Bionic models for identification of biological systems

This article proposes a clinical decision support system that processes biomedical data. For this purpose a bionic model has been designed based on neural networks, genetic algorithms and immune systems. The developed system has been tested on data from pregnant women. The paper focuses on the approach to enable selection of control actions that can minimize the risk of adverse outcome. The control actions (hyperparameters of a new type) are further used as an additional input signal. Its values are defined by a hyperparameter optimization method. A software developed with Python is briefly described

A Double-Mode RR Lyrae Star with a Strong Fundamental Mode Component

NSVS 5222076, a thirteenth magnitude star in the Northern Sky Variability Survey, was identified by Oaster as a possible new double-mode RR Lyrae star. We confirm the double-mode nature of NSVS 5222076, supplementing the survey data with new V band photometry. NSVS 5222076 has a fundamental mode period of 0.4940 day and a first overtone period of 0.3668 day. Its fundamental mode light curve has an amplitude twice as large as that of the first overtone mode, a ratio very rarely seen. Data from the literature are used to discuss the location in the Petersen diagram of double-mode RR Lyrae stars having strong fundamental mode pulsation. Such stars tend to occur toward the short period end of the Petersen diagram, and NSVS 5222976 is no exception to this rule.Comment: 14 pages, 4 figures, To be published in the March, 2006, issue of PAS

An In-Depth Spectroscopic Analysis of the Blazhko Star RR Lyr. I. Characterisation of the star: abundance analysis and fundamental parameters

The knowledge of accurate stellar parameters is a keystone in several fields of stellar astrophysics, such as asteroseismology and stellar evolution. Although the fundamental parameters can be derived both from spectroscopy and multicolour photometry, the results obtained are sometimes affected by systematic uncertainties. In this paper, we present a self-consistent spectral analysis of the pulsating star RR Lyr, which is the primary target for our study of the Blazhko effect. We used high-resolution and high signal-to-noise ratio spectra to carry out a consistent parameter determination and abundance analysis for RR Lyr. We provide a detailed description of the methodology adopted to derive the fundamental parameters and the abundances. Stellar pulsation attains high amplitudes in RR Lyrae stars, and as a consequence the stellar parameters vary significantly over the pulsation cycle. The abundances of the star, however, are not expected to change. From a set of available high-resolution spectra of RR Lyr we selected the phase of maximum radius, at which the spectra are least disturbed by the pulsation. Using the abundances determined at this phase as a starting point, we expect to obtain a higher accuracy in the fundamental parameters determined at other phases. The set of fundamental parameters obtained in this work fits the observed spectrum accurately. Through the abundance analysis, we find clear indications for a depth-dependent microturbulent velocity, that we quantified. We confirm the importance of a consistent analysis of relevant spectroscopic features, application of advanced model atmospheres, and the use of up-to-date atomic line data for the determination of stellar parameters. These results are crucial for further studies, e.g., detailed theoretical modelling of the observed pulsations.Comment: 12 pages, accepted for publication in Astronomy & Astrophysic

DeeDP: vulnerability detection and patching based on deep learning

We present the DeeDP system for automatic vulnerabilities detection and patch providing. DeeDP allows to detect vulnerabilities in C/C++ source code and generate patch for fixing detected issue. This system uses deep learning methods to organize rules for deciding whether a code fragment is vulnerable. Patch generation processes can be performed based on neural network and rule-based approaches. The system uses the abstract syntax tree (AST) representations of the source code fragments. We have tested effectiveness of our approach on different open source projects. For example, Microsoft/Terminal (https://github.com/microsoft/Terminal) was analyzed with DeeDP: our system detected security issue and generated patch which was successfully approved and applied by Microsoft maintainers

Р-стереогенні діамандоїдні фосфіни

Despite diamondoid phosphines have found many synthetic applications and are even available commercially the chemistry of chiral diamondoid phosphines remains largely unexplored.Aim. To develop the convenient preparative method for the preparation of sterically-congested P-stereogenic secondary diamodoidyl phosphines as potential organocatalysts and ligands in the asymmetric synthesis.Results and discussion. A convenient method for the synthesis of P-stereogenic diamondoid phosphines with high yields through the phosphorylation of hydroxydiamondoids in trifluoroacetic acid followed by the reduction of the corresponding asymmetric chlorophosphonates has been proposed. The secondary phosphines obtained form stable complexes with borane that can be used to separate diamondoid phosphines into enantiomers.Experimental part. The experimental procedures for the preparation of 1- and 4-diamantyl-1-adamantyl- and phenylphosphines were developed; the structures of new compounds were confirmed by NMR and HRMS spectral data.Conclusions. A number of P-stereogenic mixed diamondoidylaryl phosphines and the secondary phosphines containing exclusively diamondoid substituents has been prepared. A degree of steric bulkiness is determined by the combination of diamondoid substituents around a phosphorus atom where 1-diamantyl derivatives are the most sterically-congested. The compounds obtained are potential ligands in asymmetric catalysis.Received: 31.03.2020Revised: 24.06.2020Accepted: 27.08.2020Незважаючи на те, що діамандоїдні фосфіни широко використовуються в органічному синтезі і навіть доступні комерційно, хімія хіральних діамандоїдних фосфінів залишається не дослідженою.Мета. Розробити зручний препаративний метод синтезу стереоускладнених Р-стереогенних вторинних діамандоїдних фосфінів, які можуть бути використані як ліганди в асиметричному синтезі, а також як органокаталізатори.Результати та їх обговорення. Запропоновано зручний метод синтезу P-стереогенних діамандоїдних фосфінів шляхом фосфорилювання гідроксипохідних діамандоїдів у трифтороцтовій кислоті з подальшим відновленням відповідних асиметричних хлорофосфонатів з високими виходами. Одержані таким чином фосфіни утворюють стійкі комплекси з бораном, які розглядаються як проміжні сполуки для подальшого розділення енантіомерів.Експериментальна частина. Був розроблений препаративний метод синтезу 1- і 4-діамантил-, 1-адамантил- і фенілфосфінів, структури яких підтверджено мас-спектрометричними і ЯМР-спектральними даними.Висновки. Одержано ряд Р-стереогенних змішаних діамандоїларилфосфінів та вторинних фосфінів, які містять виключно діамандоїдні замісники. Ступінь стеричного навантаження сполук визначається комбінацією діамандоїдних замісників навколо атома фосфору, де похідні 1-діамантилу найбільш стерично ускладнені. Одержані сполуки є потенційними лігандами в асиметричному каталізі.Received: 31.03.2020 Revised: 24.06.2020 Accepted: 27.08.202

Features of superconducting transition in nanocomposite consisting of "insulating matrix (porous alkali-borosilicate glass)" - "granular metallic filler (indium)"

Patterns in temperature and magnetic field behavior of the electrical resistance of nanocomposite consisting of "insulating matrix (7 nm-pore alkali-borosilicate glass)" - "granular metallic filler (indium)" (PG7+In) has been found and analyzed in the vicinity of superconducting transition. Insulating behavior in the electrical resistivity has been observed in a normal state. External magnetic field shifts the transition to lower temperatures and the same time gradually strengths the insulating behavior above the superconducting transitio

An investigation of the close environment of beta Cep with the VEGA/CHARA interferometer

High-precision interferometric measurements of pulsating stars help to characterize their close environment. In 1974, a close companion was discovered around the pulsating star beta Cep using the speckle interferometry technique and features at the limit of resolution (20 milli-arcsecond or mas) of the instrument were mentioned that may be due to circumstellar material. Beta Cep has a magnetic field that might be responsible for a spherical shell or ring-like structure around the star as described by the MHD models. Using the visible recombiner VEGA installed on the CHARA long-baseline interferometer at Mt. Wilson, we aim to determine the angular diameter of beta Cep and resolve its close environment with a spatial resolution up to 1 mas level. Medium spectral resolution (R=6000) observations of beta Cep were secured with the VEGA instrument over the years 2008 and 2009. These observations were performed with the S1S2 (30m) and W1W2 (100m) baselines of the array. We investigated several models to reproduce our observations. A large-scale structure of a few mas is clearly detected around the star with a typical flux relative contribution of 0.23 +- 0.02. Our best model is a co-rotational geometrical thin ring around the star as predicted by magnetically-confined wind shock models. The ring inner diameter is 8.2 +- 0.8 mas and the width is 0.6 +- 0.7 mas. The orientation of the rotation axis on the plane of the sky is PA = 60 +- 1 deg, while the best fit of the mean angular diameter of beta Cep gives UD[V] = 0.22 +- 0.05 mas. Our data are compatible with the predicted position of the close companion of beta Cep. These results bring additional constraints on the fundamental parameters and on the future MHD and asteroseismological models of the star.Comment: Paper accepted for publication in A&A (in press

Показания к коронарошунтографии в раннем послеоперационном периоде аортокоронарного шунтирования

Aim. To determine indications to emergency coronary artery bypass angiography.Methods. 7,616 medical records of patients with coronary artery disease who underwent isolated CABG in the period from 2012 to 2019 at the Federal Center for Cardiovascular Surgery were reviewed. Of them, 103 (1.35%) patients underwent emergency coronary artery bypass graft angiography in the early postoperative period to verify signs of myocardial damage. Patients were assigned to two groups based on angiographic findings and selected treatment strategy. Out of 75 patients, 57 patients from Group 1 had no severe angiographic signs of occlusive changes of the grafts and native arteries. But 18 patients reported failed graft and required conservative management. Group 2 (n = 28) included patients who had failed coronary artery bypass grafts according to angiography findings. 20 patients underwent endovascular treatment, and 8 patients underwent repeated surgery. The control group included 30 patients (0.39%) without any signs of ischemic myocardial damage. Intraoperative flow was assessed as well as postoperative electrocardiographic and echocardiographic records. Biochemical markers of myocardial damage were measured.Results. Blood flow velocity was less than 20 ml/min, and the pulsatility index exceeded 3.0 according to the intraoperative flow assessment of coronary artery bypass grafts with impaired blood flow according to angiography findings. There was no relationship found between ischemic changes according to ECG, ECHO-CG, and angiographic findings. Significant differences were found in troponin I levels between Group 1 (patients with coronary artery graft dysfunction) and the control group (Group 3) at all time intervals (1, 6, 12, 24 and 48 hours).Conclusion. The predictors of failed coronary artery bypass grafts in the early postoperative period allowed identifying indications to emergency angiography.Цель. Определение показаний к проведению неотложной коронарошунтографии (КШГ) после аортокоронарного шунтирования. Материалы и методы. Проведен ретроспективный анализ данных 7 616 пациентов с ишемической болезнью сердца, которым в ФГБУ «ФЦССХ» Минздрава России (г. Челябинск) с 2012 по 2019 г. выполнено изолированное аортокоронарное шунтирование. Проанализированы все пациенты, подвергшиеся неотложной КШГ в связи с появлением в раннем послеоперационном периоде признаков повреждения миокарда (n = 103; 1,35%). В зависимости от вида ангиографических находок и выбранной лечебной тактики сформированы две группы. В I группе (n = 75) у 57 пациентов гемодинамически значимых ангиографических дефектов шунтов и нативных артерий не выявлено, у 18 больных таковые дефекты отмечены, всем участникам применена консервативная терапия. Во II группу (n = 28) вошли пациенты, у которых по данным КШГ отмечены ангиографические дефекты в зоне крупных шунтированных коронарных артерий: 20 пациентам проведено эндоваскулярное лечение, 8 - повторное «открытое» хирургическое вмешательство. В III, контрольную, группу вошли 30 пациентов (0,39%) без признаков ишемического повреждения миокарда. Проанализированы данные интраоперационного флоуметрического контроля, послеоперационного электро- и эхокардиографического исследований, а также значения биохимических маркеров повреждения миокарда.  При ретроспективном анализе интраоперационных флоуметрических показателей коронарных шунтов с нарушенным кровотоком по данным КШГ скорость кровотока составила менее 20 мл/мин, а пульсовой индекс превышал 3,0.Результаты. Устойчивой связи между ишемическими изменениями, зафиксированными на ЭКГ и ЭхоКГ, и ангиографическими данными не обнаружено. При сравнительном анализе значений тропонина у пациентов I группы (группа с нарушением функции коронарных шунтов) и группы контроля (группа III) выявлены достоверные отличия во всех временных интервалах (1, 6, 12, 24 и 48 ч).Заключение. Совокупность выявленных предикторов дисфункции коронарных шунтов в раннем послеоперационном периоде аортокоронарного шунтирования позволяет определить показания к проведению неотложной КШГ

Stereo sensitivity of exchange interactions in Ni^II and Cu^II heterospin complexes with 5-formylpyrrolyl-substituted nitroxides

© 2016, Springer Science+Business Media New York.5-Formylpyrrolyl-substituted nitronyl and imino nitroxide radicals HL1 and HL2 were synthesized. Their solid phases are formed by packing pairs of the molecules. In the {HL1..HL1} pairs, the dominant interaction is the ferromagnetic exchange with J/kB = 8.8 K (Hamiltonian H= 2 J(s1→ · s2→)). The ferromagnetic exchange occurs also in the heterospin molecules [Ni(L1)2], [Cu(L1)2], and [Ni(L2)2(MeOH)2]. In the complexes [Ni(L1)2] and [Cu(L1)2], a small change in the mutual orientation of the coordinated ligands has a considerable effect on the value and the sign of the energy of exchange interactions between the unpaired electrons of the metal ion and paramagnetic ligands