O MUNDO DO TRABALHO NA CÂMARA ESCURA – FOTOGRAFIA E HISTÓRIA

A produção de imagens de si mesma, da natureza que a cerca, de sonhos e de pesadelos constitui um dos traços mais fortes e mais primitivos da humanidade. Traços, desenhos, pinturas, esculturas, gravuras, decorações, tecidos... Diferentes formas de ver-se ou de ocultar-se fazem parte de repertórios imagéticos com suportes, formas, cores e padrões dos mais variados

FORMAÇÃO DOS TRABALHADORES E LUTA DE CLASSES

Tece considerações sobre processos de formação e de educação para a classe trabalhadora em sociedades capitalistas, voltados para a inserção no mercado de trabalho (formação para o capital), deseducadores e des-formadores. Destaca as formas de ingerência empresarial direta e indireta na educação pública brasileira. Apresenta a Educação do Campo como experiência original, capaz de apontar possibilidades para a educação-formação da classe trabalhadora, com elaboração, formulação e execução paralelas à organização da própria classe e estreita conexão entre ensino e pesquisa

AS LUTAS DE CLASSES VISTAS PELO SEU AVESSO: A subversão reacionária

Partindo da categoria gramsciana de subalterno, pretendemos mostrar como os aparelhos privados de hegemonia das classes dominantes incidem sobre a educação e formação político-intelectual das classes trabalhadoras do campo e da cidade, com vistas a sua conformação psicofísica. Deste modo, olhando pelo avesso, isto é, através da observação das práticas dos dominantes, podemos supor que o que se afigura como fragmentação das classes subalternas é a forma concreta atual da sujeição do trabalho ao capital. Deste modo, abordar o processo histórico atual através da subalternização (com seu lastro de hierarquias, expropriações, exploração, opressões e devastação da natureza) permite a abertura de um ângulo de visão importante para a definição tanto das condições objetivas quanto subjetivas da constituição e lutas das classes subalternas

BRICS e capital-imperialismo-novas contradições em debate

The understanding of the emergence of a group of countries like the BRICS requests a broader reflection on the transformations of contemporary capitalism and the resulting explanation of new contradictions on the economical, political and, specially, social field. We present a set of features which we call capital-imperialism. We assume that the analyses of the various national contexts need to incorporate both the action of internal social sectors, as its growing internationalization.A compreensão da emergência de um grupo de países tal como os BRICS solicita reflexão mais ampla sobre as transformações do capitalismo contemporâneoe da consequente explicitação de novas contradições no âmbito econômico, político e, sobretudo, social. Apresentamos um conjunto de características do que designamos capitalimperialismo. Pressupomos que as análises sobre os diversos contextos nacionais precisam incorporar tanto a atuação dos setores sociais internos como sua crescente internacionalização

Expression of genes controlling fat deposition in two genetically diverse beef cattle breeds fed high or low silage diets

Articles in International JournalsBackground: Both genetic background and finishing system can alter fat deposition, thus indicating their influence on adipogenic and lipogenic factors. However, the molecular mechanisms underlying fat deposition and fatty acid composition in beef cattle are not fully understood. This study aimed to assess the effect of breed and dietary silage level on the expression patterns of key genes controlling lipid metabolism in subcutaneous adipose tissue (SAT) and longissimus lumborum (LL) muscle of cattle. To that purpose, forty bulls from two genetically diverse Portuguese bovine breeds with distinct maturity rates, Alentejana and Barrosã, were selected and fed either low (30% maize silage/70% concentrate) or high silage (70% maize silage/30% concentrate) diets. Results: The results suggested that enhanced deposition of fatty acids in the SAT from Barrosã bulls, when compared to Alentejana, could be due to higher expression levels of lipogenesis (SCD and LPL) and β-oxidation (CRAT) related genes. Our results also indicated that SREBF1 expression in the SAT is increased by feeding the low silage diet. Together, these results point out to a higher lipid turnover in the SAT of Barrosã bulls when compared to Alentejana. In turn, lipid deposition in the LL muscle is related to the expression of adipogenic (PPARG and FABP4) and lipogenic (ACACA and SCD) genes. The positive correlation between ACACA expression levels and total lipids, as well trans fatty acids, points to ACACA as a major player in intramuscular deposition in ruminants. Moreover, results reinforce the role of FABP4 in intramuscular fat development and the SAT as the major site for lipid metabolism in ruminants. Conclusions: Overall, the results showed that SAT and LL muscle fatty acid composition are mostly dependent on the genetic background. In addition, dietary silage level impacted on muscle lipid metabolism to a greater extent than on that of SAT, as evaluated by gene expression levels of adipogenic and lipogenic factors. Moreover, the response to diet composition evaluated through mRNA levels and fatty acid composition showed interesting differences between Alentejana and Barrosã bulls. These findings provide evidence that the genetic background should be taken into account while devising diet-based strategies to manipulate fatty acid composition of beef cattle tissues

Quantitative correlation between transcriptional levels of ER chaperone, peroximal protein and FVIII productivity in human Hek-293 cell line

Hek-293 cell line presents good production platform for recombinant therapeutic proteins, however little is known about the components that contribute to the cellular control of recombinant protein production. In this study, we generated a Hek-293 producing recombinant factor VIII (FVIII) and we evaluated the immunoglobulin-binding protein (BiP) and phytanoil-CoA α-hydroxylase (PAHX) expression levels which are known for diminishing FVIII production. Our analyses showed that the recombinant cell population expresses 3.1 ± 1.4 fold of BIP mRNA (P = 0.0054) and 97.8 ± 0.5 fold of PAHX mRNA (P = 0.0016) compared to nontransduced cells. The amount of these proteins was inversely correlated to the secreted FVIII. In conclusion, BIP and PAHX expression are augmented in human cells producing FVIII and they antagonize the amount of therapeutic factor VIII in the cell culture.This study was supported by the Center for Cell-based Therapy (CTC) and Fundação de Amparo à Pesquisa do Estado de São Paulo – FAPESP. The authors acknowledge Dr. Garry P. Nolan for contributing with the pBMN-I-GFP vector and David Marco Antonio for statistical support. We thank Fernanda Udinal and Alessandra Almeida for English language support. We also thank Sandra Navarro Bresciani for preparing the figures.This study was supported by the Center for Cellbased Therapy (CTC) and Fundação de Amparo à Pesquisa do Estado de São Paulo – FAPESP. The authors acknowledge Dr. Garry P. Nolan for contributing with the pBMNIGFP vector and David Marco Antonio for statistical support. We thank Fernanda Udinal and Alessandra Almeida for English language support. We also thank Sandra Navarro Bresciani for preparing the figures

State, State Institutions, and Political Power in Brazil

The political conflicts during the Workers’ Party administrations led by Luís Inácio Lula da Silva and Dilma Rousseff have been driven by disputes between two fractions of the country’s bourgeoisie: the internal and the internationalized bourgeoisie. Their ideologies, policies, institutions, and forms of political representation have determined government policies and outcomes. These processes have unfolded within an authoritarian democracy whose structures have not been challenged by the party. The party’s limited power and continuing timidity have produced an aggressive reaction by the internationalized bourgeoisie and the upper middle class, leading to a severe crisis in the administration of President Dilma Rousseff