Fast and Accurate Retrieval of Methane Concentration From Imaging Spectrometer Data Using Sparsity Prior

The strong radiative forcing by atmospheric methane has stimulated interest in identifying natural and anthropogenic sources of this potent greenhouse gas. Point sources are important targets for quantification, and anthropogenic targets have the potential for emissions reduction. Methane point-source plume detection and concentration retrieval have been previously demonstrated using data from the Airborne Visible InfraRed Imaging Spectrometer-Next Generation (AVIRIS-NG). Current quantitative methods have tradeoffs between computational requirements and retrieval accuracy, creating obstacles for processing real-time data or large data sets from flight campaigns. We present a new computationally efficient algorithm that applies sparsity and an albedo correction to matched the filter retrieval of trace gas concentration path length. The new algorithm was tested using the AVIRIS-NG data acquired over several point-source plumes in Ahmedabad, India. The algorithm was validated using the simulated AVIRIS-NG data, including synthetic plumes of known methane concentration. Sparsity and albedo correction together reduced the root-mean-squared error of retrieved methane concentration-path length enhancement by 60.7% compared with a previous robust matched filter method. Background noise was reduced by a factor of 2.64. The new algorithm was able to process the entire 300 flight line 2016 AVIRIS-NG India campaign in just over 8 h on a desktop computer with GPU acceleration

Fast and Accurate Retrieval of Methane Concentration from Imaging Spectrometer Data Using Sparsity Prior

The strong radiative forcing by atmospheric methane has stimulated interest in identifying natural and anthropogenic sources of this potent greenhouse gas. Point sources are important targets for quantification, and anthropogenic targets have potential for emissions reduction. Methane point source plume detection and concentration retrieval have been previously demonstrated using data from the Airborne Visible InfraRed Imaging Spectrometer Next Generation (AVIRIS-NG). Current quantitative methods have tradeoffs between computational requirements and retrieval accuracy, creating obstacles for processing real-time data or large datasets from flight campaigns. We present a new computationally efficient algorithm that applies sparsity and an albedo correction to matched filter retrieval of trace gas concentration-pathlength. The new algorithm was tested using AVIRIS-NG data acquired over several point source plumes in Ahmedabad, India. The algorithm was validated using simulated AVIRIS-NG data including synthetic plumes of known methane concentration. Sparsity and albedo correction together reduced the root mean squared error of retrieved methane concentration-pathlength enhancement by 60.7% compared with a previous robust matched filter method. Background noise was reduced by a factor of 2.64. The new algorithm was able to process the entire 300 flightline 2016 AVIRIS-NG India campaign in just over 8 hours on a desktop computer with GPU acceleration.Comment: 13 pages, 11 figure

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis

A "Candidate-Interactome" Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis

Though difficult, the study of gene-environment interactions in multifactorial diseases is crucial for interpreting the relevance of non-heritable factors and prevents from overlooking genetic associations with small but measurable effects. We propose a “candidate interactome” (i.e. a group of genes whose products are known to physically interact with environmental factors that may be relevant for disease pathogenesis) analysis of genome-wide association data in multiple sclerosis. We looked for statistical enrichment of associations among interactomes that, at the current state of knowledge, may be representative of gene-environment interactions of potential, uncertain or unlikely relevance for multiple sclerosis pathogenesis: Epstein-Barr virus, human immunodeficiency virus, hepatitis B virus, hepatitis C virus, cytomegalovirus, HHV8-Kaposi sarcoma, H1N1-influenza, JC virus, human innate immunity interactome for type I interferon, autoimmune regulator, vitamin D receptor, aryl hydrocarbon receptor and a panel of proteins targeted by 70 innate immune-modulating viral open reading frames from 30 viral species. Interactomes were either obtained from the literature or were manually curated. The P values of all single nucleotide polymorphism mapping to a given interactome were obtained from the last genome-wide association study of the International Multiple Sclerosis Genetics Consortium & the Wellcome Trust Case Control Consortium, 2. The interaction between genotype and Epstein Barr virus emerges as relevant for multiple sclerosis etiology. However, in line with recent data on the coexistence of common and unique strategies used by viruses to perturb the human molecular system, also other viruses have a similar potential, though probably less relevant in epidemiological terms

A “Candidate-Interactome” Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis

Though difficult, the study of gene-environment interactions in multifactorial diseases is crucial for interpreting the relevance of non-heritable factors and prevents from overlooking genetic associations with small but measurable effects. We propose a "candidate interactome" (i.e. a group of genes whose products are known to physically interact with environmental factors that may be relevant for disease pathogenesis) analysis of genome-wide association data in multiple sclerosis. We looked for statistical enrichment of associations among interactomes that, at the current state of knowledge, may be representative of gene-environment interactions of potential, uncertain or unlikely relevance for multiple sclerosis pathogenesis: Epstein-Barr virus, human immunodeficiency virus, hepatitis B virus, hepatitis C virus, cytomegalovirus, HHV8-Kaposi sarcoma, H1N1-influenza, JC virus, human innate immunity interactome for type I interferon, autoimmune regulator, vitamin D receptor, aryl hydrocarbon receptor and a panel of proteins targeted by 70 innate immune-modulating viral open reading frames from 30 viral species. Interactomes were either obtained from the literature or were manually curated. The P values of all single nucleotide polymorphism mapping to a given interactome were obtained from the last genome-wide association study of the International Multiple Sclerosis Genetics Consortium & the Wellcome Trust Case Control Consortium, 2. The interaction between genotype and Epstein Barr virus emerges as relevant for multiple sclerosis etiology. However, in line with recent data on the coexistence of common and unique strategies used by viruses to perturb the human molecular system, also other viruses have a similar potential, though probably less relevant in epidemiological terms