Oils and fats on food: is it possible to have a healthy diet?

Oils and fats are an important part of our diet as components of many food formulations. Thus, they are retailed for domestic or hostelry uses and broadly used by food industry for the elaboration of margarines, ice cream, canned food, pre-cooked dishes, bakery, confectionary, chocolates, etc. Chemically, the main component of oils and fats are triacylglycerols (TAGs), which account for up to 95% of their total weight. They consisted of a molecule of glycerol esterified with three fatty acids, usually the saturated, palmitic and stearic, the monounsatu�rated oleic, and the polyunsaturated, linoleic or linolenic, all with 18 carbons excepting the palmitic which has 16 carbons. Out of those most common fatty acids, we can found other fatty acids present only in certain oils such as saturated medium chained fatty acids like lauric and myristic, which contain 12 and 14 carbons respectively

Oils and fats on food: is it possible to have a healthy diet?

Oils and fats are an important part of our diet as components of many food formulations. Thus, they are retailed for domestic or hostelry uses and broadly used by food industry for the elaboration of margarines, ice cream, canned food, pre-cooked dishes, bakery, confectionary, chocolates, etc. Chemically, the main component of oils and fats are triacylglycerols (TAGs), which account for up to 95% of their total weight. They consisted of a molecule of glycerol esterified with three fatty acids, usually the saturated, palmitic and stearic, the monounsatu�rated oleic, and the polyunsaturated, linoleic or linolenic, all with 18 carbons excepting the palmitic which has 16 carbons. Out of those most common fatty acids, we can found other fatty acids present only in certain oils such as saturated medium chained fatty acids like lauric and myristic, which contain 12 and 14 carbons respectively

Serine 58 of 14-3-3ζ Is a molecular switch regulating ASK1 and oxidant stress-induced cell death

Oxidant stress is a ubiquitous stressor with negative impacts on multiple cell types. ASK1 is a central mediator of oxidant injury, but while mechanisms of its inhibition, such as sequestration by 14-3-3 proteins and thioredoxin, have been identified, mechanisms of activation have remained obscure and the signaling pathways regulating this are not clear. Here, we report that phosphorylation of 14-3-3ζ at serine 58 (S58) is dynamically regulated in the cell and that the phosphorylation status of S58 is a critical factor regulating oxidant stress-induced cell death. Phosphorylation of S58 releases ASK1 from 14-3-3ζ, and ASK1 then activates stress-activated protein kinases, leading to cell death. While several members of the mammalian sterile 20 (Mst) family of kinases can phosphorylate S58 when overexpressed, we identify Ste20/oxidant stress response kinase 1 (SOK-1), an Mst family member known to be activated by oxidant stress, as a central endogenous regulator of S58 phosphorylation and thereby of ASK1-mediated cell death. Our findings identify a novel pathway that regulates ASK1 activation and oxidant stress-induced cell death

Geologic Evolution of Trail Ridge Eolian Heavy-Mineral Sand and Underlying Peat, Northern Florida

The southern portion of Trail Ridge in Clay County, Fla., has been an important domestic source of altered ilmenite, zircon, and other minerals since 1949. The ridge as a physiographic feature extends in a north-south direction over 160 km and is 1 to 2 km wide. The ore is a fine- to medium-grained sand body that extends down from the crest of the ridge about 20 m. Average heavy-mineral content is about 4 percent. Over half of the ilmenite and zircon is contained in thin, dark laminae dipping 26° to 41 ° southwest; these laminae extend deep within the ore and outline the slip faces of a great eolian dune complex. The subordinate dark laminae differ in heavy mineralogy and grain size from the encasing light-colored sand. The dark laminae have a modal grain size of 0.2 mm and average about 6 percent heavy minerals, among which altered ilmenite, zircon, and rutile predominate. The light-colored laminae have a coarser modal grain size of 0.3 mm and average only 1 percent heavy minerals, among which the lighter heavy minerals staurolite, sillimanite, and tourmaline form half. Grain size variables and grain surfaces are appropriate for eolian sand. Over­printed on these original features of the dune are a surficial weathering zone over 3 m thick, where tan leucoxene takes the place of black altered ilmenite, and several underlying humate-cemented zones that probably represent water-table stillstands. The immediately underlying unit is a lignitic peaty layer 1.5 m thick, here referred to as peat. The organic fraction is derived entirely from freshwater plants. In-place tree stumps have been noted, but the predominant component of the peat is fragments of wood and other transported plant debris. The peat and its constituents indicate depo­sition in a swamp environment, and local horizons enriched with charcoal and fungal remains indicate periodic subaerial exposure. Vegetation varied from open shrub swamp to cypress forest. The age of the peat has been determined palynologically as post­Miocene. Its carbon-14 age is greater than 4.5 x 104 years; that is, pre-latest Pleistocene. The upper portion of the peat layer contains admixtures of sand. This sand is present as isolated grains embedded in laminated organic matrix and is dominantly well rounded and frosted. As a grain population, the sand in the peat matches the overlying Trail Ridge ore sand in mineralogy and grain morphology but is slightly finer in grain size. This sand we regard as an important clue to the history of the area. The sand was apparently deposited from aerial suspension, and its characteristics were acquired in the adjacent high-energy eolian environment. Upward increase of sand in peat records the approach of the dune that eventually prograded the swamp. The peat and the overlying sand are essentially the same age. Fine sand found in peat represents the sand fraction remaining suspended in flow separation at the top of the slip face of the dune. Ore represents the traction-load fraction. The Trail Ridge dune itself is probably the drainage dam that impounded the swamp it later overrode. The sand embedded in peat is also an important clue to the weath­ering history of Trail Ridge heavy minerals, as entombment in peat probably arrested oxidation. The presence of leucoxene, and other features of the mineral assemblage, shows that the minerals were already weathered at deposition. This evidence is in accord with grain-surface features and grain-size-density relations. Thus, mineral alteration at Trail Ridge occurred in two stages, one before and one after deposition. Trail Ridge apparently represents a coast-parallel transgressive dune complex, analogous to younger dunes elsewhere that have become completely decoupled from parental shorelines. The Trail Ridge body was probably composite, made up of individual parabolic dunes, each migrating southwestward. The base of the Trail Ridge body was probably originally higher at the southern end than at the northern end

Systematic review of psychological approaches to the management of neuropsychiatric symptoms of dementia

Objective: The authors systematically reviewed the literature on psychological approaches to treating the neuropsychiatric symptoms of dementia.Method: Reports of studies that examined effects of any therapy derived from a psychological approach that satisfied prespecified criteria were reviewed. Data were extracted, the quality of each study was rated, and an overall rating was given to each study by using the Oxford Centre for Evidence-Based Medicine criteria.Results: A total of 1,632 studies were identified, and 162 satisfied the inclusion criteria for the review. Specific types of psychoeducation for caregivers about managing neuropsychiatric symptoms were effective treatments whose benefits lasted for months, but other caregiver interventions were not. Behavioral management techniques that are centered on individual patients' behavior or on caregiver behavior had similar benefits, as did cognitive stimulation. Music therapy and Snoezelen, and possibly sensory stimulation, were useful during the treatment session but had no longer-term effects; interventions that changed the visual environment looked promising, but more research is needed.Conclusions: Only behavior management therapies, specific types of caregiver and residential care staff education, and possibly cognitive stimulation appear to have lasting effectiveness for the management of dementia-associated neuropsychiatric symptoms. Lack of evidence regarding other therapies is not evidence of lack of efficacy. Conclusions are limited because of the paucity of high-quality research ( only nine level-1 studies were identified). More high-quality investigation is needed

Monitoring asthma in childhood : symptoms, exacerbations and quality of life

Acknowledgements The Task Force members and their affiliations are as follows. Paul L.P. Brand: Princess Amalia Children’s Centre, Isala Hospital, Zwolle, and UMCG Postgraduate School of Medicine, University Medical Centre and University of Groningen, Groningen, The Netherlands; Mika J. Mäkelä: Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland; Stanley J. Szefler: Children’s Hospital Colorado and University of Colorado Denver School of Medicine, Denver, CO, USA; Thomas Frischer: Dept of Paediatrics and Paediatric Surgery, Wilhelminenspital, Vienna, Austria; David Price: Dept of Primary Care Respiratory Medicine, Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UK; Eugenio Baraldi: Women’s and Children’s Health Dept, Unit of Respiratory Medicine and Allergy, University of Padova, Padova, Italy; Kai-Hakon Carlsen: Dept of Paediatrics, Women and Children’s Division, University of Oslo, and Oslo University Hospital, Oslo, Norway; Ernst Eber: Respiratory and Allergic Disease Division, Dept of Paediatrics and Adolescence Medicine, Medical University of Graz, Graz, Austria; Gunilla Hedlin: Dept of Women’s and Children’s Health and Centre for Allergy Research, Karolinska Institutet, and Astrid Lindgren Children’s hospital, Stockholm, Sweden; Neeta Kulkarni: Leicestershire Partnership Trust and Dept of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK; Christiane Lex: Dept of Paediatric Cardiology and Intensive Care Medicine, Division of Paediatric Respiratory Medicine, University Hospital Goettingen, Goettingen, Germany; Karin C. Lødrup Carlsen: Dept of Paediatrics, Women and Children’s Division, Oslo University Hospital, and Dept of Paediatrics, Faculty of Medicine, University of Oslo, Oslo, Norway; Eva Mantzouranis: Dept of Paediatrics, University Hospital of Heraklion, University of Crete, Heraklion, Greece; Alexander Moeller: Division of Respiratory Medicine, University Children’s Hospital Zurich, Zurich, Switzerland; Ian Pavord: Dept of Respiratory Medicine, University of Oxford, Oxford, UK; Giorgio Piacentini: Paediatric Section, Dept of Life and Reproduction Sciences, University of Verona, Verona, Italy; Mariëlle W. Pijnenburg: Dept Paediatrics/Paediatric Respiratory Medicine, Erasmus MC - Sophia Children’s Hospital, Rotterdam, The Netherlands; Bart L. Rottier: Dept of Pediatric Pulmonology and Allergology, GRIAC Research Institute, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Sejal Saglani: Leukocyte Biology and Respiratory Paediatrics, National Heart and Lung Institute, Imperial College London, London, UK; Peter D. Sly: Queensland Children’s Medical Research Institute, The University of Queensland, Brisbane, Australia; Steve Turner: Dept of Paediatrics, University of Aberdeen, Aberdeen, UK; Edwina Wooler: Royal Alexandra Children’s Hospital, Brighton, UK.Peer reviewedPublisher PD

Verification of computer-aided designs of traveling-wave tubes utilizing novel dynamic refocusers and graphite electrodes for the multistage depressed collector

A computational procedure for the design of TWT-refocuser-MDC systems was used to design a short dynamic refocusing system and highly efficient four-stage depressed collector for a 200-W, 8- to 18-GHz, TWT. The computations were carried out with advanced, multidimensional computer programs which model the electron beam as a series of disks of charge and follow their trajectories from the RF input of the TWT, through the slow-wave structure and refocusing section, to their points of impact in the depressed collector. Secondary emission losses in the MDC were treated semi-quantitatively by injecting a representative beam of secondary electrons into the MDC analysis at the point of impact of each primary beam. A comparison of computed and measured TWT and MDC performance showed very good agreement. The electrodes of the MDC were fabricated from a particular form of isotropic graphite that was selected for its low secondary electron yield, ease of machinability, and vacuum properties. This MDC was tested (at CW) for more than 1000 hr with negligible degradation in TWT and MDC performances

Combined Global Navigation Satellite Systems in the Space Service Volume

Besides providing position, navigation, and timing (PNT) services to traditional terrestrial and airborne users, GPS is also being increasingly used as a tool to enable precision orbit determination, precise time synchronization, real-time spacecraft navigation, and three-axis attitude control of Earth orbiting satellites. With additional Global Navigation Satellite System (GNSS) constellations being replenished and coming into service (GLONASS, Beidou, and Galileo), it will become possible to benefit from greater signal availability and robustness by using evolving multi-constellation receivers. The paper, "GPS in the Space Service Volume," presented at the ION GNSS 19th International Technical Meeting in 2006 (Ref. 1), defined the Space Service Volume, and analyzed the performance of GPS out to seventy thousand kilometers. This paper will report a similar analysis of the signal coverage of GPS in the space domain; however, the analyses will also consider signal coverage from each of the additional GNSS constellations noted earlier to specifically demonstrate the expected benefits to be derived from using GPS in conjunction with other foreign systems. The Space Service Volume is formally defined as the volume of space between three thousand kilometers altitude and geosynchronous altitude circa 36,000 km, as compared with the Terrestrial Service Volume between 3,000 km and the surface of the Earth. In the Terrestrial Service Volume, GNSS performance is the same as on or near the Earth's surface due to satellite vehicle availability and geometry similarities. The core GPS system has thereby established signal requirements for the Space Service Volume as part of technical Capability Development Documentation (CDD) that specifies system performance. Besides the technical discussion, we also present diplomatic efforts to extend the GPS Space Service Volume concept to other PNT service providers in an effort to assure that all space users will benefit from the enhanced interoperability of GNSS services in the space domain. A separate paper presented at the conference covers the individual GNSS performance parameters for respective Space Service Volumes