Fiscal transparency: cross-country comparisons

The evaluation of fiscal transparency impact on budget indicators performance is examined in the article according to the grouping of countries by the following features: budget transparency, income per capita, level of economic development and economic freedom. The main aim of the study is to determine the relationship between fiscal transparency indexes and indicators of countries’ development. As the result of evaluation it was determined that the main indicators of budget execution under the influence of its transparency vary in different groups of countries. In particular, the studies have shown that the value of Open Budget Index causes the reduction of public debt and the increase in the share of public expenditure, but in countries with high and medium level of development the opposite effect of budget transparency on public debt is characteristic, and the positive impact of budget transparency on the share of public expenditure is characteristic only for countries with high economic freedom

Improvement of the Management Strategy Material Inventories at Industrial Enterprise

Analyzed the management system of material inventories in warehouses of an industrial enterprise. Are revealed the main problems that hamper effective management of inventories of material values, on the basis of which the proposed recommendations for improvement of their management strategy. Is determined the scientific novelty which consists in the use of a joint matrix of ABC- and XYZ-analysis, which links the grouping of material values to their importance in the production process and the selection of their management strategy

Synthesis and properties of zwitterionic phosphonioglycolates

Reaction of diphenylphosphane with glyoxylic acid hydrate in diethyl ether furnished diphenylphosphanylglycolic acid 1 and in a 1:2 molar ratio almost quantitatively the zwitterionic phosphonioglycolic acid glycolate 2. Tertiary phosphanes with aryl or alkyl groups (phenyl, m/p-tolyl, p-anisyl, n-butyl, tert-butyl) react similarly to triorganylphosphonioglycolates 3a-h, which like 2 precipitate from the etheral solutions of the reactants. Tri-n- butylphosphonioglycolate (3e) forms an ionic liquid and tri-tert- butylphosphonioglycolate (3f) a viscous product whereas the other phosphonioglycolates are solids. Yields and stabilities of 3a-e increase with the P-basicity of the starting phosphane whereas bulky groups like tert-butyl cause destabilization. Compound 2 is the most stable phosphonioglycolate with only minor amounts of 1 in the solvolysis equilibrium in D2O. The triaryl and tributylphosphonioglycolates 3a-f decompose in protic solvents with recovery of tertiary phosphanes. On heating at 100 C the compounds decompose to the corresponding phosphine oxides, minor amounts of glycolic acid and unidentified products. © 2013 Elsevier Ltd. All rights reserved

A Human Islet Cell-Culture System for High-Throuput screening.

A small-molecule inducer of beta-cell proliferation in human islets represents a potential regeneration strategy for treating type 1 diabetes. However, the lack of suitable human beta cell lines makes such a discovery a challenge. Here, we adapted an islet cell culture system to high-throughput screening to identify such small molecules. We prepared microtiter plates containing extracellular matrix from a human bladder carcinoma cell line. Dissociated human islets were seeded onto these plates, cultured for up to 7 days, and assessed for proliferation by simultaneous Ki67 and C-peptide immunofluorescence. Importantly, this environment preserved beta-cell physiological function, as measured by glucose-stimulated insulin secretion. Adenoviral overexpression of cdk-6 and cyclin D(1), known inducers of human beta cell proliferation, was used as a positive control in our assay. This induction was inhibited by cotreatment with rapamycin, an immunosuppressant often used in islet transplantation. We then performed a pilot screen of 1280 compounds, observing some phenotypic effects on cells. This high-throughput human islet cell culture method can be used to assess various aspects of beta-cell biology on a relatively large number of compounds

Search for sterile neutrinos at the DANSS experiment

DANSS is a highly segmented 1~m${}^3$ plastic scintillator detector. Its 2500 one meter long scintillator strips have a Gd-loaded reflective cover. The DANSS detector is placed under an industrial 3.1~$\mathrm{GW_{th}}$ reactor of the Kalinin Nuclear Power Plant 350~km NW from Moscow. The distance to the core is varied on-line from 10.7~m to 12.7~m. The reactor building provides about 50~m water-equivalent shielding against the cosmic background. DANSS detects almost 5000 $\widetilde\nu_e$ per day at the closest position with the cosmic background less than 3$\%$. The inverse beta decay process is used to detect $\widetilde\nu_e$. Sterile neutrinos are searched for assuming the $4\nu$ model (3 active and 1 sterile $\nu$). The exclusion area in the $\Delta m_{14}^2,\sin^22\theta_{14}$ plane is obtained using a ratio of positron energy spectra collected at different distances. Therefore results do not depend on the shape and normalization of the reactor $\widetilde\nu_e$ spectrum, as well as on the detector efficiency. Results are based on 966 thousand antineutrino events collected at 3 distances from the reactor core. The excluded area covers a wide range of the sterile neutrino parameters up to $\sin^22\theta_{14}<0.01$ in the most sensitive region.Comment: 10 pages, 13 figures, version accepted for publicatio

ДОСВІД РОБОТИ СИМУЛЯЦІЙНОГО ЦЕНТРУ ВІННИЦЬКОГО НАЦІОНАЛЬНОГО МЕДИЧНОГО УНІВЕРСИТЕТУ: ПІДСУМКИ ТА ПЕРСПЕКТИВИ

The aim of the work – to highlight the experience of M. Pyrohov Vinnytsia National Medical University in the field of stimulation medicine and conduct an objective structured clinical examination. The main body. Structured simulation programs are extremely useful in those areas of medicine where many very dangerous manipulations – obstetrics, anesthesiology, urgent and intensive care, surgery or pediatrics, for training personnel, work on improving existing clinical protocols and practical algorithms and/or approbation of organizational factors in dealing with urgent situations. The leading healthcare organizations have recommended the following standards of medical care that make simulation training Employees of the symulation center of M. Pyrohov Vinnytsia National Medical University used for simulation training in medicine: an objective structured clinical examination (OSCE/OSCE’s) designed to test competencies and implement practical skills such as communication, clinical examination, medical manipulation/appointment, appointment of exercises, etc. It consists of real or “false” patients (patient actors), passing through several points, each of which has its examiner and allocated a certain time. Before and after conducting such an examination, we held a briefing and debriefing Conclusions. The training of specialists who in future are called to be responsible for the life and health of people, in particular in critical situations, is impossible without training skills in stimulation centers. Recently, the interest in simulation medical training in Ukraine has increased significantly. Equipment appears, new training centers open. In order to fully utilize the potential of simulation training, it is important to adhere to an effective methodology, to establish cooperation between the simulation centers and to provide appropriate training for teachers capable of organizing the learning process in the light of modern European experience.Мета роботи – висвітлити досвід Вінницького національного медичного університету ім. М. І. Пирогова в галузі симуляційної медицини та проведенні об’єктивного структурованого клінічного іспиту. Основна частина. Структуровані програми симуляційного навчання надзвичайно корисні в тих галузях медицини, де виконується багато дуже небезпечних маніпуляцій – в акушерстві, анестезіології, ургентній та інтенсивній терапії, хірургії або педіатрії, для навчання персоналу, роботи з удосконалення чинних клінічних протоколів та практичних алгоритмів та/або апробації організаційних чинників у веденні ургентних ситуацій. Провідні організації охорони здоров’я порекомендували такі стандарти медичної допомоги, які змушують запроваджувати симуляційне навчання. Співробітники симуляційного центру ВНМУ ім. М. І. Пирогова&nbsp; використовують для симуляційного навчання в медицині: проведення об’єктивного структурованого клінічного іспиту (ОСКІ/OSCE’s), призначеного для перевірки компетенції та виконання практичних навичок, таких, як комунікація, клінічне обстеження, медичні маніпуляції/призначення, призначення вправ тощо. Його складають з реальними або «удаваними» пацієнтами (пацієнтами-акторами), проходячи через декілька пунктів, на кожному з яких є свій екзаменатор та виділено певний час. До та після проведення такого іспиту ми проводили брифінг та дебрифінг. Висновки. Підготовка фахівців, які у майбутньому покликані відповідати за життя та здоров’я людей, зокрема у критичних ситуаціях, не можлива без відпрацювання навичок у симуляційних центрах.&nbsp; Останнім часом зацікавленість щодо симуляційного медичного навчання в Україні значно зростає. З’являється обладнання, відкриваються нові навчальні центри. Щоб повною мірою використати потенціал симуляційного навчання, важливо дотримуватися ефективної методології, налагодити співпрацю між симуляційними центрами та&nbsp;належну підготовку викладачів, здатних організувати навчальний процес з&nbsp;урахуванням сучасного європейського досвіду

Bio-precipitation of uranium by two bacterial isolates recovered from extreme environments as estimated by potentiometric titration, TEM and X-ray absorption spectroscopic analyses

This is the post-print version of the final paper published in Journal of Hazardous Materials. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2011 Elsevier B.V.This work describes the mechanisms of uranium biomineralization at acidic conditions by Bacillus sphaericus JG-7B and Sphingomonas sp. S15-S1 both recovered from extreme environments. The U–bacterial interaction experiments were performed at low pH values (2.0–4.5) where the uranium aqueous speciation is dominated by highly mobile uranyl ions. X-ray absorption spectroscopy (XAS) showed that the cells of the studied strains precipitated uranium at pH 3.0 and 4.5 as a uranium phosphate mineral phase belonging to the meta-autunite group. Transmission electron microscopic (TEM) analyses showed strain-specific localization of the uranium precipitates. In the case of B. sphaericus JG-7B, the U(VI) precipitate was bound to the cell wall. Whereas for Sphingomonas sp. S15-S1, the U(VI) precipitates were observed both on the cell surface and intracellularly. The observed U(VI) biomineralization was associated with the activity of indigenous acid phosphatase detected at these pH values in the absence of an organic phosphate substrate. The biomineralization of uranium was not observed at pH 2.0, and U(VI) formed complexes with organophosphate ligands from the cells. This study increases the number of bacterial strains that have been demonstrated to precipitate uranium phosphates at acidic conditions via the activity of acid phosphatase

Baseline Demographics, Comorbidities, Treatment Patterns and Burden of Atopic Dermatitis in Adults and Adolescents from the GLOBOSTAD Long-Term Observational Study

Introduction: Insights into real-world treatment of atopic dermatitis (AD) are relevant to clinical decision making. The aim of this analysis was to characterize patients who receive dupilumab for AD in a real-world setting. Methods: The GLOBOSTAD registry is an ongoing, longitudinal, prospective, observational study of patients with AD who receive dupilumab according to country-specific prescribing information. We report baseline characteristics, comorbidities and treatment patterns for patients enrolled from July 11, 2019 to March 31, 2022. Analyses are descriptive; no formal statistical comparisons were performed. Results: Nine hundred fifty-two adults and adolescents were enrolled in GLOBOSTAD. Patients had a high disease burden before starting dupilumab: (mean [standard deviation]) percent body surface area affected (44.8 [24.42]), Eczema Area and Severity Index total score (24.8 [12.95]), SCORing Atopic Dermatitis total score (60.5 [16.34]), Patient-Oriented Eczema Measure total score (19.7 [6.37]) and Dermatology Life Quality Index total score (13.7 [7.02]). Overall, 741 (77.8%) patients reported ≥ 1 type 2 inflammatory comorbidities, most frequently allergic rhinitis (492 [51.7%]), asthma (323 [33.9%]), food allergy (294 [30.9%]) or another allergy (274 [28.8%]). In the previous 12 months, 310 (32.6%) patients had received systemic non-steroidal immunosuppressants and 169 (17.8%) systemic corticosteroids; 449 (47.2%) had received topical corticosteroids, most commonly potent topical corticosteroids; 141 (14.8%) had received topical calcineurin inhibitors and 32 (3.4%) ultraviolet therapy. Most (713 [74.9%]) patients started dupilumab because of prior treatment failure. Conclusion: Patients enrolled in GLOBOSTAD demonstrated considerable multidimensional burden of disease across AD signs, symptoms and quality of life despite previous use of systemic and non-systemic AD treatments

Electrochemical properties and catalytic activity in the ethylene polymerization processes of nickel complexes with 2,2′-bipyridine in the presence of ortho-phosphinophenol derivatives

© 2015, Pleiades Publishing, Ltd. Electrochemical properties of the [NiBr2(bpy)2] complex, where bpy = 2,2′-bipyridyl, have been studied in the presence of derivatives of ortho-phosphine phenol: 2-diphenyl phosphanyl-4-methyl phenol CH3C6H3(PPh2)OH (1), 2-diphenyl phosphanyl-4-methylphenyldiphenyl phosphinate CH3C6H3(PPh2)OP(O)Ph2 (2), and 2-diphenylphosphoryl-4-methyl phenol CH3C6H3(P(O)Ph2)OH (3). It is found that interaction of products of electrochemical reduction of complex [NiBr2(bpy)2] with 1 and 2 results in formation of active catalysts of the process of homogeneous oligomerization/polymerization of ethylene