Cell Proliferation and Viability Inhibition by Resveratrol on Breast Cancer Cell Lines

Antioxidants are well-known for their various health benefits. They are able to protect cells from being damaged by free radicals that are produced by vital biochemical processes. It has long been known that antioxidants are important in our everyday health, but their potential as disease preventers and potential therapeutic agents is a relatively new field of study. Resveratrol, a natural polyphenol and well-known antioxidant, is found in plants, fruits, and products derived from them, like red wine. Resveratrol has been shown to have various properties, including antiaging, anti-aggregation of platelets, anti-inflammatory, and anticancer activities. Because of their many health benefits, antioxidants have become a hot topic in cancer research. Oxidative stress, which occurs when there is an imbalance between reactive oxygen species (ROS) and antioxidants, has been shown to be a potential cause of cancer development. Our research group tested the effects of resveratrol, vitamins C and E, and the green tea catechin, epigallocatechin gallate (EGCG), on various breast cancer cell lines, though this review will focus on the chemotherapeutic potential of resveratrol. In the experiments, breast cancer MCF-7, MDA-MB-231, BOM 231, and MCF-7-BOM cell lines were treated with various concentrations of resveratrol. A Sulforhodamine B viability assay was used to assess the percent inhibition of resveratrol on each cell line. The experiments showed that resveratrol is an inhibitor of breast cancer cells in a concentration and cell line dependent manner

An Analog Model for Quantum Lightcone Fluctuations in Nonlinear Optics

We propose an analog model for quantum gravity effects using nonlinear dielectrics. Fluctuations of the spacetime lightcone are expected in quantum gravity, leading to variations in the flight times of pulses. This effect can also arise in a nonlinear material. We propose a model in which fluctuations of a background electric field, such as that produced by a squeezed photon state, can cause fluctuations in the effective lightcone for probe pulses. This leads to a variation in flight times analogous to that in quantum gravity. We make some numerical estimates which suggest that the effect might be large enough to be observable.Comment: 15 pages, no figure

UA62 Bowling Green College of Commerce

Brief history of the WKU Gordon Ford College of Business from its creation in 1964 as the Bowling Green College of Commerce through 1969. Includes background history of WKU\u27s departments of business, government, economics, sociology, accounting, business administration and office administration

UA62 Tenth Annual Awards Banquet

Program recognizing WKU Gordon Ford College of Business student award winners. Includes information regarding each scholarship awarded

UA62/2 Grapevine, Vol. 1, No. 1

Newsletter created by the Bowling Green College of Business & Public Affairs which is now the Gordon Ford College of Business

UA62 Grapevine, Vol. I, No. 1

Newsletter created by and about the Bowling Green College of Business & Public Affairs. Jenkins, William. The Dean\u27s Soapbox The Word on the Paper Itself This is US - The Dean\u27s Doings Business Administration Business Education & Office Administration Economics Government Mid-Management & Distributive Education Public Service Institute Sociology & Anthropology The Editor\u27s Rambling

The role of working memory and contextual constraints in children's processing of relative clauses

An auditory sentence comprehension task investigated the extent to which the integration of contextual and structural cues was mediated by verbal memory span with 32 English-speaking 6- to 8-year old children. Spoken relative clause sentences were accompanied by visual context pictures which fully (depicting the actions described within the relative clause) or partially (depicting several referents) met the pragmatic assumptions of relativisation. Comprehension of the main and relative clauses of centre-embedded and right-branching structures was compared for each context. Pragmatically-appropriate contexts exerted a positive effect on relative clause comprehension, but children with higher memory spans demonstrated a further benefit for main clauses. Comprehension for centre-embedded main clauses was found to be very poor, independently of either context or memory span. The results suggest that children have access to adult-like linguistic processing mechanisms, and that sensitivity to extra-linguistic cues is evident in young children and develops as cognitive capacity increases

Brugada Syndrome and Sudden Cardiac Death: An Electrocardiographic History

Case Presentation: A 22-year-old male with a history of anti-neutrophil cytoplasmic antibody vasculitis, renal transplant, hypertension, and no known family history of sudden cardiac death suffered a witnessed cardiac arrest. An initial rhythm strip recorded by emergency medical services revealed ventricular fibrillation. Return of spontaneous circulation was achieved after three rounds of cardiopulmonary resuscitation, defibrillation, and intravenous epinephrine. The patient was brought to the emergency department and admitted to the intensive care unit. He was diagnosed with Brugada syndrome, and an automatic implantable cardioverter-defibrillator (AICD) was placed after discharge. Discussion: Brugada syndrome is characterized electrocardiographically by ≥2 millimeters (mm) ST-segment elevation in leads V1–V2 with either “coved type” (type 1) or “saddleback” (type 2) ST-segment morphology, or ≤2 mm ST-segment elevation in V1–V2 with either “coved” or “saddleback” morphology (type 3). The absence of these patterns on isolated electrocardiograms (ECG) does not exclude the diagnosis, as dynamic fluctuations in ECG patterns are well-documented and can be induced by various physiologic stressors. This case provides an uncommon, complete electrocardiographic history of Brugada syndrome, from out-of-hospital cardiac arrest to AICD placement and depicts dynamic fluctuations between Brugada patterns and normal ECGs. This highlights the importance of serial ECGs in diagnosis, as sudden cardiac death is often the first or only presentation of Brugada syndrome

Changing the way the world thinks about computer security

Small changes in an established system can result in larger changes in the overall system (e.g. network effects, émergence, criticality, broken Windows theory). However, in an immature discipline, such as computer security, such changes can be difficult to envision and even more difficult to amplement, as the immature discipline is likely to lack the scientific framework that would allow for the introduction of even minute changes. (Cairns, P. and Thimbleby, H, 2003) describe three of the signs of an immature discipline as postulated by (Kuhn, 1970): a. squabbles over what are legitimate tools for research b. disagreement over which phenomenon are legitimate to study, and c. inability to scope the domain of study. The research presented in this document demonstrates how the computer security field, at the time this research began, was the embodiment of thèse characteristics. It presents a cohesive analysis of the intentional introduction of a séries of small changes chosen to aid in maturation of the discipline. Summarily, it builds upon existing theory, exploring the combined effect of coordinated and strategie changes in an immature system and establishing a scientific framework by which the impact of the changes can be quantified. By critically examining the nature of the computer security system overall, this work establishes the need for both increased scientific rigor, and a multidisciplinary approach to the global computer security problem. In order for these changes to take place, many common assumptions related to computer security had to be questioned. However, as the discipline was immature, and controlled by relatively few entities, questioning the status quo was not without difficulties. However, in order for the discipline to mature, more feedback into the overall computer security (and in particular, the computer malware/virus) system was needed, requiring a shift from a mostly closed system to one that was forced to undergo greater scrutiny from various other communities. The input from these communities resulted in long-term changes and increased maturation of the system. Figure 1 illustrates the specific areas in which the research presented herein addressed these needs, provides an overview of the research context, and outlines the specific impact of the research, specifically the development of new and significant scientific paradigms within the discipline.EThOS - Electronic Theses Online ServiceGBUnited Kingdo