Particle-stabilized water droplets that sprout millimeter-scale tubes

A layer of colloidal particles will become irreversibly trapped at a fluid–fluid interface if they exhibit partial wettability with both fluid phases. This effect has been exploited to create Pickering emulsions, armored bubbles, and new materials of various kinds. When the interfaces are densely coated with particles, they behave like rigid elastic sheets with moduli that are proportional to the underlying interfacial tension. The interfaces are permeable, a characteristic that can, for example, lead to compositional ripening of Pickering emulsions Here we show that when particle-stabilized water droplets are created in a bath of toluene with ethanol, millimeter-scale tubes are observed to sprout from the top of the droplets. Growth is driven by the ethanol partitioning from the toluene into the water which leads to an internal overpressure. Vertical growth occurs over many minutes; finally the tube buckles when it can no longer support its own weight (Figure 1). There are several different growth modes controlled by the concentration of ethanol and of silica particles.[1] An alternative way to manipulate the system is by using a different alcohol, leading to insight on the role of the underlying three-fluid phase diagram. Our work paves the way for future studies of droplet growth because the liquid droplets and the interfacial properties can be independently studied. Please click Additional Files below to see the full abstract

The 2011 Workplace Employment Relations Study: first findings

The 2011 Workplace Employment Relations Study (WERS) is the sixth survey of employment relations in Britain. It collected data from a representative sample of 2,680 British workplaces, from: 2,680 workplace managers responsible for employment relations and personnel 1,002 worker representatives 21,981 employee

The COPE-Trial-Communicating prognosis to parents in the neonatal ICU: Optimistic vs. PEssimistic: study protocol for a randomized controlled crossover trial using two different scripted video vignettes to explore communication preferences of parents of preterm infants.

BACKGROUND One of the numerous challenges preterm birth poses for parents and physicians is prognostic disclosure. Prognoses are based on scientific evidence and medical experience. They are subject to individual assessment and will generally remain uncertain with regard to the individual. This can result in differences in prognostic framing and thus affect the recipients' perception. In neonatology, data on the effects of prognostic framing are scarce. In particular, it is unclear whether parents prefer a more optimistic or a more pessimistic prognostic framing. OBJECTIVE To explore parents' preferences concerning prognostic framing and its effects on parent-reported outcomes and experiences. To identify predictors (demographic, psychological) of parents' communication preferences. DESIGN, SETTING, PARTICIPANTS Unblinded, randomized controlled crossover trial (RCT) at the Division of Neonatology of the University Medical Center Mainz, Germany, including German-speaking parents or guardians of infants born preterm between 2010 and 2019 with a birth weight < 1500 g. Inclusion of up to 204 families is planned, with possible revision according to a blinded sample size reassessment. INTERVENTION Embedded in an online survey and in pre-specified order, participants will watch two video vignettes depicting a more optimistic vs. a more pessimistic framing in prognostic disclosure to parents of a preterm infant. Apart from prognostic framing, all other aspects of physician-parent communication are standardized in both videos. MAIN OUTCOMES AND MEASURES At baseline and after each video, participants complete a two-part online questionnaire (baseline and post-intervention). Primary outcome is the preference for either a more optimistic or a more pessimistic prognostic framing. Secondary outcomes include changes in state-anxiety (STAI-SKD), satisfaction with prognostic framing, evaluation of prognosis, future optimism and hope, preparedness for shared decision-making (each assessed using customized questions), and general impression (customized question), professionalism (adapted from GMC Patient Questionnaire) and compassion (Physician Compassion Questionnaire) of the consulting physician. DISCUSSION This RCT will explore parents' preferences concerning prognostic framing and its effects on physician-parent communication. Results may contribute to a better understanding of parental needs in prognostic disclosure and will be instrumental for a broad audience of clinicians, scientists, and ethicists. TRIAL REGISTRATION German Clinical Trials Register DRKS00024466 . Registered on April 16, 2021

Software that goes with the flow in systems biology

A recent article in BMC Bioinformatics describes new advances in workflow systems for computational modeling in systems biology. Such systems can accelerate, and improve the consistency of, modeling through automation not only at the simulation and results-production stages, but also at the model-generation stage. Their work is a harbinger of the next generation of more powerful software for systems biologists

Loudly sing cuckoo : More-than-human seasonalities in Britain

This research was funded by a grant from the Arts and Humanities Research Council, grant number AH/E009573/1.Peer reviewedPostprin

Tops and Writhing DNA

The torsional elasticity of semiflexible polymers like DNA is of biological significance. A mathematical treatment of this problem was begun by Fuller using the relation between link, twist and writhe, but progress has been hindered by the non-local nature of the writhe. This stands in the way of an analytic statistical mechanical treatment, which takes into account thermal fluctuations, in computing the partition function. In this paper we use the well known analogy with the dynamics of tops to show that when subjected to stretch and twist, the polymer configurations which dominate the partition function admit a local writhe formulation in the spirit of Fuller and thus provide an underlying justification for the use of Fuller's "local writhe expression" which leads to considerable mathematical simplification in solving theoretical models of DNA and elucidating their predictions. Our result facilitates comparison of the theoretical models with single molecule micromanipulation experiments and computer simulations.Comment: 17 pages two figure

A laboratory study on cold-mix, cold-lay emulsion mixtures

This paper describes laboratory experiments and presents results for the performances of cold-mix, cold-lay emulsion mixtures. The main objective of the experiments was to evaluate and improve the properties of the cold mixtures. The mixture properties evaluated were: volumetric properties, indirect tensile stiffness modulus (ITSM), repeated load axial creep and fatigue. These properties were compared with conventional hot asphalt mixtures not containing any waste/recycled materials. To optimise the performances of the mixtures, a target of ITSM value of 2000 MPa was selected. At full curing conditions, the stiffness of the cold mixes was found to be very similar to that of hot mixtures of the same penetration grade base bitumen (100 pen). Test results also show that the addition of 1–2% cement significantly improved the mechanical performance of the mixes and significantly accelerated their strength gain. The fatigue behaviour of the cold mixes that incorporated cement was comparable with that of the hot mixtures

An Agent Architecture for Concurrent Bilateral Negotiations

Abstract. We present an architecture that makes use of symbolic decision-making to support agents participating in concurrent bilateral negotiations. The architecture is a revised version of previous work with the KGP model [23, 12], which we specialise with knowledge about the agent’s self, the negotiation opponents and the environment. Our work combines the specification of domain-independent decision-making with a new protocol for concurrent negotiation that revisits the well-known alternating offers protocol [22]. We show how the decision-making can be specialised to represent the agent’s strategies, utilities and prefer-ences using a Prolog-like meta-program. The work prepares the ground for supporting decision-making in concurrent bilateral negotiations that is more lightweight than previous work and contributes towards a fully developed model of the architecture

Pattern formation in directional solidification under shear flow. I: Linear stability analysis and basic patterns

An asymptotic interface equation for directional solidification near the absolute stabiliy limit is extended by a nonlocal term describing a shear flow parallel to the interface. In the long-wave limit considered, the flow acts destabilizing on a planar interface. Moreover, linear stability analysis suggests that the morphology diagram is modified by the flow near the onset of the Mullins-Sekerka instability. Via numerical analysis, the bifurcation structure of the system is shown to change. Besides the known hexagonal cells, structures consisting of stripes arise. Due to its symmetry-breaking properties, the flow term induces a lateral drift of the whole pattern, once the instability has become active. The drift velocity is measured numerically and described analytically in the framework of a linear analysis. At large flow strength, the linear description breaks down, which is accompanied by a transition to flow-dominated morphologies, described in a companion paper. Small and intermediate flows lead to increased order in the lattice structure of the pattern, facilitating the elimination of defects. Locally oscillating structures appear closer to the instability threshold with flow than without.Comment: 20 pages, Latex, accepted for Physical Review