Quaternary warping at Gorge Saddle, western Southland

Gorge Saddle is one low point on a drainage divide between Fiordland and the Southland Plain. Eastward sloping Quaternary terraces east of the divide and westward sloping terraces to the west contain granitic pebbles which could have been derived only from the west. This suggests doming at the present divide concurrent with transport from the west

Sea-cliff Erosion with Rising Sea-Level along Shores Exposing Glacial Material in Atlantic Canada: The Effect of Bedrock Slope and an Example from Isle Madame, Nova Scotia

Rapid retreat rates of sea cliffs exposing glacial material are a widespread problem, especially in Atlantic Canada, and one that will continue. Prediction of retreat rates at specific sites involves many variables, but a factor that has commonly been overlooked in such prediction is the slope of the bedrock surface under the glacial material. A glaciated bedrock platform is generally necessary to establish a stable situation of temporary equilibrium, and as sea-level rises, the bedrock slope determines the location of the new equilibrium position. An example from Nova Scotia shows that bedrock slope is so low on some coasts that the only long-range limiting factor is kinetic, i.e. how fast hydrodynamic energy can remove glacial material. Prediction of coastal retreat scenarios requires better information on the bedrock surface than is commonly available.SOMMAIRELes taux de retrait rapide des falaises qui exposent des matériaux glaciaires est un problème très répandu et qui va perdurer, surtout dans le Canada atlantique. La prévision des taux de retrait sur des sites spécifiques comporte de nombreuses variables et, la pente du substratum rocheux sur lequel reposent ces matériaux glaciaires et une variable qui a souvent été négligée. L’existence d’un substratum rocheux glacié est généralement une condition nécessaire pour l’établissement d’une situation d'équilibre stable temporaire, et lorsque le niveau de la mer monte, la pente du substratum rocheux a une influence déterminante sur le lieu de la nouvelle position d'équilibre. Un exemple en Nouvelle-Écosse montre que la pente du substratum rocheux est si faible sur certaines côtes que le seul facteur déterminant à long terme est la cinétique, c'est-à-dire la vitesse d’abrasion du matériau glaciaire correspondant à l’énergie hydrodynamique. La prévision des scénarios de retrait de la ligne côtière requière une meilleure connaissance du substratum rocheux.

Provenance of the Lower Carboniferous Horton Group, Petit-de-Grat Island, Nova Scotia, as revealed by detrital zircon ages

A quartz sandstone bed in a dominantly conglomeratic section in the central part of the Lower Carboniferous Horton Group on Petit-de-Grat Island, offshore southern Cape Breton Island, Nova Scotia, contains detrital zircon grains with ages ranging from mid-Devonian to Archean. The similarity of the Devonian and Neoproterozoic age spectrum to ages of igneous units in the adjacent Avalonian Mira terrane, in particular the Coastal belt, indicates that it was the main source area. This interpretation is supported by the similarity of the Neoproterozoic and older detrital zircon age spectrum to that of the detrital zircon age spectrum in a Cambrian sandstone unit from the Mira terrane. This interpretation indicates post-depositional dextral fault motion between the Isle Madame area and the Coastal belt.RésuméUne couche de grès quartzeux repérée dans une section principalement conglomératique dans la partie centrale du groupe de Horton du Carbonifère inférieur sur l’île Petit-de-Grat, au sud de l’île du Cap-Breton, en Nouvelle- Écosse, contient des grains de zircon détritique dont l’âge va du Dévonien moyen à l’Archéen. La similitude du spectre d’âge du Dévonien et du Néoprotérozoïque avec celui des unités ignées trouvées dans le terrane Mira d’Avalon adjacent, en particulier la ceinture côtière, indique qu’il s’agit de la région source principale. Cette interprétation est étayée par la similitude du spectre d’âge du zircon détritique du Néoprotérozoïque et de périodes plus anciennes avec celui du zircon détritique trouvé dans une unité de grès du Cambrien provenant du terrane Mira. Cette interprétation indique un mouvement postsédimentaire d’une faille dextre entre la région de l’île Madame et la ceinture côtière.[Traduit par la redaction

Optometric Measurements Predict Performance but Not Comfort on a Virtual Object Placement Task With a Stereoscopic 3D Display

Twelve participants were tested on a simple virtual object precision placement task while viewing a stereoscopic 3D (S3D) display. Inclusion criteria included uncorrected or best corrected vision of 20/20 or better in each eye and stereopsis of at least 40 arc sec using the Titmus stereo test. Additionally, binocular function was assessed, including measurements of distant and near phoria (horizontal and vertical) and distant and near horizontal fusion ranges using standard optometric clinical techniques. Before each of six 30 minute experimental sessions, measurements of phoria and fusion ranges were repeated using a Keystone View Telebinocular and an S3D display, respectively. All participants completed experimental sessions in which the task required the precision placement of a virtual object in depth at the same location as a target object. Subjective discomfort was assessed using the Simulator Sickness Questionnaire (SSQ). Individual placement accuracy in S3D trials was significantly correlated with several of the binocular screening outcomes: viewers with larger convergent fusion ranges (measured at near distance), larger total fusion ranges (convergent plus divergent ranges, measured at near distance), and/or lower (better) stereoscopic acuity thresholds were more accurate on the placement task. No screening measures were predictive of subjective discomfort, perhaps due to the low levels of discomfort induced

Study of 124^{124}Sn+136^{136}Xe fusion-evaporation: analysis of a rare-event experiment

7 pages, 4 figuresFusion-evaporation in the $^{124}$Sn+$^{136}$Xe system is studied using a high intensity xenon beam provided by the Ganil accelerator and the LISE3 wien filter for the selection of the products. Due to the mass symmetry of the entrance system, the rejection of the beam by the spectrometer was of the order of $5times10^8$. We have thus performed a detailed statistical analysis to estimate random events and to infer the fusion-evaporation cross sections. No signicant decay events were detected and upper limit cross sections of 172~pb, 87~pb and 235~pb were deduced for the synthesis of $^{257}$Rf, $^{258}$Rf and $^{259}$Rf, respectively

TBCRC 039: a phase II study of preoperative ruxolitinib with or without paclitaxel for triple-negative inflammatory breast cancer

Background Patients with inflammatory breast cancer (IBC) have overall poor clinical outcomes, with triple-negative IBC (TN-IBC) being associated with the worst survival, warranting the investigation of novel therapies. Preclinical studies implied that ruxolitinib (RUX), a JAK1/2 inhibitor, may be an effective therapy for TN-IBC. Methods We conducted a randomized phase II study with nested window-of-opportunity in TN-IBC. Treatment-naïve patients received a 7-day run-in of RUX alone or RUX plus paclitaxel (PAC). After the run-in, those who received RUX alone proceeded to neoadjuvant therapy with either RUX + PAC or PAC alone for 12 weeks; those who had received RUX + PAC continued treatment for 12 weeks. All patients subsequently received 4 cycles of doxorubicin plus cyclophosphamide prior to surgery. Research tumor biopsies were performed at baseline (pre-run-in) and after run-in therapy. Tumors were evaluated for phosphorylated STAT3 (pSTAT3) by immunostaining, and a subset was also analyzed by RNA-seq. The primary endpoint was the percent of pSTAT3-positive pre-run-in tumors that became pSTAT3-negative. Secondary endpoints included pathologic complete response (pCR). Results Overall, 23 patients were enrolled, of whom 21 completed preoperative therapy. Two patients achieved pCR (8.7%). pSTAT3 and IL-6/JAK/STAT3 signaling decreased in post-run-in biopsies of RUX-treated samples, while sustained treatment with RUX + PAC upregulated IL-6/JAK/STAT3 signaling compared to RUX alone. Both treatments decreased GZMB+ T cells implying immune suppression. RUX alone effectively inhibited JAK/STAT3 signaling but its combination with PAC led to incomplete inhibition. The immune suppressive effects of RUX alone and in combination may negate its growth inhibitory effects on cancer cells. Conclusion In summary, the use of RUX in TN-IBC was associated with a decrease in pSTAT3 levels despite lack of clinical benefit. Cancer cell-specific-targeting of JAK2/STAT3 or combinations with immunotherapy may be required for further evaluation of JAK2/STAT3 signaling as a cancer therapeutic target.Trial registrationwww.clinicaltrials.gov, NCT02876302. Registered 23 August 2016

The Five AhMTP1 Zinc Transporters Undergo Different Evolutionary Fates towards Adaptive Evolution to Zinc Tolerance in Arabidopsis halleri

Gene duplication is a major mechanism facilitating adaptation to changing environments. From recent genomic analyses, the acquisition of zinc hypertolerance and hyperaccumulation characters discriminating Arabidopsis halleri from its zinc sensitive/non-accumulator closest relatives Arabidopsis lyrata and Arabidopsis thaliana was proposed to rely on duplication of genes controlling zinc transport or zinc tolerance. Metal Tolerance Protein 1 (MTP1) is one of these genes. It encodes a Zn2+/H+ antiporter involved in cytoplasmic zinc detoxification and thus in zinc tolerance. MTP1 was proposed to be triplicated in A. halleri, while it is present in single copy in A. thaliana and A. lyrata. Two of the three AhMTP1 paralogues were shown to co-segregate with zinc tolerance in a BC1 progeny from a cross between A. halleri and A. lyrata. In this work, the MTP1 family was characterized at both the genomic and functional levels in A. halleri. Five MTP1 paralogues were found to be present in A. halleri, AhMTP1-A1, -A2, -B, -C, and -D. Interestingly, one of the two newly identified AhMTP1 paralogues was not fixed at least in one A. halleri population. All MTP1s were expressed, but transcript accumulation of the paralogues co-segregating with zinc tolerance in the A. halleri X A. lyrata BC1 progeny was markedly higher than that of the other paralogues. All MTP1s displayed the ability to functionally complement a Saccharomyces cerevisiæ zinc hypersensitive mutant. However, the paralogue showing the least complementation of the yeast mutant phenotype was one of the paralogues co-segregating with zinc tolerance. From our results, the hypothesis that pentaplication of MTP1 could be a major basis of the zinc tolerance character in A. halleri is strongly counter-balanced by the fact that members of the MTP1 family are likely to experience different evolutionary fates, some of which not concurring to increase zinc tolerance

The Mock LISA Data Challenges: from Challenge 1B to Challenge 3

The Mock LISA Data Challenges are a programme to demonstrate and encourage the development of LISA data-analysis capabilities, tools and techniques. At the time of this workshop, three rounds of challenges had been completed, and the next was about to start. In this article we provide a critical analysis of entries to the latest completed round, Challenge 1B. The entries confirm the consolidation of a range of data-analysis techniques for Galactic and massive--black-hole binaries, and they include the first convincing examples of detection and parameter estimation of extreme--mass-ratio inspiral sources. In this article we also introduce the next round, Challenge 3. Its data sets feature more realistic waveform models (e.g., Galactic binaries may now chirp, and massive--black-hole binaries may precess due to spin interactions), as well as new source classes (bursts from cosmic strings, isotropic stochastic backgrounds) and more complicated nonsymmetric instrument noise.Comment: 20 pages, 3 EPS figures. Proceedings of the 12th Gravitational Wave Data Analysis Workshop, Cambridge MA, 13--16 December 2007. Typos correcte

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts