Transforming Yekaterinburg into a Safe, Resilient-Smart and Sustainable City

The initiative (since 2014) project described in this paper is a product of a joint innovative research and implementation effort of the Civil Engineering and Architecture Institute, Ural Federal University, the Science and Engineering Centre "Reliability and Safety of Large Systems and Machines", Ural Branch Russian Academy of Sciences (both Yekaterinburg), Start-up OptiCits, Barcelona, Spain and the Old Dominion University, Norfolk, VA, USA. The project is based on using the MAICS convergent technology [1] to create a versatile multi-purpose tool for optimizing the science and art of risk based governance of resilience-smart and sustainable city infrastructure and communities operating in usual and extreme conditions. The tool being developed is tailored to the needs of the City of Yekaterinburg-the capital of the Urals Region and allegedly the third most important and vibrant city of Russia. It is also being offered to the Yekaterinburg City Administration as an every-day decision-support work-tool and addendum to the Strategic Program "Yekaterinburg 2030 - a Safe City"[2] during preparation of the city for winning and conducting the World Expo-2025. Authors believe that the findings of this research would also be useful to the Sverdlovsk Oblast cities of every size and type of communities that inhabit them, including, first and foremost, Nizhny Tagil, Kamensk Uralsky, Serov, Pervouralsk, Revda, Verkhnyaya Pyshma, multiple mono-cities et al. The project also incorporates block-chain technology, smart contracts and digital currency as an effective tool for implementing the project. © 2018 Institute of Physics Publishing. All rights reserved

Resilience to cope with climate change in urban areas - A multisectorial approach focusing on water - The RESCCUE project

This is the final version. Available on open access from MDPI via the DOI in this recordThe RESCCUE Project is an H2020 research project that aims to help cities around the world to become more resilient to physical, social, and economic challenges, using the water sector as the central point of the approach. RESCCUE will generate models and tools to bring this objective to practice, while delivering a framework enabling city resilience assessment, planning and management. This will be achieved by integrating software tools, methods, and new knowledge related to the detailed urban services performance into novel and promising loosely coupled models (integrated models), multi-risk assessment method, and a comprehensive resilience platform. These tools will allow urban resilience assessment from a multisectorial approach, for current and future climate change scenarios, including multiple hazards and cascading effects. The RESCCUE approach will be implemented in three EU cities (Barcelona, Bristol, and Lisbon) and, with the support of UN-Habitat, disseminate their results among other cities belonging to major international networks. The aim of this paper is to present the main goals of this project, as well as the approach followed and the main expected results after the four years of implementation, so other cities around the world can use the RESCCUE approach to increase their resilience.The RESCCUE Project (RESilience to cope with Climate Change in Urban arEas—a multisectorial approach focusing on water) has received funding from European Commission by means of Horizon 2020, the EU Framework Program for Research and Innovation, under Grant Agreement No. 700174

El papel de los estudios bioarqueológicos en las interpretaciones sobre las comunidades neolíticas del noreste peninsular

Resumen del trabajo presentado al VI Congreso del Neolítico en la Península Ibérica: "Los cambios económicos y sus implicaciones sociales durante el Neolítico de la Península Ibérica", celebrado en Granada del 22 al 26 de junio de 2016.-- et al.El marco del proyecto I+D: “Aproximación a las primeras comunidades neolíticas del NE peninsular a través de sus prácticas funerarias” (2011-2015), y su continuidad para los próximos cuatro años al haber sido renovado, tiene por objetivo conocer cada día más y mejor las comunidades de agricultores y pastores que entre finales del V e inicios del IV milenio cal BC ocuparon y enterraron a sus muertos en el noreste de la Península Ibérica. El contexto de estudio es excepcional, puesto que aquellas comunidades inhumaron sistemáticamente a sus congéneres en tumbas habitualmente individuales y ocasionalmente junto a otro individuo. En esta presentación no sólo queremos mostrar los nuevos análisis y metodologías que estamos aplicando al estudio de los restos humanos, sino también el modelo de trabajo que hemos seguido. A este respecto, tres aspectos son fundamentales: 1) las dataciones absolutas son el eje que vertebra los posteriores análisis; 2) la colaboración con los distintos investigadores/as y laboratorios debe ser estrecha (no es cuestión de solicitar los resultados de un análisis a un laboratorio sino trabajar con las personas que manipulan las muestras y conocen los pros y contras de cada una de las técnicas empleadas) y 3) los estudios y análisis a realizar confluyen para responder a las hipótesis planteadas. A este respecto, en el proyecto hemos tenido la fortuna de poder colaborar con numerosos investigadores/as cuya especialidad versa alrededor de los restos funerarios y que firman la presente comunicación: análisis isotópicos, Adn, tafonomía funeraria, estudios de stress muscular y análisis de morfología dental.Peer Reviewe

A Phase I/II Clinical Trial to evaluate the efficacy of baricitinib to prevent respiratory insufficiency progression in onco-hematological patients affected with COVID19: a structured summary of a study protocol for a randomised controlled trial

Objectives: Baricitinib is supposed to have a double effect on SARS-CoV2 infection. Firstly, it reduces the inflammatory response through the inhibition of the Januse-Kinase signalling transducer and activator of transcription (JAK-STAT) pathway. Moreover, it reduces the receptor mediated viral endocytosis by AP2-associated protein kinase 1 (AAK1) inhibition. We propose the use of baricinitib to prevent the progression of the respiratory insufficiency in SARS-CoV2 pneumonia in onco-haematological patients. In this phase Ib/II study, the primary objective in the safety cohort is to describe the incidence of severe adverse events associated with baricitinib administration. The primary objective of the randomized phase (baricitinib cohort versus standard of care cohort) is to evaluate the number of patients who did not require mechanical oxygen support since start of therapy until day +14 or discharge (whichever it comes first). The secondary objectives of the study (only randomized phase of the study) are represented by the comparison between the two arms of the study in terms of mortality and toxicity at day+30. Moreover, a description of the immunological related changes between the two arms of the study will be reported. Trial design: The trial is a phase I/II study with a safety run-in cohort (phase 1) followed by an open label phase II randomized controlled trial with an experimental arm compared to a standard of care arm

La nécropole néolithique de la Feixa del Moro (Juberri, Andorre): Examen et nouvelles données

At the beginning of the 1980s, a series of archaeological interventions carried out by what was previously called the 'Servei d'Investigacions Arqueológiques del Patrimoni Artistic Nacional d'Andorra' in a Pyrenean valley in Andorra allowed the investigation of the Feixa del Moro site. In a high-altitude area below a series of abandoned terraces, several dwellings and burial structures were located, all of them with chronologies ranging between the Early and the Middle Neolithic (from the mid 5th millennium to the early 4th millennium cal. BC). The distinctiveness of this site does not only lie in its geographical location, nor in the kind of structures discovered, but also in the very good state of preservation of the human bone material recovered from the burials, making Feixa del Moro one of the reference sites for the Neolithic in the Pyrenees and, in general, the Western Mediterranean. So far, sites with a similar conservation of both bones and burial structures are really uncommon. Moreover, the concentration in so small an area, and in the same stratigraphic unit, of such a diversity of evidence, including burials, silos and hearths, is yet more unusual. There are no similar sites in Andorra, or even in the entire Pyrenees. The only other burial site of comparable chronology discovered in the area is the Segudet site, and only a few high-altitude Neolithic dwelling sites are known. Even if cist burials are quite common in the northeast of the Iberian Peninsula and in Southern France, Feixa del Moro is the first that has been found at high altitude. The archaeological work undertaken between 1983 and 1985 provided a picture of a farming community belonging to the so-called 'Sepulcros de fosa' Culture, established in the very heart of the Pyrenees and, thus, highlighted the complexity of Neolithic settlement patterns, even in mountainous zones. At the same time, several analyses of the archaeological materials were already carried out, making Feixa del Moro a reference site for archaeological research even now. Nevertheless, three decades later, new methodologies and the technical advances available are allowing archaeologists to refine old interpretations, to reopen old debates and to carry out new analyses that can improve our understanding of the past. In this respect, since 2011, within the research project 'Aproximación a las primeras comunidades neolíticas del NE peninsular a través de sus prácticas funerarias' (HAR2011-23149), funded by the Spanish Ministry for the Economy and Competitiveness, a group of interdisciplinary researchers have begun to study several Neolithic burial contexts in the northeast of the Iberian Peninsula, among which Feixa del Moro. Following this perspective, in this paper, we present the outcome of the new analyses carried out on the burial goods and of the biochemistry and radiocarbon analyses carried out on the human bone material from the three cist burials of Feixa del Moro, with the aim of better understanding the early farming communities who settled in the Pyrenees. Since the last archaeological work carried out in the 1990s, large quantities of data have been lost. This has produced a certain degree of confusion and misunderstanding that has been repeated in other studies undertaken a posteriori on the site by other scholars. Some of these interpretations need to be revised. That it is why, within the current research project, we are not only bringing in new analyses, but also re-examining all the old written and graphic information available, as well as the state of the conserved archaeological material. The data presented in this paper resume all the available information on the Feixa del Moro site, correcting old mistakes and bias, updating the 1980s archaeological registers and presenting new analyses as well. Our aim is to ensure that Feixa del Moro remains a reference site for the Pyrenean and Western Mediterranean Neolithic. At the same time, we wish to encourage other researchers to undertake new analyses and to embrace new perspectives in order to improve our understanding of Neolithic societies

Rapid identification and antimicrobial susceptibility profiling of Gram-positive cocci in blood cultures with the Vitek 2 system

Rapid identification and antimicrobial susceptibility profiling of the bacteria in blood cultures can result in clinical and financial benefits. Addition of saponin to the fluid from blood culture bottles promotes the recovery of the bacteria and thus may shorten the turnaround time of the microbiological analyses. In this study we compared the identification and susceptibility profiles of saponin-treated and untreated (standard method) blood cultures monomicrobial for Gram-positive cocci using Vitek 2. We concordantly identified 49 (89%) of 55 monobacterial cultures using the results with the standard method as reference. Complete categorical agreement between the susceptibility profiles with the new and the standard method was found for 26 (53%) of 49 isolates, while discrepancies were seen for 23 (47%) cultures. E-tests indicated that the new method resulted in a correct susceptibility profile for 8 (35%) of these 23 blood cultures. Therefore, 34 (69%) of 49 cultures showed a concordant/correct susceptibility profile for all antimicrobials with an overall error rate of 2.3%. Thus, addition of saponin to the fluid from blood culture bottles of the Bactec 9240 leads to the rapid (results available ≥12 hours earlier) and reliable identification and susceptibility profiling of Gram-positive cocci in blood cultures with Vitek 2

Monitorización del consumo de sustancias de abuso legales e ilegales en España a través de las aguas residuales en el marco de la red ESAR-Net

Trabajo presentado en el 4th Congreso Internacional y XLIX Jornadas Nacionales de Socidrogalcohol - VIII Congreso Nacional Patología Bio-Psicosocial, celebrado en Tenerife del 06 al 08 de octubre de 2022

Laboratori remot d'experimentació en fenòmens oscil·latoris i ondulatoris, circuits i electrometria i en experimentació en electrotècnia

Este proyecto es la continuación de dos proyectos anteriores: Laboratorio de experimentación remoto interactivo en física. Experiencia en oscilaciones y ondas. Laboratorio de experimentación remoto interactivo. Experiencias en circuitos y electrometría. Fueron proyectos calificados positivamente por el ICE en la convocatoria de diciembre de 1999 y que por la envergadura de los mismos no pudieron ser concluidos. El proyecto de experiencia en oscilaciones y ondas consta de tres bancadas experimentales en las que se estudian oscilacionmes amortiguadas, ondas estacionarias en una cuerda y ondas estacionarias en un tubo de aire. El proyecto de circuitos tiene la finalidad de poder estudiar remotamente un circuito con diferentes componentes conectados con la topología requerida a partir de la conexión de múltiples relés sobre un conjunto de elementos

Kinetic, Isotherm and Thermodynamic Analysis on Adsorption of Cr(VI) Ions from Aqueous Solutions by Synthesis and Characterization of Magnetic-Poly(divinylbenzene-vinylimidazole) Microbeads

The magnetic-poly(divinylbenzene-1-vinylimidazole) [m-poly(DVB-VIM)] microbeads (average diameter 53–212 μm) were synthesized and characterized; their use as adsorbent in removal of Cr(VI) ions from aqueous solutions was investigated. The m-poly(DVB-VIM) microbeads were prepared by copolymerizing of divinylbenzene (DVB) with 1-vinylimidazole (VIM). The m-poly(DVB-VIM) microbeads were characterized by N2 adsorption/desorption isotherms, ESR, elemental analysis, scanning electron microscope (SEM) and swelling studies. At fixed solid/solution ratio the various factors affecting adsorption of Cr(VI) ions from aqueous solutions such as pH, initial concentration, contact time and temperature were analyzed. Langmuir, Freundlich and Dubinin–Radushkvich isotherms were used as the model adsorption equilibrium data. Langmuir isotherm model was the most adequate. The pseudo-first-order, pseudo-second-order, Ritch-second-order and intraparticle diffusion models were used to describe the adsorption kinetics. The apparent activation energy was found to be 5.024 kJ mol−1, which is characteristic of a chemically controlled reaction. The experimental data fitted to pseudo-second-order kinetic. The study of temperature effect was quantified by calculating various thermodynamic parameters such as Gibbs free energy, enthalpy and entropy changes. The thermodynamic parameters obtained indicated the endothermic nature of adsorption of Cr(VI) ions. Morever, after the use in adsorption, the m-poly(DVB-VIM) microbeads with paramagnetic property were separeted via the applied magnetic force. The magnetic beads could be desorbed up to about 97% by treating with 1.0 M NaOH. These features make the m-poly(DVB-VIM) microbeads a potential candidate for support of Cr(VI) ions removal under magnetic field