Corporate Financing in Great Britain

Background: The antifungal compound ketoconazole has, in addition to its ability to interfere with fungal ergosterol synthesis, effects upon other enzymes including human CYP3A4, CYP17, lipoxygenase and thromboxane synthetase. In the present study, we have investigated whether ketoconazole affects the cellular uptake and hydrolysis of the endogenous cannabinoid receptor ligand anandamide (AEA). Methodology/Principal Findings: The effects of ketoconazole upon endocannabinoid uptake were investigated using HepG2, CaCo2, PC-3 and C6 cell lines. Fatty acid amide hydrolase (FAAH) activity was measured in HepG2 cell lysates and in intact C6 cells. Ketoconazole inhibited the uptake of AEA by HepG2 cells and CaCo2 cells with IC50 values of 17 and 18 mu M, respectively. In contrast, it had modest effects upon AEA uptake in PC-3 cells, which have a low expression of FAAH. In cell-free HepG2 lysates, ketoconazole inhibited FAAH activity with an IC50 value (for the inhibitable component) of 34 mu M. Conclusions/Significance: The present study indicates that ketoconazole can inhibit the cellular uptake of AEA at pharmacologically relevant concentrations, primarily due to its effects upon FAAH. Ketoconazole may be useful as a template for the design of dual-action FAAH/CYP17 inhibitors as a novel strategy for the treatment of prostate cancer

Chloroplast microsatellites: measures of genetic diversity and the effect of homoplasy

Chloroplast microsatellites have been widely used in population genetic studies of conifers in recent years. However, their haplotype configurations suggest that they could have high levels of homoplasy, thus limiting the power of these molecular markers. A coalescent-based computer simulation was used to explore the influence of homoplasy on measures of genetic diversity based on chloroplast microsatellites. The conditions of the simulation were defined to fit isolated populations originating from the colonization of one single haplotype into an area left available after a glacial retreat. Simulated data were compared with empirical data available from the literature for a species of Pinus that has expanded north after the Last Glacial Maximum. In the evaluation of genetic diversity, homoplasy was found to have little influence on Nei's unbiased haplotype diversity (H(E)) while Goldstein's genetic distance estimates (D2sh) were much more affected. The effect of the number of chloroplast microsatellite loci for evaluation of genetic diversity is also discussed

Gauge Coupling Instability and Dynamical Mass Generation in N=1 Supersymmetric QED(3)

Using superfield Dyson-Schwinger equations, we compute the infrared dynamics of the semi-amputated full vertex, corresponding to the effective running gauge coupling, in N-flavour {\mathcal N}=1 supersymmetric QED(3). It is shown that the presence of a supersymmetry-preserving mass for the matter multiplet stabilizes the infrared gauge coupling against oscillations present in the massless case, and we therefore infer that the massive vacuum is thus selected at the level of the (quantum) effective action. We further demonstrate that such a mass can indeed be generated dynamically in a self-consistent way by appealing to the superfield Dyson-Schwinger gap equation for the full matter propagator.Comment: 14 pages ReVTeX; four axodraw figures incorporate

Diffractive Dissociation In The Interacting Gluon Model

We have extended the Interacting Gluon Model (IGM) to calculate diffractive mass spectra generated in hadronic collisions. We show that it is possible to treat both diffractive and non-diffractive events on the same footing, in terms of gluon-gluon collisions. A systematic analysis of available data is performed. The energy dependence of diffractive mass spectra is addressed. They show a moderate narrowing at increasing energies. Predictions for LHC energies are presented.Comment: 12 pages, latex, 14 figures (PostScript Files included); accepted for publication in Phys. Rev. D (Feb.97

Strangelet spectra from type II supernovae

We study in this work the fate of strangelets injected as a contamination in the tail of a "strange matter-driven" supernova shock. A simple model for the fragmentation and braking of the strangelets when they pass through the expanding oxygen shell is presented and solved to understand the reprocessing of this component. We find that the escaping spectrum is a scaled-down version of the one injected at the base of the oxygen shell. The supernova source is likely to produce low-energy particles of $A \sim 100-1000$ quite independently of the initial conditions. However, it is difficult that ultrarrelativistic strangelets (such as the hypothetical Centauro primaries) can have an origin in those explosive events.Comment: RevTex file, 5 pp., no figure

Temperature dependent BCS equations with continuum coupling

The temperature dependent BCS equations are modified in order to include the contribution of the continuum single particle states. The influence of the continuum upon the critical temperature corresponding to the phase transition from a superfluid to a normal state and upon the behaviour of the excitation energy and of the entropy is discussed.Comment: 9 pages, 3 figures, to appear in Phys. Rev.

Certainty Closure: Reliable Constraint Reasoning with Incomplete or Erroneous Data

Constraint Programming (CP) has proved an effective paradigm to model and solve difficult combinatorial satisfaction and optimisation problems from disparate domains. Many such problems arising from the commercial world are permeated by data uncertainty. Existing CP approaches that accommodate uncertainty are less suited to uncertainty arising due to incomplete and erroneous data, because they do not build reliable models and solutions guaranteed to address the user's genuine problem as she perceives it. Other fields such as reliable computation offer combinations of models and associated methods to handle these types of uncertain data, but lack an expressive framework characterising the resolution methodology independently of the model. We present a unifying framework that extends the CP formalism in both model and solutions, to tackle ill-defined combinatorial problems with incomplete or erroneous data. The certainty closure framework brings together modelling and solving methodologies from different fields into the CP paradigm to provide reliable and efficient approches for uncertain constraint problems. We demonstrate the applicability of the framework on a case study in network diagnosis. We define resolution forms that give generic templates, and their associated operational semantics, to derive practical solution methods for reliable solutions.Comment: Revised versio

Effect of Magnetic Field on the Phase Transition from Nuclear Matter to Quark Matter during Proto-Neutron Star Evolution

We have studied phase transition from hadron matter to quark matter in the presence of high magnetic fields incorporating the trapped electron neutrinos at finite temperatures. We have used the density dependent quark mass (DDQM) model for the quark phase while the hadron phase is treated in the frame-work of relativistic mean field theory. It is seen that the nuclear energy at phase transition decreases with both magnetic field and temperature. A brief discussion of the effect of magnetic field in supernova explosions and proto-neutron star evolution is given.Comment: LaTex2e file with four postscript figure

Quantum Phase Diagram of the t-Jz Chain Model

We present the quantum phase diagram of the one-dimensional $t$-$J_z$ model for arbitrary spin (integer or half-integer) and sign of the spin-spin interaction $J_z$, using an {\it exact} mapping to a spinless fermion model that can be solved {\it exactly} using the Bethe ansatz. We discuss its superconducting phase as a function of hole doping $\nu$. Motivated by the new paradigm of high temperature superconductivity, the stripe phase, we also consider the effect the antiferromagnetic background has on the $t$-$J_z$ chain intended to mimic the stripe segments.Comment: 4 pages, 2 figure