First M87 Event Horizon Telescope Results. III. Data Processing and Calibration

We present the calibration and reduction of Event Horizon Telescope (EHT) 1.3 mm radio wavelength observations of the supermassive black hole candidate at the center of the radio galaxy M87 and the quasar 3C 279, taken during the 2017 April 5-11 observing campaign. These global very long baseline interferometric observations include for the first time the highly sensitive Atacama Large Millimeter/submillimeter Array (ALMA); reaching an angular resolution of 25 mu as, with characteristic sensitivity limits of similar to 1 mJy on baselines to ALMA and similar to 10 mJy on other baselines. The observations present challenges for existing data processing tools, arising from the rapid atmospheric phase fluctuations, wide recording bandwidth, and highly heterogeneous array. In response, we developed three independent pipelines for phase calibration and fringe detection, each tailored to the specific needs of the EHT. The final data products include calibrated total intensity amplitude and phase information. They are validated through a series of quality assurance tests that show consistency across pipelines and set limits on baseline systematic errors of 2% in amplitude and 1 degrees in phase. The M87 data reveal the presence of two nulls in correlated flux density at similar to 3.4 and similar to 8.3 G lambda and temporal evolution in closure quantities, indicating intrinsic variability of compact structure on a. timescale of days, or several light-crossing times for a. few billion solar-mass black hole. These measurements provide the first opportunity to image horizon-scale structure in M87.Academy of Finland [274477, 284495, 312496]; European Commission Framework Programme Horizon 2020 Research and Innovation action [731016]; Black Hole Initiative at Harvard University through John Templeton Foundation [60477]; Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT, Chile) [PIA ACT172033, Fondecyt 1171506, BASAL AFB-170002, ALMA-conicyt 31140007]; Consejo Nacional de Ciencia y Tecnologia (CONACYT, Mexico) [104497, 275201, 279006, 281692]; Direccion General de Asuntos del Personal Academico-Universidad Nacional Autonoma de Mexico (DGAPA-UNAM) [IN112417]; European Research Council Synergy Grant "BlackHoleCam: Imaging the Event Horizon of Black Holes" [610058]; Generalitat Valenciana postdoctoral grant [APOSTD/2018/177]; Gordon and Betty Moore Foundation [GBMF 947, GBMF-3561, GBMF-5278]; Japanese Government (Monbukagakusho: MEXT) Scholarship; Japan Society for the Promotion of Science (JSPS) [JP17J08829]; JSPS Overseas Research Fellowships; Key Research Program of Frontier Sciences, Chinese Academy of Sciences (CAS) [QYZDJ-SSW-SLH057, QYZDJ-SSW-SYS008]; Leverhulme Trust Early Career Research Fellowship; MEXT/JSPS KAKENHI [18KK0090, JP18K13594, JP18K03656, JP18H03721, 18K03709, 18H01245, 25120007]; MIT International Science and Technology Initiatives (MISTI) Funds; Ministry of Science and Technology (MOST) of Taiwan [105-2112-M-001-025-MY3, 106-2112-M-001-011, 106-2119-M-001-027, 107-2119-M-001-017, 107-2119-M-001-020, 107-2119-M-110-005]; National Aeronautics and Space Administration (NASA) [80NSSC17K0649]; National Key Research and Development Program of China [2016YFA0400704, 2016YFA0 400702]; National Science Foundation (NSF) [AST-0096454, AST-0352953, AST-0521233, AST-0705062, AST-0905844, AST-0922984, AST-1126433, AST-1140030, DGE-1144085, AST-1207704, AST-1207730]; Natural Science Foundation of China [11573051, 11633006, 11650110427, 10625314, 11721303, 11725312, 11873028, 11873073, U1531245, 11473010]; Natural Sciences and Engineering Research Council of Canada (NSERC); National Research Foundation of Korea [2015-R1D1A1A01056807, NRF-2015H1A2A1033752, NRF-2015H1D3A1066561]; Netherlands Organization for Scientific Research (NWO) VICI award [639.043.513]; Spinoza Prize [SPI 78-409]; Swedish Research Council [2017-00648]; Government of Canada through the Department of Innovation, Science and Economic Development Canada; Province of Ontario through the Ministry of Economic Development, Job Creation and Trade; Russian Science Foundation [17-12-01029]; Spanish Ministerio de Economia y Competitividad [AYA2015-63939-C2-1-P, AYA2016-80889-P]; US Department of Energy (USDOE) through the Los Alamos National Laboratory [89233218CNA000001]; Italian Ministero dell'Istruzione Universita e Ricerca through the grant Progetti Premiali 2012-iALMA [CUP C52I13000140001]; ALMA North America Development Fund; NSF [ACI-1548562, DBI-0735191, DBI-1265383, DBI-1743442]; Smithsonian Institution; Academia Sinica; National Key R&D Program of China [2017YFA0402700]; Science and Technologies Facility Council (UK); CNRS (Centre National de la Recherche Scientifique, France); MPG(Max-Planck-Gesellschaft, Germany); IGN (Instituto Geografico Nacional, Spain); State of Arizona; NSF Physics Frontier Center award [PHY-0114422]; Kavli Foundation; National Science Foundation [PLR-1248097]; NSF Physics Frontier Center [PHY-1125897]; Jansky Fellowship program of the National Radio Astronomy Observatory (NRAO); South African Radio Astronomy Observatory (SARAO), which is a facility of the National Research Foundation (NRF), an agency of the Department of Science and Technology (DST) of South Africa; State Agency for Research of the Spanish MCIU through the "Center of Excellence Severo Ochoa" award [SEV-2017-0709]; European Union' s Horizon 2020 research and innovation programme [730562 RadioNet]; GBMF [GBMF-947]; Compute Ontario; Calcul Quebec; Compute Canada; NSF; CyVerse; [Chandra TM6-17006X]; [AST-1207752]; [MRI-1228509]; [OPP-1248097]; [AST-1310896]; [AST-1312651]; [AST-1337663]; [AST-1440254]; [AST-1555365]; [AST-1715061]; [AST-1615796]; [AST-1716327]; [OISE-1743747]; [AST-1816420]; [AST-1614868]This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Studies on the genetic and non-genetic (physiological) variation of human erythrocyte glutamic oxaloacetic transaminase

The thermostability profile of seven different electrophoretic variants of human erythrocyte GOT found in 13 different, unrelated families from a racially heterogeneous population was examined. The five different slow-variant and the two different fast-variant classes could be grouped into four different thermostability classes which were termed unstable, less stable, normal and more stable than normal. The thermostability differences among and within the electrophoretic variant classes permitted differentiation of the 13 individusals possessing an electrophoretic variant phenotype into a total of ten different variants.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66025/1/j.1469-1809.1982.tb00711.x.pd

Intermixing-Driven Surface and Bulk Ferromagnetism in the Quantum Anomalous Hall Candidate MnBi6Te10

The recent realizations of the quantum anomalous Hall effect (QAHE) in MnBi2Te4 and MnBi4Te7 benchmark the (MnBi2Te4)(Bi2Te3)n family as a promising hotbed for further QAHE improvements. The family owes its potential to its ferromagnetically (FM) ordered MnBi2Te4 septuple layers (SLs). However, the QAHE realization is complicated in MnBi2Te4 and MnBi4Te7 due to the substantial antiferromagnetic (AFM) coupling between the SLs. An FM state, advantageous for the QAHE, can be stabilized by interlacing the SLs with an increasing number n of Bi2Te3 quintuple layers (QLs). However, the mechanisms driving the FM state and the number of necessary QLs are not understood, and the surface magnetism remains obscure. Here, robust FM properties in MnBi6Te10 (n = 2) with Tc ≈ 12 K are demonstrated and their origin is established in the Mn/Bi intermixing phenomenon by a combined experimental and theoretical study. The measurements reveal a magnetically intact surface with a large magnetic moment, and with FM properties similar to the bulk. This investigation thus consolidates the MnBi6Te10 system as perspective for the QAHE at elevated temperatures

Effect of Coenzyme Q10 on ischemia and neuronal damage in an experimental traumatic brain-injury model in rats

<p>Abstract</p> <p>Background</p> <p>Head trauma is one of the most important clinical issues that not only can be fatal and disabling, requiring long-term treatment and care, but also can cause heavy financial burden. Formation or distribution of free oxygen radicals should be decreased to enable fixing of poor neurological outcomes and to prevent neuronal damage secondary to ischemia after trauma. Coenzyme Q₁₀(CoQ₁₀), a component of the mitochondrial electron transport chain, is a strong antioxidant that plays a role in membrane stabilization. In this study, the role of CoQ₁₀in the treatment of head trauma is researched by analyzing the histopathological and biochemical effects of CoQ₁₀administered after experimental traumatic brain injury in rats. A traumatic brain-injury model was created in all rats. Trauma was inflicted on rats by the free fall of an object of 450 g weight from a height of 70 cm on the frontoparietal midline onto a metal disc fixed between the coronal and the lambdoid sutures after a midline incision was carried out.</p> <p>Results</p> <p>In the biochemical tests, tissue malondialdehyde (MDA) levels were significantly higher in the traumatic brain-injury group compared to the sham group (<it>p </it>< 0.05). Administration of CoQ₁₀after trauma was shown to be protective because it significantly lowered the increased MDA levels (<it>p </it>< 0.05). Comparing the superoxide dismutase (SOD) levels of the four groups, trauma + CoQ₁₀group had SOD levels ranging between those of sham group and traumatic brain-injury group, and no statistically significant increase was detected. Histopathological results showed a statistically significant difference between the CoQ₁₀and the other trauma-subjected groups with reference to vascular congestion, neuronal loss, nuclear pyknosis, nuclear hyperchromasia, cytoplasmic eosinophilia, and axonal edema (<it>p </it>< 0.05).</p> <p>Conclusion</p> <p>Neuronal degenerative findings and the secondary brain damage and ischemia caused by oxidative stress are decreased by CoQ₁₀use in rats with traumatic brain injury.</p

High on-off conductance switching ratio in optically-driven self-assembled conjugated molecular systems

A new azobenzene-thiophene molecular switch is designed, synthesized and used to form self-assembled monolayers (SAM) on gold. An "on/off" conductance ratio up to 7x1E3 (with an average value of 1.5x1E3) is reported. The "on" conductance state is clearly identified to the cis isomer of the azobenzene moiety. The high "on/off" ratio is explained in terms of photo-induced, configuration-related, changes in the electrode-molecule interface energetics (changes in the energy position of the molecular orbitals with respect to the Fermi energy of electrodes) in addition to changes in the tunnel barrier length (length of the molecules). First principles DFT calculations demonstrate a better delocalization of the frontier orbitals, as well as a stronger electronic coupling between the azobenzene moiety and the electrode for the cis configuration over the trans one. Measured photoionization cross-sections for the molecules in the SAM are close to the known values for azobenzene derivatives in solution.Comment: 1 file with main text, figure and suppementary informatio

First M87 Event Horizon Telescope Results. III. Data Processing and Calibration

We present the calibration and reduction of Event Horizon Telescope (EHT) 1.3 mm radio wavelength observations of the supermassive black hole candidate at the center of the radio galaxy M87 and the quasar 3C 279, taken during the 2017 April 5-11 observing campaign. These global very long baseline interferometric observations include for the first time the highly sensitive Atacama Large Millimeter/submillimeter Array (ALMA); reaching an angular resolution of 25 μas, with characteristic sensitivity limits of ∼1 mJy on baselines to ALMA and ∼10 mJy on other baselines. The observations present challenges for existing data processing tools, arising from the rapid atmospheric phase fluctuations, wide recording bandwidth, and highly heterogeneous array. In response, we developed three independent pipelines for phase calibration and fringe detection, each tailored to the specific needs of the EHT. The final data products include calibrated total intensity amplitude and phase information. They are validated through a series of quality assurance tests that show consistency across pipelines and set limits on baseline systematic errors of 2% in amplitude and 1° in phase. The M87 data reveal the presence of two nulls in correlated flux density at ∼3.4 and ∼8.3 Gλ and temporal evolution in closure quantities, indicating intrinsic variability of compact structure on a timescale of days, or several light-crossing times for a few billion solar-mass black hole. These measurements provide the first opportunity to image horizon-scale structure in M87

The "Statinth" wonder of the world: a panacea for all illnesses or a bubble about to burst

After the introduction of statins in the market as effective lipid lowering agents, they were shown to have effects other than lipid lowering. These actions were collectively referred to as 'pleiotropic actions of statins.' Pleiotropism of statins formed the basis for evaluating statins for several indications other than lipid lowering. Evidence both in favour and against is available for several of these indications. The current review attempts to critically summarise the available data for each of these indications