Lung volume reduction reoperations

BACKGROUND: Optimal management of emphysematous patients who have lost the benefits achieved after lung volume reduction surgery is a clinical dilemma. We have hypothesized that in stringently selected instances, lung volume reduction reoperations might be considered as a salvage surgical treatment. We sought to analyze the results of a series of patients undergoing lung volume reduction reoperations after successful bilateral lung volume reduction surgery. METHODS: Between January 2000 and April 2006, 17 patients (mean age, 66 +/- 3 years) with radiologic evidence of distinct regional lung hyperinflation underwent lung volume reduction reoperations. Surgical procedures entailed completion lobectomy in 7 patients, nonanatomic resection of lung target areas were performed in 5 patients under general anesthesia with one-lung ventilation, and awake lung plication was performed in 5 patients under sole epidural anesthesia. Follow-up at 6 and 12 months was complete in all survivors. RESULTS: Mean operative time was 100 +/- 12 minutes. Two patients (11.7%) died perioperatively of adult respiratory distress syndrome. Hospital stay was 9 +/- 2 days. Significant improvements occurred for up to 12 months in forced expiratory volume in 1 second (FEV(1); p < 0.001), forced vital capacity (p < 0.002), residual volume (p < 0.001), 6-minute walk test (p < 0.001), and modified Medical Research Council dyspnea index (p < 0.001). At 6-months, improvements in FEV(1) were greater than 200 mL in 11 patients and correlated with the postoperative reduction in residual volume (r = -0.62, p = 0.01); baseline residual volume was inversely correlated with the degree of improvement in the dyspnea index (r = -0.54, p = 0.03). CONCLUSIONS: Lung volume reduction reoperations can offer significant clinical improvement to stringently selected patients who have lost the clinical benefit achieved after lung volume reduction surgery

N=1 Chern-Simons theories, orientifolds and Spin(7) cones

We construct three dimensional N=1 Chern-Simons theories living on M2 branes probing Spin(7) cones. We consider Spin(7) manifolds obtained as quotients of Calabi-Yau four-folds by an anti-holomorphic involution, following a construction by Joyce. The corresponding Chern-Simons theories can be obtained from N=2 theories by an orientifolding procedure. These theories are holographically dual to M theory solutions AdS_4 \times H, where the weak G_2 manifold H is the base of the Spin(7) cone.Comment: 26 pages, 3 figures, reference added

Brane Tilings and Specular Duality

We study a new duality which pairs 4d N=1 supersymmetric quiver gauge theories. They are represented by brane tilings and are worldvolume theories of D3 branes at Calabi-Yau 3-fold singularities. The new duality identifies theories which have the same combined mesonic and baryonic moduli space, otherwise called the master space. We obtain the associated Hilbert series which encodes both the generators and defining relations of the moduli space. We illustrate our findings with a set of brane tilings that have reflexive toric diagrams.Comment: 42 pages, 16 figures, 5 table

New Gauged Linear Sigma Models for 8D HyperKahler Manifolds and Calabi-Yau Crystals

We propose two kinds of gauged linear sigma models whose moduli spaces are real eight-dimensional hyperKahler and Calabi-Yau manifolds, respectively. Here, hyperKahler manifolds have sp(2) holonomy in general and are dual to Type IIB (p,q)5-brane configurations. On the other hand, Calabi-Yau fourfolds are toric varieties expressed as quotient spaces. Our model involving fourfolds is different from the usual one which is directly related to a symplectic quotient procedure. Remarkable features in newly-found three-dimensional Chern-Simons-matter theories appear here as well, such as dynamical Fayet-Iliopoulos parameters, one dualized photon and its residual discrete gauge symmetry.Comment: 20 pages, 1 figure; v2: minor changes and references added; v3: statements improved, newer than JHEP versio

Scattering Amplitudes and Toric Geometry

In this paper we provide a first attempt towards a toric geometric interpretation of scattering amplitudes. In recent investigations it has indeed been proposed that the all-loop integrand of planar N=4 SYM can be represented in terms of well defined finite objects called on-shell diagrams drawn on disks. Furthermore it has been shown that the physical information of on-shell diagrams is encoded in the geometry of auxiliary algebraic varieties called the totally non negative Grassmannians. In this new formulation the infinite dimensional symmetry of the theory is manifest and many results, that are quite tricky to obtain in terms of the standard Lagrangian formulation of the theory, are instead manifest. In this paper, elaborating on previous results, we provide another picture of the scattering amplitudes in terms of toric geometry. In particular we describe in detail the toric varieties associated to an on-shell diagram, how the singularities of the amplitudes are encoded in some subspaces of the toric variety, and how this picture maps onto the Grassmannian description. Eventually we discuss the action of cluster transformations on the toric varieties. The hope is to provide an alternative description of the scattering amplitudes that could contribute in the developing of this very interesting field of research.Comment: 58 pages, 25 figures, typos corrected, a reference added, to be published in JHE

M2-Branes and Fano 3-folds

A class of supersymmetric gauge theories arising from M2-branes probing Calabi-Yau 4-folds which are cones over smooth toric Fano 3-folds is investigated. For each model, the toric data of the mesonic moduli space is derived using the forward algorithm. The generators of the mesonic moduli space are determined using Hilbert series. The spectrum of scaling dimensions for chiral operators is computed.Comment: 128 pages, 39 figures, 42 table

The Hilbert Series of the One Instanton Moduli Space

The moduli space of k G-instantons on R^4 for a classical gauge group G is known to be given by the Higgs branch of a supersymmetric gauge theory that lives on Dp branes probing D(p + 4) branes in Type II theories. For p = 3, these (3 + 1) dimensional gauge theories have N = 2 supersymmetry and can be represented by quiver diagrams. The F and D term equations coincide with the ADHM construction. The Hilbert series of the moduli spaces of one instanton for classical gauge groups is easy to compute and turns out to take a particularly simple form which is previously unknown. This allows for a G invariant character expansion and hence easily generalisable for exceptional gauge groups, where an ADHM construction is not known. The conjectures for exceptional groups are further checked using some new techniques like sewing relations in Hilbert Series. This is applied to Argyres-Seiberg dualities.Comment: 43 pages, 22 figure

Counting Exceptional Instantons

We show how to obtain the instanton partition function of N=2 SYM with exceptional gauge group EFG using blow-up recursion relations derived by Nakajima and Yoshioka. We compute the two instanton contribution and match it with the recent proposal for the superconformal index of rank 2 SCFTs with E6, E7 global symmetry.Comment: 16 pages, references adde

Global avian influenza surveillance in wild birds: A strategy to capture viral diversity

Wild birds play a major role in the evolution, maintenance, and spread of avian influenza viruses. However, surveillance for these viruses in wild birds is sporadic, geographically biased, and often limited to the last outbreak virus. To identify opportunities to optimize wild bird surveillance for understanding viral diversity, we reviewed responses to a World Organisation for Animal Health-administered survey, government reports to this organization, articles on Web of Knowledge, and the Influenza Research Database. At least 119 countries conducted avian influenza virus surveillance in wild birds during 2008-2013, but coordination and standardization was lacking among surveillance efforts, and most focused on limited subsets of influenza viruses. Given high financial and public health burdens of recent avian influenza outbreaks, we call for sustained, cost-effective investments in locations with high avian influenza diversity in wild birds and efforts to promote standardized sampling, testing, and reporting methods, including full-genome sequencing. (Résumé d'auteur