One-loop Neutron Electric Dipole Moment from Supersymmetry without R-parity

We present a detailed analysis together with exact numerical calculations on one-loop contributions to neutron electric dipole moment from supersymmetry without R-parity, focusing on the gluino, chargino, and neutralino contributions. Apart from the neglected family mixing among quarks, complete formulae are given for the various contributions, through the quark dipole operators, to which the present study is restricted. We discuss the structure and main features of the R-parity violating contributions and the interplay between the R-parity conserving and violating parameters. In particular, the parameter combination $\mu_i^*\lambda^{\prime}_{i11}$, under the optimal parametrization adopted, is shown to be solely responsible for the R-parity violating contributions in the supersymmetric loop diagrams. While $\mu_i^*\lambda^{\prime}_{i11}$ could bear a complex phase, the latter is not necessary to have a R-parity violating contribution.Comment: 43 pages Revtex with 15 eps- and 4 ps- figure files incoporated; proofread version to be published in Phys. Rev.

An assessment of the Indian Ocean mean state and seasonal cycle in a suite of interannual CORE-II simulations

We present an analysis of annual and seasonal mean characteristics of the Indian Ocean circulation and water masses from 16 global ocean–sea-ice model simulations that follow the Coordinated Ocean-ice Reference Experiments (CORE) interannual protocol (CORE-II). All simulations show a similar large-scale tropical current system, but with differences in the Equatorial Undercurrent. Most CORE-II models simulate the structure of the Cross Equatorial Cell (CEC) in the Indian Ocean. We uncover a previously unidentified secondary pathway of northward cross-equatorial transport along 75 °E, thus complementing the pathway near the Somali Coast. This secondary pathway is most prominent in the models which represent topography realistically, thus suggesting a need for realistic bathymetry in climate models. When probing the water mass structure in the upper ocean, we find that the salinity profiles are closer to observations in geopotential (level) models than in isopycnal models. More generally, we find that biases are model dependent, thus suggesting a grouping into model lineage, formulation of the surface boundary, vertical coordinate and surface salinity restoring. Refinement in model horizontal resolution (one degree versus degree) does not significantly improve simulations, though there are some marginal improvements in the salinity and barrier layer results. The results in turn suggest that a focus on improving physical parameterizations (e.g. boundary layer processes) may offer more near-term advances in Indian Ocean simulations than refined grid resolution

Measurement of a small atmospheric νμ/νe\nu_\mu/\nu_e ratio

From an exposure of 25.5~kiloton-years of the Super-Kamiokande detector, 900 muon-like and 983 electron-like single-ring atmospheric neutrino interactions were detected with momentum $p_e > 100$ MeV/$c$, $p_\mu > 200$ MeV/$c$, and with visible energy less than 1.33 GeV. Using a detailed Monte Carlo simulation, the ratio $(\mu/e)_{DATA}/(\mu/e)_{MC}$ was measured to be $0.61 \pm 0.03(stat.) \pm 0.05(sys.)$, consistent with previous results from the Kamiokande, IMB and Soudan-2 experiments, and smaller than expected from theoretical models of atmospheric neutrino production.Comment: 14 pages with 5 figure

Uncertainty estimates in regional and global observed temperature changes: A new data set from 1850

The historical surface temperature data set HadCRUT provides a record of surface temperature trends and variability since 1850. A new version of this data set, HadCRUT3, has been produced, benefiting from recent improvements to the sea surface temperature data set which forms its marine component, and from improvements to the station records which provide the land data. A comprehensive set of uncertainty estimates has been derived to accompany the data: Estimates of measurement and sampling error, temperature bias effects, and the effect of limited observational coverage on large-scale averages have all been made. Since the mid twentieth century the uncertainties in global and hemispheric mean temperatures are small, and the temperature increase greatly exceeds its uncertainty. In earlier periods the uncertainties are larger, but the temperature increase over the twentieth century is still significantly larger than its uncertainty

Modulation of metalloproteinase-9 in U87MG glioblastoma cells by A3 adenosine receptors.

In this work, we investigated the biological functions of adenosine (ado) in metalloproteinase-9 (MMP-9) regulation in U87MG human glioblastoma cells. The nucleoside was able to increase both MMP-9 mRNA and protein levels through A3 receptors activation. We revealed that A3 receptor stimulation induced an increase of MMP-9 protein levels in cellular extracts of U87MG cells by phosphorylation of extracellular signal-regulated protein kinases (ERK1/2), c-Jun N-terminal kinase/stress-activated protein kinase (pJNK/SAPK), protein kinase B (Akt/PKB) and finally activator protein 1 (AP-1). A3 receptor activation stimulated also an increase of extracellular MMP-9 in the supernatants from U87MG glioblastoma cells. Finally, the Matrigel invasion assay demonstrated that A3 receptors, by inducing an increase in MMP-9 levels, was responsible for an increase of glioblastoma cells invasion. Collectively, these results suggest that ado, through A3 receptors activation, modulates MMP-9 protein levels and plays a role in increasing invasion of U87MG cells

MODULATION OF MMP-9 IN U87MG GLIOBLASTOMA CELLS BY A3 ADENOSINE RECEPTORS

Adenosine (Ado) regulates a wide variety of physiological processes interacting with one or more of four known cell-surface receptors named A1, A2A, A2B and A3. The development of potent A3 agonists and selective antagonists revealed that the A3 subtype plays a pivotal role in the ado-induced modulation of tumor cells biology and the A3 subtype has been found up-regulated in cancer.1,2 Local invasive growth is one of the key features of primary brain tumors and metalloproteinases (MMPs) play a major role in promoting tumor metastasis. The involvement of ado in the regulation of MMP-9 in tumor cells have not been investigated by now. In this work, we investigated the biological functions of adenosine (ado) in metalloproteinase-9 (MMP-9) regulation in U87MG human glioblastoma cells. The nucleoside was able to increase both MMP-9 mRNA and protein levels through A3 receptors activation. We revealed that A3 receptor induced an increase of MMP-9 protein levels by phosphorylation of extracellular signal-regulated protein kinase (ERK1/2), c-Jun N-terminal kinase/stress-activated protein kinase (pJNK/SAPK), protein kinase B (Akt/PKB) and finally activator protein 1 (AP-1). A3 receptor activation stimulated also an increase of MMP-9 secretion and activity in supernatants from U87MG glioblastoma cells. Finally, the Matrigel invasion assay demonstrated that A3 receptors, by inducing an increase in MMP-9 levels, was responsible for an increase of glioblastoma cells invasion. Collectively, these results suggest for the first time that ado, through A3 receptors activation, modulates MMP-9 protein levels and plays a role in inducing invasion of U87MG cells. (1) Gessi, S.; Merighi, S.; Varani, K.; Leung, E.; Mac Lennan, S.; Borea, P.A. The A3 adenosine receptor: an enigmatic player in cell biology. Pharmacol. Ther. 2008, 117, 123-40. (2) Gessi, S.; Cattabriga, E.; Avitabile, A.; Gafa', R.; Lanza, G.; Cavazzini, L.; Bianchi, N.; Gambari, R.; Feo, C.; Liboni, A.; Gullini, S.; Leung, E.; Mac-Lennan, S.; Borea, P.A. Elevated expression of A3 adenosine receptors in human colorectal cancer is reflected in peripheral blood cells. Clin. Cancer Res. 2004, 10, 5895-901

Erratum to Regional hydrological cycle changes in response to an ambitious mitigation scenario

International audienceUnfortunately, in the aforementioned contribution, Fig. 5 (Monthly multi-model (mean and range) precipitation change (mm/day) for 2080–2099 minus 1980–1999 averaged over the 26 regions, E1 (black) and A1B (grey) scenarios) contains an error. For two of the contributing models (ECHAM5-C and INGVCE) the evapotranspiration data had the wrong sign, leading to an opposing annual cycle in these models compared to the other models. The corrected Fig. 5 is presented here. It can be seen that the annual cycles of the climate change signals in evapotranspiration in the two scenarios agree much better between the different models than previously estimated. The general picture clearly underscores the findings from the preceding Figs. 3 and 4 that the climate change signals are much reduced under the E1 scenario compared to the A1B scenario. This is true for the ensemble properties (means, percentiles, ..

Results on θ13 Neutrino Oscillations from Reactor Experiments

Definitive measurements of the smallest neutrino mixing angle θ13 were made by Daya Bay, Double Chooz and RENO in 2012, based on the disappearance of electron antineutrinos emitted from reactors. The new generation reactor experiments have significantly improved a sensitivity for θ13 down to the sin2(2θ13)~0.01 level using two identical detectors of 10 ~ 40 tons at near (300 ~ 400 m) and far (1 ~ 2 km) locations. The θ13 measurements by the three reactor experiments are presented with their future expected sensitivities