380 research outputs found
2-(Nitroaryl)-5-substituted-1,3,4-thiadiazole derivatives with antiprotozoal activities: in vitro and in vivo study
Nitro-containing compounds are a well-known class of anti-infective agents, especially in the field of anti-parasitic drug discovery. HAT or sleeping sickness is a neglected tropical disease caused by a protozoan parasite, Trypanosoma brucei. Following the approval of fexinidazole as the first oral treatment for both stages of T. b. gambiense HAT, there is an increased interest in developing new nitro-containing compounds against parasitic diseases. In our previous projects, we synthesized several megazole derivatives that presented high activity against Leishmania major promastigotes. Here, we screened and evaluated their trypanocidal activity. Most of the compounds showed submicromolar IC50 against the BSF form of T. b. rhodesiense (STIB 900). To the best of our knowledge, compound 18c is one of the most potent nitro-containing agents reported against HAT in vitro. Compound 18g revealed an acceptable cure rate in the acute mouse model of HAT, accompanied with noteworthy in vitro activity against T. brucei, T. cruzi, and L. donovani. Taken together, these results suggest that these compounds are promising candidates to evaluate their pharmacokinetic and biological profiles in the futu
(E)-5-Phenyl-N-(2-thienylmethylene)-1,3,4-thiadiazole-2-amine
In the title compound, C13H9N3S2, the thiophene and phenyl rings are oriented at dihedral angles of 8.00 (7) and 6.31 (7)°, respectively, with respect to the central thiadiazole ring. No significant C—H⋯S and π–π interactions exist in the crystal structure
Synthesis and investigation of antioxidant activities of 2-benzylidene-3-coumaranones
A number of 6-hydroxy-2-benzylidene-3-coumaranones were synthesized from condensation of 6-hydroxy-3-coumaranone with appropriate aldehydes and were evaluated for their antioxidant activities. The antioxidant activity was assessed using two methods, including, 1,1-biphenyl-2-picrylhydrazyl (DPPH) radical scavenging, and reducing power assays. Some of the benzylidene coumaranones showed antioxidant activity more than Trolox as reference antioxidant
In Vitro Antiplasmodial Activity and Cytotoxic Effect of (Z)-2-Benzylidene-4, 6-Dimethoxybenzofuran-3 (2H)-One Derivatives
Background: Aurones are naturally occurring compounds that belong to flavenoids
family and have antiplasmodial effects. This study investigated some new aurones
derivatives against chloroquine sensitive Plasmodium falciparum. Here we report
the synthesis, in vitro antiplasmodial activity and cytotoxic evaluation of 11 compound
from derivatives of (Z)-2- benzylidene-4, 6-dimethoxybenzofuran-3(2H)-
one.
Methods: The cytotoxic evaluations of active compounds were performed with
MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyltetrazolium bromide) assay on human
breast cancer cell lines; MCF7 and T47D.
Results: From 11 compounds M3, M6 and M7 compounds showed good antiplasmodial
effect against chloroquine-sensitive 3D strain of P. falciparum with IC50
(50% inhibitory concentration) values of 7.82, 7.27 and 2.3 µM respectively. No
noticeable toxicity was observed with these compounds when tested against tested
cell lines.
Conclusion: The replacement of the 4 and 5 positions at ring B of aurone derivatives,
with propoxy and bromide (Br) respectively was revealed highly advantageous
for their antiplasmodial effect
N-[(E)-(5-Methylthiophen-2-yl)methylidene]-1H-1,2,4-triazol-3-amine
In the title Schiff base, C8H8N4S, a condensation product of 5-methylthiophene-2-carboxaldehyde and 3-amino-1,2,4-triazole, the dihedral angle between the triazolyl and thienyl rings is 6.44 (14)°. The compound exists as a polymeric chain arising from intermolecular N—H⋯N bonding
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