STS-3 Induced Environment Contamination Monitor (IECM): Quick-look report

The STS-3/Induced Environment Contamination Monitor (IECM) mission is described. The IECM system performance is discussed, and IECM mission time events are briefly described. Quick look analyses are presented for each of the 10 instruments comprising the IECM on the flight of STS-3. Finally, a short summary is presented and plans are discussed for future IECM flights, and opportunities for direct mapping of Orbiter effluents using the Remote manipulator System

Extending the Ehresmann-Schein-Nambooripad Theorem

We extend the `join-premorphisms' part of the Ehresmann-Schein-Nambooripad Theorem to the case of two-sided restriction semigroups and inductive categories, following on from a result of Lawson (1991) for the `morphisms' part. However, it is so-called `meet-premorphisms' which have proved useful in recent years in the study of partial actions. We therefore obtain an Ehresmann-Schein-Nambooripad-type theorem for meet-premorphisms in the case of two-sided restriction semigroups and inductive categories. As a corollary, we obtain such a theorem in the inverse case.Comment: 23 pages; final section on Szendrei expansions removed; further reordering of materia

Sexual Violence, the AD HOC Tribunals And The International Criminal Court: Reconciling Akayesu And Kunarac

The International Criminal Court (ICC) will soon be the dominant international forum adjudicating allegations of international crimes, as those currently in operation are projected to complete their mandates in the next few years

Revolutionary Rooms

Residence Halls are a social center on college campuses. The common spaces within a residence hall are a space for informal collectivism. However, they have become increasingly task specific and redundant. How do social constructs influence design? Should common spaces within the residence hall typology influence the design of the entire domicile? This thesis develops a methodology that prioritizes sociospatial relationships in the design of residence halls. This was accomplished through the exploration of college culture, socio-spatial relationships, and notions from sister typologies

Cost effectiveness analysis of laparoscopic hysterectomy compared with standard hysterectomy: results from a randomised trial

Objective: To assess the cost effectiveness of laparoscopic hysterectomy compared with conventional hysterectomy (abdominal or vaginal). Design: Cost effectiveness analysis based on two parallel trials: laparoscopic (n = 324) compared with vaginal hysterectomy (n = 163); and laparoscopic (n = 573) compared with abdominal hysterectomy (n = 286). Participants: 1346 women requiring a hysterectomy for reasons other than malignancy. Main outcome measure: One year costs estimated from NHS perspective. Health outcomes expressed in terms of QALYs based on women's responses to the EQ-5D at baseline and at three points during up to 52 weeks' follow up. Results: Laparoscopic hysterectomy cost an average of pound401 ($708; C571) more (95$471789; E380 437). The, probability that laparoscopic hysterectomy is cost effective was below 50% for a large range of values of willingness to pay for an additional QALY. Laparoscopic hysterectomy cost an average of pound186 ($328; E265) more than abdominal hysterectomy, although 95$46 893; E37 813). If the NHS is willing to pay pound30 0 00 for an additional QALY, the probability that laparoscopic hysterectomy is cost effective is 56%. Conclusions: Laparoscopic hysterectomy is not cost effective relative to vaginal hysterectomy. Its cost effectiveness relative to the abdominal procedure is finely balanced

Field Work Reflections: Journeys in Knowing and Not-Knowing

In this paper, I retrace my interest in narrative forms of inquiry. I begin by revisiting a series of research projects that I conducted early in my career, describing some of my own dissatisfactions with the methods I used at the time. I move on to a detailed reexamination of my first piece of narrative research, completed during my PhD. In that project I used a narrative pointed psychosocial method in an attempt to develop new knowledge in the field of drugs, ‘race’ and ethnicity. In the final section, I consider what I have learned from this approach in terms of knowing and not-knowing and how I have used this experience to explore different approaches to narrative inquiry. I finish by drawing out some lessons I have learned from these different studies, which I hope might be of relevance to other social work researchers

Influence of ER leak on resting cytoplasmic Ca2+ and receptormediated Ca2+ signalling in human macrophage

Mechanisms controlling endoplasmic reticulum (ER) Ca2+ homeostasis are important regulators of resting cytoplasmic Ca2+ concentration ([Ca2+]cyto) and receptor-mediated Ca2+ signalling. Here we investigate channels responsible for ER Ca2+ leak in THP-1 macrophage and human primary macrophage. In the absence of extracellular Ca2+ we employ ionomycin action at the plasma membrane to stimulate ER Ca2+ leak. Under these conditions ionomycin elevates [Ca2+]cyto revealing a Ca2+ leak response which is abolished by thapsigargin. IP3 receptors (Xestospongin C, 2-APB), ryanodine receptors (dantrolene), and translocon (anisomycin) inhibition facilitated ER Ca2+ leak in model macrophage, with translocon inhibition also reducing resting [Ca2+]cyto. In primary macrophage, translocon inhibition blocks Ca2+ leak but does not influence resting [Ca2+]cyto. We identify a role for translocon-mediated ER Ca2+ leak in receptor-mediated Ca2+ signalling in both model and primary human macrophage, whereby the Ca2+ response to ADP (P2Y receptor agonist) is augmented following anisomycin treatment. In conclusion, we demonstrate a role of ER Ca2+ leak via the translocon in controlling resting cytoplasmic Ca2+ in model macrophage and receptor-mediated Ca2+ signalling in model macrophage and primary macrophage