habitat and provide flood defence benefits. Inevitably, there will be conflict between the need to maintain intertidal and other coastal habitats (e.g. saltmarsh, mud flat and sand dune) by realignment, and the need to protect valuable inland coastal habitats, such as grazing marsh and saline lagoons. - Future changes in coastal habitats are hard to predict because it is difficult to separate the impacts of rising sea levels from those of coastal management, including sea defences. Coastal zone management and adaptation, and the interactions with other climate drivers, nutrient deposition and habitat management, will have significant influence on the quantity, quality and location of future coastal habitats

Director\u27s report of research in Kansas 2001

This report contains the title, author, and publication information for manuscripts published by station scientists. It also contains a list of the research projects that were active during that period and a financial statement for the fiscal year

Second Twenty-five Year Index: Volumes 26–50, 1994–2018

The first 50 years of the Prairie Naturalist reside on the shelves of libraries and personal collections. The articles and notes published over those years provide invaluable knowledge about Great Plains biota, communities, conservation, and landscape ecologies. Awareness of the wealth of information in those 50 print volumes has been limited, relying on references from other published papers or the limited number of articles that have been made available online by authors. This index serves as resource for individuals to digitally tap into the information published since 1994. This index, together with the first 25-year index, serves to complement the growing number of Prairie Naturalist volumes that are being available online at the University of Nebraska’s Digital Commons (https://digitalcommons.unl.edu/tpn/). This index to the Prairie Naturalist is the third to be completed. The first, covering the first 10 volumes was compiled by Virginia Steinhaus. That material was incorporated by editor Dr. Paul Kannowski into the second index that covered the first 25 years of the Prairie Naturalist (1969-1993). That index is available online as a searchable PDF at the University of Nebraska’s Digital Commons under 1997, the year it was published (https://digitalcommons.unl.edu/tpn/index.4.html#year_1997). This index covers the second 25 years, 1994–2018. Along with regular articles, notes, and book reviews, it also includes two special issues: Lesser Prairie Chickens (2000, 32[3]) and the Proceedings of the 23rd North American Prairie Conference (2014, 42[Special Issue]). Journal editors during 1994–2018 include Dr. Paul Kannowski (1969–1995), Dr. Elmer Finck (1996–2009), and Dr. Christopher Jacques (2009–2018). The journal is a product of the Great Plains Natural Science Society, formerly the North Dakota Natural Science Society. The society’s name was changed in 2004 to better reflect the greater breadth of regional interests and journal content. The structure used here follows that established in the first 25-year index, with some modifications. The Author Index provides full citations for articles, notes, book reviews, and editorials; the end of that section includes Corrections, cross-referenced to the original paper. The following sections provide shorter citations (author, year, volume:pages) for readers to refer back to the Author Index. Books Reviewed are listed by book author, year, and book title, with a short citation to the book review in the Author Index. The Subject Index was developed using key words and additional information representative of papers’ content. Some decisions to include additional subject words were subjective but always focused on core findings and study objectives. Locations included in the Geographic Index represent the location of actual field work or findings. The Taxonomic Index includes scientific and common names of taxa studied. One of the challenges in compiling this section was the changes in taxonomy since the papers were published. A cross-reference is provided from the original taxonomy to the current taxonomy, as determined in January 2022 with online authorities, to the best of my ability using information in the original article. I have benefited from the contributions of various individuals during the development of this index. Larry Igl provided constructive comments during development and final drafts. I appreciate the assistance of several individuals who reviewed the Taxonomic Index sections or provided valuable guidance: Andre DeLorme (invertebrates), Keith Geluso (amphibians, reptiles, mammals), David Lambeth (birds), and Steve Chipps (fishes)

The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs

G protein coupled receptors (GPCRs) are the most historically successful therapeutic targets. Despite this success there are many important aspects of GPCR pharmacology and function that have yet to be exploited to their full therapeutic potential. One in particular that has been gaining attention in recent times is that of GPCR ligands that bind to allosteric sites on the receptor distinct from the orthosteric site of the endogenous ligand. As therapeutics, allosteric ligands possess many theoretical advantages over their orthosteric counterparts, including more complex modes of action, improved safety, more physiologically appropriate responses, better target selectivity, and reduced likelihood of desensitisation and tachyphylaxis. Despite these advantages, the development of allosteric ligands is often difficult from a medicinal chemistry standpoint due to the more complex challenge of identifying allosteric leads and their often flat or confusing SAR. The present review will consider the advantages and challenges associated with allosteric GPCR ligands, and examine how the particular properties of these ligands may be exploited to uncover the therapeutic potential for free fatty acid sensitive GPCRs

Twenty-Five Year Index to THE PRAIRIE NATURALIST, Volumes 1-25, 1968-1993

Forward Author Index 1.Articles and Notes 2. Book Reviews 3. Editorials Subject Index Geographic Index Taxonomic Index Plants Animals Other Record